Glucocorticoid Receptor 

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  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Clinical, Journal:  Comparison of the efficacy of corticosteroid, dry needling, and PRP application in lateral epicondylitis. (Pubmed Central) -  Oct 26, 2022   
    This OFA regimen without dexmedetomidine for a low-resource setting has a promising success rate with few perioperative complications including mild intraoperative hemodynamic changes, decrease postoperative complications, pain, and opioid consumption in patients undergoing elective gynecology surgery. Dry needling is an effective and safe application for the short-term treatment of lateral epicondylitis.
  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Review, Journal:  Glucocorticoid receptor blockers. (Pubmed Central) -  Oct 26, 2022   
    Mifepristone is the only glucocorticoid receptor antagonist currently approved for the treatment of Cushing's syndrome...Treatment of severe adrenal insufficiency requires high doses of dexamethasone...These potential adverse effects can largely be avoided with careful attention to detail. My opinion is that its current place in therapy is in patients with severe disease and in those not responding to other treatments.
  • ||||||||||  dexamethasone / Generic mfg., desmopressin / Generic mfg.
    Review, Journal:  Cushing's disease: risk of recurrence following trans-sphenoidal surgery, timing and methods for evaluation. (Pubmed Central) -  Oct 26, 2022   
    Interestingly, several studies have shown that the desmopressin test performed in the early post-op period may have some promise in predicting more precisely the risk of recurrence...The methods used to detect recurrence are similar to those used to assess the cortisol secretory status and include assessment of: (i) abnormal circadian rhythm by late night salivary cortisol (LNSC) or midnight serum cortisol; (ii) impaired cortisol feedback by the dexamethasone suppression test and; (iii) increased 24-h bioavailable cortisol by urinary free cortisol...Currently LNSC is regarded as the earliest and most sensitive biochemical alteration in detecting recurrence; a major caveat for LNSC, however, is its great variability. In practice, the diagnosis of recurrence is a challenge due to the fact that recurrence is usually a slow process with apparent clinical manifestations that may be delayed and alterations of classical biomarkers that may be delayed as well.
  • ||||||||||  Triesence (triamcinolone acetonide injectable suspension) / Novartis, Avastin (bevacizumab) / Roche
    Retrospective data, Review, Journal:  IRVAN syndrome: A retrospective review of 9 cases from Tunisia. (Pubmed Central) -  Oct 26, 2022   
    Multimodal imaging confirms the diagnosis by showing retinal macroaneurysms. Early treatment of macular edema and/or peripheral retinal non-perfusion is mandatory to improve prognosis.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Biomarker, Retrospective data, Journal:  Inflammatory and thrombotic parameters associated with the COVID-19 course in Poland (SARSTer study). (Pubmed Central) -  Oct 26, 2022   
    Severe course of the disease is associated with lower PLT and lymphocyte count, higher D-dimer, CRP, neutrophil count and IL-6 concentration. The best predictors of no clinical improvement in COVID-19 are: IL-6>100 ​pg/ml, D-dimer>1000 ​ng/ml and PLT<150,000/μl.
  • ||||||||||  tranexamic acid oral / Generic mfg.
    Journal:  Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty. (Pubmed Central) -  Oct 26, 2022   
    The best predictors of no clinical improvement in COVID-19 are: IL-6>100 ​pg/ml, D-dimer>1000 ​ng/ml and PLT<150,000/μl. The combination of TXA (15 mg/kg; before skin incision and 3 hours later) and DEX (20 mg dexamethasone intravenously after the onset of anesthesia, and again 24 hours later) is an effective and safe strategy for patients undergoing total hip arthroplasty.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Endogenous hydrocortisone caused metabolic perturbation and nutritional deterioration of animal-derived food in a dose-dependent manner. (Pubmed Central) -  Oct 26, 2022   
    Animal-derived foods under hydrocortisone-bioaccumulation cause metabolic perturbation by regulating glutamine synthetase expression at the transcriptional level contributed to hydrocortisone-induced toxicity and accelerating the down-regulation of essential amino acids (l-Histidine 10.74-6.48 mg kg, l-Phenylalanine 3.70-1.57 mg kg), purine nucleotides (GMP 40.29-5.00 μg kg, etc) that provide nutritional value in a positive feedback loop. Protein-metabolite interactions suggesting that hydrocortisone enhanced nitric oxide synthase and GMP reductase expression (LOQ 3.24-63.39 μg kg), and affected meat flavor perception, eventually lead to the decline of nutritional value and flesh quality of pork.
  • ||||||||||  prednisone / Generic mfg., budesonide / Generic mfg.
