- |||||||||| Stelara (ustekinumab) / J&J, Entyvio (vedolizumab) / Takeda
A PROSPECTIVE, PILOT, REAL-WORLD STUDY TO ASSESS THE PRESENCE AND SEVERITY OF URGENCY IN PATIENTS WITH CROHN (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1530;
Validation of the terminology in different ethnic languages may also pose additional barriers in patient understanding and reporting the symptom in the presence of additional IBS-type symptoms. Large studies are needed to assess if urgency is present in patients with iCD and how reliably is reported especially in multinational RCTs.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
IMPACT OF COVID-19 INFECTION ON INFLAMMATORY BOWEL DISEASE COURSE: A SYSTEMATIC REVIEW AND META-ANALYSIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1427;
Large studies are needed to assess if urgency is present in patients with iCD and how reliably is reported especially in multinational RCTs. Following meta-regression, neither sex nor duration of follow-up were found to be significant predictors of individual study effect size.StudyCountrySource PopulationStudy Period COVID-19 cohortReference cohortSummary estimates with 95% CI: type of relative estimateAdverse IBD-outcomeROBINS-E overall Risk of Bias (RoB)
- |||||||||| TESTING MACHINE LEARNING WITH FINNISH REGISTER DATA TO PREDICT NON-RESPONSE TO CONVENTIONAL TREATMENT IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1426;
Even though Finnish registries provide access to comprehensive longitudinal data allowing the generation of relatively large analysis cohorts, our ML model demonstrated a weak predictive potential, with low AUCs and accuracies (0.6 range), in line with previous findings.3 Due to scarcity of information on additional clinical variables available in the Finnish IBD registry, their use did not improve prediction of CT failure. Additional prediction difficulty is introduced by non-standardized data recording practices.
- |||||||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
RISK FACTORS FOR ORAL AND ESOPHAGEAL CANDIDIASIS DURING BUDESONIDE TREATMENT IN EOSINOPHILIC ESOPHAGITIS PATIENTS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1093;
Our results suggest that consistent eosinophilic count (> 35/HPF) and concomitant PPI therapy could represent risk factors in developing mycosis in EoE patients. According to literature, major esophageal inflammation, PPI-induced elimination of the gastric acid barrier and corticosteroid immunosuppression are the main mechanisms leading to oral and esophageal candida colonization.
- |||||||||| fluticasone / Generic mfg.
COHORT PROFILE UPDATE: THE SWISS EOSINOPHILIC EESOPHAGITIS COHORT STUDY (SEECS) (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1085;
At inclusion, 694 (96.9%) of EoE patients have an ongoing treatment [orodispersible budesonide tablet: 290 patients (41.8%); budesonide/fluticasone syrup: 281 patients (40.5%); PPI: 162 patients (23.3%); elimination diets: 103 patients (14.8%); esophageal dilation at last visit: 166 patients (23.9%)]... Our findings are in line with the available literature on EoE
- |||||||||| Darzalex (daratumumab) / J&J
A CASE OF ACUTE PANCREATITIS DUE TO DARATUMUMAB USE (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_1003;
In order to say that any drug causes pancreatitis, other causes that may cause pancreatitis must be excluded, there must be findings such as regression of pancreatitis after discontinuation of the accused drug and recurrence of the pancreatitis attack when the drug is used again. We aimed to draw attention to drug use, which is a rare cause in the etiology of pancreatitis, by presenting a case of acute pancreatitis due to daratumumab use.
- |||||||||| Remicade (infliximab) / J&J
DIFFICULT-TO-TREAT AUTOIMMUNE HEPATITIS MANAGED WITH INFLIXIMAB-BASED TRIPLE THERAPY (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_971;
AIH exhibited inadequate response to steroids and another immunosuppressive drugs (azathioprine, mycophenolate mofetil, tacrolimus)...By 2020, sustained biochemical response was achieved with infliximab, prednisone and AZA without infectious side effects...Patient was hospitalized, intravenous methylprednisolone was administered with mild decrease in liver tests...Our case underscores that in rare instances, AIH may necessitate triple combination therapy to induce and maintain remission, including infliximab. Given the possible long-term risks of this level of immunosuppression, it is mandatory to carefully evaluate such patients in a case-by-case manner.
