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186 Products |
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1696 Diseases |  |
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- | triamcinolone acetonide / Generic mfg.
Journal: A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis. (Pubmed Central) - Aug 22, 2022
The intra-articular administration of blood cell secretome improved the clinical signs and scores of several clinical metrology instruments in dogs with hip OA, particularly when combined with triamcinolone. Further studies are required.
- | dexamethasone / Generic mfg.
Journal: Effect of dexamethasone on the growth and differentiation of osteoblast-like cells derived from the human alveolar bone. (Pubmed Central) - Aug 21, 2022
Human alveolar bone cells exhibit improved osteogenic efficacy in terms of osteogenic differentiation when cultured in the presence of dexamethasone. The cell number (total DNA content) decreased in the presence of dexamethasone; however, an increased differentiation of osteoblast-like cells was observed.
- | nintedanib / Generic mfg.
Journal: PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120. (Pubmed Central) - Aug 21, 2022
The cell number (total DNA content) decreased in the presence of dexamethasone; however, an increased differentiation of osteoblast-like cells was observed. This study provides new insights in high-risk Ph-like leukaemia and identifies a potential therapy for targeting PAX5-fusion poor risk group.
- dexamethasone / Generic mfg.
Use And Outcomes Of Dexamethasone For The Treatment Of Malignant Small Bowel Obstruction (mSBO) (SDCC - 6A - Upper) - Aug 21, 2022 - Abstract #ACSCLINCON2022ACS_CLINCON_535;
Dexamethasone was used in 1 in 4 mSBO admissions with some evidence of higher rates of mSBO resolution and lower rates of operative intervention. Given trial data and NCCN guidelines, more consistent use of dexamethasone for mSBO may represent an opportunity for quality improvement.
- hydrocortisone / Generic mfg.
Single centre use of Hydrocortisone granules (Alkindi) in children with Adrenal Insufficiency: the patient experience. (Session Room 6) - Aug 21, 2022 - Abstract #ESPE2022ESPE_169;
- amiodarone / Generic mfg.
The Dynamic Duo of Electrical and Thyroid Storm Caused by Amiodarone (Zone 4, Science and Technology Hall, Level 3; Poster Board no. 4108) - Aug 20, 2022 - Abstract #AHA2022AHA_6225;
Amiodarone is the most efficacious medication for VT. However, it is important to recognize possible life-threatening complications of this medication, such as AIT, which itself can exacerbate VT.
- |||| dexamethasone / Generic mfg.
Clinical, Combination therapy: Combination Therapy of Physical Activity and Dexamethasone for Cancer-Related Fatigue: A Phase II Randomized Double… https://t.co/DmLpi5lXW4 (Twitter) - Aug 20, 2022
- || dexamethasone / Generic mfg., acetazolamide / Generic mfg.
Loved hiking the Inca Trail in late May. Took acetazolamide and kept dexamethasone in my pocket like a good luck charm. Had weird dreams but no other effects hiking at 14,000 feet. We should have had a journal club at #MacchuPicchu (Twitter) - Aug 20, 2022
- remdesivir / Generic mfg., dexamethasone / Generic mfg.
To Cool or Not to Cool for Brugada Syndrome (Zone 4, Science and Technology Hall, Level 3; Poster Board no. 4188) - Aug 20, 2022 - Abstract #AHA2022AHA_5909;
His cardiac function normalized on repeat TTE and he was discharged home. We report a unique case of TTM use in a patient with BrS with VT secondary to infection with COVID-19, as a way to decrease fevers and prevent further triggering of VT.
- vamorolone (VBP15) / Santhera
Daily regimens of prednisone, deflazacort and vamorolone improve motor function similarly in patients with Duchenne muscular dystrophy (Poster area - Ballroom B1-B2) - Aug 20, 2022 - Abstract #WMS2022WMS_308;
In other efficacy measures (6-minute walk test, NSAA score, time to run/walk 10 meters velocity), comparable increases were seen in all three treatment groups, with no statistically significant differences between PDN vs VAM or DFZ vs VAM. These data show that daily regimens of prednisone, deflazacort and vamorolone have comparable effect in improving motor function in patients with DMD.
