Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Effects of antenatal corticosteroids on neonatal blood glucose fluctuation in late-preterm infants. (Pubmed Central) -  Nov 29, 2022   
    The patients in the complete course group had the highest proportion of neonatal hypoglycemia (16.4% vs. 3.6% and 6.5%).The patients exposed to a complete course of dexamethasone had significantly lower blood glucose levels within 12 h of birth than the control group, although no significant differences were observed after 24 h...The effects are more pronounced in the first 12 h of life, with males being more severely affected; however, the effects on blood glucose levels were not significant 24 h after birth. This can provide a reference for future clinical studies.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Cultured Neonatal Murine Primary Myotubes as a Model to Study Muscle Atrophy. (Pubmed Central) -  Nov 29, 2022   
    This can provide a reference for future clinical studies. Here, we describe protocols for the isolation, culture, and differentiation of primary murine myotubes and the induction of myotube atrophy using dexamethasone, a synthetic corticosteroid..
  • ||||||||||  dexamethasone / Generic mfg.
    Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizures. ACTH and Dexamethasone induce different pathway enrichments (Hall B, Level 3) -  Nov 29, 2022 - Abstract #AES2022AES_1196;    
    Establishing a causal link will be important to determine if anti-inflammatory therapy can modulate long term consequences of early life FS in AS. Our results in this study indicate that the genes and pathways ACTH influences help push gene expression in the brain back to a normal state of expression by upregulating genes which support homeostatic balance and downregulating those which might contribute to excitotoxic cell damage post-ELS; in support of the more targeted and brain-specific differential gene expression, we suggest that ACTH may exert its differential actions through pathways that are dependent on melanocortin receptors in the brain.
  • ||||||||||  azathioprine / Generic mfg.
    Trial completion date, Trial initiation date, Trial primary completion date:  MOGwAI: Azathioprine in MOGAD (clinicaltrials.gov) -  Nov 28, 2022   
    P3,  N=126, Not yet recruiting, 
    Thus, ibrutinib may be a safe and effective therapeutic option for patients with RS and CNS involvement. Trial completion date: Oct 2028 --> Jan 2029 | Initiation date: Oct 2022 --> Jan 2023 | Trial primary completion date: Oct 2025 --> Jan 2026
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca, budesonide/formoterol (PT009) / AstraZeneca
    Trial completion date, Trial primary completion date:  Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (LOGOS) (clinicaltrials.gov) -  Nov 28, 2022   
    P3,  N=2200, Recruiting, 
    Trial completion date: Oct 2028 --> Jan 2029 | Initiation date: Oct 2022 --> Jan 2023 | Trial primary completion date: Oct 2025 --> Jan 2026 Trial completion date: Dec 2024 --> Mar 2024 | Trial primary completion date: Dec 2024 --> Mar 2024
  • ||||||||||  Symproic (naldemedine) / Shionogi, Collegium Pharma, Movantik (naloxegol) / AstraZeneca, RedHill, Kyowa Kirin
    Review, Journal:  The Impact of P-Glycoprotein on Opioid Analgesics: What's the Real Meaning in Pain Management and Palliative Care? (Pubmed Central) -  Nov 27, 2022   
    Peripherally acting mu-opioid receptors antagonists (PAMORAs), such as naloxegol and naldemedine, are substrates of P-gp, which prevent their penetration in the central nervous system. In our review, we explore the interactions between P-gp and opioidergic drugs, with their implications in clinical practice.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg.
