- |||||||||| Decadron (dexamethasone) / Merck (MSD), Actemra IV (tocilizumab) / Roche, JW Pharma
REACTIVATION MILIARY TB IN THE SETTING OF POSTINFECTIOUS COVID-19 LUNGS (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3319;
He was treated for COVID pneumonia for ten days in the hospital with Decadron, Lasix, and tocilizumab. Patients with latent TB are likely at a high risk of reactivation post recovering from COVID-19 infection, due to immunosuppression and lung parenchymal damage
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
RITUXIMAB-INDUCED ARDS IN THE SETTING OF LUNG TRANSPLANT: A RARE BUT NEAR-FATAL REACTION (Convention Center Exhibit Hall: Rapid Area 1A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3316;
He was treated with pulse-dose IV Methylprednisolone (MP), plasmapheresis (PLEX), and intravenous immunoglobulin. While RALI is a rare complication, our case highlights the importance of high suspicion of RALI in patients that develop ARDS after administration of rituximab, as it is increasingly used in SOT.
- |||||||||| hydralazine hydrochloride / Generic mfg.
A RARE CASE OF DIFFUSE ALVEOLAR HEMORRHAGE SECONDARY TO HYDRALAZINE-INDUCED LUPUS (Convention Center Exhibit Hall: Rapid Area 1B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3299;
Delay or failure to recognize the DIL and the offending drug can prove catastrophic. Early diagnosis and immediate discontinuation of the offending drug, along with immunosuppressant treatment may lead to favorable outcomes.
- |||||||||| budesonide/salbutamol (PT027) / AstraZeneca, Avillion
PATHOPHYSIOLOGY OF LACTIC ACIDOSIS IN PATIENTS WITH ASTHMA (Convention Center Exhibit Hall: Rapid Area 2A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3288;
The patient was started on inhaled Salbutamol and Budesonide... Providers are increasingly challenged by hyperlactatemia,it is not harmful but elevated Lactic acid levels and clearance rate is used for prognostication,hyperlactatemia might be misleading,and all possible causes of elevated lactic acid levels must be explored.
- |||||||||| CALCIUM OXALATE DEPOSITION IN PULMONARY ASPERGILLOSIS (Convention Center 209A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3234;
CASE PRESENTATION: A 62-year-old-woman with limited breast cancer was admitted to the hospital seven days after her last cycle of docetaxel and cyclophosphamide with COVID-19 pneumonia and hypoxemic respiratory failure...She received a full course of dexamethasone and remdesivir... Pulmonary oxalosis, calcium oxalate deposition, can be seen in aspergillus infection and should be considered as an early diagnostic tool for invasive pulmonary aspergillosis.
- |||||||||| remdesivir / Generic mfg.
A CASE OF PROLONGED SARS-COV-2 INFECTION IN AN IMMUNOSUPPRESSED PATIENT WHO RESPONDED TO TREATMENT WITH REMDESIVIR AND MONOCLONAL ANTIBODIES (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3089;
CASE PRESENTATION: The patient is a 51 year old male with a past medical history of bilateral optic neuritis (treated with rituximab), polysubstance use disorder, bipolar disorder, and hypertension...A PCR test for SARS-CoV-2 returned positive and he was initiated on treatment with intravenous dexamethasone and antibiotics for presumed community acquired pneumonia...Serum testing for SARS COV2 IgG antibody, 10 weeks after the initial onset of his symptoms, returned negative, therefore he was then treated with a 5 day course of remdesivir, as well as monoclonal antibody therapy with casirivimab-imdevimab... This case demonstrates an immunocompromised patient with persistent symptoms of Covid-19 who eventually responded to treatment with the antiviral remdesivir, as well as monoclonal antibodies.
- |||||||||| rivaroxaban / Generic mfg.
