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- dexamethasone / Generic mfg.
Effects of a new recombinant human collagen on skin aging () - Mar 4, 2023 - Abstract #ISID2023ISID_1550;
In terms of anti-inflammatory effect, the collagen (0.002mg/ml) had no significant effect on inhibiting the secretion of TNF-?, but its effect on inhibiting IL-6 is significantly better than that of dexamethasone (5?g/ml). Our data highlight the possible application of recombinant type III collagen as a bioactive agent to regulate the skin aging process through anti-aging, repairing, and modulating inflammation.
- Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Enhanced the therapeutic effects of desoximetasone by inhibiting cytochrome P450 3A4 metabolism in the imiquimod-induced psoriasis animal model () - Mar 4, 2023 - Abstract #ISID2023ISID_1327;
Our results show that topical 0.05% desoximetasone loaded in a cytochromes P450 3A4 enzyme inhibitor excipient base emollient formulation restores imiquimod induced barrier disruption and showed fewer severe clinical and pathological features than commercial 0.25% desoximetasone ointment and 0.5% clobetasol ointment. The results might provide a new concept of topical drug development for inflammatory skin diseases treatment.
- Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Oral prednisolone suppresses imiquimod-induced skin inflammation in a healthy volunteer challenge model () - Mar 4, 2023 - Abstract #ISID2023ISID_1321;
Oral prednisolone suppresses IMQ-induced skin inflammation, which underlines the value of this cutaneous challenge model in clinical pharmacology studies with novel anti-inflammatory compounds. In such studies, prednisolone effect can be used as benchmark.
- fluocinolone acetonide / Generic mfg.
Characterization of transcriptomic and proteomic changes in the skin after chronic fluocinolone acetonide treatment () - Mar 4, 2023 - Abstract #ISID2023ISID_1074;
Interestingly, proteins affected during and after chronic FA treatment were largely different. Our results provide fundamental information of molecular changes induced by FA treatment in the skin.
- methylprednisolone sodium succinate / Generic mfg.
A single-center retrospective study evaluating the efficacy of intravenous methylprednisolone pulse therapy for 113 patients with alopecia areata () - Mar 4, 2023 - Abstract #ISID2023ISID_904;
In conclusion, long disease duration and disease progression during IVMP treatment are poor prognostic factors for the therapeutic response. Oral JAKi can be considered as a rescue treatment for AA patients refractory to IVMP therapy.
- triamcinolone acetonide / Generic mfg.
The enigma and great mimicker: A case of a 57 year old Filipino male with cutaneous pseudolymphoma () - Mar 4, 2023 - Abstract #ISID2023ISID_664;
He was treated with a combination of clobetasol propionate 0.05% ointment applied twice daily and intralesional triamcinolone acetonide 10 mg/ml injections on the affected area with 3-week interval...Skin punch biopsy along with extensive work-up is essential to arrive at the proper dermatological diagnosis and rule out extracutaneous involvement. Furthermore, it is important to emphasize close monitoring and regular follow-up as some lesions may evolve into a cutaneous lymphoma.
- triamcinolone acetonide / Generic mfg.
Topical corticosteroids inhibit allergic skin inflammation but are ineffective in impeding the formation and expansion of resident memory T cells (Room A (Concord Ballroom) ) - Mar 4, 2023 - Abstract #ISID2023ISID_146;
We assessed the impact of a standard topical corticosteroid (TCS) treatment, triamcinolone acetonide (TA), on the formation, maintenance and reactivation of epidermal T RM cells in ACD...Interestingly, T RM re-expansion correlated with the decreased clearance of hapten moieties from the skin induced by repeated TA applications. Our results thus demonstrate that TCS successfully treat ACD inflammation, but are mostly ineffective in impeding the formation and expansion of allergen-specific T RM in the skin.
