- |||||||||| Xofigo (radium Ra-223 dichloride) / Bayer
Review, Journal: Bone Health Management in the Continuum of Prostate Cancer Disease. (Pubmed Central) - Sep 13, 2022
However, these diagnostics and treatment options are not very accurate nor efficient enough to treat bone metastases and manage bone health. In this review, we present the pathogenesis of PCa-induced bone metastasis, its deleterious impacts on vital organs, the impact of metastatic PCa on bone health, treatment interventions for bone metastasis and management of bone- and skeletal-related events, and possible current and future therapeutic options for bone management in the continuum of prostate cancer disease.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: Intravenous Corticosteroid Therapy for Acute Lumbar Radicular Pain. (Pubmed Central) - Sep 13, 2022
Our study found daily 24 mg IV dexamethasone for ALRP to be an effective treatment and helpful in most patients admitted. This study supports the common practice used by spine units.
- |||||||||| ondansetron intravenous / Generic mfg.
Journal: Compatibility and Physical Properties of Dexamethasone-Ondansetron Intravenous Admixture. (Pubmed Central) - Sep 13, 2022
The benzyl alcohol used as a preservative affected the compatibility of the IV admixture compatibility. Thus, for the preparation of clear, physically compatible normal saline solutions of dexamethasone-ondansetron IV admixture, the maximum amounts of the respective drugs should not exceed 8 and 16 mg in total volume of 50 ml or 20 and 16 mg in a final volume of 100 ml.
- |||||||||| Journal: Perspectives of topical formulations for melasma. (Pubmed Central) - Sep 12, 2022
In conclusion, we have compiled specific topical therapies for treating melasma and discussed those that are the most used currently. We consider it important that prescribers and researchers evaluate the best cost-benefit ratio of topical therapeutic options and develop new formulations, enabling efficacy in the treatment with safety and comfort during application, through the reduction of adverse effects.
- |||||||||| dexamethasone injection / Generic mfg.
Journal: GOLDIC therapy in degenerative lumbar spinal stenosis: randomized, controlled trial. (Pubmed Central) - Sep 12, 2022
GOLDIC has shown the highest mean differences and number of cases with minimal important difference among groups for every primary outcome. GOLDIC therapy could be a new option for the nonoperative, symptomatic treatment of degenerative lumbar spinal stenosis and is not inferior to epidural steroid injections and manual therapy.
- |||||||||| remdesivir / Generic mfg., ivermectin oral / Generic mfg.
Preclinical, Journal: In vitro evaluation of the impact of Covid-19 therapeutic agents on the hydrolysis of the antiviral prodrug remdesivir. (Pubmed Central) - Sep 12, 2022
The present study assessed the potential influence of nine therapeutic agents (hydroxychloroquine, ivermectin, erythromycin, clarithromycin, roxithromycin, trimethoprim, ciprofloxacin, vancomycin, and dexamethasone) commonly used in treating COVID-19 and 5 known CES1 inhibitors on the metabolism of RDV...Patients carrying the CES1 G143E variant may exhibit a slower biotransformation and clearance of RDV. Further clinical studies would be required to evaluate and characterize the clinical significance of a CBD-RDV interaction.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Review: Pediatric therapeutic options in autoimmune neurologic diseases (Pubmed Central) - Sep 11, 2022
We will focus on current therapies, including high doses of intravenous methylprednisolone, followed by its progressive reduction, as well as intravenous immunoglobulin or plasmapheresis as second line therapies. Early institution of these treatments can save the patient's life and decrease their risk of permanent disability.
- |||||||||| dexamethasone / Generic mfg.
