Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone injection / Generic mfg.
    Trial completion date, Trial primary completion date:  Postoperative Dexamethasone on Post-Cesarean Pain (clinicaltrials.gov) -  Feb 28, 2023   
    P4,  N=40, Recruiting, 
    Trial completion date: Mar 2028 --> Dec 2027 | Trial primary completion date: Mar 2023 --> Aug 2023 Trial completion date: May 2023 --> May 2024 | Trial primary completion date: Nov 2022 --> Nov 2023
  • ||||||||||  Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
    Trial completion date, Trial primary completion date:  ALL Adult Consortium Trial: Adult ALL Trial (clinicaltrials.gov) -  Feb 28, 2023   
    P2,  N=112, Active, not recruiting, 
    Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Dec 2022 --> Dec 2023 Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023
  • ||||||||||  Trial completion date, Trial primary completion date:  A Study in Adults With Untreated Acute Lymphoblastic Leukemia (clinicaltrials.gov) -  Feb 28, 2023   
    P2,  N=100, Active, not recruiting, 
    Trial completion date: Dec 2022 --> Dec 2023 | Trial primary completion date: Dec 2022 --> Dec 2023 Trial completion date: Jul 2023 --> Jul 2024 | Trial primary completion date: Jan 2023 --> Jan 2024
  • ||||||||||  prednisolone / Generic mfg.
    Review, Journal:  Acne agminata: dermoscopic features and a short review. (Pubmed Central) -  Feb 27, 2023   
    He achieved complete clinical resolution with oral prednisolone in 6 weeks. We also reviewed the literature regarding the reported treatment regimens used.
  • ||||||||||  remdesivir / Generic mfg., dexamethasone / Generic mfg.
    Journal:  Dexamethasone mitigates remdesivir-induced liver toxicity in human primary hepatocytes and COVID-19 patients. (Pubmed Central) -  Feb 27, 2023   
    We also reviewed the literature regarding the reported treatment regimens used. Our findings obtained from in vitro cell-based experiments and patient data analysis provide evidence suggesting combination of DEX and RDV holds the potential to reduce the likelihood of RDV-induced liver injury in hospitalized COVID-19 patients.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Addition of nebulised lidocaine to prevent refractory bronchospasms in a patient receiving serial bronchoscopies. (Pubmed Central) -  Feb 27, 2023   
    During his 8th to 15th bronchoscopies, nebulised lidocaine was added to the pretreatment regimen, which eliminated perioperative bronchospasms and allowed for the elimination of all other adjunctive preventative treatments. This case highlights the novel perioperative use of nebulised lidocaine, in combination with nebulised albuterol and intravenous hydrocortisone, to successfully prevent previously refractory bronchospasms in a patient undergoing a general anaesthetic.
  • ||||||||||  triamcinolone acetonide / Generic mfg., Triesence (triamcinolone acetonide injectable suspension) / Novartis
    Journal:  An ultralow-cost portable centrifuge from discarded materials for medical applications. (Pubmed Central) -  Feb 27, 2023   
    This case highlights the novel perioperative use of nebulised lidocaine, in combination with nebulised albuterol and intravenous hydrocortisone, to successfully prevent previously refractory bronchospasms in a patient undergoing a general anaesthetic. Sedimentation of 1.0
  • ||||||||||  Avastin (bevacizumab) / Roche, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Bilateral central retinal vein occlusion as an initial presentation of Waldenstr (Pubmed Central) -  Feb 27, 2023   
    Retrospectively registered May 11, 2020. Adequate hydration, plasmapheresis, and a combination of bortezomib, dexamethasone, and rituximab regimen as a systemic therapy may represent an ideal choice for patients with hyperviscosity in Waldenstr
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Sensitivity of Different ACTH and Cortisol Concentration Values in Corticotropin-Releasing Hormone Based Tests in Cushing's Disease. (Pubmed Central) -  Feb 27, 2023   
    Thus, topical 0.1% CBD might be more appropriate for RAU patients who decline to take topical steroids, except for cases where CBD is contraindicated. In Cushing's disease (CD) patients, the aim of the present study is to confirm sensitivity of several ACTH and cortisol concentration values in different time points, during corticotropin-releasing hormone (CRH) stimulation test and during CRH stimulation following dexamethasone suppression (DEX-CRH) test...The best sensitivity of ACTH and cortisol increment was obtained 15
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Case of concurrence of bullous pemphigoid and Norwegian scabies. (Pubmed Central) -  Feb 27, 2023   
