- |||||||||| dexamethasone / Generic mfg.
Journal: First evidence of dermo-protective activity of marine sulfur-containing histidine compounds. (Pubmed Central) - Oct 19, 2022
Moreover, the protective action of ovo and 5-thio resulted to be stronger when compared with dexamethasone, a corticosteroid drug currently used to treat skin inflammatory conditions. Our findings suggest that ovo and 5-thio can ameliorate skin damage and may be used to develop natural skin care products to prevent the inflammatory status induced by environmental stressors and aging.
- |||||||||| dexamethasone / Generic mfg.
Journal: 309 patients treated with fluoroscopy-guided caudal epidural injection for lumbar disc herniation. (Pubmed Central) - Oct 19, 2022
Our findings suggest that ovo and 5-thio can ameliorate skin damage and may be used to develop natural skin care products to prevent the inflammatory status induced by environmental stressors and aging. Fluoroscopy-guided caudal epidural injection for LDH is safe, and the procedure reduced pain and improved functional capacity compared with baseline.
- |||||||||| dexamethasone injection / Generic mfg.
Retrospective data, Journal: Corticosteroid effectiveness among hospitalised COVID-19 patients in Malaysia. (Pubmed Central) - Oct 19, 2022
However, close follow-up is required due to the possibility of relapse or progression to plasma cell myeloma. This study concludes that using low-dose corticosteroids is recommended for hospitalised COVID-19 patients to ensure clinical outcomes are optimised.
- |||||||||| dexamethasone / Generic mfg.
Journal: Demystifying the Relevance of Size Amongst Macro- and Micro-Corticotropinoma: Experience in 206 Patients. (Pubmed Central) - Oct 18, 2022
They also had a higher ACTH (139 vs. 65.8 pg/ml), 0800h cortisol (1200 vs. 880 nmol/l), 2300h cortisol (1100 vs. 700 nmol/l) and cortisol levels after high dose dexamethasone suppression test (1050 vs. 244.5 nmol/l)...Micro-corticotropinoma ≤6 mm and 6-10 mm have a similar clinical and biochemical profile. As compare to CD, ECS is characterised by a higher disease burden as reflected in their higher cortisol, more autonomicity and loss of rhythmicity.
- |||||||||| idebenone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Leber Hereditary Optic Neuropathy-Plus Syndrome Mimicking a Neuro-inflammatory Disorder (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_1778;
Imaging findings improved after five days of IV methylprednisolone; however, he had persistent bilateral dense central scotomas and dyschromatopsia...Treatment with idebenone was initiated... LHON+ should be considered in patients with atypical progressive optic neuropathy and concomitant non-enhancing symmetric imaging findings involving the AP, particularly if symptoms are unresponsive to immunotherapy.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Clinical course of idiopathic acute transverse myelitis in adults with myelin oligodendrocyte glycoprotein antibody, aquaporin-4 antibody, and seronegative (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_1183;
Only four IATM cases were positive for MOG-IgG, and a comparison of groups was performed between those positive for AQP4-IgG and seronegative ones; Afro-descendants predominated among AQP4 positives and whites among seronegative; in AQP4 positive patients, there was more significant disability in the acute phase of the first TM as well as greater severity of motor and sphincter dysfunctions; the time of immunosuppression was longer in the AQP4 positive group as well as the spinal cord atrophy on MRI. The severity of neurological dysfunctions and long-term disability were not different in the groups.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Atypical polyphasic presentation of Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy (ePoster Area) - Oct 18, 2022 - Abstract #ECTRIMS2022ECTRIMS_874;
We presented an atypical polyphasic stepwise presentation of GFAP astrocytopathy which responded well with immunotherapy. Further research into pathophysiology of this rare but treatable autoimmune meningoencephalomyelitis is needed and hopefully will come up with an international consensus in management protocol one day.
- |||||||||| Humira (adalimumab) / Eisai, AbbVie
Clinical, Journal: Unique Features of Posterior Ocular Involvement of Whipple's Disease in a Patient with No Gastrointestinal Symptoms. (Pubmed Central) - Oct 18, 2022
A diagnosis of noninfectious uveitis was made and oral prednisolone was started...Because of the initial response, the anti-tumor necrosis factor agent Adalimumab was started...WD was considered and confirmed by polymerase chain reaction test and duodenal biopsy. Posterior ocular involvement in WD may present with a wide clinical spectrum including intraocular inflammation and unique features of sub-RPE deposits, widespread retinal hemorrhages, and optic disc edema.
