Glucocorticoid Receptor 

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  • ||||||||||  mirtazapine / Generic mfg.
    Trial completion date, Trial primary completion date:  Mirtazapine Versus Dexamethasone in Preventing Postoperative Nausea and Vomiting (clinicaltrials.gov) -  Aug 5, 2022   
    P1,  N=90, Recruiting, 
    Initiation date: Jul 2022 --> Apr 2022 Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022
  • ||||||||||  morphine sulphate / Generic mfg.
    Trial completion date, Trial primary completion date, Surgery:  LUMBES: Lumbar Erector Spinae Plane Block for Back Surgery (clinicaltrials.gov) -  Aug 5, 2022   
    P3,  N=80, Recruiting, 
    Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022 Trial completion date: Dec 2021 --> Dec 2023 | Trial primary completion date: Dec 2021 --> Dec 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Enrollment open:  Perineural Dexamethasone for Continuous Femoral Nerve Block (clinicaltrials.gov) -  Aug 5, 2022   
    P=N/A,  N=80, Recruiting, 
    Trial completion date: Jul 2022 --> Jul 2023 Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal:  Hospital-Acquired Infections among Adult Patients Admitted for COVID-19. (Pubmed Central) -  Aug 5, 2022   
    In a multicenter cohort of 963 adults hospitalized due to COVID-19, 5% had a proven hospital-acquired infection (HAI) and 21% had a proven/probable or possible HAI. Risk factors for proven/probable HAIs included intensive care unit admission, dexamethasone use, severe COVID-19, heart failure and antibiotic exposure upon admission.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Hair cortisol levels in schizophrenia and metabolic syndrome. (Pubmed Central) -  Aug 5, 2022   
    In a subgroup of schizophrenia patients, psychosis may be associated with a blunted HPA axis with lower long-term cortisol output. MetS was associated with an increase in HCC and elevated cortisol levels observed in schizophrenia may be related to increased rates of MetS in schizophrenia patients.
  • ||||||||||  Spikevax (elasomeran) / Moderna
    Journal:  New-onset kidney biopsy-proven IgA vasculitis after receiving mRNA-1273 COVID-19 vaccine: case report. (Pubmed Central) -  Aug 5, 2022   
    Over the following 2-week period, serum creatinine level improved from 1.24 to 1.06 mg/dL and proteinuria decreased from 2.98 to 0.36 g/g Cr, though occult blood persisted. Findings in the present case indicate that new-onset IgA vasculitis after receiving mRNA-1273 COVID-19 vaccine can be treated with corticosteroid therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Magnesium isoglycyrrhizinate alleviate airway inflammatory responses in ovalbumin-induced mouse model of allergic asthma. (Pubmed Central) -  Aug 5, 2022   
    Subsequently, mice sensitized with OVA were randomly assigned into fourgroups: asthma model group (MDL), dexamethasone group (DXM), MgIG group (MgIG), and normal mice were used as normal control (CON)...Also, an increase of NLRP3 and Caspase-1 protein levels were suppressed by MgIG treatment. Our study findings support that nebulizer inhalation of MgIG as an effective therapy in treating the allergy induced asthma.
  • ||||||||||  clobetasol propionate topical / Generic mfg.
    Journal:  Application of E model to assess the potency of topical corticosteroid products. (Pubmed Central) -  Aug 5, 2022   
    This reversal of potency may be attributed to the effect of formulation factors. The comparison of the potencies of TCPs with inherent potencies of their corresponding TCs confirmed the influence of formulation parameters on the potency of those products.
  • ||||||||||  Veramyst (fluticasone furoate nasal spray) / GSK
    Journal:  Inhaled glucocorticoid-induced metabolome changes in asthma. (Pubmed Central) -  Aug 5, 2022   
    Dose-dependent metabolomic changes occurred with inhaled GCs but were seen predominately at highest/supratherapeutic doses, supporting the safety of low and mid therapeutic doses. At comparable therapeutic doses (FF 100, FP 500 and BUD 800 µg/day), FF had the least effect on the most sensitive markers (adrenal steroids) vs BUD and FP.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Journal:  Subtype-specific pattern of white blood cell differential in endogenous hypercortisolism. (Pubmed Central) -  Aug 5, 2022   
    Total leukocytes and neutrophils correlated positively with serum cortisol after 1-mg dexamethasone (r = 0.314 and r = 0.428), while a negative correlation was observed for lymphocytes and eosinophils (r = -0.374 and r= -0.380) (each P < 0.0001)...Most immune cells correlate with the degree of hypercortisolism and differ among CS subtypes. WBCD changes are already identified 3 months after remission from endogenous hypercortisolism.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Commentary: Dexamethasone and dilemma. (Pubmed Central) -  Aug 5, 2022   
    By contrast, DR-HC treatment is associated with improvement of BMD. No abstract available
  • ||||||||||  Simulect (basiliximab) / Novartis, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Experiences of performing ABO-incompatible kidney transplantation in Bangladesh. (Pubmed Central) -  Aug 4, 2022   
    All patients received basiliximab for induction therapy...Two patients were suspected of having developed acute rejection and received intravenous methylprednisolone, resulting in improved kidney function...ABOi KT in Bangladesh will substantially expand the living kidney donor pool and bring hope to a large number of ESRD patients without ABO-compatible donors. However, the high cost and risk of acute rejection and infection remain major concerns.