- vamorolone (VBP15) / Santhera
Results of a double-blind cross-over trial of vamorolone in DMD: A safer alternative to corticosteroids (Flash Poster Presentation areas - Ballroom or Ballroom Salon) - Aug 20, 2022 - Abstract #WMS2022WMS_291;
Placebo-treated participants in Period 1 that crossed over to vamorolone in Period 2 (delayed starters) showed an improvement in multiple efficacy outcomes after the switch to vamorolone. In summary, the trial showed compelling evidence of efficacy of vamorolone with improved safety compared to prednisone.
- methylprednisolone sodium succinate / Generic mfg.
Double seropositive inflammatory myositis with anti-PL-7 and anti-Mi-2 antibodies (Poster area - Ballroom B1-B2) - Aug 20, 2022 - Abstract #WMS2022WMS_191;
We started intravenous methylprednisolone, then transitioned to oral prednisolone...To date, the overlapping clinical features, pathogenesis, or treatment guideline for double MSAs in inflammatory myositis are not clear. Further studies will be needed to bring out better clinical outcomes.
- vamorolone (VBP15) / Santhera
Vamorolone has less impact than daily prednisone or deflazacort on height and body mass index in patients with Duchenne muscular dystrophy (DMD) (Poster area - Ballroom B1-B2) - Aug 20, 2022 - Abstract #WMS2022WMS_145;
After 2.5 years of treatment, large increases of BMI (>0.5, >0.75 or >1.0 SDS) were seen most frequently in DFZ and PDN groups and the change in BMI z-score was less with VAM than with PDN and DFL when the baseline BMI was taken into account (conditional BMI change analysis). In conclusion, this between study comparisons suggest that daily vamorolone has less effect of height and BMI than daily prednisone or deflazacort.
- vamorolone (VBP15) / Santhera
The spine fracture burden in boys with DMD treated with the novel dissociative steroid vamorolone versus deflazacort and prednisone (Flash Poster Presentation areas - Ballroom or Ballroom Salon) - Aug 20, 2022 - Abstract #WMS2022WMS_50;
VAM may be a bone-sparing strategy to improve muscle strength. Longer-term follow-up is needed to assess comparative effects on VF burden relative to muscle strength.
- ||| Venclexta (venetoclax) / Roche, AbbVie, dexamethasone / Generic mfg.
Clinical: At some point the treatment of AL with t(11;14) (approx 50% of cases) will be anti CD38 ab (like Dara/Isa) + bcl-2i (like venetoclax) + dexamethasone. That is the Tweet (Twitter) - Aug 19, 2022
- | mycophenolate mofetil / Generic mfg.
New trial: Clinical Analysis of Juvenile Dermatomyositis Patients (clinicaltrials.gov) - Aug 19, 2022
P=N/A, N=12, Completed, Sponsor: The First Hospital of Jilin University
- ribavirin / Generic mfg.
Successful ribavirin treatment of donor-transmitted acute hepatitis E infection in a liver transplant recipient () - Aug 19, 2022 - Abstract #BTS2022BTS_169;
It confirms that prompt HEV clearance from stool and blood can be achieved with ribavirin, even with post-transplant immunomodulation where viral clearance might be predicted to be delayed. Finally, it demonstrates that efficient communication between national transplant organisations and local units can positively influence post-transplant care.
- || Tazverik (tazemetostat) / Eisai, Ipsen, Rituxan (rituximab) / Roche
Trial primary completion date: Epi-RCHOP: Study of Tazemetostat in Newly Diagnosed Diffuse Large B Cell and Follicular Lymphoma Patients Treated by Chemiotherapy (clinicaltrials.gov) - Aug 19, 2022
P1/2, N=201, Recruiting, Sponsor: The Lymphoma Academic Research Organisation
Finally, it demonstrates that efficient communication between national transplant organisations and local units can positively influence post-transplant care. Trial primary completion date: Apr 2022 --> Sep 2022
- | dexamethasone injection / Generic mfg.