- atorvastatin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Nonspecific cutaneous eruption in a patient with statin-associated autoimmune myopathy (New Orleans Ernest N. Morial Convention Center (Level 1, Hall E, Poster Center 2)) - Mar 4, 2023 - Abstract #AAD2023AAD_2749;
Despite treatment with intravenous immunoglobulin and intravenous methylprednisolone, she continued to deteriorate and died eleven days after admission from respiratory failure. This case demonstrates the nonspecific, dermatomyositis-like eruption that can be seen in statin induced myopathies, as well as the potentially swift and morbid nature of this auto-immune myopathy.
- Bullous pemphigoid presenting as erythema multiforme-like targetoid lesions () - Mar 4, 2023 - Abstract #AAD2023AAD_2717;
The patient was started on prednisone and triamcinolone 0.1% ointment with improvement...The majority of these cases were classified as drug-induced BP, and implicated medications included cephalosporins, penicillin, furosemide, amlodipine and a combination of citalopram, thioridazine and flupenthixol...To our knowledge, this is the third reported case of idiopathic targetoid BP resembling EM. This case highlights the importance of identifying atypical presentations of BP in order to provide appropriate treatment promptly and decrease morbidity.
- methylprednisolone oral / Generic mfg.
Efficacy and Predictive Factors of Systemic Corticosteroid in Alopecia Areata : Reappraisal of Oral Methylprednisolone Tapering Treatment () - Mar 4, 2023 - Abstract #AAD2023AAD_2686;
Our study suggests that young age and extensive alopecia are predictive factors of poor response to ETMT. Vitamin D level might be helpful for predicting relapse.
- clobetasol propionate topical / Generic mfg.
Topical calcineurin inhibitors vs. topical corticosteroids in the treatment of lichen planopilaris (New Orleans Ernest N. Morial Convention Center (Level 1, Hall E, Poster Center 2)) - Mar 4, 2023 - Abstract #AAD2023AAD_2653;
Most patients in both groups were also taking hydroxychloroquine and practicing allergen avoidance... TCIs may offer better control of inflammation when compared to TCS and avoid potential adverse effects of long-term steroid use.
- rofecoxib (TRM-201) / Tremeau Pharma
Aquagenic Wrinkling of the Palms () - Mar 4, 2023 - Abstract #AAD2023AAD_2317;
TCIs may offer better control of inflammation when compared to TCS and avoid potential adverse effects of long-term steroid use. She was prescribed fluocinonide ointment and tacrolimus 0.1% ointment...AWP can also occur in patients with hyperhidrosis, Raynaud
- Hidradenitis Suppurativa Patients with Positive Anaerobic Cultures May Require More Aggressive Treatments (New Orleans Ernest N. Morial Convention Center (Level 1, Hall E, Poster Center 2)) - Mar 4, 2023 - Abstract #AAD2023AAD_2291;
Study limitations include small sample size and cross-sectional design. Further longitudinal research is needed to optimize therapies for anaerobe positive HS.
- bortezomib / Generic mfg.
Administration of bortezomib in patients with refractory scleromyxedema: A case report () - Mar 4, 2023 - Abstract #AAD2023AAD_2284;
Background: We present a case of refractory scleromyxedema, a rare cutaneous mucinosis, treated with bortezomib and dexamethasone...Approximately 60-70% resolution of plaques was achieved with subcutaneous immunoglobulin, plaquenil, and prednisone...High-dose immunoglobulins are considered the treatment of choice, followed by thalidomide and systemic glucocorticosteroids (2)...Our patient has remained in remission for three years, the longest documented to date. Notably, our case achieved remission with fewer cycles compared to other cases, with prior studies citing a minimum of four cycles and a maximum of eight cycles (1,3).
- triamcinolone acetonide / Generic mfg., clobetasol propionate topical / Generic mfg.
