Glucocorticoid Receptor 

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  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Hydrocortisone-induced symptomatic sinus bradycardia. (Pubmed Central) -  Nov 21, 2022   
    Her symptoms entirely resolved after discontinuation of the steroid. This case highlights the importance of obtaining baseline ECG and cardiac monitoring in patients treated with pulsed high-dose steroids.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Efficacy and safety of heparin plus dexamethasone after partial splenic embolization for liver cirrhosis with massive splenomegaly. (Pubmed Central) -  Nov 21, 2022   
    In this updated analysis, D-Vd maintained significant efficacy benefits versus Vd alone and demonstrated a consistent safety profile, further supporting the use of D-Vd as a standard of care in Chinese patients with RRMM. The combined use of dexamethasone and low-molecular-weight heparin after PSE is a safe and effective treatment strategy that can significantly reduce the incidence of complications after PSE (such as post-embolization syndrome, PVT, refractory ascites).
  • ||||||||||  Advantan (methylprednisolone aceponate) / Bayer
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Immune cell:  Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids (clinicaltrials.gov) -  Nov 21, 2022   
    P1,  N=35, Completed, 
    The combined use of dexamethasone and low-molecular-weight heparin after PSE is a safe and effective treatment strategy that can significantly reduce the incidence of complications after PSE (such as post-embolization syndrome, PVT, refractory ascites). Recruiting --> Completed | N=60 --> 35 | Trial completion date: Oct 2023 --> Nov 2022 | Trial primary completion date: Oct 2023 --> May 2022
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Glucocorticoid-based pharmacotherapies preventing PTSD. (Pubmed Central) -  Nov 20, 2022   
    Preclinical studies provide precise insight into the mechanisms mediating this preventive effect, showing glucocorticoid-based prevention to reduce long-lasting behavioral and neurobiological abnormalities caused by traumatic stress. However, further research is needed to delineate the precise mechanisms and the extent to which these interventions can translate into lower PTSD rates and morbidity.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Residual effects of intra-articular betamethasone and triamcinolone acetonide in an equine acute synovitis model. (Pubmed Central) -  Nov 19, 2022   
    Current regulatory guidelines may be insufficient if the concern is residual anti-inflammatory effects. Additionally, intra-articular corticosteroid administration is not without risk, as evidenced by a significant suppression of serum cortisol concentration and, as such, the benefits of their administration should be weighed against those risks.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical data, Journal:  Early antiviral and supervisory dexamethasone treatment improve clinical outcomes of nonsevere COVID-19 patients. (Pubmed Central) -  Nov 19, 2022   
    The unfavorable prognostic factors for symptom deterioration were advanced age, body weight ≥ 90 kg, unvaccinated status, higher reverse transcription-polymerase chain reaction cycle threshold, and late favipiravir treatment. The early delivery of essential treatment, including antiviral and supervisory dexamethasone, to ambulatory nonsevere COVID-19 patients yielded favorable outcomes during the COVID-19 pandemic in Thailand.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Preclinical, Journal:  The effectiveness of essential oil from Citrus limon peel on Candida albicans biofilm formation: An experimental in vivo study. (Pubmed Central) -  Nov 19, 2022   
    Male Wistar rats weighing 200-300 g were inoculated with C. albicans for 48 h and then given a single dose of oral methylprednisolone as an immunosuppressant...Essential oil from C. limon peel at a dose of 1.56% showed the strongest ability to inhibit cyto-morphometric changes and biofilm formation. These findings demonstrate that essential oil of C. limon peel is a potential antifungal candidate for the treatment of candidiasis.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, Adverse events:  No Adverse Effects on Periarticular Tissue by Intra-articular Vitamin D analogue Calcipotriol in a Reduced-Dose Zymosan-Induced Arthritis Model in Rats. (Pubmed Central) -  Nov 19, 2022   
    The rats were divided into four groups: vehicle (n=9), dexamethasone 0.1 mg/kg (n=9), calcipotriol 0.1 mg/kg (n=8) and negative control (n=10) with no injections...Calcipotriol did not cause adverse effects on cartilage or subchondral bone within a week, suggesting that it could be safely used in local treatment of arthritis. The alleviated model caused synovitis with local and systemic inflammatory response without cartilage erosions, which might be useful in studying self-limiting synovitis where cartilage or bone effects are not of primary interest.
