Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Variability of Steroid Prescription for COVID-19 Associated Pneumonia in Real-Life, Non-Trial Settings. (Pubmed Central) -  Dec 8, 2022   
    The RECOVERY study documented lower 28-day mortality with the use of dexamethasone in hospitalized patients on invasive mechanical ventilation or oxygen with COVID-19 Pneumonia...The prescription of steroids in Covid-19 ARDS is variable. The dose of steroids impacts mortality rate and length of stay in ICU, although patients treated with high dose steroids seem to stay more days in ICU.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes. (Pubmed Central) -  Dec 8, 2022   
    Gene expression of Ctsk and protein levels of cathepsin K were assessed in MLO-Y4 cell lines exposed to dexamethasone (Dex) of different time (0, 12, 24 hours) and dose (0, 10-8 and 10-6 M) courses by RT-qPCR and western blotting, respectively...GC-induced PINK1-mediated mitophagy substantially modulates the production of cathepsin K in osteocytes, which could be an underlying mechanism by which osteocytes contribute to the extracellular matrix degradation during bone loss. Findings of the current study indicate a possible role of osteocyte mitophagy in GC-induced bone loss, which provides a potential therapeutic approach to alleviate GC-induced osteoporosis by targeting PINK1-mediated osteocytic mitophagy.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal, IO biomarker:  Sini Decoction inhibits TLR4/NF-κB signaling pathway to improve airway remodeling of allergic asthmatic mice (Pubmed Central) -  Dec 7, 2022   
    Forty-eight SPF-grade BALB/c mice were randomly assigned into a blank control group, a model group, a dexamethasone group, and high-, medium-, and low-dose Sini Decoction groups, with 8 mice in each group...Furthermore, the decoction down-regulated the protein and mRNA levels of TLR4, NF-κB, caspase-1, and IL-13 in mouse lung tissue. In conclusion, Sini Decoction can improve air remodeling by inhibiting the TLR4/NF-κB signaling pathway.
  • ||||||||||  budesonide / Generic mfg.
    Journal:  Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis. (Pubmed Central) -  Dec 7, 2022   
    The treatment with BUD-loaded micelles alleviates the colitis severity as analyzed in histopathology and efficiently, overcoming the disease severity via downregulation of various related cytokines (MPO, NO, and TNF-α) and inflammatory enzymes such as COX-2 and iNOS. Results of the study suggest that BUD-loaded nano-sized micelles effectively attenuate the disease conditions in colitis.
  • ||||||||||  Review, Journal:  Progress and Challenges in Bacterial Meningitis: A Review. (Pubmed Central) -  Dec 7, 2022   
    Bacterial meningitis affects approximately 0.9 per 100 000 individuals to 80 per 100 000 individuals per year and has a mortality rate as high as 54%. First-line therapy is prompt empirical intravenous antibiotic therapy and adjunctive dexamethasone.
  • ||||||||||  Journal:  Postoperative Nausea and Vomiting in Opioid-Free Anesthesia Versus Opioid Based Anesthesia in Laparoscopic Cholecystectomy. (Pubmed Central) -  Dec 7, 2022   
    Introduction to anesthesia consisted of giving midazolam at 0.04 mg/kg, lidocaine at 1 mg/kg, propofol at 2 mg/kg, ketamine at 0.5 mg/kg, and 0.6 mg/kg of rocuronium bromide...Immediately after extraction of the gallbladder patients from group 2 (OFAG) received 2.5 g of metamizole intravenously...Even not statistically significant, PONV have occurred more often in patients who received opioid anesthesia. Postoperative nausea and vomiting occurs more often in patients who received opioids during laparoscopic cholecystectomy compared to patients who received opioid free anesthesia, but without statistical significance.
