Glucocorticoid Receptor 

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  • ||||||||||  diphenhydramine / Generic mfg., hydrocortisone / Generic mfg., epinephrine / Generic mfg.
    Protamine Reaction In A Patient Undergoing Transcatheter Aortic Valve Replacement (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_1766;    
    In the setting of a presumed allergic reaction to Protamine, hydrocortisone, and diphenhydramine were also administered. Patient recovered and was discharged home two days later.
  • ||||||||||  dexamethasone injection / Generic mfg., ropivacaine / Generic mfg.
    Comparison Of Low Dose Versus High Dose Of Dexamethasone As Adjuvant Of Caudal Block For Children Undergoing Surgery (Virtual - Mobile App) -  Aug 15, 2022 - Abstract #ASA2022ASA_1236;    
    Introduction Administration of intravenous (IV) dexamethasone is known to increase the duration of neuraxial block and improve the quality of analgesia...The caudal block was conducted before surgery, and 1.2ml/kg of 0.15% ropivacaine was administered...Conclusions In present study, administration of low dose dexamethasone showed comparable effects on caudal block as high dose of dexamethasone. A total of 274 patients will be enrolled.
  • ||||||||||  dexamethasone / Generic mfg., ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    No Room To Breathe (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_1061;    
    The surgery proceeded uneventfully with edema improvement after local infiltration with dexamethasone and adrenaline. After a successful cuff leak test the patient was extubated and discharged on POD4, after a 3-day course of methylprednisolone.
  • ||||||||||  hydrocortisone / Generic mfg.
    Not So Local Steroid Injections (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_1051;    
    Her hypotension resolved following hydrocortisone administration. Chronic pain patients should be screened preoperatively regarding recent steroid injections and evaluated for signs of hypothalamic-pituitary-adrenal axis suppression to avoid perioperative adrenal crisis.
  • ||||||||||  Caldolor (ibuprofen) / Grifols, Cumberland
    Angioedema During Elective Outpatient Procedure (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_978;    
    Patient was given Dexamethasone and transported to PACU while intubated and sedated with Dexmedetomidine. Patient was able to be extubated later that day.
  • ||||||||||  Intraoperative Grade 3 Anaphylaxis Following Induction For Neurovascular Procedure (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_957;    
    She underwent IV induction with midazolam, fentanyl, lidocaine, propofol, and rocuronium...Patient was given epinephrine, hydrocortisone, famotidine, and diphenhydramine...Patient was extubated and taken to the ICU for observation. Tryptase came back elevated.
  • ||||||||||  Bridion (sugammadex) / Merck (MSD)
    Isolated Bronchospasm After Sugammadex Administration (Hall C) -  Aug 15, 2022 - Abstract #ASA2022ASA_955;    
    She remained hemodynamically stable and had no skin urticaria. She was extubated in the OR and discharged home on POD1.
  • ||||||||||  Outcomes Of Non-opioid Analgesia In Adult Cardiac Surgical Patients: A Network Meta-analysis (Virtual - Mobile App) -  Aug 15, 2022 - Abstract #ASA2022ASA_443;    
    Other analgesics, including magnesium, clonidine, ketamine, dexamethasone, acetaminophen, pregabalin, and gabapentin also led to improvements in patient-important outcomes. Conversely, methylprednisolone and ketorolac were associated with an increased risk of MI and increased opioid consumption, respectively, though this should be interpreted with caution due to limited direct evidence.
  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    Cardiopulmonary Resucitation In A Pregnant With Guillain Barre Syndrome And Covid19: Case Report (Virtual - Mobile App) -  Aug 15, 2022 - Abstract #ASA2022ASA_306;    
    At the end, bilateral quadratus lumborum block (QL1) guided by US was indicated, with 0.25 levobupivacaine + 1% lidocaine, both with vasoconstrictor 20mL on each side...CPR reestablished the flow even before the arrival of the defibrillator, verified by pulse oximetry and capnography, leading to a quick outcome, which favored extubation in OR, and block for analgesic supplementation favored recovery. ICU discharge on the 1st postoperative day (PD), and hospital discharge on the 4PD with his newborn.
  • ||||||||||  fentanyl citrate / Generic mfg., prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Seeing Double! Anesthetic Management During The Delivery Of A High-risk Pregnant Patient With Myasthenia Gravis - A Case Report (Virtual - Mobile App) -  Aug 15, 2022 - Abstract #ASA2022ASA_303;    
    During this presentation, neurology was consulted and recommended starting pyridostigmine and a course of solumedrol...CSE was performed with 25 mcg of intrathecal fentanyl...There were no respiratory complications after dosing the intrathecal opioid and gradually loading the epidural with local anesthetic proved efficacious. Clear communication regarding intra-operative and post-operative contingency plans aided in the success of this high-risk delivery.
  • ||||||||||  Chirocaine (levobupivacaine) / Purdue, AbbVie
    Cardiopulmonary Resuscitation In A Pregnant With Guillain Barre Syndrome And COVID19: Case Report (Virtual - Mobile App) -  Aug 15, 2022 - Abstract #ASA2022ASA_298;    
    At the end, bilateral quadratus lumborum block (QL1) guided by US was indicated, with 0.25 levobupivacaine + 1% lidocaine, both with vasoconstrictor 20mL on each side...CPR reestablished the flow even before the arrival of the defibrillator, verified by pulse oximetry and capnography, leading to a quick outcome, which favored extubation in OR, and block for analgesic supplementation favored recovery. ICU discharge on the 1st postoperative day (PD), and hospital discharge on the 4PD with his newborn.
  • ||||||||||  hydrocortisone / Generic mfg., flutamide / Generic mfg.
