Glucocorticoid Receptor 

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  • ||||||||||  Darzalex (daratumumab) / J&J
    Journal, Residual disease, Minimal residual disease:  Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients. (Pubmed Central) -  Jan 24, 2023   
    Alternative methods to estimate long-term survival outcomes, such as a response-based PSM, can reduce uncertainty in modeling predictions around cost-effectiveness estimates for health technology assessment bodies and payers, thereby supporting faster market access for novel therapies with immature survival data. Use of MRD status in a response-based PSM reduces uncertainty in modeling long-term survival in patients with NDMM and provides a greater number of clinically plausible extrapolations compared with a standard PSM.
  • ||||||||||  dexamethasone / Generic mfg., modafinil / Generic mfg.
    Review, Journal, Metastases:  Corticosteroids for the management of cancer-related fatigue in adults with advanced cancer. (Pubmed Central) -  Jan 24, 2023   
    We included four small studies that provided very low-certainty of evidence for the efficacy of corticosteroids in the management of CRF. Further high-quality randomised controlled trials with larger sample sizes are required to determine the effectiveness of corticosteroids in this setting.
  • ||||||||||  thyroxine / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Endocrine disorders in patients with transfusion-dependent hereditary anemias (Pubmed Central) -  Jan 24, 2023   
    Growth, pubertal and carbohydrate metabolism disorders were diagnosed in patients with TD hereditary anemias, that confirms the necessity of regularly endocrine investigation. To detect impairment of carbohydrate metabolism investigation of fasting blood glucose, OGTT, and CGM is recommended; glycated hemoglobin measurement is not considered reasonable.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  European guidelines on perinatal care: corticosteroids for women at risk of preterm birth. (Pubmed Central) -  Jan 24, 2023   
    Even a single-dose administration should be given to women with imminent preterm birth, as this is likely to improve neurodevelopmental outcome (Moderate-quality evidence; conditional recommendation).Either betamethasone (12 mg administered intramuscularly twice, 24-hours apart) or dexamethasone (6 mg administered intramuscularly in four doses, 12-hours apart, or 12 mg administered intramuscularly twice, 24-hours apart), may be used (Moderate-quality evidence; Strong recommendation)...However, existing evidence suggests that it should be reserved for pregnancies at high-risk of delivering within a 7-day interval (Low-quality evidence; Conditional recommendation). Maternal diabetes mellitus is not a contraindication to the use of antenatal corticosteroids (Moderate quality evidence; Strong recommendation).A single repeat course of corticosteroids can be considered in pregnancies at less than 34weeks gestation, if the previous course was completed more than seven days earlier, and there is a renewed risk of imminent delivery (Low-quality evidence; Conditional recommendation).
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Genomic glucocorticoid action in embryonic mouse neural stem cells. (Pubmed Central) -  Jan 24, 2023   
    These data reveal that GR binds preferentially to predetermined regions of accessible chromatin to influence gene programming and cell fate decisions. In addition, we identify SOX2 as a transcription factor that impacts the genomic response of select GR target genes to sGCs (i.e., dexamethasone) in NSPCs.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  The combined effects of treadmill exercise and steroid administration on anterior cruciate ligament reconstruction-induced joint contracture and muscle atrophy in rats. (Pubmed Central) -  Jan 24, 2023   
    After surgery, they were divided into four groups: no intervention, treadmill exercise (started from day three post-surgery, 12 m/min, 60 min/d, 6 d/week), treatment with the steroidal drug dexamethasone (250 μg/kg on days 0-5, 7, and 9 post-surgery), and dexamethasone treatment plus treadmill exercise...The two treatments combined improved both joint contracture and atrophy of the rectus femoris and gastrocnemius. Exercise therapy combined with steroid administration may therefore be a novel therapeutic strategy for joint contracture and muscle atrophy following ACL reconstruction.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  Identification of Two Novel Hydroperoxide Impurities in Fluocinolone Acetonide Topical Solution by Liquid Chromatography Mass Spectrometry. (Pubmed Central) -  Jan 23, 2023   
    A possible mechanism for the formation of these two novel hydroperoxide impurities is based on the neighboring group participation effect of adjacent hydroxyl group (Internal SN2) which results in the loss of fluorine atom and formation of epoxide intermediate followed by the addition of the HOOH group. Since most of the hydroperoxide impurities are genotoxic in nature, one should eliminate these impurities from Active Pharmaceutical Ingredient (API) or protect the formulation product from these oxidative impurities.
  • ||||||||||  Empliciti (elotuzumab) / AbbVie, BMS, iberdomide (CC-220) / BMS
    Enrollment open, Trial initiation date, Combination therapy:  A Study of Iberdomide (CC-220) in Combination With Elotuzumab and Dexamethasone for Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Jan 23, 2023   
    P1,  N=31, Recruiting, 
    Since most of the hydroperoxide impurities are genotoxic in nature, one should eliminate these impurities from Active Pharmaceutical Ingredient (API) or protect the formulation product from these oxidative impurities. Not yet recruiting --> Recruiting | Initiation date: Oct 2022 --> Feb 2023
  • ||||||||||  dapansutrile (OLT1177) / Olatec Therap
    Journal:  Dexamethasone and OLT1177 Cooperate in the Reduction of Melanoma Growth by Inhibiting STAT3 Functions. (Pubmed Central) -  Jan 22, 2023   
    In addition, metabolic analyses revealed a marked reduction of ATP production rate and glycolytic reserve in cells treated with the combination of OLT1177 plus dexamethasone. These findings demonstrate that the combination of OLT1177 and dexamethasone reduces tumor growth by targeting nuclear as well as mitochondrial functions of STAT3.
