Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Macromolecular Dexamethasone Prodrug Ameliorates Neuroinflammation and Prevents Bone Loss Associated with Traumatic Brain Injury. (Pubmed Central) -  Nov 9, 2022   
    While probing the potential glucocorticoid side effects that may associate with P-Dex treatment, we discovered that the TBI mice develop osteopenia. Interestingly, the P-Dex-treated TBI mice demonstrated higher bone mineral density and better bone microarchitecture parameters when compared to free Dex and the saline control, revealing the osteoprotective effect of P-Dex in addition to its neuronal protection benefits post-TBI.
  • ||||||||||  Rubraca (rucaparib) / Clovis
    Journal, PARP Biomarker:  Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder. (Pubmed Central) -  Nov 9, 2022   
    According to the results of the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, immune cell infiltration analysis, gene set enrichment analysis (GSEA), Connectivity Map (CMap) analysis, quantitative real-time polymerase chain reaction (qRT-PCR), the genes that were not related to the central nervous system were removed, and finally, mmu_circ_0000331/miR-1224-3p/Unc13c and mmu_circ_0000406/miR-24-3p/St8sia2 ceRNA networks were identified. In addition, the CMap method was used to select the top 4 active compounds with the largest negative correlation absolute values, including cimaterol, Rucaparib, FG-7142, and Hydrocortisone.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Potential influence of COVID-19 and dexamethasone on the reproductive system: what we know and can expect. (Pubmed Central) -  Nov 9, 2022   
    Our review will help medical professionals in the prognosis and follow-up of patients treated with dexamethasone. In addition, given that a considerable amount of uncertainty, confusion and even controversy that still remains, further studies and more clinical trials are urgently needed to improve the understanding of the parameters and the effects of dexamethasone on reproductive function of patients with severe acute respiratory syndrome coronavirus 2 infection.
  • ||||||||||  dordaviprone (ONC201) / Chimerix
    Trial primary completion date:  Oral ONC201 in Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Nov 9, 2022   
    P1/2,  N=21, Active, not recruiting, 
    The type of anti-VEGF agents used made no difference in the results. Trial primary completion date: Sep 2022 --> Dec 2022
  • ||||||||||  Emend intravenous (fosaprepitant) / Merck (MSD), Ono Pharma
    Enrollment closed, Trial primary completion date, Surgery:  Triple Therapy for Postoperative Nausea and Vomiting in Laparoscopic Gastrointestinal Surgery (clinicaltrials.gov) -  Nov 9, 2022   
    P3,  N=1154, Active, not recruiting, 
    Active, not recruiting --> Recruiting | Trial completion date: Nov 2024 --> Jul 2025 | Trial primary completion date: Jun 2022 --> Feb 2025 Recruiting --> Active, not recruiting | Trial primary completion date: Dec 2023 --> Apr 2022
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Inflammation-responsive nanoparticles suppress lymphatic clearance for prolonged arthritis therapy. (Pubmed Central) -  Nov 9, 2022   
    To balance the conflicting requirements, an inflammation-responsive shape transformable nanoparticle, comprised of amyloid β-derived KLVFF peptide and polysialic acid (PSA), coupled with therapeutic agent dexamethasone (Dex) via an acid-sensitive linker, was fabricated and termed as Dex-KLVFF-PSA (DKPNPs)...Our results reveal that intravenously injected DKPNPs display prolonged in vivo circulation and preferential distribution in inflamed joints, where DKPNPs undergo shape transition to fibrous structures, leading to declined lymphatic clearance and prolonged efficacy. Overall, our dual-stimulus responsive transformable nanoparticle offers an intelligent solution to achieve enhanced therapeutic efficacy in RA.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Microalgae extract induces antidepressant-like activity via neuroinflammation regulation and enhances the neurotransmitter system. (Pubmed Central) -  Nov 8, 2022   
    Our results showed that pretreatment of SH-SY5Y cells with ME and MM ameliorated dexamethasone (depression-causing substance)-induced cytotoxicity...ME also induced an increase in neurotransmitter and brain-derived neurotrophic factor levels, and a decrease in corticosterone and pro-inflammatory cytokine levels in the serum, cerebral cortex, and hypothalamus. Altogether, our study is the first to report that 50 mg/kg ME (not 100 mg/kg) exerts antidepressant-like effects via regulating neuroinflammation and modulating neurotransmitter systems in the mouse brain, highlighting the prospects of ME in the treatment of depressive disorders of a psychosocial nature.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Anti-asthmatic activity of standardized hydro-ethanolic and aqueous extracts of Stachytarpheta cayennensis (Rich.) Vahl in a murine model. (Pubmed Central) -  Nov 8, 2022   
    Altogether, our study is the first to report that 50 mg/kg ME (not 100 mg/kg) exerts antidepressant-like effects via regulating neuroinflammation and modulating neurotransmitter systems in the mouse brain, highlighting the prospects of ME in the treatment of depressive disorders of a psychosocial nature. The results presented herein demonstrate for the first time the anti-asthmatic activity of S. cayennensis extracts in a murine model, thereby supporting the ethnopharmacological uses of the plant.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Study on the effect of koumiss on reactivation of Toxoplasma gondii infection. (Pubmed Central) -  Nov 8, 2022   