Trial completion date, Trial primary completion date: The Effect of Dexamethasone on Rebound Pain in Patients Receiving Ilioinguinal and Iliohypogastric Nerve Block (clinicaltrials.gov) - Aug 19, 2022
P=N/A, N=60, Recruiting, Sponsor: Karaman Training and Research Hospital
Trial primary completion date: Apr 2022 --> Sep 2022 Trial completion date: Aug 2022 --> Nov 2022 | Trial primary completion date: Jul 2022 --> Nov 2022
- |||||| iberdomide (CC-220) / BMS
Enrollment open, Trial completion date: EXCALIBER: Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) (clinicaltrials.gov) - Aug 19, 2022
P3, N=864, Recruiting, Sponsor: Celgene
Trial completion date: Aug 2022 --> Nov 2022 | Trial primary completion date: Jul 2022 --> Nov 2022 Not yet recruiting --> Recruiting | Trial completion date: Feb 2031 --> May 2029
- || Venclexta (venetoclax) / Roche, AbbVie, Blincyto (blinatumomab) / Astellas, Amgen, Rituxan (rituximab) / Roche
Enrollment open, Combination therapy: NCI-2021-01791: Venetoclax, Dasatinib, Prednisone, Rituximab and Blinatumomab for the Treatment of Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Mixed Phenotype Acute Leukemia (clinicaltrials.gov) - Aug 19, 2022
P1, N=20, Recruiting, Sponsor: OHSU Knight Cancer Institute
Not yet recruiting --> Recruiting | Trial completion date: Feb 2031 --> May 2029 Not yet recruiting --> Recruiting
- | dexamethasone / Generic mfg., ondansetron intravenous / Generic mfg., dexamethasone injection / Generic mfg.
Trial completion, Trial completion date: Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy (clinicaltrials.gov) - Aug 19, 2022
P3, N=96, Completed, Sponsor: Hospital for Special Surgery, New York
Not yet recruiting --> Recruiting Active, not recruiting --> Completed | Trial completion date: Dec 2021 --> Sep 2021
- | Nplate (romiplostim) / Amgen, Kyowa Kirin
New P3 trial: Clinical study in order to compare the effectiveness and safety of two different treatments in patients with newly diagnosed primary immune thrombocytopenia Estudio cl (EUDRACT) - Aug 18, 2022
P3, N=126, Ongoing, Sponsor: FISEVI
- ||| fluticasone propionate ODT (APT-1011) / Ellodi Pharma
Trial primary completion date: Efficacy and Safety APT-1011 in Adult Subjects With Eosinophilic Esophagitis (EoE) (FLUTE-2) (clinicaltrials.gov) - Aug 18, 2022
P3, N=143, Active, not recruiting, Sponsor: Ellodi Pharmaceuticals, LP
Active, not recruiting --> Completed | Trial completion date: Dec 2021 --> Sep 2021 Trial primary completion date: Aug 2022 --> May 2022
- | dexamethasone / Generic mfg.
Trial completion date, Trial primary completion date: DEXAML-03: Dexamethasone in Refractory or First Relapsed Acute Myeloid Leukemia (clinicaltrials.gov) - Aug 18, 2022
P3, N=142, Recruiting, Sponsor: University Hospital, Toulouse
Trial primary completion date: Aug 2022 --> May 2022 Trial completion date: Sep 2024 --> Dec 2025 | Trial primary completion date: Sep 2024 --> Dec 2025
- | dexamethasone / Generic mfg.
Trial completion date, Surgery: SPIES: Surgery Prevention by Transforaminal Injection of Epidural Steroids for Cervical Radicular Pain (clinicaltrials.gov) - Aug 18, 2022
P4, N=65, Active, not recruiting, Sponsor: OrthoCarolina Research Institute, Inc.