  • ||||||||||  lenalidomide / Generic mfg.
    Journal:  AT-101 Enhances the Antitumor Activity of Lenalidomide in Patients with Multiple Myeloma. (Pubmed Central) -  Jan 22, 2023   
    When combined with lenalidomide and dexamethasone (Rd), AT-101 significantly reduced tumor burden in an in vivo xenograft model of MM...Three patients were lenalidomide-refractory, 2 were bortezomib-refractory and 3 were daratumumab-refractory...Patients responsive to ARd showed a decrease in Bcl-2:Bim or Mcl-1:Noxa protein complexes, increased CD8+ T and NK cells and depletion of T and B-regulatory cells. The ARd regimen demonstrated an acceptable safety profile and promising efficacy in patients with relapsed/refractory MM prompting further investigation in additional patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Immunomodulating:  Immuno-Modulatory Effects of Dexamethasone in Severe COVID-19-A Swedish Cohort Study. (Pubmed Central) -  Jan 22, 2023   
    Among a subgroup of patients who received Dex early, within 14 days of COVID-19 debut, the adjusted mortality risk was 0.4 (95% CI 0.2-0.8), i.e., 40% compared with Without-Dex. Dex administration in a cohort of critically ill COVID-19 patients resulted in altered immunological and physiologic responses, some of which were associated with mortality.
  • ||||||||||  Aerospan (flunisolide HFA) / Viatris, AbbVie
    Journal:  In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data. (Pubmed Central) -  Jan 22, 2023   
    Using genes from top-activated pathways, we detected several promising small molecules to reverse MS immune cells' transcriptomic signatures, including AG14361, FGIN-1-27, CA-074, ARP 101, Flunisolide, and JAK3 Inhibitor VI. Among these molecules, we also detected an FDA-approved MS drug Mitoxantrone, supporting the reliability of our approach.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The Effects of Prenatal Dexamethasone Exposure on Brain Metabolic Homeostasis in Adulthood: Implications for Depression. (Pubmed Central) -  Jan 22, 2023   
    These changes appear to be mainly due to decreased expression of pyruvate dehydrogenase, impairment of lactate transport to neurons, and pyruvate to the mitochondria. Acute stress in adulthood only slightly modified the observed alterations in the frontal cortex, while in the case of the hippocampus, prenatal exposure to dexamethasone made this structure more sensitive to future adverse factors.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Combination of a Chaperone Synthesis Inducer and an Inhibitor of GAPDH Aggregation for Rehabilitation after Traumatic Brain Injury: A Pilot Study. (Pubmed Central) -  Jan 22, 2023   
    Two proteins, Hsp70 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were recently described as modulating post-traumatic processes, and in this study, we test them as targets for combination therapy using an inhibitor of GAPDH aggregation (derivative of hydrocortisone RX624) and an inducer of Hsp70 synthesis (the pyrrolylazine derivative PQ-29)...Using a rat weight drop model of TBI, we found that the combined use of both drugs prevented memory impairment and motor deficits, as well as a reduction of neurons and accumulation of GAPDH aggregates in brain tissue. In conclusion, we developed and tested a new approach to the treatment of TBI based on influencing distinct molecular mechanisms in brain cells.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Kinetics of Immune Subsets in COVID-19 Patients Treated with Corticosteroids. (Pubmed Central) -  Jan 22, 2023   
    Therefore, the hydrogel containing sesamol in the nanoencapsulated form seemed to have a therapeutic potential in treating irritant contact dermatitis. The lymphocyte kinetics differ between DXM-treated and control COVID-19 patients and are associated with clinical outcomes.
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  The Role of Glucocorticoids in Breast Cancer Therapy. (Pubmed Central) -  Jan 21, 2023   
    The glucocorticoid receptor (GR) and its endogenous ligand cortisol (CORT) in humans, and corticosterone in rodents or its exogenous ligand, dexamethasone (DEX), have been extensively studied in breast cancer...Specifically, in breast cancer, GR is considered a marker of poor prognosis, and a therapeutic target for the triple-negative breast cancer (TNBC) subtype, and efforts are being made to develop better GR antagonists with fewer side effects. It is necessary to know the type of breast cancer to differentiate the treatment for estrogen receptor (ER)-positive, ER-negative, and TNBC, to implement therapies that include the use of GCs.
  • ||||||||||  carfilzomib / Generic mfg.
    Journal:  Multiple extramedullary plasmacytomas responding to a reduced dose of carfilzomib following drug-induced thrombotic microangiopathy (Pubmed Central) -  Jan 20, 2023   
    He was diagnosed with plasma cell leukemia 3 years ago; he demonstrated a very good partial response (VGPR) after undergoing two regimens, including either bortezomib or lenalidomide, and he had been followed up without any other treatment due to complications of infection...Drug-induced TMA has been reported to be caused by either immune-mediated or dose-dependent toxicity mechanisms. In patients who develop dose-dependent TMA with carfilzomib, dose reduction could be considered in cases showing an effective response to the treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E and Leukotriene Biosynthesis Inhibitors. (Pubmed Central) -  Jan 20, 2023   
    The hit compounds also efficiently interfered with leukotriene biosynthesis in cell-based systems and modulated IL-6 and PGE biosynthesis in a lipopolysaccharide-stimulated J774A.1 macrophage cell line. The most promising compound 3 showed prominent in vivo anti-inflammatory activity in a mouse model, with efficacy comparable to that of dexamethasone, attenuating zymosan-induced leukocyte migration in mouse peritoneum with considerable modulation of the levels of typical pro-/anti-inflammatory cytokines.