  • ||||||||||  dexamethasone / Generic mfg.
    Trial completion date, Trial primary completion date:  EARLYDEXCoV2: DEXamethasone EARLY Administration in Hospitalized Patients With Covid-19 Pneumonia (clinicaltrials.gov) -  Aug 4, 2022   
    P3,  N=126, Recruiting, 
    The predictors of this association included medication factors and patient characteristics, among which eosinophil counts ≥ 200/μL was the strongest predictor. Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Mar 2022 --> Sep 2022
  • ||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen, Rylaze (recombinant Erwinia asparaginase) / Jazz
    Trial completion date, Trial primary completion date:  A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia (clinicaltrials.gov) -  Aug 4, 2022   
    P2,  N=200, Recruiting, 
    Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Mar 2022 --> Sep 2022 Trial completion date: Jun 2027 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Retrospective data, Journal:  Effectiveness of methylprednisolone therapy in patients with a high-risk common type of COVID-19 pneumonia: a retrospective cohort study. (Pubmed Central) -  Aug 4, 2022   
    Patients in the SDT + MPT group treated with methylprednisolone received an intravenous injection for a median interval of five days (interquartile range of 3 to 7 days)...The 16-day nucleic acid negative rate was higher in the SDT + MPT group than in the SDT group, 81.73% (104/127) versus 65.27% (180/276) (p = 0.0006). MPT effectively prevents patients with HRCT COVID-19 pneumonia from progressing to the severe stage.
  • ||||||||||  Proleukin (aldesleukin) / Clinigen, Novartis, Prometheus, ZFN modified T cell (SB-313) / Sangamo Therap
    Journal, CAR T-Cell Therapy:  Off-the-shelf, Steroid Resistant, IL13Rα2-Specific CAR T Cells for Treatment of Glioblastoma. (Pubmed Central) -  Aug 4, 2022   
    These results led to the rational design of a clinical trial. This first-in-human experience establishes a foundation for future adoptive therapy studies using off-the-shelf, zinc-finger modified, and/or glucocorticoid resistant CAR T cells.
  • ||||||||||  prednisolone / Generic mfg.
    Journal:  A case of localized fasciitis with ulcerative colitis (Pubmed Central) -  Aug 4, 2022   
    We administered 60 mg (1.0 mg/kg/day) of prednisolone orally on day 9 and the pain and swelling in both legs promptly resolved...Gastrocnemius myalgia syndrome, which causes pain and localized fasciitis, is often reported as a complication of Crohn's disease but is rare in conjunction with ulcerative colitis. It is important that clinicians are aware of this syndrome so it can be recognized early and successfully treated.
  • ||||||||||  clobetasol propionate topical / Generic mfg.
    PK/PD data, Journal:  Fitting Pharmacodynamic Data to the E Model to Assess the Inherent Potency of Topical Corticosteroids. (Pubmed Central) -  Aug 4, 2022   
    The application of the VCA to classify inherent potency provides a reliable method to establish a classification system for TCs. Inherent potency assessment of TCs provides information that will be useful when choosing an appropriate TC for the development of a TCP for a specific clinical indication.
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Prediction Model for Croup Admission Need. (Pubmed Central) -  Aug 4, 2022   
    Inherent potency assessment of TCs provides information that will be useful when choosing an appropriate TC for the development of a TCP for a specific clinical indication. The croup admission need predictive model appears to support clinical decision making in the ED, with the potential to improve decision making when pediatric expertise is limited.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Journal:  Clinical course and imaging characteristics of benign adrenal cysts: a single-center study of 92 patients. (Pubmed Central) -  Aug 4, 2022   
    On hormonal evaluation, 10% (5/50 tested) had an abnormal overnight dexamethasone suppression test, and 9.5% (4/42 tested) had an abnormal case detection testing for primary aldosteronism...Benign adrenal cysts are usually incidentally discovered, non-functional, homogenous lesions without vascular enhancement that demonstrate minimal growth. Adrenalectomy should be reserved for patients with heterogeneous lesions, abnormal hormonal evaluation, or those with mass effect symptoms.