Glucocorticoid Receptor 

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  • ||||||||||  dordaviprone (ONC201) / Chimerix
    Trial primary completion date:  Oral ONC201 in Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Aug 9, 2022   
    P1/2,  N=21, Active, not recruiting, 
    Trial primary completion date: Jun 2022 --> Sep 2022
  • ||||||||||  triamcinolone acetonide topical / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date, Surgery:  Safety and Effectiveness of Drop-free Small Incision Cataract Surgery (clinicaltrials.gov) -  Aug 9, 2022   
    P=N/A,  N=100, Not yet recruiting, 
    Trial primary completion date: Jun 2022 --> Sep 2022 Trial completion date: Nov 2022 --> Feb 2023 | Initiation date: Jun 2022 --> Oct 2022 | Trial primary completion date: Nov 2022 --> Feb 2023
  • ||||||||||  carfilzomib / Generic mfg.
    Trial completion date, Trial primary completion date:  CarMob: Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma (clinicaltrials.gov) -  Aug 9, 2022   
    P1,  N=18, Recruiting, 
    Trial completion date: Nov 2022 --> Feb 2023 | Initiation date: Jun 2022 --> Oct 2022 | Trial primary completion date: Nov 2022 --> Feb 2023 Trial completion date: Jun 2022 --> Feb 2023 | Trial primary completion date: Jun 2022 --> Feb 2023
  • ||||||||||  Neupogen (filgrastim) / Kyowa Kirin, Amgen
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  GraCiAH: Efficacy and Safety of G-CSF in Patients With Severe Alcoholic Hepatitis With Null or Partial Response to Steroid (clinicaltrials.gov) -  Aug 8, 2022   
    P3,  N=64, Terminated, 
    Trial completion date: Feb 2023 --> Aug 2024 | Trial primary completion date: Feb 2022 --> Aug 2023 N=268 --> 64 | Trial completion date: Dec 2022 --> Jul 2022 | Recruiting --> Terminated | Trial primary completion date: Apr 2022 --> Jul 2022; failure to recruit eligible patients
  • ||||||||||  dexamethasone / Generic mfg.
    Trial primary completion date:  Anosmia and / or Ageusia and Early Corticosteroid Use (clinicaltrials.gov) -  Aug 8, 2022   
    P4,  N=300, Recruiting, 
    N=268 --> 64 | Trial completion date: Dec 2022 --> Jul 2022 | Recruiting --> Terminated | Trial primary completion date: Apr 2022 --> Jul 2022; failure to recruit eligible patients Trial primary completion date: Jun 2022 --> Oct 2022
  • ||||||||||  Adcetris (brentuximab vedotin) / Takeda, Pfizer, Matulane (procarbazine hydrochloride) / Leadiant Biosci
    Trial primary completion date, Metastases:  Uni-Koeln-1762: HD21 for Advanced Stages (clinicaltrials.gov) -  Aug 8, 2022   
    P3,  N=1500, Recruiting, 
    Trial primary completion date: Jun 2022 --> Oct 2022 Trial primary completion date: Jun 2021 --> Dec 2022
  • ||||||||||  Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis
    Journal:  Legal obligation in the general population: face mask influence on endophthalmitis after intravitreal injection. (Pubmed Central) -  Aug 7, 2022   
    Although some potential confounders (wearing time, skin flora) could not be considered, there was no clear signal that the introduction of compulsory face masking in public life did alter the risk for PIE in our patient population. Three and six months after PIE, no difference in visual acuity was detectable between the two study periods.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg., cyclophosphamide / Generic mfg.
    Chronic Ocular Redness And Pain In A 59 Y/O Woman (Screen # 2) -  Aug 7, 2022 - Abstract #PANLAR2022PANLAR_346;    
    The patient was discharged home 15 days later, but did not return to the rheumatology clinic Image 1 Image 2 Conclusion The most common ocular manifestations of AAV include granulomatous orbital or retroorbital masses, anterior segment inflammation, retinal vasculitis or optic neuritis. Scleritis can manifest as hyperemia in the anterior portion of the eye, pain with eye movement differentiates this diagnosis from episcleritis.
  • ||||||||||  Polymyositis In A Patient With Cutaneous Sarcoidosis And Chronic Right-Sided Neurologic Deficit: A Case Report (Screen # 3) -  Aug 7, 2022 - Abstract #PANLAR2022PANLAR_298;    
    The patient underwent intense physical therapy before being discharged, and continues to receive monthly IVIG, daily prednisone 30mg, and weekly methotrexate 15mg presently...However, the biopsy was performed several months after symptoms began, and sporadic inclusion body myositis is not completely ruled out. Patient should also be considered for undergoing anti-NT5c1A autoantibody test.
  • ||||||||||  Journal:  Asia Pacific perspectives on the second year of the COVID-19 pandemic: A follow-up survey. (Pubmed Central) -  Aug 7, 2022   
    Mass spectrometry suggests that the potential adjusted CR rate could reach an unprecedented 45.8% of patients treated in Isa-Kd. With access to internationally recommended standards of care including public health preventive measures, therapeutics and vaccines among most APAAACI member countries, much progress has been made over the 2-year period in minimizing the morbidity and mortality from COVID-19 disease.