Cost Evaluation of Clobetasol Propionate and Triamcinolone Acetonide Using Medicare Part D Data (New Orleans Ernest N. Morial Convention Center (Level 1, Hall E, Poster Center 2)) - Mar 4, 2023 - Abstract #AAD2023AAD_2282;
The significant expenditure savings, as evidenced by our Medicare data analysis, indicate that healthcare systems will benefit economically if prescribers select TA rather than CP. While higher potency TCS are necessary in many circumstances, the associated cost and risk of adverse events increase with long-term use, arguing for their application in acute verses chronic maintenance regimens.
- | dexamethasone / Generic mfg.
Journal: An approach for studying the contributions of childhood sexual abuse and HPA axis dysregulation to substance use disorders. (Pubmed Central) - Mar 3, 2023
While higher potency TCS are necessary in many circumstances, the associated cost and risk of adverse events increase with long-term use, arguing for their application in acute verses chronic maintenance regimens. Baseline correlations among variables showed a significant negative correlation between dexamethasone suppression and perceived stress, a potential covariate (rho
- | dexamethasone / Generic mfg., dexmedetomidine / Generic mfg.
Preclinical, Journal, IO biomarker: Dexmedetomidine Protects against Airway Inflammation and Airway Remodeling in a Murine Model of Chronic Asthma through TLR4/NF-?B Signaling Pathway. (Pubmed Central) - Mar 3, 2023
Furthermore, these protective effects of DEX were abolished by yohimbine, an ?2 adrenergic receptor antagonist. These results indicate that DEX is capable of ameliorating airway inflammation and remodeling in asthmatic mice, and this protective effect is associated with the inhibition of the TLR4/NF-?B signaling pathway.
- || dexamethasone / Generic mfg.
Review, Journal: Intratympanic corticosteroids for M (Pubmed Central) - Mar 3, 2023
These results indicate that DEX is capable of ameliorating airway inflammation and remodeling in asthmatic mice, and this protective effect is associated with the inhibition of the TLR4/NF-?B signaling pathway. The evidence for intratympanic corticosteroids in the treatment of M
- || Empliciti (elotuzumab) / AbbVie, BMS
P2 data, Journal, HEOR: Impact of Elotuzumab Plus Pomalidomide/Dexamethasone on Health-related Quality of Life for Patients With Relapsed/Refractory Multiple Myeloma: Final Data From the Phase 2 ELOQUENT-3 Trial. (Pubmed Central) - Mar 3, 2023
P2
Across measurements, there were no clinically meaningful differences in changes from baseline between treatment arms, and TTD was not significantly different for EPd versus Pd. In conclusion, HRQoL was not impacted by the addition of elotuzumab to Pd and did not significantly deteriorate in patients with RRMM previously treated with lenalidomide and a PI in ELOQUENT-3.
- | hydrocortisone / Generic mfg.
Journal: Adrenal crisis in infants and young children with adrenal insufficiency: Management and prevention. (Pubmed Central) - Mar 3, 2023
Both children on therapy with a micronized weighted formulation reported no episode of suspected adrenal crisis during the 6-month observation period. Parental education on oral stress dosing and switching to parenteral hydrocortisone when necessary are the essential approaches to prevent adrenal crisis in children.
- || Budenofalk (budesonide gastro-resistant) / Dr Falk
Retrospective data, Review, Journal: Efficacy and safety of medical therapies in microscopic colitis: a systematic review and network meta-analysis. (Pubmed Central) - Mar 3, 2023
Entocort 9?mg/day ranked first among the treatment options in inducing remission and Budenofalk 6?mg/3?mg alternate day dosing for maintaining remission in the treatment of MC. Moving forward, mechanistic studies exploring the differences between Entocort and Budenofalk would be valuable whilst future RCT studies are needed in non-corticosteroidal maintenance, particularly looking into immunomodulators, biologics and probiotics.
- | dexamethasone / Generic mfg.