FOOD FOR THOUGHT: A CAUTIONARY TALE OF RIVAROXABAN FAILURE IN A MIDDLE-AGED MAN (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3068;
Patients should be briefed on the importance of taking high dose rivaroxaban with food. Our goal is to bring awareness to providers about this significant pharmacodynamic property of rivaroxaban.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
ACUTE DIGITAL GANGRENE TRIGGERED BY COVID-19 COAGULOPATHY (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3057;
Thus physicians must always have a high index of suspicion for thromboembolic complications in patients with Covid-19. The development of severe complications despite prompt anticoagulation highlights the need for alternative or newer therapies like targeted immunotherapy that would effectively manage these complications of SARS-CoV-2.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A RARE PRESENTATION OF GRANULOMATOSIS WITH POLYANGIITIS AS EXUDATIVE PLEURAL EFFUSION (Convention Center Exhibit Hall: Poster Area) - Sep 11, 2022 - Abstract #CHEST2022CHEST_3054;
This case represents a rare initial manifestation of an already uncommon disease process. This case highlights the importance of considering GPA in the differential for patients presenting with pleural effusions, especially in association with elevated creatinine.
- |||||||||| ciprofloxacin oral / Generic mfg., fluocinolone acetonide / Generic mfg.
Journal: Two Validated Chromatographic Methods for Determination of Ciprofloxacin HCl, One of its Specified Impurities and Fluocinolone Acetonide in Newly Approved Otic Solution. (Pubmed Central) - Sep 10, 2022
The second method was based on high-performance liquid chromatography using a Zorbax ODS column (5 μm, 150 × 4.6 mm i.d.) where adequate separation was achieved through a mobile phase composed of phosphate buffer pH 3.6-acetonitrile (45:55, v/v) at flow rate 1.0 mL min-1 with ultraviolet detection at 254 nm. Linear regressions were obtained in the range of 1.0-40.0 μg mL-1 for CIP, 0.6-20.0 μg mL-1 for FLU and 1.0-40.0 μg mL-1 for CIP-imp A. The suggested methods were validated in compliance with the International Conference on Harmonization guidelines and were successfully applied for determination of CIP and FLU in bulk powder and newly marketed otic solution.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
Journal: Prediction of Respiratory Failure and Mortality in COVID-19 Patients Using Long Pentraxin PTX3. (Pubmed Central) - Sep 10, 2022
After adjustment for covariates, OR of MV was 2.34 (95% CI: 1.33-4.12, p = 0.003) in the derivation cohort and 1.64 (95% CI: 1.03-2.62, p = 0.04) in the validation cohort. PTX3 appears to be a useful clinical biomarker to predict 30-day respiratory failure and mortality risk in COVID-19 patients treated with and without remdesivir and dexamethasone.
- |||||||||| dexamethasone / Generic mfg.
Journal: Discovery of a novel nonsteroidal selective glucocorticoid receptor modulator by virtual screening and bioassays. (Pubmed Central) - Sep 10, 2022
HT-15 can selectively act on the NF-κB/AP1-mediated transrepression function of glucocorticoid receptor (GR) and repress the expression of pro-inflammation cytokines (i.e., IL-1β, IL-6, COX-2, and CCL-2) as effectively as dexamethasone (Dex)...Therefore, it may reduce the side effects induced by normal GCs. The bioactive compound HT-15 can serve as a starting point for the development of novel therapeutics for high dose or long-term anti-inflammatory treatment.
- |||||||||| dexamethasone / Generic mfg., olanzapine / Generic mfg.
Journal: The Prevention and Treatment of Nausea and Vomiting During Tumor Therapy. (Pubmed Central) - Sep 10, 2022
Detailed, effective, risk profile-adapted algorithms for the prevention and treatment of nausea and vomiting are now available for patients undergoing classic chemotherapy regimens or combined radiotherapy and chemotherapy. Optimal symptom control for patients undergoing oral tumor therapy over multiple days in the outpatient setting remains a challenge.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal, Adverse events: Adverse Effects of High Temperature On Mammary Alveolar Development In Vitro. (Pubmed Central) - Sep 10, 2022
Furthermore, the organoids precultured at 37 and 41 °C in the alveolar luminal formation model showed differences in the expression levels of caseins and tight junction proteins, which express in MECs in lactating mammary glands, after induction of MEC differentiation by prolactin and dexamethasone treatment in vitro. These results suggest that elevated temperature directly hinders mammary alveolar development; however, heat shock proteins may mitigate the adverse effects of high temperatures.