- |||||||||| Triesence (triamcinolone acetonide injectable suspension) / Novartis
Clinical, Journal: Infectious Uveitis after Local Steroid and/or Methotrexate Injections at A Tertiary Referral Center in New Zealand: A Case Series. (Pubmed Central) - Oct 18, 2022
We retrospectively reviewed the data of four patients (mean age, 67.25 ± 7.58 years) who presented to the department of ophthalmology at Auckland District Health Board with infectious uveitis which occurred or worsened after local triamcinolone acetonide (TA) and/or methotrexate (MTX) injections...Disease presentations may be atypical in the presence of marked immunosuppression following local therapy. Polymerase chain reaction (PCR) can play an important role in the diagnosis in this setting.
- |||||||||| methylprednisolone oral / Generic mfg.
Journal: Subclinical Choroidal Inflammation Revealed by Indocyanine Green Angiography in Tubulointerstitial Nephritis and Uveitis Syndrome. (Pubmed Central) - Oct 18, 2022
Given the presence of posterior uveitis and deterioration of kidney function, asystemic treatment by oral methylprednisolone was started...Persistence of retinal and choroidal inflammations under systemic corticosteroids required association with immunosuppressive agent to control the disease activity Multimodal imaging and more precisely ICGA is useful to assess subclinical choroidal inflammation and monitor treatment response in TINU syndrome. Immunosuppression needs to be revised and adapted when uveitis and/or kidney function are unresponsive to systemic steroidsAbbreviations: TINU: tubulointerstitial nephritis and uveitis; TIN: tubulointerstitial nephritis; ACE: angiotensin-converting enzyme; RF: rheumatoid factor; Uβ2M: urinary β-2microglobulin; AMPPE: acute multifocal placoid pigment epitheliopathy; FA: fluorescein angiography; ICGA: indocyanine green angiography; CT: computed tomography.
- |||||||||| Spikevax (elasomeran) / Moderna
Journal: Vogt-Koyanagi-Harada Disease following mRNA-1273 (Moderna) COVID-19 Vaccination. (Pubmed Central) - Oct 18, 2022
After treatment with oral prednisolone, the serous retinal detachment resolved and vision improved. COVID-19 vaccination might be associated with VKH disease development, and the ingredients of the mRNA vaccine or viral peptide encoded by mRNA may have activated the immunological process and induced VKH disease.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: Extramedullary plasmacytoma with colonic involvement: experience of two cases in a tertiary hospital. (Pubmed Central) - Oct 18, 2022
After bone marrow aspiration, associated IgG multiple myeloma was detected, so chemotherapy with VMP (bortezomib, melphalan and prednisone) was started...After ruling out lesions in other locations, the patient was treated with immunochemotherapy according to the Bortezomib-Rituximab-Dexamethasone scheme, with subsequent complete clinical and endoscopic remission...The clinical manifestations are similar to those of other colon neoplasms, while the treatment or prognosis may differ from those of other neoplasms. In patients with clinical suspicion, it is important to perform an early endoscopic study, especially in patients diagnosed with multiple myeloma.
- |||||||||| dexamethasone / Generic mfg.
Journal, Cytokine storm: Old drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm. (Pubmed Central) - Oct 18, 2022
Pairwise combinations of drugs targeting distinct biological pathways tended to perform significantly better than single drugs with dexamethasone emerging as a frequent high-ranking companion. While these predicted drug combinations aim to disrupt COVID-induced acute respiratory distress syndrome, the approach itself can be applied more broadly to other diseases and may provide a standard tool for drug discovery initiatives in evaluating alternative targets and repurposing approved drugs.
- |||||||||| atovaquone / Generic mfg.
Clinical, Journal: Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial. (Pubmed Central) - Oct 18, 2022
In this prospective, randomized, placebo-controlled trial, atovaquone did not demonstrate evidence of enhanced SARS-CoV-2 viral clearance compared with placebo. However, based on the observed inverse correlation between atovaquone levels and viral load, additional PK-guided studies may be warranted to examine the antiviral effect of atovaquone in COVID-19 patients.
- |||||||||| epinephrine / Generic mfg.