  • ||||||||||  Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
    P3 data, Journal:  Triamcinolone Acetonide Suprachoroidal Injectable Suspension for Uveitic Macular Edema: Integrated Analysis of Two Phase 3 Studies. (Pubmed Central) -  Nov 19, 2022   
    P3
    The alleviated model caused synovitis with local and systemic inflammatory response without cartilage erosions, which might be useful in studying self-limiting synovitis where cartilage or bone effects are not of primary interest. In this integrated analysis utilizing strict inclusion criteria, SCS-TA was found effective in the treatment of patients with macular edema associated with noninfectious uveitis and was generally well tolerated.
  • ||||||||||  OTS167 / OncoTherapy
    Journal:  Anti-leukemic properties of the kinase inhibitor OTSSP167 in T cell acute lymphoblastic leukemia. (Pubmed Central) -  Nov 19, 2022   
    OTSSP167 exhibited synergistic interactions when combined with dexamethasone, L-asparaginase, vincristine, and etoposide. Our findings reveal novel anti-leukemic properties of OTSSP167 in T-ALL and support the use of OTSSP167 as an adjuvant drug to increase treatment response and reduce relapses in pediatric T-ALL.
  • ||||||||||  fluocinonide / Generic mfg.
    Journal:  Reevaluating Corticosteroid Classification Models in Patient Patch Testing. (Pubmed Central) -  Nov 19, 2022   
    The fluocinonide positivity rate corresponded to the highest copositivity rate with other corticosteroids (mean [SD], 50.7% [26.1%])...In this qualitative study, copositivity rates were variable between corticosteroids, and overall patch test positivity for allergy to topical corticosteroids was rare. Previously published corticosteroid classifications are not supported by real patient-derived data and may not be accurate in predicting corticosteroid copositivity.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Preclinical, Journal:  Predicting in vitro lung deposition behavior of combined dry powder inhaler via rheological properties. (Pubmed Central) -  Nov 19, 2022   
    Two drugs (fluticasone propionate and salmeterol xinafoate) and their combination of DPI formulations were prepared using fine lactose content (in the range of 1%-20%) as a variable...The results of the principal component analysis showed that better flowability and suitable adhesion contributed to higher in vitro deposition of the drug in the formulation, and the contribution of adhesion (75.42%) was greater than that of flowability (24.58%). In conclusion, rheological properties is an effective tool for predicting the deposition behavior of DPI not only in single but also in combined DPIs.
  • ||||||||||  tobramycin/dexamethasone / Generic mfg.
    Journal:  High-frequency deep sclerotomy as adjunctive therapy in open angle glaucoma patients. (Pubmed Central) -  Nov 19, 2022   
    This study presents the data on our first surgical experience with high-frequency deep sclerotomy that was conducted on 23 patients who had medically-uncontrolled, primary, open-angle glaucoma. The results indicate that HFDS is safe and efficient in reducing IOP.
  • ||||||||||  clarithromycin / Generic mfg., azithromycin / Generic mfg., fluticasone / Generic mfg.
    Clinical, Journal, Combination therapy:  Introducing a Novel Combination Therapy with Macrolides for the Treatment of Chronic Rhinosinusitis: A Randomized Controlled Trial. (Pubmed Central) -  Nov 19, 2022   
    However, post-intervention, LM scores reduced considerably in both groups, but the change was significantly higher in the azithromycin group (P<0.001). In combination with conventional therapies for CRS in adults, a four-week course of treatment with azithromycin is more effective than clarithromycin.Trial Registration Number: IRCT20201209049661N1.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma. (Pubmed Central) -  Nov 18, 2022   
    Comparison across glucose tertiles revealed no differences in performance status (KPS), dexamethasone dose, MGMT methylation, or methylation subclass...Higher average glucose values were associated with poorer OS in RTKI and Mesenchymal IDH-wt GBM, but not RTKII. There were no discernible epigenetic or metabolomic differences between tumors in different glucose environments, suggesting a potential survival benefit to lowering systemic glucose in selected molecular subtypes.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Review, Journal:  Hypoxia inducible factor-1α mediates the mechanism of the Hedgehog pathway in tendinopathy repair by Asperosaponin VI. (Pubmed Central) -  Nov 18, 2022   
    The tendinopathy model group was further divided into the model group (MG), ASA VI group (AG), and triamcinolone acetonide + lidocaine group (TG)...ASA VI inhibits local vascular hyperproliferation and downregulates the HIF-1α/Hh pathway to promote the tendinous differentiation of tendon stem/progenitor cells and the repair of tendinopathy. The effect of ASA VI on HIF-1α levels may be an effective target in the treatment of tendinopathy.
  • ||||||||||  dexamethasone / Generic mfg., morphine sulphate / Generic mfg.