- |||||||||| UNRAVELLING THE PUZZLE: THE ROLE OF TRANSJUGULAR LIVER BIOPSY IN HEMOPHAGOCYTIC SYNDROME WITH LIVER INVOLVEMENT (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_945;
A contrast-enhanced abdominal computerized tomography revealed multiple infracentrimetric liver nodules.Due to high clinical suspicion of hemophagocytic syndrome the patient underwent transjugular liver biopsy, bone marrow biopsy and started dexamethasone...The patient initiated chemotherapy with cyclophosphamide, gemcitabine and vincristine, with progressive clinical improvement with bilirubin normalization, regression of cytolysis and cholestasis, and the patient was referred to outpatient Hematology clinic after discharge.Hemophagocytic or macrophage activation syndrome results from immunological hyperactivation with macrophage-mediated multiorgan failure...The presence of predominant liver involvement is rare and liver biopsy is essential in the diagnostic workup. This clinical case demonstrates liver damage mediated by both hemophagocytic syndrome and liver involvement by a T-cell lymphoma, showing the importance of high clinical suspicion for a prompt diagnosis.
- |||||||||| Entyvio (vedolizumab) / Takeda
VISCERAL LEISHMANIASIS MIMICKING ULCERATIVE COLITIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_917;
The patient was started on budesonide and mesalazine and was escalated to vedolizumab due to insufficient symptom control...The patient was then treated with liposomal amphotericin B for 14 days...This however made the diagnosis of the underlying systemic parasitic infection possible as the immune system was able to suppress the parasites without elimination. This highlights the difficulties of diagnosing latent visceral leishmaniasis when presenting with atypical symptoms like mimicking autoimmune bowel diseases like ulcerative colitis.
- |||||||||| prednisolone / Generic mfg., hydrocortisone / Generic mfg.
INTRUSIVE ENDOMETRIOSIS INVOLVING THE SMALL BOWEL (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_915;
During the surgery, cicatrizing lesions were observed in the terminal ileum, and the biopsy results confirmed the presence of endometriosis in the small bowel and appendix.Small bowel endometriosis can be a significant cause of persistent abdominal discomfort and nonspecific gastrointestinal symptoms, often challenging to diagnose initially. This presents a unique diagnostic challenge and the importance of a thorough evaluation process.
- |||||||||| Rinvoq (upadacitinib) / AbbVie
UPADACITINIB IN ACUTE SEVERE ULCERATIVE COLITIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_884;
Other available medical therapies, albeit effective in other settings, are still not validated in ASUC.We report the case of a 20-year-old male with left-sided ulcerative colitis (UC), previously treated with mesalamine, who had been started on oral prednisolone for a disease flare...The patient was admitted and started on intravenous corticoids and ganciclovir...On 1-month follow-up, the patient maintains clinical remission.As in this case, there have been other reports of the efficacy of upadacitinib in ASUC. Upon further validation, this drug might become an invaluable addition to current treatment algorithms.
- |||||||||| dexamethasone / Generic mfg., etoposide IV / Generic mfg.
ULCERATIVE COLITIS AND HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_880;
The patient was discharged and is currently in clinical remission.In an immunosuppressed patient with uncontrolled inflammatory bowel disease, colonic aspergillosis is a rare cause of ASUC and is suspected to trigger the onset of HL.(1) HL is a hyperinflammatory syndrome induced by the activation of macrophages and cytotoxic T cells, with multiple etiologies, such as infections and autoimmune diseases.(2) Timely diagnosis and treatment resulted in a positive outcome. This case is being presented due to its rarity.
- |||||||||| budesonide / Generic mfg.