Journal: Identification of DDX5 as an indispensable activator of the glucocorticoid receptor in adipocyte differentiation. (Pubmed Central) - Sep 11, 2022
The expression of CCAAT/enhancer-binding protein (C/EBP) family members and peroxisome proliferator-activated receptor γ (PPAR γ) is essential for the differentiation of pre-adipocyte 3T3-L1 cells into mature adipocytes induced by a combined stimulation with dexamethasone, 3-isobutyl-1-methylxanthine, and insulin (DMI)...Furthermore, the reconstitution of DDX5, but not the DDX5 mutant (K144N) lacking RNA helicase activity, restored DMI-induced GR activation and adipocyte differentiation in 3T3-L1 cells in which DDX5 was knocked down, confirming that the RNA helicase activity of DDX5 is essential for adipogenesis. Collectively, these results revealed for the first time that DDX5 is necessary for GR activation and plays an essential role in early adipocyte differentiation.
- |||||||||| Synacthen Depot (cosyntropin) / Novartis, Mallinckrodt, Alliance
INHALED CORTICOSTEROIDS: AN OVERLOOKED CAUSE OF ADRENAL INSUFFICIENCY (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4217;
The risk of AI associated with ICS is admittedly less compared to oral steroids. This case report highlights the need for recognizing AI and screening patients on higher ICS doses.
- |||||||||| Remicade (infliximab) / Merck (MSD), Mitsubishi Tanabe, J&J
INFLIXIMAB-INDUCED INTERSTITIAL LUNG DISEASE IN RHEUMATOID ARTHRITIS (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4213;
Given the rising use of infliximab therapy, we suggest additional analysis to understand which predisposing factors lead to the development of infliximab induced ILD. Additionally, we question if baseline pulmonary function testing and high-resolution CT should be included with tuberculin skin tests when screening infliximab patients felt to be high risk.
- |||||||||| arsenic trioxide / Generic mfg.
GROUND GLASS OPACITIES IN A PATIENT RECEIVING TREATMENT WITH ALL-TRANS RETINOIC ACID AND ARSENIC TRIOXIDE (Convention Center Exhibit Hall: Rapid Area 3C) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4208;
Her dexamethasone dose was doubled, in addition to cefepime and furosemide...Standard treatment includes IV dexamethasone 10 mg every 12 hours until resolution of symptoms for at least 3 days (1)... Prompt recognition and treatment of DS with dexamethasone is imperative to prevent progression to respiratory failure.
- |||||||||| Nplate (romiplostim) / Amgen, Kyowa Kirin, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
COVID-19-INDUCED EVANS SYNDROME: UNUSUAL COMPLICATION OF THE NEW USUAL (Convention Center Exhibit Hall: Rapid Area 3D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4202;
ES is a very rare syndrome although it requires prompt treatment. It is important to be mindful about immunological causes when a COVID-19 patient presents with cytopenia, as delay in treatment can cause poor outcomes.
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
RHABDOMYOLYSIS AS A VARIANT OF COVID-19 MYOSITIS (Convention Center Exhibit Hall: Rapid Area 3D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4201;
Oxygen requirements increased and he received dexamethasone and Baricitinib for COVID. Areas for exploration include factors predisposing patients to rhabdomyolysis, utility of checking enzyme levels and impact of vaccination on disease severity.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
ENTEROCOCCUS EMPYEMA FOLLOWING EXTRACORPEAL MEMBRANE OXYGENATION (ECMO) FOR COVID-19 ARDS: A CASE REPORT (Convention Center Exhibit Hall: Rapid Area 3D) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4199;
Here we describe a rare causative organism of empyema that has not been previously described in the literature as associated with COVID-19 or ECMO. Additionally, we demonstrate the safety of intra-pleural TPA/Dornase in this patient on full dose anticoagulation which is a frequent consideration when determining the method of treating empyema in complex medical patients.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
CASE SERIES OF SEVERE BRADYCARDIA IN COVID-19 PATIENTS: AN UNUSUAL CARDIAC MANIFESTATION (Convention Center Exhibit Hall: Rapid Area 2A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4173;
This preliminary data suggests that even severe BA that develops after COVID-19 infection may not require PPM placement. Further studies are required to elucidate implications, assess the reversibility, and clarify potential therapeutic targets including the indications for PPM in COVID-19 associated bradycardia.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
A FOUR-BODING FUTURE: POLYVIRAL INFECTION WITH SARS-COV-2, PARAINFLUENZA VIRUS TYPE 3, INFLUENZA A, AND ADENOVIRUS (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4165;
COVID-19 research has mainly focused on SARS-CoV-2 effects on the human host, but with it evolving into an endemic, its interaction and co- and superinfection with other pathogens is imperative. Further research into such interactions of SARS-CoV2 are required to help develop preventative and therapeutic measures.