Trial completion date: Sep 2024 --> Dec 2025 | Trial primary completion date: Sep 2024 --> Dec 2025 Trial completion date: Dec 2021 --> Dec 2022
- |||||||||| Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
New P3 trial: A Comparison of PT027 vs PT007 Used as Needed in Participants With Asthma (clinicaltrials.gov) - Aug 18, 2022
P3, N=1910, Not yet recruiting, Sponsor: Bond Avillion 2 Development LP
- ||||| cosibelimab (CK-301) / TG Therap, Fortress
Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy, Metastases: CONTERNO: Study of Pemetrexed+Platinum Chemotherapy With or Without Cosibelimab (CK-301) in First Line Metastatic Non-squamous Non-Small Cell Lung Cancer (clinicaltrials.gov) - Aug 18, 2022
P3, N=560, Active, not recruiting, Sponsor: Checkpoint Therapeutics, Inc.
Trial completion date: Dec 2021 --> Dec 2022 Recruiting --> Active, not recruiting | Trial completion date: May 2025 --> Dec 2025 | Trial primary completion date: May 2024 --> Dec 2024
- | Depocyte (liposomal cytarabine) / Mundipharma, Leadiant Biosci
Trial completion: Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt (clinicaltrials.gov) - Aug 18, 2022
P2/3, N=20, Completed, Sponsor: Goethe University
Recruiting --> Active, not recruiting | Trial completion date: May 2025 --> Dec 2025 | Trial primary completion date: May 2024 --> Dec 2024 Unknown status --> Completed
- | dexamethasone / Generic mfg.
Journal: Screening for strongyloidiasis in Spain in the context of the SARS-CoV-2 pandemic: Results of a survey on diagnosis and treatment. (Pubmed Central) - Aug 18, 2022
COVID-19 has highlighted the need to unify screening and treatment protocols for imported pathologies such as strongyloidiosis. Efforts to disseminate knowledge are needed to ensure that this potentially fatal disease is adequately treated in patients with the highest risk of complications, such as those with COVID-19.
- | bortezomib / Generic mfg., dexamethasone / Generic mfg., lenalidomide / Generic mfg.
Retrospective data, Journal: Efficacy and prognosis of newly diagnosed multiple myeloma patients treated with bortezomib, lenalidomide and dexamethasone (Pubmed Central) - Aug 18, 2022
VRD regimen has a promising efficacy and results in a substantial survival benefit. ASCT after VRD induction therapy is associated with higher rate of deep response, higher rate of undetectable MRD and longer survival.
- | dexamethasone / Generic mfg.
Journal: Establishment of a system evaluating the contractile force of electrically stimulated myotubes from wrinkles formed on elastic substrate. (Pubmed Central) - Aug 18, 2022
Notably, it was found that changes in the index related to contractile force can detect atrophic or hypertrophic phenotypes more sensitively than changes in myotube diameter or myosin heavy chain expression, both commonly used to evaluate myotube function. These results suggest that our proposed system will be an effective tool for assessing the contractile force-related state of myotubes, which are available for the development of drugs to prevent and/or treat muscle weakness.
- | dexamethasone / Generic mfg.
Journal: The longitudinal association of sleep and 24-hour activity rhythms with cortisol response to a very low dose of dexamethasone. (Pubmed Central) - Aug 18, 2022
These results suggest that our proposed system will be an effective tool for assessing the contractile force-related state of myotubes, which are available for the development of drugs to prevent and/or treat muscle weakness. This study shows that disturbed 24-hour activity rhythms and a poor self-rated sleep quality are associated with functioning of the negative feedback loop over a period of years.
- | Gazyva (obinutuzumab) / Roche, Biogen, Nippon Shinyaku
Journal: Prolonged COVID-19 in an Immunocompromised Patient Treated with Obinutuzumab and Bendamustine for Follicular Lymphoma. (Pubmed Central) - Aug 18, 2022
A careful observation to detect any subsequent relapse of COVID-19 symptoms is necessary in immunocompromised patients. Chemotherapy should be based on the disease status and type of lymphoma.
