- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Journal: Newly diagnosed autoimmune Addison's disease in a patient with COVID-19 with autoimmune disseminated encephalomyelitis. (Pubmed Central) - Jan 4, 2023
He was then continued on a stress dose of intravenous hydrocortisone with rapid clinical improvement leading to his extubation, and discontinuation of vasopressors and glucose on day 2 of admission...This is the first case reporting autoimmune Addison's disease in a patient with COVID-19 with a history of ADEM. The case highlights the importance of considering adrenal insufficiency as a diagnostic differential in haemodynamically unstable patients with COVID-19.
- |||||||||| bortezomib / Generic mfg.
Journal: Chalazion in a patient with multiple myeloma treated with bortezomib. (Pubmed Central) - Jan 4, 2023
On resolution of symptoms, she was rechallenged with CyBorD, and symptoms did not recur. The temporal relationship between bortezomib and the development of chalazion is based on connection and no association has been proven.
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
A CASE OF IGG4-RELATED AORTITIS PRESENTING AS ABDOMINAL PAIN (eAbstract Site) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_8503;
IgG4-related aortitis can present insidiously and can be often difficult to diagnose. IgG4-related disease should be considered in patients with aortic ectasia and chronic abdominal pain.
- |||||||||| bortezomib / Generic mfg., dexamethasone / Generic mfg.
LOST IN THE ECHO: PULMONARY HYPERTENSION & CARDIAC PLASMACYTOMA (Complex Clinical Cases Moderated Poster Theater 5_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_7930;
Generally, group 5 PH is the last to be investigated due to its heterogeneous diagnoses, which do not possess a prevailing pathophysiological mechanism for the development of PH. A multidisciplinary team approach is often key to determining the etiology of WHO group 5 PH.
- |||||||||| Kineret (anakinra) / SOBI
SUCCESSFUL USE OF ANAKINRA TO TREAT RECURRENT PERICARDITIS DUE TO DIFFERENTIATION SYNDROME IN ACUTE PROMYELOCYTIC LEUKEMIA (Complex Clinical Cases Moderated Poster Theater 5_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_7928;
Background: Differentiation syndrome (DS) is a potentially fatal complication of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) induction...However, she then developed hypoxic respiratory failure with new pulmonary edema and bilateral pleural effusions.Decision?making: Given dyspnea, radiographic opacities, and pleuropericardial effusion, prednisone was switched to IV dexamethasone for empiric management of DS... Overall, this is a rare case of recurrent pericarditis due to DS in the setting of ATRA/ATO therapy for APL successfully treated with anakinra.
- |||||||||| A RARE CASE OF TEMPI SYNDROME WITH PULMONARY HYPERTENSION (eAbstract Site) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_6402;
In patients with severe AFE with refractory RHF, and metabolic acidosis, VA-ECMO could be considered as an urgent life-saving treatment. She was diagnosed with TEMPI syndrome a year ago (A history of dyspnea, edema and rash, elevated RBC 6.41
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
A CASE OF SEVERE COVID-19 POST PREGNANCY COMPLICATED BY ACUTE THROMBOEMBOLI RESULTING IN ST-ELEVATION MYOCARDIAL INFARCTION (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_4066;
The CDC surveillance has reported that pregnant patients with COVID-19 are more likely to require invasive ventilation and ECMO, and die given the immunological changes during pregnancy. Hypercoagulable state caused by combination of pregnancy and COVID-19 resulting in coronary thrombosis is rarely described in literature, our case demonstrated the paucity of this phenomenon and how severe COVID-19 pneumonia was successfully managed with ECMO.
- |||||||||| hydrocortisone / Generic mfg.
CONTRAST INDUCED ENCEPHALOPATHY AFTER STAGED PERCUTANEOUS CORONARY INTERVENTION (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_2531;
The patient demonstrated gradual cognitive and motor improvement with full resolution of symptoms within 48 hours without additional pharmacological therapy except steroids. After excluding other possible etiologies, CIE was concluded as the final diagnosis.
- |||||||||| minocycline / Generic mfg.
AN INTERESTING CASE OF MINOCYCLINE-INDUCED EOSINOPHILIC MYOCARDITIS (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1842;
This case links the constellation of cardiac symptoms to minocycline-induced eosinophilic myocarditis, confirmed with non-invasive imaging. A long-term follow-up is further warranted.
- |||||||||| budesonide / Generic mfg., enoxaparin sodium / Generic mfg.