- |||||||||| Lagevrio (molnupiravir) / Ridgeback Biotherap, Merck (MSD)
PULMONARY ARTERY PSEUDOANEURYSM (PAP) AND MASSIVE HEMOPTYSIS AS A COMPLICATION OF MUCORMYCOSIS AND COVID-19 PNEUMONIA (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4164;
He was diagnosed with Covid-19 pneumonia and initially treated with molnupiravir...CT chest revealed mild bilateral patchy opacities and dexamethasone was started...Ultimately, thoracic surgical intervention was deemed too high risk and thus he was medically managed with a regimen of isavuconazole, amphotericin, and terbinafine... A high index of suspicion should be maintained in patients with these risk factors, as PAP can present as massive hemoptysis and is often fatal.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
AN UNUSUAL CASE OF CYTOMEGALOVIRUS PNEUMONIA IN A PATIENT WITH COVID-19 REQUIRING EXTRACORPOREAL MEMBRANOUS OXYGENATION (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4163;
This case highlights the need to maintain a high degree of suspicion for CMV pneumonia in patients with severe COVID-19 pneumonia who receive immunosuppressive therapies. While the diagnosis was made at autopsy in this case, it may be possible to arrive at an earlier diagnosis with CMV polymerase chain reaction (PCR) assays sent from the serum and bronchoalveolar lavage (as lung biopsies are usually impractical in ARDS).
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Olumiant (baricitinib) / Incyte, Eli Lilly
A CASE OF EGGERTHELLA BACTEREMIA IN A PATIENT WITH COVID-19 (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4162;
COVID-19 drug therapy was initiated, including baricitinib, remdesivir and decadron...The patient was administered vancomycin but continued to decline and eventually expired... Unusual pathogens such as Eggerthella may complicate a patient's hospital course while undergoing treatment for COVID-19.
- |||||||||| A CASE OF SARS-COV-2 ASSOCIATED WITH QUADRUPLE BACTERIAL COINFECTION (Convention Center Exhibit Hall: Rapid Area 3A) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4160;
He received dexamethasone, remdesivir, and IV fluids...Vancomycin, cefepime and metronidazole were ordered...The patient was started on azithromycin and a colonoscopy was done showing only diverticulosis... Prompt identification of co-existing pathogens can promote a safe and evidence-based approach to the treatment of patients with SARS-CoV-2.
- |||||||||| Verzenio (abemaciclib) / Eli Lilly
COMMONLY USED MAGNESIUM SULFATE UNCOMMONLY CAUSING PULMONARY EDEMA (Convention Center Exhibit Hall: Rapid Area 3B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4153;
Treatment of noncardiogenic pulmonary edema involves addressing the underlying cause of the event and is mainly supportive. Given how commonly Mgso4 is used for repletion in the inpatient setting, MgSo4 induced pulmonary edema should be in the differential for acute hypoxic respiratory failure and promptly addressed.
- |||||||||| REGEN-COV (casirivimab/imdevimab) / Regeneron, Roche
PROLONGED COVID-19 INFECTION IN AN IMMUNOSUPPRESSED PATIENT TREATED WITH CASIRIVIMAB/IMDEVIMAB (Convention Center Exhibit Hall: Rapid Area 3B) - Sep 11, 2022 - Abstract #CHEST2022CHEST_4151;
We believe this patient's case represents persistent COVID-19 infection and not re-infection due to persistent positive COVID-19 PCR, fevers, and absence of COVID-19 antibodies. This patient demonstrated dramatic improvement in his symptoms after Regeneron infusion.
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