Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Duration of symptom control following intratympanic dexamethasone injections in Meniere's disease. (Pubmed Central) -  Oct 1, 2022   
    Symptom control is achieved for a median of 14.5 months, and treatment can be repeated with no loss of efficacy. Those patients who have an underlying autoimmune co-morbidity are more likely to demonstrate a clinical response to therapy, which may provide insight into the underlying pathophysiology of Meniere's disease.
  • ||||||||||  thyroxine / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  A case of fatal myxedema coma with electrocardiogram Osborne J-wave in a patient initially diagnosed with hypothyroidism. (Pubmed Central) -  Oct 1, 2022   
    Despite subsequent intravenous administration of hydrocortisone and levothyroxine, as well as intensive supportive care, he eventually died 12 hours after hospital admission. This case illustrates some of the challenges associated with the management of patients with signs highly suggestive/diagnostic of myxedema coma, including the optimal loading dosage and intervention timing of thyroid hormone replacement.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice. (Pubmed Central) -  Oct 1, 2022   
    The aim of this research was to determine if the rich beta glucan compound called Maitake Pro4X can recover the T cell/NK population depleted by Dexamethasone treatment in lymph nodes from cancer-free BALBc female mice...Maitake Pro4X (5 mg/kg) was able to recover 42.97% of the depleted CD3Ɛ FITC cell population level in Lymph nodes from immunosuppressed female BALBc mice from 4.328 ± 6.229 to 22.646 ± 12.393 (p < 0.01) using Flow Cytometry. Maitake was also able to significantly increase the Ly6G PE cell population with p < 0.05 in lymph nodes.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  One Host-Multiple Applications: Zebrafish (Danio rerio) as Promising Model for Studying Human Cancers and Pathogenic Diseases. (Pubmed Central) -  Oct 1, 2022   
    A lower immune response is mostly generated by genetic manipulation but also by irradiation or dexamethasone treatment...In this review, we describe the main directions of using ZF in research, explain why and how zebrafish can be used as a model, what kind of limitations will be met and how to overcome them. We collected recent achievements in this field, indicating promising perspectives for the future.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Steroidal Saponins from the Rhizomes of Smilax china and Their Inhibitory Effects on Lipopolysaccharide-Induced Proinflammatory Cytokines Expression. (Pubmed Central) -  Oct 1, 2022   
    Compounds 1, 4: , and 11: showed inhibitory activity against the expression of proinflammatory mediators, inducible nitric oxide synthase, interleukin-1β, interleukin-6, and tumor necrosis factor-α in lipopolysaccharide-induced RAW264.7 cells. Compound 1: , at a concentration of 20 µM, decreased the production of inducible nitric oxide synthase, interleukin-1β, interleukin-6, and tumor necrosis factor-α by 36, 62, 72, and 67%, respectively, which is comparable to that of the positive control dexamethasone.
  • ||||||||||  dexamethasone / Generic mfg.
    Pituitary apoplexy and COVID-19 infection/vaccination () -  Oct 1, 2022 - Abstract #ENEA2022ENEA_241;    
    Biochemistry showed secondary hypogonadism and hypothyroidism and a stress dose dexamethasone was started due to the risk of adrenal insufficiency and to reduce oedema...Our case underlines that SARS-CoV-2 can associate with apoplexy by penetrating into CNS, even in cases of negative nasal swab. Patients with underlying diagnosed or undiagnosed pituitary tumours may be exposed to COVID-19 and may be at increased risk of pituitary apoplexy, therefore clinicians should be conscious of this risk, investigating pituitary hormones
  • ||||||||||  dexamethasone / Generic mfg., everolimus / Generic mfg.
    Ectopic ACTH syndrome in lung carcinoids – a case series () -  Oct 1, 2022 - Abstract #ENEA2022ENEA_226;    
    The remaining patients are disease free (follow up range 24-168 months). In this work we will review clinical features at presentation, strains in tumour location and response to therapy.
  • ||||||||||  hydrocortisone / Generic mfg.