NET SUCH AN EASY DIAGNOSIS (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_869;
Symptom resolution was noted on an initial course of oral budesonide...Small bowel tumours present a very specific diagnostic challenge given their location. This case demonstrates the importance of capsule endoscopy in the diagnosis of small bowel tumours.
- |||||||||| budesonide / Generic mfg.
GASTRIC MYELOID SARCOMA: A RARE CAUSE OF ACUTE UPPER GASTROINTESTINAL HEMORRHAGE (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_851;
During the second post-HSCT period, she developed grade I gastrointestinal graft-versus-host disease (GI GVHD), confirmed by biopsy and managed with budesonide.Five months post-HSCT, the patient was admitted due to upper gastrointestinal bleeding (melena) and worsening anemia (Hb: 5,6 g/dL)...Six months post-HSCT, the patient succumbed to AML progression.- Myeloid Sarcoma (MS) typically affects the skin, lymph nodes, and brain, making its occurrence in the gastrointestinal tract uncommon.- Endoscopic imaging may mimic other conditions therefore biopsies are required to confirm the diagnosis.- In hematologic patients post-HSCT, endoscopic evaluations are essential for diagnosing gastrointestinal complications such as opportunistic infections, GI graft-versus-host disease (GI GVHD), and progression of their underlying disease. Our case highlights the rarity of gastric MS.
- |||||||||| prednisone / Generic mfg., cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
FROM FEAR TO RELIEF: A CASE OF HYPEREOSINOPHILIC SYNDROME MIMICKING GASTRIC MALIGNANCY (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_816;
This regimen significantly improved her symptoms and reduced lesions in the lungs, stomach, and lymph nodes, as confirmed by follow-up imaging. After one year, she achieved full clinical and biochemical remission, confirming extensive stomach and multi-organ involvement from HES.
- |||||||||| prednisolone / Generic mfg.
IS THIS PRIMARY OR SECONDARY LYMPHOCYTIC OESOPHAGITIS? (Science Lounge) - Jul 18, 2024 - Abstract #UEGW2024UEGW_812;
Oral prednisolone (30mg od) replaced locally active steroids. The patient was symptom free after one month treatment.Sarcoidosis is a granulomatous disease that often affects the lungs, skin and lymph nodes; however, involvement of the digestive tract is rare, and secondary lymphocytic esophagitis has hardly ever been described.3 The investigation, primary or secondary aetiology, and management of dysphagia in this case of lymphocytic esophagitis will be discussed.
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Effectiveness of Adding Dexamethasone to Lidocaine in Upper Limbs Nerve Blocks: A Systematic Review. (Pubmed Central) - Jul 18, 2024
The patient was symptom free after one month treatment.Sarcoidosis is a granulomatous disease that often affects the lungs, skin and lymph nodes; however, involvement of the digestive tract is rare, and secondary lymphocytic esophagitis has hardly ever been described.3 The investigation, primary or secondary aetiology, and management of dysphagia in this case of lymphocytic esophagitis will be discussed. This review supported that the combination of dexamethasone (dose of 4 to 10
- |||||||||| hydrocortisone / Generic mfg.
Biomarker, Review, Journal: A Bibliometric Analysis of Clinical Trials on Salivary Biomarkers for Mental Health (2003-2024). (Pubmed Central) - Jul 18, 2024
Key terms such as "biomarkers/metabolism," AND "hydrocortisone/metabolism," AND "saliva/metabolism" were central, with significant activity from 2012 to 2018. This analysis highlights a growing focus on the metabolic processes and therapeutic applications of salivary biomarkers in mental health.
- |||||||||| dexamethasone / Generic mfg.
Journal: Choroidal Thickness in Mild Autonomous Cortisol Secretion. (Pubmed Central) - Jul 18, 2024
There was no significant correlation between CT, size of the adenoma, basal cortisol, 1mg dexamethasone suppression test, salivary cortisol, 24-hour total urine-free cortisol, ACTH and DHEAS levels...CT increases in patients with MACS and those tend to have pachychoroid pigment epitheliopathy more frequent than healthy individuals. A thicker choroid in the patients with MACS may be a novel biomarker both as a diagnostic tool for the degree of hypercortisolemia and cortisol-related comorbidity.