Preclinical, Journal: Peritoneal lavage with Glycyrrhiza glabra is effective in preventing peritoneal adhesion in a rat model. (Pubmed Central) - Mar 3, 2023
glabra could concentration-dependently mitigate peritoneal adhesion formation through its anti-inflammatory, anti-fibrosis, and anti-oxidant properties. However, further clinical investigations are required to approve that G. glabra may be a promising candidate against post-surgical adhesive complications.
- | dexamethasone / Generic mfg.
Retrospective data, Journal: Effects of 12 (Pubmed Central) - Mar 3, 2023
However, further clinical investigations are required to approve that G. glabra may be a promising candidate against post-surgical adhesive complications. Among patients with critical COVID-19, 12
- | dexamethasone / Generic mfg.
Journal, Stroma: Transplanted mesenchymal stromal cells are unable to migrate to the bone surface and subsequently improve osteogenesis in glucocorticoid-induced osteoporosis. (Pubmed Central) - Mar 3, 2023
We previously demonstrated that dexamethasone (Dex) administration caused the shifted differentiation balance of mesenchymal stromal cells (MSCs) to favor adipogenic lineage over osteoblastic lineage, which is one of the key mechanisms for Dex-induced osteoporosis (DIO)...Mechanistically, Dex inhibits TGF-?1 expression by down-regulating its promoter activity, which decreases bone matrix-deposited TGF-?1 as well as active TGF-?1 released during osteoclast-mediated bone resorption. This study indicates that blocking MSC migration in osteoporotic BM contributes to bone loss and suggests that MSC mobilization to the BS may be a promising target for treating osteoporosis.
- | dexamethasone / Generic mfg.
Journal: Dexamethasone activates c-Jun NH2-terminal kinase (JNK) which interacts with GR and protects it from ubiquitin-mediated degradation in NSCLC cells. (Pubmed Central) - Mar 3, 2023
Further, GR protein levels were significantly decreased in JNK inhibitor (JNKi, SP600125) treated cells whereas MG132 treatment restored GR levels indicating that DEX induced JNK activity regulated the GR protein levels through proteasomal-degradation pathway. In line with these in
- | prednisolone / Generic mfg.
Trial primary completion date: RFA to Prevent Metachronous Squamous Neoplasia Recurrence After Complete Endoscopic Submucosal Dissection (clinicaltrials.gov) - Mar 3, 2023
P=N/A, N=100, Recruiting, Sponsor: E-DA Hospital
In line with these in Trial primary completion date: Oct 2022 --> Oct 2025
- |||| Aliqopa (copanlisib) / Bayer
Trial completion date, Trial primary completion date, Combination therapy: CHRONOS-4: Study of Copanlisib in Combination With Standard Immunochemotherapy in Relapsed Indolent Non-Hodgkin's Lymphoma (iNHL) (clinicaltrials.gov) - Mar 3, 2023
P3, N=551, Active, not recruiting, Sponsor: Bayer
Trial primary completion date: Oct 2022 --> Oct 2025 Trial completion date: Mar 2025 --> Apr 2030 | Trial primary completion date: Feb 2023 --> Mar 2024
- | dexamethasone / Generic mfg.
New trial, Surgery, Bariatric surgery: Preoperative Dexamethasone to Improve Quality of Recovery After Laparoscopic Bariatric Surgery (clinicaltrials.gov) - Mar 3, 2023
P=N/A, N=60, Recruiting, Sponsor: Ondokuz May?s University
- | dexamethasone / Generic mfg.