Journal: Unique Treatment for Alopecia Areata Combining Epinephrine With an Intralesional Steroid. (Pubmed Central) - Oct 18, 2022
Our 2 cases of severe AA are among many in our practice that responded with seemingly permanent hair regrowth using this novel combination regimen. We hypothesize that local vasoconstriction due to epinephrine potentiates the ILTA and that epinephrine also may play an independent role.
- |||||||||| dexamethasone / Generic mfg., furosemide / Generic mfg.
Journal: Severe methyl bromide poisoning causing early acute renal failure and anuria: a case report. (Pubmed Central) - Oct 18, 2022
Notably, the patient developed sustained anuria and eventually died owing to multiple organ failure; specifically, failure of the brain, heart, lungs, and kidneys. This report presents the diagnosis, clinical course, management, and prognosis of a patient who was treated at our hospital for severe methyl bromide poisoning.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Intracranial vascular stenosis in giant cell arteritis successfully treated by two balloon angioplasty procedures. (Pubmed Central) - Oct 18, 2022
Hemiparesis and motor aphasia developed shortly after intravenous methylprednisolone pulse therapy, and magnetic resonance imaging revealed acute cerebral infarction with severe stenosis at the end of the left internal carotid artery...We also review 10 similar cases reported in the literature. Although further evidence is needed to confirm the usefulness and safety of balloon angioplasty for intracranial GCA, this case report provides valuable information about the endovascular therapy for GCA.
- |||||||||| progesterone / Generic mfg., hydrocortisone / Generic mfg.
Journal: Cortisol modulates Ca signaling and acrosome reaction in human sperm. (Pubmed Central) - Oct 18, 2022
Our data showed that HC interferes with the Pg action. Therefore, the negative correlation between anxiety symptoms and Pg-induced AR is due to the accompanying high cortisol levels of this condition and its competitive action with Pg.
- |||||||||| felzartamab (MOR202) / HIBio
Trial completion date, Trial primary completion date: TJ202 Combined With Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) - Oct 18, 2022
P2, N=113, Active, not recruiting,
Trial completion date: Jul 2022 --> May 2024 | Trial primary completion date: Jul 2022 --> May 2024 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Jul 2022 --> Jun 2023
- |||||||||| Rituxan (rituximab) / Roche
Trial completion date: Rituximab (RTX) Therapy in Patients With Active TAO (clinicaltrials.gov) - Oct 18, 2022
P4, N=26, Active, not recruiting,
Trial completion date: Jul 2028 --> Sep 2027 | Trial primary completion date: Jul 2023 --> Sep 2022 Trial completion date: Mar 2022 --> Mar 2024
- |||||||||| Rituxan (rituximab) / Roche, Tecentriq (atezolizumab) / Roche
Enrollment closed, Combination therapy: NCI-2017-01957: Testing the Addition of an Immunotherapy Agent, Atezolizumab, When Given With the Usual Chemo-Immunotherapy Drug Combination (Rituximab Plus Gemcitabine and Oxaliplatin) for Relapsed/Refractory (That Has Come Back or Not Responded to Treatment) Transformed Diffuse Large B-Cell Lymphoma (clinicaltrials.gov) - Oct 18, 2022
P1, N=24, Active, not recruiting,
Recruiting --> Active, not recruiting | N=34 --> 18 Suspended --> Active, not recruiting
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Clinical, Journal: Details and outcomes of a large cohort of MOG-IgG associated optic neuritis. (Pubmed Central) - Oct 18, 2022
This study suggests that pain precedes vision loss in the majority of ON attacks and early steroids may lead to better outcomes in MOG-IgG ON, but some patients can recover without steroid treatment. Prospective randomized clinical trials are required to confirm these findings.
- |||||||||| ketamine / Generic mfg.
Intraveinous ketamine in adult patient with severe asthma exacerbation : a therapeutic alternative to avoid mechanical ventilation . () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3637;
In acute care settings, especially in emergency departments and in pre-hospital care, sedation/analgesia with ketamine has been used for decades in complete safety thanks to its good tolerance on the respiratory level allowing its use in spontaneous ventilation. In our case, the use of ketamine associated with NIV was beneficial as alternative therapy in cases of acute severe asthma exacerbation, which opens other perspectives for these patients in the emergency departments.
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