Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


«12...258259260261262263264265266267268...10661067»
  • ||||||||||  Tri-Luma (fluocinolone acetonide/hydroquinone/tretinoin) / Galderma
    Review, Journal:  Medical therapies for Melasma. (Pubmed Central) -  Sep 29, 2022   
    The triple combination, hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.01% (Triluma, Galderma, Ft...Oral tranexamic acid alone or in combination with other modalities has also shown significant efficacy...We propose that a multimodality approach to the treatment of melasma is the most effective treatment approach. This review is focused on the medical therapies for melasma.
  • ||||||||||  ketamine / Generic mfg., dexmedetomidine / Generic mfg.
    Journal:  No Benefits of Adding Dexmedetomidine, Ketamine, Dexamethasone and Nerve Blocks to an Established Multimodal Analgesic Regimen after Total Knee Arthroplasty. (Pubmed Central) -  Sep 29, 2022   
    This review is focused on the medical therapies for melasma. In the presence of periarticular local anesthesia infiltration, intrathecal morphine, single-shot adductor canal block and dexamethasone, the addition of five analgesic interventions-local anesthetic infiltration between the popliteal artery and capsule of the posterior knee, intravenous dexmedetomidine, intravenous ketamine, an additional intravenous dexamethasone dose, and repeated adductor canal block injections-failed to further reduce opioid consumption or pain scores or to improve functional outcomes after total knee arthroplasty.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Are the Current Processes and Regulations Fit for Purpose to Deliver Novel Therapies During Pandemics? A Perspective on COVID-19 from the UK. (Pubmed Central) -  Sep 29, 2022   
    An assessment of the conduct of the RECOVERY trial and the speedy approval of dexamethasone by the UK Medicines and Healthcare products Regulatory Agency demonstrates that no compromises were made to the ethical and scientific integrity of the process...What is needed is not a major transformation in the process but the flexible adaptation of existing regulations to reduce bureaucracy and handover times. Arriving at an optimal balance between scientific standards, regulations and commercial conflicts of interest will pose considerable challenges but what the COVID-19 pandemic has shown is that where there is will, there is always a way.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Review, Journal:  Suprachoroidal Space Triamcinolone Acetonide: A Review in Uveitic Macular Edema. (Pubmed Central) -  Sep 29, 2022   
    The risk of corticosteroid-related IOP elevation appeared to be reduced in unrescued patients in the SCS triamcinolone acetonide group compared with patients in the sham control group who received rescue therapy. SCS triamcinolone acetonide is a novel and useful treatment option for uveitic macular edema.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Poplar leaf abscission through induced chlorophyll breakdown by Mg-dechelatase. (Pubmed Central) -  Sep 29, 2022   
    This study suggests a physiological role of chlorophyll breakdown in the leaf abscission of deciduous trees. Furthermore, this study shows that the dexamethasone-inducible gene expression system is an available option for deciduous tree studies.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma. (Pubmed Central) -  Sep 29, 2022   
    Treating asthmatic animals with solasodine (1 mg/kg b.w. or 10 mg/kg b.w.) or dexamethasone (2.5 mg/kg b.w.) reversed OVA-induced airway hyperresponsiveness, infiltration of inflammatory cells and histamine levels in the airways...Further, In-silico molecular docking studies performed to determine inhibitory potential of solasodine at IL-4 and IL-5, demonstrated strong affinity of phytocompound for these receptors than observed with antagonists previously reported. Results of current study imply that solasodine has therapeutic promise in allergic asthma, presumably due to its ability to prevent mast cell degranulation and consequent generation of histamine and Th2-associated cytokines in airways.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg.
    Biomarker, PK/PD data, Journal, Epigenetic controller:  DNA methylation as a pharmacodynamic marker of glucocorticoid response and glioma survival. (Pubmed Central) -  Sep 29, 2022   
    Therefore, it may also be informative in other conditions where glucocorticoids are employed. We conclude that DNA methylation remodeling within the peripheral immune compartment is a rich source of clinically relevant markers of glucocorticoid response.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Polyarteritis nodosa presenting with posterior reversible leukoencephalopathy syndrome. (Pubmed Central) -  Sep 29, 2022   
    He made a good neurological recovery with resolution of imaging changes. This case highlights the importance of a low threshold for systemic screening for young patients presenting with PRES secondary to uncontrolled hypertension and the importance of viral screening, particularly for HBV.
  • ||||||||||  montelukast / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  Study on the Effect of Self-Made Lifei Dingchuan Decoction Combined with Western Medicine on Cough Variant Asthma. (Pubmed Central) -  Sep 29, 2022   
    After investigation, follow-up, and statistics, the hospitalization time, hospitalization cost, asthma exacerbation control time, effective rate, and recurrence rate were compared between the two groups, and the differences between the two groups were statistically significant (P < 0.05). The study on the clinical efficacy and low hospitalization cost of the self-prepared lung and asthma-restorative soup in patients with cough variant asthma significantly improved the patients' arterial oxygen saturation, acid-base value, arterial partial pressure of oxygen, and partial pressure of carbon dioxide and effectively controlled the heart rate and respiratory rate with high safety, which is worth further promotion.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly
    DISSEMINATED HERPES ZOSTER VIRUS INFECTION FOLLOWING BARICITINIB IN COVID-19 (Convention Center Exhibit Hall: Rapid Area 3A) -  Sep 28, 2022 - Abstract #CHEST2022CHEST_4521;    
    He received a 14 day course of baricitinib, 10 days of dexamethasone and 5 days of remdesivir during his hospital stay...Patient received 7 days of valacyclovir with complete resolution... This case demonstrates the ability of baricitinib to cause immunosuppression and hence causing HZV infection in COVID-19 affected patients.