- |||||||||| hydrocortisone / Generic mfg.
Journal, HEOR: The Association of Early Corticosteroid Therapy With Clinical and Health-Related Quality of Life Outcomes in Children With Septic Shock. (Pubmed Central) - Sep 10, 2022
After adjusting for variables with the potential to confound the relationship between early corticosteroid administration and clinically meaningful end points, there was no improvement in outcomes associated with this therapy. Results from this propensity analysis provide additional justification for equipoise regarding corticosteroid therapy for pediatric septic shock and ascertain the need for a well-designed clinical trial to examine benefit/risk for this intervention.
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Review, Journal: Vision loss in giant cell arteritis: case-based review. (Pubmed Central) - Sep 10, 2022
With 12-day interval being the longest reported, we conclude that even though the first 2 days are the most critical for the visual outcome, blindness in the initially unaffected eye may rarely occur later. Nonetheless, immediate initiation of pulse treatment remains of vital importance to preserve vision in the contralateral eye.
- |||||||||| dexamethasone / Generic mfg., prednisolone / Generic mfg.
Observational data, Retrospective data, Journal: Exposure to corticosteroids in the first trimester is associated with an increased risk of urogenital congenital anomalies. (Pubmed Central) - Sep 10, 2022
The findings of this study, the largest of its kind, suggest that caution should be heeded when prescribing corticosteroids to women undergoing IVF/ICSI, given that this study has now identified three previously unassociated serious neonatal complications (talipes, hypospadias and cryptorchidism), plus a potential alteration in sex ratio. Physicians should be careful in using corticosteroids in the critical first trimester and should counsel patients regarding the potential risks of this treatment.
- |||||||||| dexamethasone / Generic mfg.
Journal: Inflammation-homing "living drug depot" for efficient arthritis treatment. (Pubmed Central) - Sep 10, 2022
Herein, we design a dextran sulfate (DS) functionalized nanoparticle (ZDNP) to selectively deliver anti-inflammatory agent dexamethasone (Dex) to circulating monocytes via the scavenger receptors on monocytes...When injected intravenously, ZDNP was effectively internalized by circulating monocytes via a scavenger receptor and subsequently was transported to arthritic joints, where monocytes engulfing the drug-loaded nanoparticles could switch to an anti-inflammatory phenotype to inhibit arthritis progress. We provide detailed evidence about the in vivo fate of ZDNP and unravel how monocytes act as a "living drug depot" to achieve site-directed arthritis therapy.
- |||||||||| budesonide / Generic mfg.
Journal: Characterization of Membrane-Type Dissolution Profiles of Clinically Available Orally Inhaled Products Using a Weibull Fit and a Mechanistic Model. (Pubmed Central) - Sep 10, 2022
In vitro dissolution profiles of budesonide, fluticasone propionate, and beclomethasone dipropionate delivered from three commercial drug products were determined using a membrane-type Transwell dissolution test, which consists of a donor and an acceptor compartment separated by a membrane...The faster rate extracted from the mechanistic model is expected to reflect the true dissolution rate of the drug; the Weibull model provides an effective and slower rate that represents not only drug dissolution but also diffusion across the Transwell membrane. In conclusion, the developed extended model provides superior understanding of the dissolution mechanisms in membrane-type (Transwell) dissolution tests.
- |||||||||| dexamethasone / Generic mfg., paracetamol / Generic mfg.
