Glucocorticoid Receptor 

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  • ||||||||||  ceftriaxone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Ocular Syphilis: A mimicker for giant cell arteritis () -  Feb 4, 2023 - Abstract #BSR2023BSR_472;    
    Diagnosing GCA remains a clinical challenge for rheumatologists, especially in cases with typical symptoms and signs but negative confirmatory testing on imaging and histology. There are a wide range of conditions that resemble GCA, and neuro-ocular syphilis is one such diagnosis that has been reported in the literature as a mimic, as demonstrated by this important case.
  • ||||||||||  Fragmin (dalteparin sodium) / Pfizer, Eisai, Ventavis (iloprost) / Bayer, J&J, University of Copenhagen, Opdivo (nivolumab) / Ono Pharma, BMS
    Immune Checkpoint Inhibitor Associated Vasculitis- A Limitation to Cancer Therapy () -  Feb 4, 2023 - Abstract #BSR2023BSR_470;    
    ICIs have revolutionised the management and outcomes across a range of malignancies. However, their mechanism can inadvertently induce undesired toxicity, the awareness of which is paramount.
  • ||||||||||  methotrexate / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Rheumatoid vasculitis presenting in the absence of rheumatoid arthritis () -  Feb 4, 2023 - Abstract #BSR2023BSR_374;    
    To our knowledge, only seven cases have been reported in the literature of a patient with RV at initial diagnosis of RA and two cases in which a diagnosis of RV preceded the diagnosis of RA. Due to its high mortality and morbidity we would like to increase awareness amongst clinicians of this unusual vasculitic form of clinical presentation of RA.
  • ||||||||||  prednisolone / Generic mfg., cyclophosphamide / Generic mfg.
    A rare case of coexistence of ANCA-associated vasculitis and malignancy () -  Feb 4, 2023 - Abstract #BSR2023BSR_372;    
    Co-existence of a vasculitis and a neoplastic disease is rare. ANCA positive vasculitis is most commonly reported with haematological malignancies but less so in solid tumours, presenting as a paraneoplastic phenomenon.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    COVID-19 Vaccine Induced Myositis () -  Feb 4, 2023 - Abstract #BSR2023BSR_369;    
    There are case reports of myositis following COVID-19 vaccination but our patient's case is complicated by the differential diagnosis of GVHD and concurrent myocarditis. Ongoing work is needed to clarify the exact link between vaccination and the presentation of a new inflammatory myositis, but it is important to recognise and start treatment early in order to preserve muscle bulk and ensure recovery.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    Severe myocarditis with cardiogenic shock in adult-onset Still's disease after mRNA COVID-19 vaccination: a case of atypical presentation () -  Feb 4, 2023 - Abstract #BSR2023BSR_365;    
    Severe myocarditis with acute heart failure and cardiogenic shock is a possible initial presentation of adult-onset Still's disease after mRNA COVID-19 vaccination. After exclusion of more common aetiologies, it is important to consider adult-onset Still's disease as one of the differential diagnoses in the presence of compatible features following COVID-19 vaccination, such that appropriate and timely workup and treatment can be offered.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Review, Journal:  Isolated relapse of plasma cell leukemia in the central nervous systems: a case report and literature review. (Pubmed Central) -  Feb 4, 2023   
    We recently experienced a case of plasma cell leukemia that had been in stringent complete remission for nine years after autologous stem cell transplantations with subsequent courses of lenalidomide maintenance therapy, and then relapsed as an extramedullary plasmacytoma in the central nervous system...Salvage chemotherapy with isatuximab, pomalidomide, and dexamethasone (IsaPD) was promptly initiated...When excessive serum levels of clonotypic free light chains are noted, their significance should be carefully assessed even when plasma cell propagation in the bone marrow is not observed. In such cases, hematologists should search for extramedullary proliferation of plasma cells, including in the immune-privileged central nervous system.
  • ||||||||||  triamcinolone acetonide / Generic mfg., 5-fluorouracil / Generic mfg.
    Journal:  A Rare Symptom of Secondary Infection After Facial Thread Lift and Its Treatment. (Pubmed Central) -  Feb 4, 2023   
    The patient was later cured by thread removal, local injection of 5-fluorouracil and triamcinolone acetonide. Postthreading infections have been documented in the past, but it is significant to note that, first, this patient's postinfection symptoms were distinct because she experienced both mild local symptoms and serious systemic symptoms, and second, the authors looked into a quick and efficient treatment option.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Journal:  Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant from a Single Donor:Insights from a Five Year Follow-Up. (Pubmed Central) -  Feb 3, 2023   
    Over the ensuing 5 years, the patient underwent a single episode of acute scalp rejection successfully managed with intravenous solumedrol, one resection of a basal cell carcinoma on the native scalp, and hardware removal and bony contouring...His seizures were ultimately controlled. Currently, more than 5 years following his multi-organ transplant, the patient continues to have excellent allograft function and a very satisfactory aesthetic outcome, demonstrating that in certain cases, combined vascularized composite allotransplantation with solid organ transplant can be performed safely without compromising the solid organ transplant.
  • ||||||||||  leflunomide / Generic mfg., pomalidomide / Generic mfg.
    Trial completion date, Trial primary completion date:  Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) -  Feb 3, 2023   
    P2,  N=29, Recruiting, 
    This case highlights the diversity of possible presentations of ocular syphilis, even in HIV-negative immunocompetent patients. Trial completion date: Nov 2023 --> Jun 2023 | Trial primary completion date: Nov 2023 --> Jun 2023
  • ||||||||||  relacorilant (CORT125134) / Corcept Therap
    Trial completion date, Trial primary completion date:  Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome (clinicaltrials.gov) -  Feb 3, 2023   
    P2,  N=75, Enrolling by invitation, 
    Trial completion date: Aug 2023 --> May 2023 | Trial primary completion date: Aug 2023 --> May 2023 Trial completion date: Dec 2022 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2024