Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


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  • ||||||||||  Darzalex (daratumumab) / J&J
    Trial completion date, Trial primary completion date:  DEDALO: A Trial for Relapsed and Relapsed/Refractory Multiple Myeloma Patients (clinicaltrials.gov) -  Jul 22, 2024   
    P2,  N=45, Active, not recruiting, 
    This strategy can also have no or minimal extra cost burden to patients. Trial completion date: Jul 2024 --> Jul 2025 | Trial primary completion date: Jul 2024 --> Jul 2025
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg., hydroxyurea / Generic mfg.
    Journal:  An Autopsy Case of Severe COVID-19 Pneumonia Complicated by Intrapulmonary Thrombosis in Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis. (Pubmed Central) -  Jul 22, 2024   
    His platelet count had been controlled in the normal range after treatment with hydroxyurea and 5-aza-2'-deoxycytidine...After admission, he received supplemental oxygen and was administered remdesivir and dexamethasone; however, his respiratory and circulatory status did not improve...Autopsy findings revealed massive thrombi within blood vessels and diffuse alveolar damage in both lungs, which were determined to be the cause of death. In patients with MDS/MPN RS-T combined with COVID-19 pneumonia, clinicians may need to pay close attention to the risk of pulmonary thrombosis.
  • ||||||||||  dexamethasone / Generic mfg., albendazole / Generic mfg.
    Journal:  Neurocysticercosis-Induced Monoparesis: A Case Report of a Rare Neurological Manifestation. (Pubmed Central) -  Jul 22, 2024   
    Treatment with dexamethasone and albendazole substantially improved his motor abilities, highlighting the necessity of considering NCC in differential diagnoses for monoparesis, particularly in endemic areas. This case adds a unique perspective to the clinical spectrum of NCC, highlighting the critical role of prompt and accurate diagnosis followed by appropriate treatment in achieving favorable outcomes.
  • ||||||||||  dexamethasone / Generic mfg.
    Enrollment open:  Relief of Lumbar Spinal Stenosis Symptoms (clinicaltrials.gov) -  Jul 22, 2024   
    P=N/A,  N=50, Recruiting, 
    PBPK modeling is an promising tool to optimize dosing of critically ill patients. Completed --> Recruiting
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Retrospective data, Journal:  Intralesional steroids in refractory caustic esophageal stricture. (Pubmed Central) -  Jul 22, 2024   
    Completed --> Recruiting Even though there is limited evidence available in the pediatric population, intralesional triamcinolone treatment is seemingly useful in the treatment of refractory caustic esophageal stricture, since it reduces length and dilation score.
  • ||||||||||  Jorveza (budesonide orodispersible tablets) / Dr Falk
    Trial completion, Trial completion date, Trial primary completion date:  Evaluation of Efficacy, Safety and Patient' Satisfaction of Therapeutic Switch From Off-Steroids to Budesonide (clinicaltrials.gov) -  Jul 22, 2024   
    P=N/A,  N=31, Completed, 
    Even though there is limited evidence available in the pediatric population, intralesional triamcinolone treatment is seemingly useful in the treatment of refractory caustic esophageal stricture, since it reduces length and dilation score. Not yet recruiting --> Completed | Trial completion date: Jun 2023 --> Oct 2023 | Trial primary completion date: Jun 2023 --> Oct 2023
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Gestational Exposure to Maternal Systemic Glucocorticoids and Childhood Risk of CKD. (Pubmed Central) -  Jul 21, 2024   
    The findings of this study suggest that gestational exposure to systemic glucocorticoids is associated with the occurrence of kidney disease in childhood. If these findings are confirmed, they may inform clinicians who are considering prescribing systemic glucocorticoids during pregnancy.
  • ||||||||||  dexamethasone / Generic mfg., losartan / Generic mfg.
    Review, Journal:  Treatment Approaches for Posttraumatic Stress Disorder Derived from Basic Research on Fear Extinction. (Pubmed Central) -  Jul 21, 2024   
    Pharmacological, behavioral, and device-based augmentation strategies of PTSD treatment based in basic science findings are reviewed, including those that disrupt noradrenergic receptor processes, medications that act on NMDA receptors, physical exercise, cannabinoids, estradiol, dexamethasone, yohimbine, losartan, dopamine, and MDMA, along with the evidence for their efficacy in human clinical samples. While fear extinction provides an exciting translational opportunity to improve PTSD based on basic science findings, we review limitations and challenges of the extant literature as well as future directions.
  • ||||||||||  prednisolone / Generic mfg.
    Review, Journal:  Membranous nephropathy with Kimura's disease: A case report and review of literature. (Pubmed Central) -  Jul 20, 2024   
    This patient highlights the need to regularly monitor patients with KD for the evolution of renal diseases, even if lymphadenopathy regresses. Serial monitoring for eosinophilia, inflammatory markers, and urine examination is needed to help identify subclinical disease early and prompt initiation of specific therapy.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  MAP3K8 is a potential therapeutic target in airway epithelial inflammation. (Pubmed Central) -  Jul 20, 2024   
    These results confirm that MAP3K8 is a key mediator of the early inflammatory response and that it is a potential target in inflammatory diseases. However, current tool compounds do not effectively inhibit its effects.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Balloon dilatation followed by triamcinolone acetonide injection for colostomy stenosis: A case report. (Pubmed Central) -  Jul 20, 2024   
    Overall, this study sheds light on the intricate interplay between genomic complexity and the immune microenvironment driving resistance to Dara-Rd in patients with RRMM. Balloon dilatation combined with local triamcinolone injections may be effective for recurrent stoma stenosis in patients with high-risk comorbidities after rectal cancer surgery.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Clinical, Journal:  Preoperative high dose of dexamethasone in emergency laparotomy: randomized clinical trial. (Pubmed Central) -  Jul 19, 2024   
    P4
    Balloon dilatation combined with local triamcinolone injections may be effective for recurrent stoma stenosis in patients with high-risk comorbidities after rectal cancer surgery. A single preoperative high dose of intravenous dexamethasone significantly reduces the inflammatory response after emergency laparotomy and is associated with enhanced recovery and improved outcome.