New trial, Surgery: EyeSurface: Eye Surface Properties After Using Dexamethasone Drops With and Without Preservatives in Patients After Cataract Surgery (clinicaltrials.gov) - Mar 3, 2023
P=N/A, N=40, Active, not recruiting, Sponsor: Spektrum Center of Clinical Ophthalmology
- ||| Rituxan (rituximab) / Roche
Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date: A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis (clinicaltrials.gov) - Mar 3, 2023
P1/2, N=16, Active, not recruiting, Sponsor: National Human Genome Research Institute (NHGRI)
Trial completion date: Mar 2025 --> Apr 2030 | Trial primary completion date: Feb 2023 --> Mar 2024 Recruiting --> Active, not recruiting | N=45 --> 16 | Trial completion date: Apr 2026 --> Jan 2028 | Trial primary completion date: Apr 2024 --> Jan 2028
- ||||||| Xhance (fluticasone propionate intranasal spray) / OptiNose
Trial completion, Enrollment change: OPN-FLU-CS-3206: Study Evaluating the Efficacy and Safety of Intranasal Administration of OPN-375 in Subjects With Chronic Rhinosinusitis Without the Presence of Nasal Polyps (clinicaltrials.gov) - Mar 3, 2023
P3, N=210, Completed, Sponsor: Optinose US Inc.
Recruiting --> Active, not recruiting | N=45 --> 16 | Trial completion date: Apr 2026 --> Jan 2028 | Trial primary completion date: Apr 2024 --> Jan 2028 Active, not recruiting --> Completed | N=399 --> 210
- |||| Flovent HFA (fluticasone propionate HFA) / GSK, fluticasone propionate inhalation powder / Generic mfg.
Reimbursement, US reimbursement: So this is #PBMStupidity #PayerStupidity They're denying my prescription for GENERIC Fluticasone inhaler, but Flovent HFA and Flovent Diskus is covered. Brand name is over twice as much money. If you have coinsurance, your amount is twice as much. And payers will get a rebate. (Twitter) - Mar 3, 2023
- | dexamethasone injection / Generic mfg.
Journal: Bony Canal Method of Dexamethasone Injections in Aggressive Form of Central Giant Cell Granuloma-Case Series. (Pubmed Central) - Mar 2, 2023
The indication is restricted to the cases with preserved bony borders despite deformation. Additionally, leaving vital teeth in the lesion is also possible.
- | Triesence (triamcinolone acetonide injectable suspension) / Novartis
Retrospective data, Journal: Clinic study on macular epiretinal membrane in patients under the age of 40 years. (Pubmed Central) - Mar 2, 2023
In young patients, the incidence of P-PVD was significantly higher in IMEM cases than in SMEM cases. The
- | Monofer (iron isomaltoside 1000) / Pharmacosmos
Retrospective data, Journal: Evaluation of MONOFER-induced hypersensitive reactions: A retrospective cohort study. (Pubmed Central) - Mar 2, 2023
A total of 43 (68.25%) participants who experienced hypersensitivity reactions showed clinical symptoms within one hour, 11(17.46%) showed reaction in 1-3 hours and 9 (14.29%) showed in > 3 Hours. The majority of the studied population showed significant improvement only after the administration of Pheniramine maleate, while only a few of them received Hydrocortisone.
- | dexamethasone / Generic mfg.
Journal: HDAC8 regulates protein kinase D phosphorylation in skeletal myoblasts in response to stress signaling. (Pubmed Central) - Mar 2, 2023
In this report, we show that class I histone deacetylase (HDAC) inhibition, and in particular HDAC8 inhibition, attenuated PKD phosphorylation in skeletal C2C12 myoblasts in response to phorbol ester, angiotensin II and dexamethasone signaling independent of changes in total PKD protein expression. As class I HDACs and PKD signaling are requisite for myocyte differentiation, these data suggest that HDAC8 functions as a potential feedback regulator of PKD phosphorylation to control myogenic gene expression.
- | dexamethasone / Generic mfg.
Journal: Elevation of truncated (48?kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19. (Pubmed Central) - Mar 2, 2023
Dexamethasone, steroid hormone which is widely used for treatment of severe Covid-19 patients, induced time-dependent elevation of the 48/Myo1C in blood of such patients...It was found that 48/Myo1C might bind to component 3 of the complement system and the anti-thrombin-III (Starykovych et al., 2021). Thus, the mechanisms of the pathogenic action of truncated form of Myo1C in severe COVID-19 patients may involve a suppression of the immune cells, as well as modulation of complement and coagulation cascades.
