Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Different inflammation responses modulate Müller glia proliferation in the acute or chronically damaged zebrafish retina. (Pubmed Central) -  Sep 21, 2022   
    Dexamethasone-treated retinas, to inhibit the immune response, lacked reactive microglia/macrophages and possessed fewer PCNA-positive cells, while LPS treatment increased microglia/macrophages and PCNA-labeled cells...Few TNFα pro-inflammatory microglia/macrophages were observed in the gosh retina. Understanding why acute and chronic damage results in different inflammation profiles and their effects on regulating zebrafish retinal regeneration would provide important clues toward improving therapeutic strategies for repairing injured mammalian tissues.
  • ||||||||||  INTERMITTENT BOLUS TECHNIQUE ERECTOR SPINAE PLANE BLOCK COVERS MORE DERMATOME THAN CONTINUOUS INFUSION TECHNIQUE WITH LESS OPIOID CONSUMPTION (STATION 4) -  Sep 21, 2022 - Abstract #WIP2022WIP_287;    
    All patients had received general anaesthesia along with paracetamol, ketorolac and dexamethasone...24 hours dermatomal coverage (Paravertebral region: T2-T7 vs T3-T5, Midaxillary region: T3-T7 vs T4&5, Parasternal region: T3-T6 vs T4) was wider in group I compared to group C. The median postoperative fentanyl consumption at 24 hours in group C (n = 25) was 275 (IQR 150–450) mcg, whereas in group I (n = 25) it was 150 (IQR 50–200) mcg... Programmed intermittent bolus (PIB) technique provides wider dermatomal coverage throughout resulting in less opioid consumption in patients undergoing modified radical mastectomy.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Review, Journal:  The Use of Antenatal Dexamethasone in Late Preterm and Term Pregnancies to Improve Neonatal Morbidity and Mortality: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Sep 20, 2022   
    In the >37th gestational week group, a statistically significant difference was found regarding the incidence of RDS [RR (95% CI); p-value: 0.56 (0.36, 0.87); 0.01], TTN [RR (95% CI); p-value: 0.54 (0.42, 0.71); <0.00001], need for ventilatory support [RR (95% CI); p-value: 0.71 (0.52, 0.96); 0.03] and need for mechanical ventilation [RR (95% CI); p-value: 0.56 (0.33, 0.95); 0.03]. To conclude, the antenatal administration of dexamethasone can be considered to prevent neonatal complications and reduce perinatal morbidity in term pregnancies.
  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Retrospective data, Journal:  Trajectory of plasma syndecan-1 and heparan sulfate during major surgery: A retrospective observational study. (Pubmed Central) -  Sep 20, 2022   
    Changes in syndecan-1 and heparan sulfate after surgery appear to show three different patterns, with greatest increases in those patients with greater blood loss, more liver surgery, and longer operations. These observations suggest that increases in syndecan-1 and heparan sulfate reflect the degree of surgical injury.
  • ||||||||||  Journal:  Panhypopituitarism as the first manifestation of sarcoidosis: case report (Pubmed Central) -  Sep 20, 2022   
    Later, additional examination revealed signs of intrathoracic lymphadenopathy and focal changes in the lung parenchyma on CT, as well as skin lesions. Despite the biochemical compensation of hypopituitarism, the clinical efficacy of hormonal therapy with cabergoline, testosterone, hydrocortisone and levothyroxine sodium was insufficient, and the patient's condition improved after the addition of immunosuppressive and anti-inflammatory therapy with methotrexate and methylprednisolone.
  • ||||||||||  carbocisteine / Generic mfg., dexamethasone / Generic mfg.
    Preclinical, Journal:  Carbocistein improves airway remodeling in asthmatic mice. (Pubmed Central) -  Sep 20, 2022   
    Despite the biochemical compensation of hypopituitarism, the clinical efficacy of hormonal therapy with cabergoline, testosterone, hydrocortisone and levothyroxine sodium was insufficient, and the patient's condition improved after the addition of immunosuppressive and anti-inflammatory therapy with methotrexate and methylprednisolone. SCMC intervention improves collagen fiber deposition in airway tissues and inhibits TGF-β1 expression in asthmatic mice.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Urinary free cortisol excretion is associated with lumbar bone density in patients with adrenal Cushing's syndrome. (Pubmed Central) -  Sep 20, 2022   
    Twenty-four-hour urinary free cortisol excretion, and not plasma cortisol levels after the 1- or 8-mg overnight dexamethasone suppression test, was significantly and negatively associated with lumbar spine bone density (lumbar spine bone mineral density, ρ = -0.786, P = 0.036; lumbar spine T score, ρ = -0.883, P = 0.009; and lumbar spine Z score, ρ = -0.883, P = 0.009). These results indicate that 24-h urinary free cortisol excretion is best associated with a decrease in bone density via increased adrenal cortisol overproduction and suggest that it could be used as a marker for osteoporosis in these patients.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Cytotoxic lesions of the corpus callosum after COVID-19 vaccination. (Pubmed Central) -  Sep 20, 2022   
    High-dose intravenous methylprednisolone improved their symptoms and imaging findings. CLOCCs should be considered in patients with neurological manifestation after COVID-19 vaccination.
  • ||||||||||  remifentanil / Generic mfg.
    Journal:  Effect of dexamethasone on intraoperative remifentanil dose in total knee arthroplasty surgery under general anaesthesia. (Pubmed Central) -  Sep 20, 2022   
    P4
    This explorative post hoc analysis of the randomised DEX-2-TKA trail showed that patients undergoing TKA surgery under general anaesthesia and who received dexamethasone seemed to have a higher remifentanil infusion rate compared with patients who received placebo. The clinical implications of the potentially increased remifentanil infusion rate need to be validated and explored further.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis. (Pubmed Central) -  Sep 20, 2022   
    Moreover, the ROS-responsive nanoparticles could react with osteoarthritis (OA)-induced intracellular ROS, resulting in the depolymerization of nanoparticles, which could not only eliminate excess ROS and reduce inflammation but also promote the release of dexamethasone (Dex) and kartogenin (KGN) in situ, realizing effective OA therapy...Additionally, the hydrogel microspheres, similar to bees, could target and effectively repair cartilage in the OA model. Thus, the injectable hydrogel microspheres exerted an excellent potential to repair OA and may also provide an effective avenue for inflammatory bowel disease therapy.
  • ||||||||||  A rare case of collapsing variant of focal segmental glomerulosclerosis in an eight-year old female Filipino child (Poster Area - Exhibition Hall E) -  Sep 20, 2022 - Abstract #IPNA2022IPNA_546;    
    High-dose intravenous methylprednisolone pulsing was also given but patient still had no response...   Combined treatment with steroids, oral cyclosporine resulted in significant improvement of edema and decreased proteinuria...Conversely, children that achieve partial or complete remission have been documented. Patients with this subset of difficult-to-treat nephrotic syndrome should be screened for underlying etiology and introduced with a trial of immunosuppressive treatment.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., pomalidomide / Generic mfg.
    Trial primary completion date:  Study of Combination POM, BTZ, Low-Dose DEX, and DARA (PVD-DARA) in Patients With RRMM (clinicaltrials.gov) -  Sep 19, 2022   
    P2,  N=84, Not yet recruiting, 
    Early recognition of this unique autoimmune aseptic meningitis may contribute to early diagnosis, treatment, and better outcomes. Trial primary completion date: Feb 2025 --> Oct 2025