    Incidental Discovery of Pituitary Insufficiency after Non-pituitary Surgery () -  Oct 1, 2022 - Abstract #ENEA2022ENEA_199;    
    The patient was diagnosed with the following: Pituitary Hypofunction (E27) Pituitary damage, unspecified (E27.3) Other hypothesized hypothyroidism (E03.8), Malignant tumor of the bladder, unspecified (Ch 67.9) Prescription: -Hydrocortisone 20 mg/day , In two days - Euthyrox 37 mcg/day 2-3 days after the medication administration patient’s condition improved dramatically, T/A, pulse, temperature had been normalized (Antibiotic therapy due to urine infection was going)...Repeated examination of MRT of the brain, monitoring Pituitary, thyroid hormones ,electrolytes is planned. Patient should be under constant supervision of an Oncologist and Endocrinologist.
  • ||||||||||  thyroxine / Generic mfg., hydrocortisone / Generic mfg.
    A rare case of dermoid cyst as a cause of short stature, precocious puberty, optic nerve hypoplasia, and hypopituitarism () -  Oct 1, 2022 - Abstract #ENEA2022ENEA_172;    
    The patient received appropriate hormonal supplementation (hydrocortisone and levothyroxine) and is being qualified for growth hormone therapy. Our case report highlights the importance of early diagnosis and treatment of hypopituitarism Dermoid cyst could be a rare cause of short stature, precocious puberty, optic nerve hypoplasia, and hypopituitarism
  • ||||||||||  hydrocortisone / Generic mfg.
    CRN04894: an oral, nonpeptide ACTH (MC2) receptor antagonist decreaseds basal and stimulated cortisol secretion in healthy volunteers (Auditorium Lumière) -  Oct 1, 2022 - Abstract #ENEA2022ENEA_60;    
    The protocol defined glucocorticoid deficiency as an 08:00 cortisol of <5 mcg/dl and triggered the addition of hydrocortisone (10 mg 08:00, 5 mg 14:00) to ongoing CRN04894 dosing...In summary, treatment with CRN04894 was well tolerated and resulted in meaningful suppression of cortisol and androstendione secretion despite exposure to persistent endogenous and acute exogenous ACTH challenges in healthy volunteers. Studies are planned in patients with Cushing’s disease and CAH.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Racial Disparities in Pulse Oximeter Device Inaccuracy and Estimated Clinical Impact on COVID-19 Treatment Course. (Pubmed Central) -  Oct 1, 2022   
    For people with COVID-19, this was associated with lower admission probability (-3.1 percentage-points), dexamethasone treatment (-3.1 percentage-points), and supplemental oxygen treatment (-4.5 percentage-points), as well as increased time-to-treatment: +37.2 minutes before dexamethasone initiation and +278.5 minutes before initiation of supplemental oxygen. These results call for additional investigation of pulse oximeters, and suggest that current guidelines for development, testing, and calibration of these devices should be revisited, investigated, and revised.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina. (Pubmed Central) -  Sep 30, 2022   
    Although NMDA-induced retinal damage activated NFkB in Müller glia, optic nerve crush had no effect on NFkB activation within the retina, whereas glial cells within the optic nerve were responsive. We conclude that the NFkB pathway is activated in retinal Müller glia in response to many different cell signaling pathways, and activation often depends on signals produced by reactive microglia.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Epithelial Autoantigen-Specific IgG Antibody Enhances Eosinophil Extracellular Trap Formation in Severe Asthma. (Pubmed Central) -  Sep 30, 2022   
    In conclusion, PDE-induced intrauterine hypoglucocorticoid exposure could positively program IGF1 expression in bone tissue through the GRα/miR-130a-5p/HDAC4 pathways, thus mediating osteogenic dysdifferentiation and adult osteoporosis susceptibility in male offspring rats. These suggest that EETs could enhance epithelial autoantigen (CK18)-induced autoimmune responses, further stimulating EET production and type 2 airway responses, which is a new therapeutic target for SA.
  • ||||||||||  remdesivir / Generic mfg., hydrocortisone / Generic mfg., azithromycin / Generic mfg.
    Journal:  Estimation of emerging diagnostic parameters for Coronavirus Disease 2019 patients severity and fatality. (Pubmed Central) -  Sep 30, 2022   
    The use of MMPs inhibitors and oxidative stress-reducing agents is anticipated to be beneficial in the poisoning with AFB1. Different severity levels during hospitalisation among patients of coronavirus disease 2019 were noted, and severity level was significantly associated with liver and renal function parameters.