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date, Metastases:  Dexamethasone for Symptom Burden in Advanced Cancer Patients (clinicaltrials.gov) -  Dec 7, 2022   
    P2,  N=132, Active, not recruiting, 
    Postoperative nausea and vomiting occurs more often in patients who received opioids during laparoscopic cholecystectomy compared to patients who received opioid free anesthesia, but without statistical significance. Trial completion date: Feb 2022 --> Feb 2023
  • ||||||||||  prednisone / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Treatment patterns and unmet needs in adults with classic congenital adrenal hyperplasia: A modified Delphi consensus study. (Pubmed Central) -  Dec 6, 2022   
    The limited areas of consensus obtained in this study reflect the variability in treatment practices for adults with classic CAH, even among clinicians with expertise in treating this population. However, all panelists agreed on the need for new treatments for classic CAH and the importance of many disease- and GC-related complications, which are difficult to manage with currently available treatments.
  • ||||||||||  dexamethasone / Generic mfg.
    Review:  Pituitary apoplexy and COVID-19 vaccination: a case report and literature review. (Pubmed Central) -  Dec 6, 2022   
    Adverse Drug Reaction was reported to AIFA (Italian Medicines Agency).A stress dexamethasone dose was administered due to the risk of adrenal insufficiency and to reduce oedema...Our case underlines that SARS-CoV-2 can associate with apoplexy by penetrating the central nervous system, even in cases of negative nasal swab. Patients with pituitary tumours may develop pituitary apoplexy after exposure to SARS-CoV-2, therefore clinicians should be aware of this risk.
  • ||||||||||  methylprednisolone acetate / Generic mfg., prednisone / Generic mfg.
    Journal:  Investigation of the Influence of Various Functional Groups on the Dynamics of Glucocorticoids. (Pubmed Central) -  Dec 6, 2022   
    These types of studies provide a clear picture of the structure-activity relationship of the drug molecules, which will enlighten the path of developing highly potent glucocorticoids with minimum side effects. Another important aspect of these types of studies is to provide information about the electronics configuration and nuclear spin dynamics at crystallographically different carbon nuclei sites of five glucocorticoids, which will enrich the field of "NMR crystallography".
  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion date:  MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty (clinicaltrials.gov) -  Dec 6, 2022   
    P=N/A,  N=130, Active, not recruiting, 
    Trial completion date: Feb 2026 --> Oct 2027 | Trial primary completion date: Feb 2024 --> Oct 2022 Trial completion date: Nov 2022 --> May 2023
  • ||||||||||  dexamethasone / Generic mfg.
    New P3 trial:  Dexamethasone Treatment for OSA in Children (clinicaltrials.gov) -  Dec 6, 2022   
    P3,  N=22, Recruiting, 
  • ||||||||||  Journal:  Cerebrovascular accident in a child with precursor B-cell acute lymphoblastic leukemia and coronavirus disease 2019: a case report. (Pubmed Central) -  Dec 6, 2022   
    Recruiting --> Active, not recruiting | N=38 --> 11 | Trial completion date: Jan 2023 --> Aug 2023 | Trial primary completion date: Jan 2023 --> Aug 2023 Owing to the link between coronavirus disease 2019 and hematologic cancers with hypercoagulopathy and the tendency of patients with leukemia to have coronavirus disease 2019 complications, children with leukemia as well as suspected coronavirus disease 2019 must be hospitalized to prevent blood clot formation.
  • ||||||||||  dexamethasone / Generic mfg., ondansetron / Generic mfg.
    Journal:  Combination of dexamethasone and ondansetron in prophylaxis nausea and vomiting in gynecological operation. (Pubmed Central) -  Dec 5, 2022   
    Owing to the link between coronavirus disease 2019 and hematologic cancers with hypercoagulopathy and the tendency of patients with leukemia to have coronavirus disease 2019 complications, children with leukemia as well as suspected coronavirus disease 2019 must be hospitalized to prevent blood clot formation. Based on our study and previous reports, both dexamethasone and ondansetron are efficient and safe in preventing nausea and vomiting in gynecological operations; however, combination of both provides the best results.