Journal: Clinical care pathways for ambulatory total shoulder arthroplasty. (Pubmed Central) - Sep 10, 2022
In conclusion, the developed extended model provides superior understanding of the dissolution mechanisms in membrane-type (Transwell) dissolution tests. Anesthesiologists should lead the way to create and implement pathways for ambulatory total shoulder arthroplasty, incorporating appropriate patient selection, patient education, long-lasting nerve blockade, and multimodal analgesia.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Milk kefir therapy improves the skeletal response to resistance exercise in rats submitted to glucocorticoid-induced osteoporosis. (Pubmed Central) - Sep 10, 2022
GIO was induced by dexamethasone (7 mg/kg - i.m.; 1×/wk, 5 wk)...MK and exercise administered isolated or in association increased the percentage of collagen bone filling after GIO (p < 0.05), but only ExK improved collagen maturity. Our results showed that MK associated to resistance exercise enhanced bone microarchitecture, quality and metabolism, being therefore an interesting tool to improve skeletal response during GIO.
- |||||||||| dexamethasone / Generic mfg., escin / Generic mfg.
Preclinical, Journal: Menthone supplementation protects from allergic inflammation in the lungs of asthmatic mice. (Pubmed Central) - Sep 10, 2022
To screen potent terpenoid compounds against allergic inflammation in vitro and in vivo, five terpenoid compounds including menthone, farnesol, oridonin, β-escin and lupeol, were first selected to compare their anti-allergic inflammation potential using mouse lung mast cells in vitro...There were six groups including dietary control (DC group, 0 mg menthone/kg b.w./day), 8 (ML group), 40 (MM group) as well as 200 mg menthone/kg b.w./day (MH group) by gavage, positive control (PC group, 3 mg dexamethasone/kg b.w. by gavage before OVA challenge) and non-treatment control (NTC group, normal mice without treatment) in the experiment...Menthone supplementation inhibited eosinophilia, mast cell degranulation, chemokine (C-C motif) receptor 3 (CC receptor 3) and chemokine (C-X-C motif) receptor 1 (CXC receptor 1) gene expression amounts in the lungs, but restored the percentage of monocytes/macrophages. Our results suggest that menthone supplementation may alleviate allergic asthma through regulating airway allergic inflammation, protein overproduction, eosinophils infiltration, Th1/Th2 immune balance, CC receptor 3 and CXC receptor 1 gene expression amounts in the lungs but restoring the percentage of monocytes/macrophages in allergic asthmatic mice.
- |||||||||| hydrocortisone / Generic mfg.
Preclinical, Journal: IL1β/ TNFα/COX-2/VEGF axis responsible for effective healing potential of C-glucoside xanthone (mangiferin) based ointment in immunocompromised rats. (Pubmed Central) - Sep 10, 2022
Immuno compromised state was achieved following intramuscular injection of Hydrocortisone @ 80 mg/kg body weight...Higher expression and strong signal intensity of VEGF was noticed in 2.5% mangiferin treatment group along with significant (P ≤ 0.05) upregulation IL1β and TNFα on day 7 in 2.5% mangiferin treatment group with significant (P ≤ 0.05) down regulation of COX-2 in mangiferin treatment group as compared to other groups i.e. group II and III. It is concluded from our study that mangiferin facilitates wound healing through improved wound closure, organized deposition of collagen deposition and granulation matrix formation.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Accelerated forgetting of a trauma-like event in healthy men and women after a single dose of hydrocortisone. (Pubmed Central) - Sep 10, 2022
In addition, while sex alone was not an important moderator, the combination of sex and sex-hormone levels (especially estradiol) influenced hydrocortisone's effects on involuntary aversive memories. Future well-powered experimental studies may provide a basis for a precision-psychiatry approach to optimising early post-traumatic glucocorticoid treatments that target intrusive memories, based on individual endocrinological profiles.
- |||||||||| Ninlaro (ixazomib) / Takeda
Journal: Combined Therapy with Ixazomib, Lenalidomide, and Dexamethasone for Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal Gammopathy, and Skin Changes Syndrome. (Pubmed Central) - Sep 10, 2022
Adverse events, including rash, neutropenia, sensory peripheral neuropathy, and nausea, were observed in three patients, which necessitated dose reduction or discontinuation of treatment. Conclusion IRd can be a therapeutic option for POEMS syndrome, albeit with careful monitoring of adverse events.
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