PROTEIN LOSING ENTEROPATHY (PLE) EXACERBATION AFTER HEART TRANSPLANT IN A FONTAN: THINK OUTSIDE THE BOX (HEART)! (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1821;
Heart transplantation reverses most of the physiologic abnormalities of the Fontan circulation and we often see resolution of PLE within 1 year of transplantation. Our case highlights that worsening PLE after heart transplant in a Fontan patient should alert the caregivers to assess for venous anastomotic site stenosis and that addressing it leads to complete resolution
- |||||||||| mycophenolate sodium / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
PERSISTENT BLOODY DIARRHEA IN A HEART TRANSPLANT PATIENT (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1719;
Background: Mycophenolic acid (Myfortic) is an immunosuppressive agent used in orthotopic heart transplant (OHT) patients. Although mycophenolic acid rarely causes enterocolitis, knowledge of adverse effects can help in diagnosis and management.
- |||||||||| amiodarone / Generic mfg.
AMIODARONE-INDUCED MYXEDEMA COMA PRECIPITATING ACUTE DECOMPENSATED HEART FAILURE IN A 90-YEAR-OLD MAN (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1526;
EKG and blood cultures were unremarkable.Decision?making: The patient was treated for amiodarone-induced myxedema coma precipitating acute decompensated heart failure with IV furosemide, IV levothyroxine and IV hydrocortisone that was tapered after adrenal insufficiency was ruled out with a normal cortisol level. Clinicians should have high suspicion for hypothyroidism, a rare and easily missed cause of altered mental status, when caring for older adults on amiodarone.
- |||||||||| methimazole / Generic mfg., esmolol / Generic mfg., hydrocortisone / Generic mfg.
STORM CAUSING CIRCULATORY COLLAPSE AND MULTISYSTEM ORGAN FAILURE (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_1473;
This patient illustrates reduced systolic function along with high output heart failure, circulatory collapse, and multisystem organ failure. Criteria of thyroid storm per scoring systems like BWPS may overlap with other common illness presentations, such as sepsis.
- |||||||||| Baizean (tislelizumab) / BeiGene, Novartis, Sulanda (surufatinib) / Hutchmed
ACUTE IMMUNE MYOCARDITIS AS AN IMMUNE RELATED ADVERSE EVENT CAUSED BY SURUFATINIB PLUS TISLELIZUMAB (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_987;
There may be an association of increased risk with other autoimmune conditions, though this remains an area of study. MRI can be a useful diagnostic tool, with early discontinuation of ICI, initiation of corticosteroids, and heart failure guideline-directed medical therapy as the preferred treatment.
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
RAPIDLY WORSENING ATRIOVENTRICULAR BLOCK IN GRANULOMATOSIS WITH POLYANGIITIS (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_682;
Cardiac conduction abnormalities in GPA, although rare, can result in a wide range of symptoms and can be fatal requiring close monitoring. The proposed mechanism involves granulomatous inflammation of the conduction pathways with fibrosis and hyalinization.
- |||||||||| hydrocortisone / Generic mfg., epinephrine / Generic mfg.
IN-HOSPITAL CARDIAC ARRESTS AND THE ROLE OF VASOPRESSIN AND STEROIDS (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_458;
Post-resuscitation shock in treatment arm was treated with hydrocortisone (300 mg daily for 7 days maximum with gradual taper)... Vasopressin and steroids showed statistically significant pooled results in terms of return of spontaneous circulation and survival to hospital discharge when administered for in-hospital cardiac arrests.
- |||||||||| Imfinzi (durvalumab) / AstraZeneca
DURVALUMAB INDUCED MYOCARDITIS MANIFESTING AS COMPLETE HEART BLOCK (eAbstract Site) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_156;
A diagnosis of durvalumab-induced myocarditis.was made based on elevated troponin levels, with exclusion of coronary artery disease with Coronary CT. The persistence of conduction abnormalities despite treatment with steroids lead to placement of permanent pacemaker and defibrillator.
- |||||||||| levofloxacin / Generic mfg., amiodarone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
LEGIONELLA MYOCARDITIS MASQUERADING AS DUAL CHAMBER CARDIAC ARRHYTHMIA (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_153;
There was good correlation between LGE inflammation/scar location and origin of VT, as well as active inflammation demonstrated by FDG PET imaging. The patient was successfully treated with antibiotics, steroids and anti-arrhythmic drugs.
- |||||||||| remdesivir / Generic mfg.
REMDESIVIR USE AND TRANSIENT COMPLETE ATRIOVENTRICULAR BLOCK IN THE COVID19 POSITIVE PATIENT (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_129;
Patients on remdesivir, especially those with underlying cardiomyopathy, may be at higher risk for asymptomatic to life-threatening bradyarrhythmia. Specifically, the safety of remdesivir in patients with underlying conduction disease requires further investigation.
- |||||||||| amiodarone / Generic mfg.