    Clinical guideline, Review:  AGA Clinical Practice Update on Management of Refractory Celiac Disease: Expert Review. (Pubmed Central) -  Oct 26, 2022   
    Identify local experts with expertise in celiac disease to assist with management. BEST PRACTICE ADVICE 10: Patients with refractory celiac disease without response to steroids may benefit from referral to a center with expertise for management or evaluation for inclusion in clinical trials.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Retrospective data, Journal:  Perioperative dexamethasone with neuraxial anesthesia for scheduled cesarean delivery and neonatal hypoglycemia. (Pubmed Central) -  Oct 26, 2022   
    BEST PRACTICE ADVICE 10: Patients with refractory celiac disease without response to steroids may benefit from referral to a center with expertise for management or evaluation for inclusion in clinical trials. Dexamethasone administration after neuraxial anesthesia placement for scheduled non-labor cesarean delivery is associated with altered neonatal glucose metabolism only in pregnancies complicated by diabetes.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Retrospective data, Review, Journal, HEOR:  Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis. (Pubmed Central) -  Oct 26, 2022   
    Dexamethasone administration after neuraxial anesthesia placement for scheduled non-labor cesarean delivery is associated with altered neonatal glucose metabolism only in pregnancies complicated by diabetes. This NMA demonstrates that HRQoL is responsive to treatment, is strongly related to asthma control and that it can be well-managed in patients with moderate-to-severe asthma using regular treatment with inhaled FP/Sal.
  • ||||||||||  Vexol (rimexolone ophthalmic) / Novartis
    Biomarker, Journal:  Bioinformatics methods in biomarkers of preeclampsia and associated potential drug applications. (Pubmed Central) -  Oct 26, 2022   
    This NMA demonstrates that HRQoL is responsive to treatment, is strongly related to asthma control and that it can be well-managed in patients with moderate-to-severe asthma using regular treatment with inhaled FP/Sal. In conclusion, the present study investigated key genes associated with PE pathogenesis that may contribute to identifying potential biomarkers, therapeutic agents and developing personalized treatment for PE.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Cerebellar hemorrhage in a healthy young adult: a case report. (Pubmed Central) -  Oct 26, 2022   
    A cavernous malformation with concurrent developmental venous anomalies requires accurate diagnosis. Our case report contributes to the literature on the imaging diagnosis of this disease, which is beneficial for current and future reference.
  • ||||||||||  dexamethasone / Generic mfg., thyroxine / Generic mfg.
    PERSISTENT HYPOPHARYNGEAL AND SUPRAGLOTTIC EDEMA IN THE SETTING OF MYXEDEMA COMA‐ CLINICAL CHALLENGES IN MANAGEMENT () -  Oct 26, 2022 - Abstract #ATA2022ATA_502;    
    Laryngeal edema in the setting of myxedema coma may persist for weeks after initial presentation, even after treatment with corticosteroids and levothyroxine. Understanding how this may affect the overall management and hospital course, including airway and nutrition management, is important for healthcare providers to consider while caring for these patients.
  • ||||||||||  methimazole / Generic mfg., dexamethasone / Generic mfg., propranolol / Generic mfg.
    THE AUTOIMMUNE FACE OF PLUMMER'S DISEASE: A UNIQUE CASE OF THYROTOXIC STORM WITH CARDIAC ARRHYTHMIA () -  Oct 26, 2022 - Abstract #ATA2022ATA_379;    
    On that note, unnecessary manipulation of the thyroid gland via physical examination, ultrasonography, or fine‐needle aspiration in such cases is strictly prohibited to avoid the aggravation of a thyrotoxic storm. The autoimmunity took the role of inducing hyperthyroidism independent of regulation by TSH.
  • ||||||||||  methimazole / Generic mfg., hydrocortisone / Generic mfg.
    SEIZURE MANIFESTING IN THE SETTING OF THYROID STORM: A CASE REPORT () -  Oct 26, 2022 - Abstract #ATA2022ATA_370;    
    The patient was treated with IV hydrocortisone, metoprolol, propothiouracil and potassium iodide...The patient was successfully extubated to room air 24 hours after admission and was eventually discharged on methimazole and metoprolol...Proposed mechanisms for hyperthyroid induced seizures include direct effect on cerebral tissue causing a decreased seizure threshold and GABA receptor dysfunction or inhibition. We propose that, in the right clinical context, severe hyperthyroidism may manifest as seizures and prompt recognition and treatment should be initiated to prevent further complications.
  • ||||||||||  dexamethasone / Generic mfg.