- |||||||||| methylprednisolone acetate / Generic mfg.
Percutaneous Steroid and Bupivacaine Block of the Trigeminal Ganglion for the Treatment of Classical (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2204;
This study suggests that patients with various types of TN may be treated safely with percutaneous bupivacaine and depomedrol block of the trigeminal ganglion to temporarily treat trigeminal neuralgia. This procedure presents an option for patients with debilitating pain when clinicians would like to avoid ablation.
- |||||||||| dexamethasone / Generic mfg.
Epiduroscopy Improves VAS, ODI, SF-36 in chronic back and leg pain patients (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2116;
Although we cannot quantify possible placebo effects, we have meaningful data on the improvement not only in pain on movement, but also in function and quality of life as reported by the patients. While the effect on pain at rest was not significant, pain on movement was significantly improved.
- |||||||||| dexamethasone / Generic mfg.
PHYSICAL EXERCISE REDUCES CHRONIC PAIN INTENSITY VIA IMMUNOMODULATION (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_2101;
Specifically, we found that pain improvement in response to long-term exercise is associated with downregulation of inflammatory pathways over time.In mice, voluntary exercise reversed chronic hyperalgesia induced by immunosuppression. Ongoing analysis of blood samples collected at relevant points will give insight into exercise effects on pro- and anti-inflammatory mediators overtime.
- |||||||||| triamcinolone acetonide / Generic mfg.
Comparison Of 5% Dextrose Versus Triamcinolone In The Carpal Tunnel Syndrome Patients (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1925;
Written informed consent was taken from each participant.After getting clearance from Institutional ethical committee(IECJNMC/790) and CTRI trial registration number(CTRI/2024/01/061292)Patients of group A(25 patients) was administered one session of perineural injection with 5cc D5WPatients of group B(25 patients) was administered with one session of perineural injection with 3cc triamcinolone acetonide mixed with 2 cc normal saline under ultrasound guidance... We conclude from our data is that triamcinolone is better drug as compare to 5% dextrose in analgesic effect and low relapse rate and long term effectiveness in patients of mild to moderate carpal tunnel syndrome patients
- |||||||||| triamcinolone acetonide / Generic mfg., lignocaine / Generic mfg.
Study to assess pain relief and functional outcome after intraarticular sacroiliac joint injection (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1864;
Purpose of this study is to assess the pain relief and functional outcome after fluoroscopic guided intraarticular sacroiliac joint injection of 1cc 1% lignocaine with 1cc 40 mg triamcinolone acetonide in diagnosed cases of sacroiliitis. The fluoroscopic guided intra articular sacroiliac joint injection can be an effective treatment option for patients diagnosed with sacroiliitis, those receiving medical treatment for low backache, and those who have undergone surgery for Low backache without relief.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Interventional approach of glossoharyngeal nerve hybrid technique in a pediatric patient (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1696;
PRF may represent an interesting therapeutic alternative and minimally invasive option in pediatric population. In our case, the use of hybrid technique during the performance of interventional procedures on the glossopharyngeal nerve under general anesthesia generated greater safety and therefore a better result.
- |||||||||| SUCCESSFUL MANAGEMENT OF TOTAL PAIN FOR A LADY WITH ASTROCYTOMA. (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1670;
She tolerates her anti-epileptic therapy which also covers now the behavioural and vegetative aspects. The frontal headaches most likely represented her total pain represented initially by the raised intracranial pressure and poor prognosis.
- |||||||||| morphine sulphate / Generic mfg., pregabalin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Parsonage (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1583;
Presented spontaneous recovery 3 months after first symptom arousal and electrophysiological signs of reinnervation in supraspinatus and infraspinatus muscles without any intervention or surgical management. Patient continued with medical treatment and occupational therapy sessions.
