Glucocorticoid Receptor 

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  • ||||||||||  Trial completion date, Trial primary completion date:  Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2 (clinicaltrials.gov) -  Dec 28, 2022   
    P2,  N=60, Enrolling by invitation, 
    Trial primary completion date: Jan 2023 --> Jan 2024 Trial completion date: Dec 2022 --> Apr 2023 | Trial primary completion date: Dec 2022 --> Apr 2023
  • ||||||||||  dexamethasone / Generic mfg., tropisetron / Generic mfg.
    Enrollment open:  Efficacy of Three Antiemetics in Preventing Nausea and Vomiting (clinicaltrials.gov) -  Dec 28, 2022   
    P1,  N=200, Recruiting, 
    Trial completion date: Nov 2022 --> Nov 2023 | Trial primary completion date: Nov 2022 --> Nov 2023 Not yet recruiting --> Recruiting
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Major Publications in the Critical Care Pharmacotherapy Literature: 2021. (Pubmed Central) -  Dec 27, 2022   
    If validated, future work might test whether plasma IL-6 could be used as a tool for a personalized approach to duration of dexamethasone treatment in severe COVID-19. This synoptic review provides a summary and perspective of the most impactful articles relevant to the pharmacotherapy of critically ill adults published in 2021.
  • ||||||||||  dexamethasone / Generic mfg.
    Retrospective data, Journal:  Survival and care practices of periviable births of <24 weeks' gestation-a single center retrospective study in China, 2015-2021. (Pubmed Central) -  Dec 27, 2022   
    In the delivery room, surfactant was prescribed for 46.9% of the infants, and postnatal dexamethasone (≥2 courses) was prescribed to 61.5% of the infants...No or mild neurodevelopmental impairment in surviving infants was 76.9% (10 of 13). Although the survival rate of periviable infants was shown to be improved in our study, there is still much room for improvement, and active follow-up information should be conducted.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Dexamethasone may affect the occurrence of parenteral nutrition-associated cholestasis in preterm neonates. (Pubmed Central) -  Dec 27, 2022   
    Data including the administration of dexamethasone, intravenous nutrition, and enteral feeding were collected by at least three audits...The prolonged duration of parenteral nutrition was a risk factor, and late postnatal dexamethasone treatment was a protective factor in reducing the incidence of parenteral nutrition-associated cholestasis. Dexamethasone treatment may reduce the occurrence of parenteral nutrition-associated cholestasis in preterm neonates.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Simultaneous degradation of glucocorticoids and sterilization using bubbling corona discharge plasma based systems: A promising terminal water treatment facility for hospital wastewater. (Pubmed Central) -  Dec 27, 2022   
    Due to the lack of data about GC removal using advanced treatment processes, a novel Paralleling and bubbling corona discharge reactor (PBCD) combined with iron-loaded activated-carbon fibre (Fe-ACF) was addressed in this study to degrade GCs represented by Hydrocortisone (HC) and Betamethasone (BT)...Possible degradation pathways for HC and BT were proposed, which mainly included defluorination, keto acid decarboxylation, demethylation, intramolecular cyclization, cleavage and ester hydrolysis, indicating a reduction in GC toxicity. Since GCs are widely used in patients with COVID-19 and their wastewater needs to be sterilized simultaneously, the intensive and electrically driven PBCD-based system is promising in GC pollution control and sterilization in terminal water treatment facilities.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Concurrent versus delayed exposure to corticosteroids in equine articular tissues cultured with local anesthetic. (Pubmed Central) -  Dec 27, 2022   
    Since GCs are widely used in patients with COVID-19 and their wastewater needs to be sterilized simultaneously, the intensive and electrically driven PBCD-based system is promising in GC pollution control and sterilization in terminal water treatment facilities. The lack of an effect of concurrent versus delayed treatment might indicate that concurrent therapy is acceptable.
  • ||||||||||  Journal:  Novel management of granuloma formation secondary to dermal filler: A multi-modality approach. (Pubmed Central) -  Dec 26, 2022   
    GFBR provides both a medical and aesthetic issue for these patients including mental distress, pain, and dysfunction, therefore having an effective treatment for GFBR will affect medical management of these patients, improving patient outcomes and satisfaction. Our proposed regimen for GFBR has been shown to be highly efficacious and safe for these patients, providing a significant improvement in both function and cosmesis of the area.
  • ||||||||||  ketorolac / Generic mfg., dexamethasone / Generic mfg.