TO PLEX OR NOT TO PLEX FOR AMIODARONE INDUCED THYROTOXICOSIS (Poster Hall_Hall F) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_60;
In conclusion we present the case of cardiogenic shock secondary to thyroid storm, attributed to amiodarone therapy. Mortality associated with amiodarone induced thyrotoxicosis remains high and PLEX may be considered to eliminate amiodarone and thyroid hormones from circulation rapidly as a bridge to definitive treatment such as a thyroidectomy.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
PROTECTIVE INFLUENCE OF TOCILIZUMAB IN COVID-19 PATIENTS WITH CARDIAC ARRHYTHMIAS (eAbstract Site) - Jan 4, 2023 - Abstract #ACCWCC2023ACC_WCC_39;
Patients exposed to tocilizumab were less likely to experience CA compared to a combination of remdesivir and dexamethasone. This highlights the possible protective cardiac role of tocilizumab in patients with COVID-19; however, a limitation of this study was the small sample of patients on tocilizumab which warrants future studies.
- |||||||||| Review, Journal: Circulating microRNAs as emerging regulators of COVID-19. (Pubmed Central) - Jan 4, 2023
Consequently, understanding the expression and mechanism of action of circulating miRNAs during SARS-CoV-2 infection will provide unexpected insights into circulating miRNA-based studies. In this review, we examined the recent progress of circulating miRNAs in the regulation of severe inflammatory response, immune dysfunction, and thrombosis caused by SARS-CoV-2 infection, discussed the mechanisms of action, and highlighted the therapeutic challenges involving miRNA and future research directions in the treatment of COVID-19.
- |||||||||| fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Journal: Use of Drugs Considering Route of Administration on Drug Prescription Pattern for Bronchial Asthma in a Tertiary Level Hospital. (Pubmed Central) - Jan 4, 2023
In total 245 drugs, 131 FDC drugs (Salmeterol + Fluticasone) were prescribed with inhalation therapy which is 53.46%, another 9 FDC drugs that is (Ipratropium bromide + Salbutamol) were prescribed with inhalation therapy which is 3.67%, 101 drugs (Salbutamol) were prescribed with inhalation therapy that is 41.23%, 4 drugs (Beclomethasone) were prescribed with inhalation therapy that is 1.64%. Majority of patient were taking inhalation form of anti-asthmatic drugs.
- |||||||||| triamcinolone acetonide / Generic mfg.
Review, Journal: Silicone gel sheeting for treating keloid scars. (Pubmed Central) - Jan 4, 2023
Evidence from the included studies is of very low certainty, mainly driven by the risk of bias, indirectness, and imprecision due to small sample size. Further well-designed studies that have good reporting methodologies and address important clinical, quality of life and economic outcomes are required to reduce uncertainty around decision-making in the use of SGS to treat keloid scars.
- |||||||||| navtemadlin (KRT-232) / Kartos Therap
Trial completion date, Trial primary completion date, Combination therapy: Testing the Addition of KRT-232 (AMG 232) to Usual Chemotherapy for Relapsed Multiple Myeloma (clinicaltrials.gov) - Jan 4, 2023
P1, N=40, Recruiting,
Trial completion date: Aug 2022 --> Jun 2023 | Trial primary completion date: Aug 2022 --> Jun 2023 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
- |||||||||| dexamethasone injection / Generic mfg.
Pulse Methylprednisolone Versus Dexamethasone in COVID-19: A Multicenter Cohort Study (Moscone Center South - 304) - Jan 4, 2023 - Abstract #SCCM2023SCCM_553;
METHODS : Using a Japanese multicenter database involving 350 acute care centers, we identified adults aged≥18 years admitted for COVID-19 and discharged between January 2020 and December 2021 who received pulse methylprednisolone (≥250 mg/day) or intravenous dexamethasone (≥6 mg/day) on the day of admission or the next day...CONCLUSIONS : Compared to dexamethasone, pulse methylprednisolone may be associated with worse COVID-19 outcomes, especially in patients not on IMV. Providers should be aware of the potential consequences according to the type and dose of corticosteroid therapy and tailor the treatment for COVID-19.
- |||||||||| hydrocortisone / Generic mfg.
Adaptive Immune Function and Immunoparalysis in Children With Septic Shock (Moscone Center South - 201) - Jan 4, 2023 - Abstract #SCCM2023SCCM_544;
Among septic subjects, 12% had baseline immunocompromise, 56% received hydrocortisone, and 6 (38%) had immunoparalysis...Suppression of PHA-induced IL2 and IL4 production was only seen in children with immunoparalysis. This approach could be used to drive enrollment into future clinical trials of immunomodulatory therapies aimed at restoring adaptive immune function in septic children.
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