    Mice were treated with dexamethasone to establish a reactivation model after infection with T. gondii and then treated with koumiss...Our results showed that koumiss treatment improved the clinical symptoms of mice, significantly reduced the organ parasite burden of mice, and improved the composition and structure of intestinal flora. This study provides new evidence for the alleviation and treatment of toxoplasmosis and provides a novel idea for the development and utilization of koumiss.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion date, Trial primary completion date:  Randomized Placebo-controlled Analysis of Superior Laryngeal Nerve Block for Neurogenic Cough (clinicaltrials.gov) -  Nov 8, 2022   
    P3,  N=65, Recruiting, 
    This study provides new evidence for the alleviation and treatment of toxoplasmosis and provides a novel idea for the development and utilization of koumiss. Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Oct 2021 --> Dec 2022
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Enrollment closed:  STEROHCA: Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest (clinicaltrials.gov) -  Nov 8, 2022   
    P2,  N=120, Active, not recruiting, 
    Trial completion date: Oct 2021 --> Dec 2022 | Trial primary completion date: Oct 2021 --> Dec 2022 Recruiting --> Active, not recruiting
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Preclinical, Journal:  Reversal of temperature responses to methylone mediated through bi-directional fecal microbiota transplantation between hyperthermic tolerant and naïve rats. (Pubmed Central) -  Nov 8, 2022   
    These findings suggest that transplantation of gut-microbiomes can confer phenotypic responses to a drug and that the microbiome may be playing a major role in sympathomimetic-mediated hyperthermia. Abbreviations: 3,4-methylenedioxymethamphetamine (MDMA); methylone-induced hyperthermic tolerant (MHT); methylone-naïve (MN); fecal microbiota transplantation (FMT); uncoupling protein (UCP); subcutaneous (sc); intraperitoneal (ip); brown adipose tissue (BAT); skeletal muscle (SKM); sympathetic nervous system (SNS); norepinephrine (NE); quantitative PCR (qRT-PCR); quantification cycle (Cq); High Performance Liquid Chromatography-Electrochemical Detection (HPLC-EC); amplicon sequence variants (ASVs); principal coordinates analysis (PCoA); permutational multivariate analysis (PERMANOVA).
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Review, Journal:  Intralesional Treatments in Hidradenitis Suppurativa: A Systematic Review. (Pubmed Central) -  Nov 8, 2022   
    The main limitation of the systematic review was the general quality of the articles included. In conclusion, IL treatments such as corticosteroid injections and light-based therapies seem to be effective and safe for both acute inflammatory lesions and fistulas, although more prospective studies, with higher sample sizes and with standardized outcomes are needed to provide more scientific evidence on the subject.
  • ||||||||||  nintedanib / Generic mfg.
    Preclinical, Journal:  Effect of Nintedanib Nanothermoreversible Hydrogel on Neovascularization in an Ocular Alkali Burn Rat Model. (Pubmed Central) -  Nov 8, 2022   
    Nintedanib at low concentrations (<8 μM) had no significant cytotoxicity to HCECs but significantly induced apoptosis and inhibited the expression of VEGFA and CD31 and the migration of HUVECs. Nanomorphic thermoreversible hydrogel is superior among the nintedanib ophthalmic preparations, showing better inhibition of CNV in alkali-burned eyeballs and it blocked the migration and proangiogenic ability of HUVECs.
  • ||||||||||  enzalutamide capsule / Generic mfg., docetaxel / Generic mfg.
    P3 data, Journal:  Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study. (Pubmed Central) -  Nov 8, 2022   
    P3
    Nanomorphic thermoreversible hydrogel is superior among the nintedanib ophthalmic preparations, showing better inhibition of CNV in alkali-burned eyeballs and it blocked the migration and proangiogenic ability of HUVECs. PRESIDE met its primary endpoint and showed that continuing enzalutamide with docetaxel plus androgen deprivation therapy delayed time to progression compared with docetaxel plus androgen deprivation therapy alone, supporting the hypothesis that enzalutamide maintenance could control persistent androgen-dependent clones in men with mCRPC who progress after treatment with enzalutamide alone.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater. (Pubmed Central) -  Nov 8, 2022   
    17β-estradiol was confirmed as the estrogen dominating the observed estrogenic mixture effect and triamcinolone acetonide was the dominant driver of glucocorticogenic activity...Bioassay-specific effect-based trigger values (EBTs) from the literature, but also newly calculated EBTs based on previously proposed derivation options, were applied and allowed a preliminary assessment of the water quality of the tested WWTP effluent samples. Overall, this study demonstrates the high potential of linking chemical with effect-based analysis in water quality assessment with regard to EDC contamination.
  • ||||||||||  Korlym (mifepristone) / Corcept Therap
    Enrollment change, Trial termination:  Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency (clinicaltrials.gov) -  Nov 7, 2022   
    P2,  N=3, Terminated, 
    Overall, this study demonstrates the high potential of linking chemical with effect-based analysis in water quality assessment with regard to EDC contamination. N=26 --> 3 | Recruiting --> Terminated; low recruitment