    This paper is a report on a patient with bullous pemphigoid (BP) and scabies, who developed scabs after taking dexamethasone. It should be noted that bullous pemphigoid antibody is necessary, which can distinguish bullous pemphigoid with scabies and bullous scabies, and the treatment options for the two diseases are different.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  The effect of vasopressin and hydrocortisone on cytokine trajectories. (Pubmed Central) -  Feb 27, 2023   
    Overall, this interlaboratory study demonstrated that the UALH-hAR assay is transferable, produces reliable, accurate and specific (anti)androgenic activity of chemicals, and can be considered for further regulatory validation. No abstract available
  • ||||||||||  dexamethasone / Generic mfg., vancomycin / Generic mfg., ceftriaxone / Generic mfg.
    Review, Journal:  High risk and low prevalence diseases: Adult bacterial meningitis. (Pubmed Central) -  Feb 27, 2023   
    No abstract available A better understanding of the pearls and pitfalls of acute bacterial meningitis can assist emergency clinicians in pursuing its timely diagnosis and management.
  • ||||||||||  triamcinolone acetonide / Generic mfg., verapamil / Generic mfg.
    Retrospective data, Review, Journal:  Efficacy and Safety of Verapamil Versus Triamcinolone Acetonide in Treating Keloids and Hypertrophic Scars: A Systematic Review and Meta-Analysis. (Pubmed Central) -  Feb 27, 2023   
    Concerning the treatment of keloids and hypertrophic scars, TAC was more effective than verapamil for improving vascularity; TAC was superior to verapamil in improving height within 9 weeks of treatment; TAC produced superior result for improving pliability within 18 weeks of treatment, whereas verapamil produced superior result between 18 and 24 weeks of treatment. Verapamil had fewer adverse events than TAC and can be used as a safer alternative for the treatment of keloids and hypertrophic scars.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Circulating adipokine levels and COVID-19 severity in hospitalized patients. (Pubmed Central) -  Feb 27, 2023   
    Use of 1 mg kgvs 0.3 mg kg i.v. dexamethasone in low pain responders after TKA did not improve early postoperative pain or other outcomes in contrast to benefits in a high pain responder population. Circulating adipokine levels are associated with COVID-19 hospitalization, i.e., the need for oxygen support (general ward), or the need for mechanical ventilation and other organ support in the ICU, but not mortality.
  • ||||||||||  Journal:  Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles. (Pubmed Central) -  Feb 27, 2023   
    Significance Statement The established correlation of CYP3A4 mRNA in human hepatocytes to PXR activation provides a clear cut-off to identify a compound showing an in vitro induction risk, complementing current regulatory guidance. Also, the demonstrated in vitro-in vivo translation of induction data strongly supports clinical development program although limitations remain for drug candidates showing complex disposition pathways such as involvement of auto-inhibition/induction, active transport and high protein binding.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, IO biomarker:  TNFR2 antagonistic antibody induces the death of tumor infiltrating CD4Foxp3 regulatory T cells. (Pubmed Central) -  Feb 27, 2023   
    Also, the demonstrated in vitro-in vivo translation of induction data strongly supports clinical development program although limitations remain for drug candidates showing complex disposition pathways such as involvement of auto-inhibition/induction, active transport and high protein binding. This study, therefore, provides clear experimental evidence that TNFR2 antagonistic antibody, TY101, can promote the death of Tregs, and this effect may be attributable to the antitumor effect of TNFR2 antagonistic antibody.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Journal:  A stratified therapeutic model incorporated with studies on regulatory B cells for elderly patients with newly diagnosed multiple myeloma. (Pubmed Central) -  Feb 27, 2023   
    The qualitative assessment of systemic (enzyme therapy, dexamethasone, betamethasone, and Venoplant) and nonsystemic therapies (thermotherapy and K-Taping) appear to reduce edema...Thermotherapy reduced edema after 48 hours (CI: -48.47 to -13.31; P For the elderly NDMM, the CEMM2021 algorithm in our center might provide a valuable reference for the guidance of therapeutic strategies, with the combination of Bregs resulting in an effective and clinically meaningful prediction in contemporary treatment.