    Journal:  Effects of Different Corticosteroid Doses in Elderly Unvaccinated Patients with Severe to Critical COVID-19. (Pubmed Central) -  Nov 27, 2022   
    For this reason, the use of 6 mg of dexamethasone has become a standard of care, although this regime may not be optimal...We showed that in patients receiving a higher dose of prednisone, the time to negative swab was significantly longer...Finally, the BMI, WBC number, and NLR value were directly related to death. In conclusion, although the optimal glucocorticoid dose is still undefined, our retrospective study supports the absence of beneficial effects in the utilization of higher doses of corticosteroids in elderly patients with severe to critical COVID-19.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Analgesic and Anti-Inflammatory Properties of Ethanolic Extract of Piper vicosanum Leaves. (Pubmed Central) -  Nov 27, 2022   
    The oral administration of EEPV (100, 300, and 700 mg/kg) and dexamethasone (1 mg/kg) were performed in carrageenan-induced pleurisy, in formalin and acetic-acid-induced nociception, and in zymosan-induced articular inflammation models in Swiss mice...The EEPV also significantly inhibited carrageenan-induced leukocyte rolling and adhesion. The present study revealed, for the first time, the antiarthritic and antinociceptive effects of the EEPV.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Rebound pain after peripheral nerve blocks. (Pubmed Central) -  Nov 26, 2022   
    Possible interventions constitute patient education, bridging analgesia from the resolution of the nerve block, multimodal analgesic regimes, block adjuvants, or continuous pain catheters. Factors such as low age, female gender, bone surgery, and absence of IV dexamethasone are likely to be associated with rebound pain, as argued in this review.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Electrochemical deposition of Ppy/Dex/ECM coatings and their regulation on cellular responses through electrical controlled drug release. (Pubmed Central) -  Nov 26, 2022   
    In this study, the porous network-like titanium matrix was constructed and polypyrrole/dexamethasone (Ppy/Dex) composite coatings with three-dimensional nano-network structure were prepared by electrochemical deposition...In terms of anti-inflammatory properties, ECM exhibited simultaneous inhibition of both pro- and anti-inflammatory process, while Dex demonstrated significant promotion of anti-inflammatory processes. In this work, the effect of electrical controlled drug release on osteogenic differentiation and inflammation in the ECM cell microenvironment was achieved by preparing Ppy/Dex/ECM composite coatings, which is of great significance for bone tissue engineering and regenerative medicine.
  • ||||||||||  montelukast / Generic mfg., fluticasone / Generic mfg.
    Trial primary completion date:  Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Montelukast vs Fluticasone (clinicaltrials.gov) -  Nov 25, 2022   
    P=N/A,  N=75678, Active, not recruiting, 
    In this work, the effect of electrical controlled drug release on osteogenic differentiation and inflammation in the ECM cell microenvironment was achieved by preparing Ppy/Dex/ECM composite coatings, which is of great significance for bone tissue engineering and regenerative medicine. Trial primary completion date: Jul 2022 --> Nov 2022
  • ||||||||||  Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi, Nulojix (belatacept) / BMS
    Trial completion, Trial primary completion date:  Belatacept Pilot Study in Lung Transplantation Immunosuppression in Lung Transplantation (clinicaltrials.gov) -  Nov 25, 2022   
    P2,  N=27, Completed, 
    Trial primary completion date: Jul 2022 --> Nov 2022 Active, not recruiting --> Completed | Trial primary completion date: Aug 2021 --> Aug 2022
  • ||||||||||  fluticasone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  Respiratory questionnaire-based analysis of awareness of COPD in a large multicenter rural population-based study in India. (Pubmed Central) -  Nov 25, 2022   
    Total 42% cases received oral treatment as theophylline in 16% cases, salbutamol in 7% cases, oral steroids in 19% cases (p < 0.0001). "Doctor-patient-drug trio" discordance clubbed as "difficult doctor, difficult patient, and difficult treatment" is a very crucial issue observed during diagnosis and management of COPD in peripheral settings in India.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  All aspects of sciatic nerve injection injury: an experiment with 78 rats. (Pubmed Central) -  Nov 25, 2022   
    Collectively, our findings demonstrate for the first time that BMI contributes to GC insensitivity in eosCRSwNP patients. We have demonstrated that any medical injections applied to the epineurial, endoneurial, or intrafascicular compartments of the sciatic nerve may cause functional and electrophysiological loss with or without deterioration of the peripheral nerve architecture.
  • ||||||||||  dexamethasone sodium phosphate-loaded RBC (EDS-EP) / Erydel
    Journal:  New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease. (Pubmed Central) -  Nov 25, 2022   
    No cure is currently available for these patients but positive effects on neurologic features in AT patients have been achieved by dexamethasone administration through autologous erythrocytes (EryDex) in phase II and phase III clinical trials, leading us to explore the molecular mechanisms behind the drug action...These outcomes are triggered by the kinase and further functional domains of the tested ATM variants, that are useful for restoring cellular functionality. The in silico designed ATM variant eliciting most of the functionality recover may be exploited in gene therapy or gene delivery for the treatment of AT patients.