- | hydrocortisone / Generic mfg.
Journal: Multisystem Inflammatory Syndrome in Adults Accompanied with Kikuchi-Fujimoto Disease: A Case Report. (Pubmed Central) - Aug 18, 2022
After the initiation of hydrocortisone and diuretics, his symptoms resolved immediately. This case suggested that post-viral immune dysregulation in MIS-A could play a role in the etiology of KFD.
- | dexamethasone / Generic mfg.
Journal: The interplay of collagen/bioactive glass nanoparticle coatings and electrical stimulation regimes distinctly enhanced osteogenic differentiation of human mesenchymal stem cells. (Pubmed Central) - Aug 18, 2022
Additionally, dexamethasone was excluded to enable an accurate interpretation of BGN and EF in supporting osteogenic differentiation...These results provide the fundamentals for further exploitations on BGN composites with metal ions and rotation of EF regimes to enhance osteogenic differentiation. The goal is sustaining continual osteogenic differentiation and achieving a more physiologically-relevant state and bone constructs in vitro.
- | hydrocortisone / Generic mfg.
Journal: Highly efficient amino-functionalized aluminum-based metal organic frameworks mesoporous nanorods for selective extraction of hydrocortisone in pharmaceutical wastewater. (Pubmed Central) - Aug 18, 2022
These results demonstrate that the facile one-step preparation and excellent adsorption capacity makes Al-MOFs@NH attractive to capture and remove environmental steroid hormone pollutants. More importantly, the method proposed in this work is expected to provide a prospective solution for analysis of strong bioactive contaminants in pharmaceutical wastewater.
- | prednisolone / Generic mfg.
Clinical protocol, Journal: COCOS trial: COrticosteroids for COVID-19-induced loss of Smell-protocol for a single-centred, double-blind, randomised, placebo-controlled trial. (Pubmed Central) - Aug 18, 2022
P4
We will conduct a single-centre, randomised, placebo-controlled trial to determine the efficacy of a short high-dose treatment of oral prednisolone for persistent loss of smell after COVID-19 in the early phase...NL9635. EUCTR2021-004021-71-NL.
- || dexamethasone / Generic mfg.
Clinical, Journal: Dexamethasone for Postoperative Nausea and Vomiting in Papillary Thyroid Carcinoma Patients: A Randomized Clinical Trial. (Pubmed Central) - Aug 18, 2022
EUCTR2021-004021-71-NL. A single dose of dexamethasone is effective and safe for preventing PONV in PTC patients.
- | dexamethasone / Generic mfg.
Journal: Invited Commentary: Effect of Dexamethasone on Postoperative Nausea and Vomiting in Thyroid Surgery. (Pubmed Central) - Aug 18, 2022
A single dose of dexamethasone is effective and safe for preventing PONV in PTC patients. No abstract available
- | mometasone furoate / Generic mfg., mupirocin / Generic mfg.
New P2 trial, HEOR: Topical Steroids & Bacterial Decolonization for Radiation Dermatitis (clinicaltrials.gov) - Aug 17, 2022
P2, N=216, Not yet recruiting, Sponsor: Montefiore Medical Center
- || fluvoxamine / Generic mfg., budesonide / Generic mfg.