  • ||||||||||  hydrocortisone / Generic mfg.
    Preclinical, Journal:  In vivo formation of adrenal organoids in a novel porcine model of adrenocortical cell transplantation. (Pubmed Central) -  Jul 19, 2024   
    Hydrocortisone support was provided during adrenocortical cell engraftment and weaned as tolerated...These results demonstrate potential for ACT based on the development of adrenal organoids at the BTM site. However, the inability to achieve clinically relevant systemic hormone production suggests insufficient function, likely attributable to insufficient cells through delivered dose and subsequent proliferation.
  • ||||||||||  Journal:  Locked-In Syndrome: A Rare Manifestation of Neuropsychiatric Lupus. (Pubmed Central) -  Jul 19, 2024   
    The findings suggested promising avenues for future treatment strategies in patients with severe coronavirus disease-2019 and cytokine release syndrome. Empiric acyclovir, ampicillin, ceftriaxone, and vancomycin were initiated without clinical improvement...Despite these interventions, no discernible clinical improvement was observed, prompting the commencement of 500 mg/m2
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Dynamic stress- and inflammatory-based regulation of psychiatric risk loci in human neurons. (Pubmed Central) -  Jul 19, 2024   
    Across 240 genome-wide association study (GWAS) loci linked to ten brain traits/disorders, the impact of hydrocortisone, interleukin 6, and interferon alpha on transcriptional activity is empirically evaluated in human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons...The dynamic nature of genetic regulation informs the influence of environmental factors, reveals a mechanism underlying pleiotropy and variable penetrance, and identifies specific risk variants that confer greater disorder susceptibility after exposure to stress or inflammation. Understanding neurodevelopmental GxE interactions will inform mental health trajectories and uncover novel targets for therapeutic intervention.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial primary completion date:  Steroid Injection With Exercise for Subacromial Bursitis (clinicaltrials.gov) -  Jul 19, 2024   
    P=N/A,  N=60, Recruiting, 
    In prepubertal children, PP could be Trial primary completion date: Apr 2024 --> Sep 2024
  • ||||||||||  Rituxan (rituximab) / Roche
    Journal:  Two Cases of Pediatric Leucine-Rich Glioma-Inactivated Protein-1 Encephalitis: Clinical Course, Challenges, and Implications. (Pubmed Central) -  Jul 18, 2024   
    This case series underscores the significance of considering LGI-1 encephalitis in the differential diagnosis of pediatric patients exhibiting unexplained neuropsychiatric symptoms and focal seizures and emphasizes the importance of performing both serum and CSF antibody testing. It is necessary to conduct further research to identify the full range of pediatric presentations and to determine the optimal treatment protocol.
  • ||||||||||  tofacitinib / Generic mfg.
    tofacitinib in alopecia totalis (Poster Area) -  Jul 18, 2024 - Abstract #EADV2024EADV_1472;    
    However, emerging therapies such as tofacitinib, a Janus kinase (JAK) inhibitor, have shown promising results and gives potential treatment resulting in promoting hair regrowth n some patients with alopecia totalis. Tofacitinib is an off-label treatment option that requires careful consideration of the potential risks and benefits, as well as the challenges associated with insurance coverage and monitoring.
  • ||||||||||  Jorveza (budesonide orodispersible tablets) / Dr Falk
    BUDESONIDE ORODISPERSIBLE TABLETS EFFECTIVELY INDUCE CLINICO-HISTOLOGICAL REMISSION IN PATIENTS WITH EOSINOPHILIC ESOPHAGITIS PREVIOUSLY TREATED WITH SWALLOWED TOPICAL CORTICOSTEROIDS (Poster Stage 5) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_2752;    
    This post-hoc analysis of the BUL-1 and BUL-2 study program demonstrates that pre-treatment with STC other than BOT does not reduce the likelihood of achieving clinico-histological remission by treatment with BOT.One explanation for successful induction of remission despite prior STC treatment is that initial relapse on STC may be due to insufficient delivery of STC to the esophageal mucosa, and/or insufficient equivalent dose of alternative topical steroid compound, rather than patients becoming truly corticosteroid-refractory. In addition, the specialized formulation of BOT that delivers budesonide precisely to the esophageal mucosa may also improve adherence, owing to a more standardized and convenient method of administration.
  • ||||||||||  Remicade (infliximab) / J&J
    MANAGEMENT OF ACUTE SEVERE COLITIS IN CROHN'S DISEASE (Science Lounge) -  Jul 18, 2024 - Abstract #UEGW2024UEGW_1669;    
    Management must be urgent, and requires medical-surgical coordination. The first-line medical treatment is intravenous corticosteroid therapy.