    Trial completion date, Trial primary completion date, Combination therapy:  Three Drug Combination Therapy Versus Conventional Treatment of Children With Congenital Adrenal Hyperplasia (clinicaltrials.gov) -  Aug 15, 2022   
    P2,  N=62, Active, not recruiting, 
    Trial completion date: Jan 2024 --> Jun 2024 | Trial primary completion date: Jan 2022 --> Dec 2023 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  dexamethasone / Generic mfg., gemcitabine / Generic mfg.
    PK/PD data, Journal:  An integrated PK/PD model investigating the impact of tumor size and systemic safety on animal survival in SW1990 pancreatic cancer xenograft. (Pubmed Central) -  Aug 14, 2022   
    Only the mice with good tumor growth inhibition and relatively stable NBW had an improved survival result after DEX and GEM combination therapy, and the simulations based on the parametric TTE model showed that NBW played more important role in animals' survival compared with tumor size. The established model in this study demonstrates that tumor size was not always the most important reason for cancer-related death, and parametric survival analysis together with safety issues was also important in the evaluation of oncology therapies in preclinical studies.
  • ||||||||||  GLY-200 / Glyscend, Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma
    Retrospective data, Journal:  Comparing the Efficacy and Safety Profile of Triple Fixed-Dose Combinations in COPD: A Meta-Analysis and IBiS Score. (Pubmed Central) -  Aug 14, 2022   
    Treatment improved hyperglycaemia, insulin resistance and beta cell reduction induced by dexamethasone injections. All triple FDCs are effective and safe in COPD regardless of the regimen of administration (twice daily vs. once daily), with no relevant difference in the risk of CV SAEs and pneumonia.
  • ||||||||||  Journal:  Machine Learning Can Predict the Probability of Biologic Therapy in Patients with Inflammatory Bowel Disease. (Pubmed Central) -  Aug 14, 2022   
    In summary, this study reveals the advantages of ML-based models in predicting biologic therapy in IBD patients based on pre-treatment and demographic variables. There is a need for further studies in this regard that take into account individual patient characteristics, i.e., genetics and gut microbiota, to adequately address the challenges of finding optimal treatment strategies for patients with IBD.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Vitreoschisis and retinal detachment: New insight in proliferative vitreoretinopathy. (Pubmed Central) -  Aug 14, 2022   
    These findings indicate that dexamethasone may improve macular ischemia with no significant effects on peripapillary microvasculature in DME patients. The presence of p-VCRs seems to be associated with a higher incidence of PVR development and might also result in more complex RD recurrence, this suggests the need for more aggressive VCRs removal during the first surgery.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Preclinical, Journal:  Shifts in the intestinal microflora of meat rabbits in response to glucocorticoids. (Pubmed Central) -  Aug 14, 2022   
    The presence of p-VCRs seems to be associated with a higher incidence of PVR development and might also result in more complex RD recurrence, this suggests the need for more aggressive VCRs removal during the first surgery. It was concluded that glucocorticoids caused changes in the composition of intestinal microflora.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Adding Dexamethasone to Adductor Canal Block Combined with iPACK Block Improve Postoperative Analgesia of Total Knee Arthroplasty. (Pubmed Central) -  Aug 14, 2022   
    Taken together, this study demonstrated that antenatal dexamethasone exposure resulted in vascular adverse outcomes in male offspring that is linked to the increases of IP3R1 and Cav1.2 mediated by epigenetic modifications in the vasculature. Compared with using ropivacaine alone, ultrasonic guided ACB combined with iPACK using ropivacaine and dexamethasone could prolong the duration of postoperative analgesia and strength analgesic intensity and promote the early rehabilitation exercise of patients undergoing TKA.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Bidirectional regulation of BDE-47 on 3T3-L1 cell differentiation based on a restricted cubic spline model. (Pubmed Central) -  Aug 14, 2022   
    The methylisobutylxanthine, dexamethasone, and insulin method was used to study the effect of BDE-47 on the differentiation of 3T3-L1 cells...BDE-47 may induce adipocyte differentiation by activating PPARγ, resulting in the differential expression of genes related to the AMPK signaling pathway, insulin resistance, and other metabolic pathways. The highest and lowest-dose BDE-47 exposure groups had the greatest impact on adipocyte differentiation.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements. (Pubmed Central) -  Aug 14, 2022   
    Statistical differences were not found in treatment response by age groups, including dexamethasone induction, bone marrow (BM) smear status and minimal residual disease (MRD) level at different time points (TP), treatment-related mortality (TRM), or complete remission (CR) rate (P > 0.05); MRD levels monitored by FCM or PCR were unequal at the same TP...Seven patients quit, 15 patients relapsed, and the 5 yr cumulative relapse rate was 59.16 ± 9.16%; the 5 yr prospective EFS (pEFS) for patients who were included or excluded from the TRM group was 36.86 ± 8.48% or 40.84 ± 9.16%, respectively. Multivariate analysis for prognosis and hazard ratio was performed for 37 patients without TRM and revealed that an initial WBC count of > 300 × 10/L and a positive level of FCM-MRD were strongly related to a poor outcome for B-ALL patients with KMT2Ar (P < 0.05).
  • ||||||||||  hydroxychloroquine / Generic mfg., dexamethasone / Generic mfg., lopinavir/ritonavir / Generic mfg.
    Journal:  Should RECOVERY have used response adaptive randomisation? Evidence from a simulation study. (Pubmed Central) -  Aug 14, 2022   
    Deciding how to balance the needs of patients within a trial and future patients who have yet to fall ill is an important ethical question for the trials community to address. Response-adaptive randomisation deserves to be considered as a design feature in future trials of COVID-19 and other diseases.