  • ||||||||||  fluocinolone acetonide / Generic mfg., dexamethasone injection / Generic mfg.
    Retrospective data, Journal:  Foveal eversion patterns in diabetic macular edema. (Pubmed Central) -  Aug 7, 2022   
    Foveal eversion patterns were correlated with progressively worse DME outcome. Foveal eversion may be associated to the loss of foveal homeostasis, with consequent poor response to intravitreal treatments and worse DME outcome.
  • ||||||||||  bleomycin / Generic mfg.
    Journal:  Efficacy and safety of ultrasound-guided bleomycin combined with dexamethasone in the treatment of pediatric lymphangiomas. (Pubmed Central) -  Aug 6, 2022   
    Although there was no significant difference in the recurrence rate between the two groups, this retrospective study demonstrated that the excellent response rates were dramatically improved between the two groups, suggesting that bleomycin combined with DEX was an effective and highly safe treatment for all types of pediatric lymphangiomas. Moreover, this study also identified three novel features as the significant risk factors for recurrence.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Jacareubin inhibits TLR4-induced lung inflammatory response caused by the RBD domain of SARS-CoV-2 Spike protein. (Pubmed Central) -  Aug 6, 2022   
    S-RBD domain promotes lung TNF-α and IL-6 production in a TLR4-dependent fashion in C57BL6/J mice. Xanthone Jacareubin possesses potential anti-COVID-19 properties that, together with the previously tested anti-inflammatory activity, safety, and tolerance, make it a valuable drug to be further investigated for the treatment of cytokine production caused by SARS-CoV-2 infection.
  • ||||||||||  Retrospective data, Journal:  Efficacy and safety of modified hemophagocytic lymphohistiocytosis 04 regimen in Beijing Children's Hospital (Pubmed Central) -  Aug 6, 2022   
    Compared with the control group, fewer children in the modified group died as a result of side effects from chemotherapy (8.0% (2/25) vs.30.3% (10/33), χ=4.31, P=0.038). The BCH modified HLH-04 regimen reduced the intensity of chemotherapy, with overall efficacy no worse than the standard HLH-04 regimen, and significantly reduced the rate of chemotherapy-related myelosuppression, fungal infection and mortality.
  • ||||||||||  dexamethasone / Generic mfg., carboplatin / Generic mfg., paclitaxel / Generic mfg.
    Journal, IO biomarker:  Improved T cell immunity following neoadjuvant chemotherapy in ovarian cancer. (Pubmed Central) -  Aug 6, 2022   
    NACT may alleviate tumor-associated immunosuppression by reducing tumor burden and may enhance antigen processing and presentation. These findings have implications for the successful combinatorial applications of immune checkpoint blockade and therapeutic vaccine approaches in EOC.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Recurrent pulmonary infection leads to the diagnosis of triple A syndrome: a case report. (Pubmed Central) -  Aug 6, 2022   
    This syndrome is often misdiagnosed, especially in regions where it is expected to have a high prevalence rate (regions with documented cases and high rate of consanguinous marriage), This study is the first documentation of triple A syndrome in Syria, a country where consanguineous marriage is common. This syndrome should be kept in mind when a child presents with one or more of its characteristic features.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Mimicking chronic glaucoma over 6 months with a single intracameral injection of dexamethasone/fibronectin-loaded PLGA microspheres. (Pubmed Central) -  Aug 6, 2022   
    In conclusion, a new chronic glaucoma animal model was created by a single injection of MsDexaFibro very similar to open-angle glaucoma occurring in humans. This model would impact in different fields such as ophthalmology, allowing long period of study of this pathology; pharmacology, evaluating the neuroprotective activity of active compounds; and pharmaceutical technology, allowing the correct evaluation of the efficacy of long-term sustained ocular drug delivery systems.
  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Journal:  The variation of antenatal corticosteroids administration for the singleton preterm birth in China, 2017 to 2018. (Pubmed Central) -  Aug 6, 2022   
    This model would impact in different fields such as ophthalmology, allowing long period of study of this pathology; pharmacology, evaluating the neuroprotective activity of active compounds; and pharmaceutical technology, allowing the correct evaluation of the efficacy of long-term sustained ocular drug delivery systems. The ACS exposure was variable among maternity hospitals and quality improvement of ACS administration is warranted.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Should dexamethasone alone or in combination be the initial steroid for adult ITP: Still a relevant question. (Pubmed Central) -  Aug 6, 2022   
    Across the studies, treatment with high-dose dexamethasone seems to be safer, with lower incidence of all adverse events compared to PDN, which might be a reflection of shorter treatment duration and possibly also lower cumulative steroid dose. Dexamethasone in combination with rituximab in first-line treatment produced higher response rates with better long-term results compared to high-dose dexamethasone alone and is a particularly good option in younger women.