    HOLD YOUR BREATH: A CASE OF ENLARGING GOITER IN THE SETTING OF HIGH‐GRADE GASTRIC B‐CELL LYMPHOMA () -  Oct 26, 2022 - Abstract #ATA2022ATA_319;    
    She presented 2 weeks later with worsening neck pain and dyspnea where was admitted to the ICU for airway watch and started on dexamethasone 40 mg with R‐EPOCH chemotherapy...TP53 mutation has been associated with tumor aggressiveness in follicular, poorly differentiated, and anaplastic thyroid cancers and can be synergistic with MYC mutation in aggressive B cell lymphoma. Further research is needed on the role this mutation plays in the pathogenesis of thyroid lymphoma.
  • ||||||||||  PLASMAPHARESIS FOR THYROTOXICOSIS () -  Oct 26, 2022 - Abstract #ATA2022ATA_268;    
    DESCRIPTION OF THE CASE: A 44 Yr female with recently diagnosed Graves' Disease managed with Methimazole presented to the ER with fever and chills...Management was started for neutropenic fever along with impending thyroid storm (Burch‐Wartofsky Point Scale Scaore of 30) in ICU setting with IV Antibiotics, B‐Blockers, Hydrocortisone, Iodine drops, Cholestyramine and Filgastrim...She successfully underwent total thyroidectomy and following clinical improvement was discharge with outpatient follow up on Levothyroxine therapy...But rebound increase of Free T4 levels can be expected post therapy therefore plasmapharesis is usually a bridging therapy towards thyroidectomy. Purorpse of this case presentation is to highlight the importance of plasmapharesis as therapeutic option in thyrotoxicosis treatment when thioamides are ineffective, not tolerated or contraindicated.
  • ||||||||||  dexamethasone / Generic mfg.
    UNUSUAL PRESENTATION OF ANAPLASTIC THYROID CARCINOMA AS SUPPURATIVE THYROIDITIS () -  Oct 26, 2022 - Abstract #ATA2022ATA_206;    
    Hospital course was further complicated by acute respiratory distress with stridor for which dexamethasone was initiated along with antibiotics...In summary, we present a case of an anaplastic thyroid carcinoma mimicking acute suppurative thyroiditis at presentation. Excisional biopsy should be considered in patients who do not rapidly respond to antibiotics.
  • ||||||||||  dexamethasone / Generic mfg., thyroxine / Generic mfg.
    ISOLATED PREMATURE MENARCHE: AN UNUSUAL PRESENTATION OF UNDIAGNOSED HYPOTHYROIDISM () -  Oct 26, 2022 - Abstract #ATA2022ATA_149;    
    Other laboratory blood parameters include, fT3 : 1.44 pg /ml (n = 2.6 – 4.8), fT4 : 0.09 ng/dl (n = 0.8‐2), TSH : >500 micro IU/ml (n = 0.6‐4.84), anti TPO antibody : >1300 IU/ml (n = <30), FSH = 5.37 IU/L (n = 1‐4.2), LH = < 0.1 IU/ L (n = 0.02‐0.18) and 8 am cortisol : 1.4 microgram/dl (n = <1.8) after suppression by 1 mg dexamethasone and prolactin: 32 ng/ml (n = <20)...Diagnosis of isolated premature menarche secondary to autoimmune primary hypothyroidism was made and treatment started with Levothyroxine at dosage of 50 micrograms per day...Normal puberty had started by last follow up with breasts in tanner 2 and pubic hair in tanner stage 1. While dealing with cases of precocious puberty or isolated premature menarche, we should consider primary hypothyroidism too in differential diagnoses.
  • ||||||||||  Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion, albuterol sulfate metered dose inhaler (PT007) / AstraZeneca
    Enrollment open:  PT027 Compared to PT007 in Patients With Asthma With Mannitol-induced Acute Airway Obstruction (clinicaltrials.gov) -  Oct 26, 2022   
    P3,  N=76, Recruiting, 
    Trial completion date: Feb 2027 --> Mar 2028 | Trial primary completion date: Aug 2022 --> Nov 2023 Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg., lopinavir/ritonavir / Generic mfg.
    Journal:  Unsupervised clustering reveals phenotypes of AKI in ICU COVID-19 patients. (Pubmed Central) -  Oct 25, 2022   
    When applied to an ICU cohort of COVID-19 patients, we were able to differentiate three groups of patients. Each expressed specific AKI characteristics and outcomes, which probably reflect a distinct pathophysiology.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  SIRT6 Prevents Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Rats. (Pubmed Central) -  Oct 25, 2022   
    SIRT6 can inhibit ferroptosis and restore the ability of bone formation and angiogenesis. SIRT6 can inhibit the occurrence of ferroptosis, reduce the damage of vascular endothelium, and promote osteogenic differentiation, so as to prevent the occurrence of osteonecrosis of the femoral head.