- |||||||||| Chirocaine (levobupivacaine) / Purdue, AbbVie
Case Report: Hip Radiofrecuency Ablation in a 12 years Old Cancer Pain Girl (Rhabdomyosarcoma) (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1270;
Using the hip denervation technique described, the sciatic innervation remains and reduces the possibility of a Charcot joint. Regardless, hip denervation in a pediatric patient should be considered a last resort in the treatment of hip pain.Hip denervation is a potentially useful pain intervention when conservative or surgical options fail.
- |||||||||| dexamethasone / Generic mfg.
Factors Affecting Efficacy of Genicular Nerve Block for Treatment of Knee Joint Osteoarthritis Pain (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1101;
The patients who underwent ultrasound guided superomedial, superolateral and inferomedial genicular nerve block with bupivacaine 0.25% with 1 mg dexamethasone at each site included in the study whereas the patients with incomplete outcome data at 24 months were excluded... USG guided genicular nerve block is an effective minimally invasive treatment modality for knee osteoarthritis pain with age, BMI, type of toilet and exercises affecting its long-term efficacy.
- |||||||||| Dynastat (parecoxib) / Pfizer
Opioid-induced hyperalgesia in a patient submit to ressection of myxoid chondrosarcoma: Case report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_1034;
The patient is a 44-year-old male, ASA II, obese, with a surgical history of cytoreductiveendoprosthesis due to myxoid chondrosarcoma in the left shoulder and subsequent follow-upfor a difficult-to-control mixed pain syndrome, using Methadone, Pregabalin, andAmitriptyline...The intraoperative anesthetic management involved a multimodal strategy,including the administration of dexamethasone, ondansetron, parecoxib, and dipyrone,followed by pre-induction with dexmedetomidine, magnesium sulfate, and lidocaine, andanesthesia induction with dextrocetamine, propofol, and rocuronium bromide. Patients on chronic opioid use, such as Methadone, may be prone to OIH, emphasizing the importance of a strategic intraoperative anesthetic management to control hyperalgesia and postoperative pain without the need for additional opioid doses, as evidenced in this case.
- |||||||||| Growth Factor Concentrate in Traumatic Peripheral Neuropathy of Ulnar and Median Nerve (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_854;
GFs play important roles in peripheral nerve regeneration, including regulating cellular survival, growth, proliferation, differentiation, migration, neuroinflammation, and neurotrophic factor secretion. At the site of peripheral nerve injury, exogenous local administration of growth factor concentrate derived from platelets, creates microenvironment that supports peripheral nerve repair and regeneration.
- |||||||||| fentanyl citrate / Generic mfg., dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
Neurolysis of Superior Hypogastric Plexus in Patient with Penile Cancer Pain and HIV: a Case Report (Exhibition Hall/Poster Area) - Jul 18, 2024 - Abstract #IASP2024IASP_720;
Despite this, superior and inferior hypogastric plexus and ganglion impar block are choices for pelvic pain and genito-urinaria. Bilateral neurolysis of the superior hypogastric plexus was chosen to control pain relating to penile cancer pain at a level that can be acceptable to the patient.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Late-onset Schmidt's Syndrome Presenting with Severe Hyponatremia: A Case Report. (Pubmed Central) - Jul 18, 2024
aAD should be suspected in each case of severe hyponatremia [2], especially in patients with AIT independent of age. Furthermore, caution is needed in managing high-dose glucocorticoids along with fludrocortisone in elderly patients with cardiac disease to limit the risk of excessive mineralocorticoid activity and heart failure [3].
- |||||||||| dexamethasone / Generic mfg.
Review, Journal: Intrathecal dexamethasone as an adjuvant for spinal anesthesia: a systematic review. (Pubmed Central) - Jul 18, 2024
Given the wide heterogeneity of methodological approaches, further investigation is needed. Considering the limitations of the included studies and awaiting more conclusive evidence, the prudent use of dexamethasone could be recommended in those specific situations where general anesthesia or higher local anesthetics should be avoided.
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