  • ||||||||||  bortezomib / Generic mfg.
    ACUTE PULMONARY HYPERTENSION AFTER BORTEZOMIB THERAPY (Convention Center Exhibit Hall: Rapid Area 1A) -  Sep 28, 2022 - Abstract #CHEST2022CHEST_4383;    
    CASE PRESENTATION: The patient is a 57-year-old male with multiple myeloma (MM) treated with dexamethasone, bortezomib and lenalidomide...He was started on aspirin, clopidogrel, heparin infusion and taken emergently for a cardiac catheterization...Dobutamine was started with improvement in his CI...Due to the improvement, the sildenafil dose was decreased... This case depicts a reversible, acute pulmonary hypertension in a patient on bortezomib.
  • ||||||||||  bamlanivimab/etesevimab (LY-CoV555/LY-CoV016) / Eli Lilly
    THE PANDEMIC'S FUNGAL REVENGE: COVID-19 ASSOCIATED PULMONARY ASPERGILLOSIS (CAPA) (Convention Center Exhibit Hall: Rapid Area 3C) -  Sep 28, 2022 - Abstract #CHEST2022CHEST_4358;    
    Bronchoalveolar lavage alone without tissue biopsy might miss the diagnosis in the context of invasive aspergillosis like the scenario we observed in our case. Doing tissue biopsy through bronchoscopy might add more clinical benefit when Aspergillus infections are suspected.
  • ||||||||||  Ventolin (albuterol) / GSK, QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva
    Journal:  Two-way coupling and Kolmogorov scales on inhaler spray plume evolutions from Ventolin, ProAir, and Qvar. (Pubmed Central) -  Sep 28, 2022   
    For the three inhalers considered (Ventolin, ProAir, and Qvar), significant differences were predicted using two-way and one-way coupling despite the level and manifestation of these differences varied. Two-way coupling effects were significant for MDI sprays and should be considered in future numerical studies.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD), Asparlas (calaspargase pegol-mknl) / Servier, Takeda, Leadiant Biosci, Adcetris (brentuximab vedotin) / Takeda, Pfizer
    Trial completion date, Trial primary completion date, Metastases:  Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma (clinicaltrials.gov) -  Sep 28, 2022   
    P1,  N=40, Recruiting, 
    No abstract available Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Spinal meningeal mass lesion: a rare presentation of follicular lymphoma (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_956;    
    He developed intermittent numbness of the bilateral lower extremities, nuchal rigidity, difficulty sleeping, and night sweats. An MRI of the thoracic spine demonstrated a dorsal intradural, extramedullary enhancing lesion from T6-T9 extending outside the spinal canal.
  • ||||||||||  dexamethasone / Generic mfg.
    A single-institution retrospective series of SARs-Cov-2 infection in adult glioma patients (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_866;    
    All but one patient was vaccinated against Covid-19, and 6 were taking dexamethasone at the time of infection...Our data suggest that glioma patients seen at Stanford Cancer Center do not experience an exceptionally high Covid-19 infectivity, hospitalization, or mortality rate, especially when compared to other vulnerable populations such as lung cancer patients. High vaccination rates, fairly low prevalence of cardiovascular comorbidities, and adherence to pandemic precautions among this cohort may have contributed to these results.
  • ||||||||||  Tecentriq (atezolizumab) / Roche
    Plasma Exchange for Immune Checkpoint Inhibitor Induced Acute Demyelinating Polyneuropathy refractory to IVIG (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_836;    
    We present a case of a 69-year-old male with urothelial carcinoma status post left nephrectomy who developed bilateral lower extremity weakness that began following his first dose of Atezolizumab...He was treated with three days of intravenous methylprednisolone every six hours for three days followed by three days of 0.4gm/kg IVIG...He is now ambulating with a cane. This case highlights the effectiveness of plasma exchange in a case that was refractory to IVIG
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD), Gazyva (obinutuzumab) / Roche, Biogen, Nippon Shinyaku, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Unique Paraneoplastic Syndrome Associated with CLL (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_835;    
    She failed trials of Pembrolizumab, ibrutinib, and Obinutuzumab due to side effects...She was then trialed on intravenous methylprednisolone and still experienced no relief...Finally, she was given rituximab infusions with slight improvement...This case is unique in that her symptoms presented with an ataxic syndrome with positive KLHL11 antibodies. It is important to be aware that some cases of CLL can present with unique paraneoplastic syndromes.
  • ||||||||||  dianhydrogalactitol (VAL-083) / Kintara Therap
    VAL-083 in Patients with Recurrent Glioblastoma Treated under Expanded Access Program (West/Central Hall) -  Sep 28, 2022 - Abstract #SNO2022SNO_522;    
    P=N/A
    All patients had received chemoradiation with temozolomide...Five patients with cerebral edema refractory to steroids received bevacizumab (BEV; 10 mg/kg) concurrently with VAL-083, and 8 patients received dexamethasone (Dex; >4 mg/day) with VAL-083...Additional treatment, safety and outcome data will be presented at the meeting.Clinicaltrials.gov Identifier: NCT03138629. EA treatment plans were approved by MD Anderson Cancer Center IRB.