Or budesonide plus fluvoxamine combo. (Twitter) - Aug 17, 2022
- | Keytruda (pembrolizumab) / Merck (MSD), Anktiva (nogapendekin alfa inbakicept-pmln) / ImmunityBio
Trial completion date, Trial primary completion date, Metastases: Lung-MAP Non-Match Sub-Study: Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) (clinicaltrials.gov) - Aug 17, 2022
P2/3, N=478, Recruiting, Sponsor: Southwest Oncology Group
No abstract available Trial completion date: Feb 2025 --> Dec 2027 | Trial primary completion date: Feb 2024 --> Feb 2027
- | Exparel (bupivacaine liposome injectable suspension) / Pacira
Trial completion date, Trial primary completion date: TAP Block Using Liposomal Bupivacaine for Post-cesarean Delivery Analgesia- Walking Towards Recovery (clinicaltrials.gov) - Aug 17, 2022
P4, N=200, Recruiting, Sponsor: Yale University
Trial completion date: Feb 2025 --> Dec 2027 | Trial primary completion date: Feb 2024 --> Feb 2027 Trial completion date: Aug 2022 --> Aug 2024 | Trial primary completion date: May 2022 --> May 2024
- | hydrocortisone / Generic mfg.
Journal: Methods for Establishing a Renal Cell Carcinoma Tumor Spheroid Model With Immune Infiltration for Immunotherapeutic Studies. (Pubmed Central) - Aug 17, 2022
We present a protocol for RCC dissociation using Liberase TM and introduce a culture medium containing Epithelial Growth Factor and Hydrocortisone allowing for faster growth of RCC primary cells...Finally, we provide an example of application by implementing an immune spheroid killing assay allowing observing increased spheroid destruction after treatment with PD-1 inhibitors. Thus the straightforward methods presented here allow for efficient spheroid formation for a simple RCC 3D model that can be standardized and infused with immune cells to study immunotherapies.
- || dexamethasone / Generic mfg., lignocaine / Generic mfg.
Awesome talk Sir! Would lignocaine with an additive like dexamethasone provide the same duration as bupivacaine in a block? I was thinking in terms of making it safer… (Twitter) - Aug 17, 2022
- || dexamethasone / Generic mfg.
Review: ACTH-independent Cushing's syndrome due to ectopic endocrinologically functional adrenal tissue caused by a GNAS heterozygous mutation: a rare case of McCune-Albright syndrome accompanied by central amenorrhea and hypothyroidism: a case report and literature review. (Pubmed Central) - Aug 17, 2022
Her plasma ACTH was <1.5 pg/mL, and her serum cortisol was 21.4 pg/mL after the 8 mg dexamethasone suppression test, revealing the presence of ACTH-independent Cushing's syndrome; however, her bilateral adrenal glands were atrophied...Considering the combination of GNAS mutation with one of the typical clinical triad characteristics, fibrous dysplasia of bone, we diagnosed this patient with McCune-Albright syndrome accompanied by ACTH-independent Cushing's syndrome caused by an ectopic residual adrenal tumor due to GNAS mutation. This case highlights that GNAS involves a previously unknown pathological mechanism in which inhibition of the natural elimination of remnant tissue leads to ectopic endocrine hypersecretion.
- | Noxafil (posaconazole) / Merck (MSD)
Journal: Papilledema and idiopathic intracranial hypertension due to the possible potentiation of ATRA by posaconazole in a case of acute promyelocytic leukemia. (Pubmed Central) - Aug 17, 2022
To the best of our knowledge, our case is the first APL case with a IIH who treated with ATRA-based therapy and used posaconazole. In case of development of side effects, drugs should be interrupted and this combination should be avoided if possible after appropriate approach and clinical improvement.
- | carboplatin / Generic mfg.
Journal: Complete metabolic response after carboplatin desensitization in Peritoneal Carcinomatosis. (Pubmed Central) - Aug 17, 2022
And in patients that present hypersensitivity reactions, a safe and effective carboplatin desensitization protocol can be carried out to reach the administration of a full dose. Desensitization protocol induces tolerance to a drug temporarily and is dependent on continuous exposure.
- | Journal: Efficacy of novel agents in patients with nephropathy associated with POEMS syndrome. (Pubmed Central) - Aug 17, 2022
Novel agents improved clinical manifestations in patients with nephropathy associated with POEMS syndrome. In addition, novel-agent-based regimens such as BD treatment improved renal pathological manifestations, which suggested that novel agents could improve renal prognosis of the patients from the perspective of renal pathology.