  • ||||||||||  fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
    Journal:  How do we manage asthma? Assessment of knowledge, attitude, and practice patterns among pulmonologists and allergists. (Pubmed Central) -  Feb 27, 2023   
    Formoterol/budesonide was the most preferred ICS/LABA combination, followed by beclomethasone/formoterol and fluticasone/salmeterol for asthma treatment...While recent updates of the guidelines indicate that salbutamol should not be used solely in mild asthmatics due to its harmful effects in long-term use, it still was the most preferred drug by pulmonologists. Postgraduate education programs are needed to improve compliance with the guidelines.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg., fluticasone / Generic mfg.
    Journal:  Glucocorticoids increase tissue cell protection against pore-forming toxins from pathogenic bacteria. (Pubmed Central) -  Feb 27, 2023   
    Dexamethasone protected several cell types against the cholesterol-dependent cytolysin, pyolysin, from Trueperella pyogenes...Hydrocortisone and fluticasone also protected against pyolysin-induced cell damage...However, cytoprotection was dependent on the glucocorticoid receptor and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR). Collectively, our findings imply that glucocorticoids could be exploited to limit tissue damage caused by pathogens secreting pore-forming toxins.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Enrollment open, Trial completion date, Trial primary completion date:  PF-RCT: Plantar Fasciitis Randomized Clinical Control Trial (clinicaltrials.gov) -  Feb 27, 2023   
    P=N/A,  N=62, Recruiting, 
    Not yet recruiting --> Recruiting Suspended --> Recruiting | Trial completion date: Dec 2022 --> Jan 2024 | Trial primary completion date: Dec 2022 --> Jan 2024
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Journal:  Effect of preoperative intravenous steroids on seroma formation after modified radical mastectomy. (Pubmed Central) -  Feb 26, 2023   
    Embolization was performed as preventive treatment, and a genetic study was conducted as it is potentially useful for primary prevention in the patient's offspring. A single preoperative dose of Injection methylprednisolone acetate was effective in terms of post-mastectomy outcomes.
  • ||||||||||  dexamethasone / Generic mfg., nitazoxanide / Generic mfg.
    Preclinical, Journal:  Polyphenolic Profile of Herniaria hemistemon Aerial Parts Extract and Assessment of Its Anti-Cryptosporidiosis in a Murine Model: In Silico Supported In Vivo Study. (Pubmed Central) -  Feb 25, 2023   
    Regarding the anticryptosporidial activity, fifty dexamethasone-immunosuppressed mice were separated into five groups: GI, un-infected (normal control); GII, infected but not treated (model); GIII, infected and received NTZ, the reference drug; GIV, infected and received H. hemistemon extract (100 mg/kg); and GV, infected and received H. hemistemon extract (200 mg/kg)...The docked compounds showed the same binding interactions as oxamic acid, where they established H-bond interactions with ARG-109, ASN-140, ASP-168, ARG-171, and HIS-195. To sum up, H. hemistemon is a promising natural therapeutic agent for cryptosporidiosis.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Development of Triamcinolone Acetonide Nanocrystals for Ocular Administration. (Pubmed Central) -  Feb 25, 2023   
    In vivo studies proved that treatment with self-dispersible TA-NC alleviated the inflammatory response in the anterior chamber and iris in EUI rabbit eyes. Dispersible TA-NC are a promising approach to obtaining a novel nanometric TA formulation for ocular disorders.