    Preclinical, Journal:  Triptonide, a Diterpenoid Displayed Anti-Inflammation, Antinociceptive, and Anti-Asthmatic Efficacy in Ovalbumin-Induced Mouse Model. (Pubmed Central) -  Nov 18, 2022   
    Animals were also managed with the standard drug dexamethasone (50 mg/kg) followed by the asthma induction, which is also efficient over OVA-induced experimental animals...The animals were administered with triptonide (5, 10, and 15 mg/kg) and separate standard drugs like diclofenac sodium (10 mg/kg) and morphine (5 mg/kg) over chemical-induced nociceptive animals...Ultimately, the present work explored the evident powerful anti-inflammation, antinociceptive, and anti-asthma properties of a diterpenoid, triptonide experimental animal models. And it is recommended that triptonide is an excellent compound in the management of asthma and its related diseases.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Glycosaminoglycans Influence Extracellular Matrix of Human Trabecular Meshwork Cells Cultured on 3D Scaffolds. (Pubmed Central) -  Nov 18, 2022   
    Our findings show that GAGs and dexamethasone play an influencing role in hTM ECM turnover at both transcriptional and translational levels by altering expression levels of elastin, laminin, and MMP-2. Understanding the role of exogeneous factors on hTM cell behavior is helpful in gaining insights on glaucoma pathogenesis and ultimately pivotal in development of novel therapeutics against the disease.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Systemic corticosteroids for the treatment of COVID-19: Equity-related analyses and update on evidence. (Pubmed Central) -  Nov 18, 2022   
    Findings of equity-related subgroup analyses should be interpreted with caution because of their explorative nature, low precision, and missing data. We identified 42 ongoing and 23 completed studies lacking published results or relevant information on the study design, suggesting there may be possible changes of the effect estimates and certainty of the evidence in the future.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone. (Pubmed Central) -  Nov 18, 2022   
    Altogether, our findings suggest Zol+Dex block the differentiation of osteoclasts through the expression of IFN-β. Revealing the molecular pathway behind this regulation may lead to the development of IFN-β-based therapy to inhibit osteoclastogenesis in multiple myeloma patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Dexamethasone application for in vitro fertilisation in non-classic 17-hydroxylase/17,20-lyase-deficient women. (Pubmed Central) -  Nov 18, 2022   
    Two healthy boys, weighing 2100 and 2000 g, were delivered at 36 weeks' gestation. Rational use of dexamethasone synchronised embryonic development with the endometrial implantation window, while not using in post-implantation avoided its side effects and promoted healthy live births in women non-classic 17OHD undergoing in vitro fertilisation.
  • ||||||||||  Atectura Breezhaler (indacaterol/mometasone furoate) / Novartis, Merck (MSD)
    Enrollment closed, Trial completion date, Trial primary completion date:  Anti-inflammatory Effects Glycopyrronium (clinicaltrials.gov) -  Nov 18, 2022   
    P3,  N=28, Active, not recruiting, 
    Rational use of dexamethasone synchronised embryonic development with the endometrial implantation window, while not using in post-implantation avoided its side effects and promoted healthy live births in women non-classic 17OHD undergoing in vitro fertilisation. Unknown status --> Active, not recruiting | Trial completion date: Feb 2022 --> Dec 2022 | Trial primary completion date: Feb 2022 --> Dec 2022
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly, REGEN-COV (casirivimab/imdevimab) / Regeneron, Roche, Actemra IV (tocilizumab) / Roche, JW Pharma
    Journal:  Establishing COVID-19 trials at scale and pace: Experience from the RECOVERY trial. (Pubmed Central) -  Nov 18, 2022   
    In particular, its focus on recruiting large numbers of patients to identify or rule out moderate but worthwhile benefits of treatment, and the design decisions that followed from this. Similar large streamlined trials could produce similarly clear answers about the treatment of many other common diseases.
  • ||||||||||  hydrocortisone / Generic mfg., desmopressin / Generic mfg.
    Review, Journal, HEOR:  The Cost Effectiveness of Implementation of a Postoperative Endocrinopathy Management Protocol after Resection of Pituitary Adenomas. (Pubmed Central) -  Nov 18, 2022   
    There was no significant change in length of stay or need for hydrocortisone supplementation postoperatively between the two groups...There was no significant change in the rate of 30-day readmission. Conclusion  Implementation of a postoperative management protocol results in a more efficient diagnosis and management of endocrinopathy after pituitary adenoma surgery which translates to decreased cost.