    Journal:  A novel post-operative drop regimen reduces risk of ocular hypertension following pars plana vitrectomy. (Pubmed Central) -  Dec 26, 2022   
    Our proposed regimen for GFBR has been shown to be highly efficacious and safe for these patients, providing a significant improvement in both function and cosmesis of the area. A post-PPV drop regimen of one week dexamethasone 0.1%/antibiotic and one month ketorolac may be as effective as an anti-inflammatory but safer in terms of OHT incidence than standard care one month dexamethasone 0.1%.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  An autopsy case of polyarteritis nodosa accompanied with multiple immune-specific autoantibodies and rhabdomyolysis (Pubmed Central) -  Dec 26, 2022   
    We started intravenous methylprednisolone pulse and plasma exchange therapies...Positivity for collagen-disease-specific autoantibodies and accompanying rhabdomyolysis are atypical findings with PAN. This patient was not clinically diagnosed as PAN, and so promptly starting immunotherapies should be considered when a case presents with evidence of vasculitis.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Shrunken Pore Syndrome Is Frequently Occurring in Severe COVID-19. (Pubmed Central) -  Dec 24, 2022   
    In dexamethasone-naïve patients, C-reactive protein (CRP ), TNF-alpha, and interleukin-6 did not differ between SPS and non-SPS patients...Female gender was associated with a higher proportion of SPS. Demographic factors and illness severity were independent predictors of SPS.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly
    Biomarker, Journal:  Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients. (Pubmed Central) -  Dec 24, 2022   
    Our ANOVA model estimated that all patients with less than 12.42 Log2 CPM had a short LOS, or a good prognosis, whereas all patients with over 12.42 Log2 CPM had a long LOS, or a poor prognosis. In sum, we show that circulatory miR-6741-5p may serve as a prognostic biomarker effectively predicting mortality risk and LOS of hospitalized COVID-19 patients.
  • ||||||||||  Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma
    Journal, HEOR, Cost-effectiveness, Cost effectiveness:  Cost-Effectiveness of Once-Daily Single-Inhaler COPD Triple Therapy in Spain: IMPACT Trial. (Pubmed Central) -  Dec 24, 2022   
    FF/UMEC/VI was cost-effective versus FF/VI and UMEC/VI across all analyses. FF/UMEC/VI was predicted to be a cost-effective treatment option versus FF/VI or UMEC/VI in symptomatic COPD patients at risk of exacerbations in Spain, across all scenarios and sensitivity analyses.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Transcriptomic changes underlying glucocorticoid-induced suppression of milk production by dairy cows. (Pubmed Central) -  Dec 24, 2022   
    Whereas previous studies identified that an exogenous GC such as dexamethasone (DEX) transiently suppresses milk yield in several species without any pronounced effect on milk protein or fat percentage, the mechanism underlying this effect has not been established...This work supports the hypothesis that there is a direct relationship between the response to DEX and the concurrent suppression of milk yield due to the reduced synthesis of α-lactalbumin and lactose by the mammary epithelium. The ability of glucocorticoids to modulate the homeorrhetic requirements for glucose during stressful states concurrent with immune activation bears significance for dairy animals as well as a broad range of lactating mammals.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Journal:  The Evolving Impact of Myocardial Injury in Patients With COVID-19 Amid the Omicron Wave of the Pandemic. (Pubmed Central) -  Dec 24, 2022   
    In conclusion, patients with COVID-19 with elevated troponin during phase 3 tended to have improved outcomes when compared with patients in earlier waves of the pandemic. This improvement could be attributed to the implementation of the COVID-19 vaccines, advances in COVID-19 treatment options, provider experience, and less virulent variants.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Hydrocortisone-induced blood pressure reduction in a patient with anterior pituitary hypofunction: a case report. (Pubmed Central) -  Dec 24, 2022   
    According to World Health Organization Uppsala Monitoring Centre (WHO-UMC) causality assessment and Naranjo scale, there was a probable relationship of reduced blood pressure with hydrocortisone. To the best of our knowledge, we have presented the first case of an anaphylaxis reaction of blood pressure reduction following hydrocortisone administration in the anterior pituitary hypofunction patient.
  • ||||||||||  hydrocortisone / Generic mfg.
    Review, Journal:  Perioperative Evaluation and Management of Patients on Glucocorticoids. (Pubmed Central) -  Dec 23, 2022   
    Considering that oral GC intake may be unreliable in the early postoperative period, providing the daily GC plus a short course of IV hydrocortisone 25 to 100 mg per day based on the degree of surgical stress seems reasonable...In conclusion, our literature review indicates that lower doses and shorter duration of supplemental GCs perioperatively are sufficient to maintain homeostasis. We emphasize the need for well-designed randomized studies on this frequently encountered clinical scenario.
  • ||||||||||  magrolimab (ONO-7913) / Ono Pharma
    Trial completion date, Trial primary completion date:  Study of Magrolimab Combinations in Patients With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Dec 23, 2022   
    P2,  N=153, Recruiting, 
    Although no ideal strategy was identified, the use of NSAIDs, ketamine and dexamethasone were associated with less pain and less side effects. Trial completion date: May 2024 --> Dec 2024 | Trial primary completion date: May 2024 --> Dec 2024