- | Xpovio (selinexor) / Karyopharm, Menarini, FORUS Therap
Journal, IO biomarker: E3 ubiquitin ligase ASB8 promotes selinexor-induced proteasomal degradation of XPO1. (Pubmed Central) - Mar 2, 2023
Mechanistically, we showed that ASB8 promotes selinexor-induced proteasomal degradation of XPO1. This study provides insight into the genetic factors that influence response to selinexor treatment and could support both the development of predictive biomarkers as well as new drug combinations.
- | prednisolone / Generic mfg.
Journal: A case of non-thymomatous refractory anti-AChR, Kv1.4 and titin antibodies positive generalized myasthenia gravis successfully treated by extended thymectomy (Pubmed Central) - Mar 2, 2023
We initiated her treatment with a minimum dose of oral prednisolone...Shortly thereafter her symptoms disappeared, followed by the titers of the antibodies above found all markedly decreased. It remains unclear how the atrophic thymus acted on the pathogenesis of refractory generalized MG.
- | dexamethasone / Generic mfg.
Journal: Overexpression of Wnt7b antagonizes the inhibitory effect of dexamethasone on osteoblastogenesis of ST2 cells. (Pubmed Central) - Mar 2, 2023
It remains unclear how the atrophic thymus acted on the pathogenesis of refractory generalized MG. We found that Wnt7b can rescue the suppressed osteoblast differentiation and function without cell viability caused by dexamethasone.
- | bortezomib / Generic mfg., dexamethasone / Generic mfg., pomalidomide / Generic mfg.
Journal, Combination therapy: Molecular bottlebrush prodrugs as mono- and triplex combination therapies for multiple myeloma. (Pubmed Central) - Mar 2, 2023
BPDs carrying a statistical mixture of three drugs in a synergistic ratio outperform the free-drug combination at the same ratio as well as a mixture of single-drug BPDs in the same ratio. Our results address unanswered questions in the field of nanomedicine, offering design principles for combination nanomedicines and strategies for improving current front-line monotherapies and combination therapies for multiple myeloma.
- | Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva, beclometasone/formoterol / Generic mfg.
Preclinical, Journal: The Impact of Possible Misuses Conditions on in Vitro Performance of NEXThaler in Comparison with Ellipta Inhaler. (Pubmed Central) - Mar 2, 2023
Our results address unanswered questions in the field of nanomedicine, offering design principles for combination nanomedicines and strategies for improving current front-line monotherapies and combination therapies for multiple myeloma. One reservoir multidose device (Foster-NEXThaler
- | dexamethasone / Generic mfg.
Journal: Effects of Dexamethasone Use on Viral Clearance Among Patients with COVID-19: A Multicenter Cohort Study. (Pubmed Central) - Mar 2, 2023
The study revealed that dexamethasone therapy and Ct values are independent predictors of late viral clearance. Patients with severe disease course due to older age, increased number of comorbidities, and worse clinical outcomes experienced delayed viral clearance.
- | dexamethasone / Generic mfg.
Preclinical, Journal: In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction. (Pubmed Central) - Mar 2, 2023
The anti-AD effect of QSD might be related to the reconstruction of the epidermal barrier and inhibition of inflammation, which regulated the MAPK pathway. Hence, it provided a promising idea for the study of Tibetan medicine prescriptions for the treatment of AD.
- || dexamethasone / Generic mfg.
PK/PD data, Preclinical, Journal, IO biomarker, Cytokine release syndrome, Immunomodulating: Pharmacokinetic/Pharmacodynamic Modeling of Dexamethasone Anti-Inflammatory and Immunomodulatory Effects in LPS-Challenged Rats: A Model for Cytokine Release Syndrome. (Pubmed Central) - Mar 2, 2023
Interrelations among DEX and relevant biomarkers were reflected in the mechanistic model structure. The mPBPK/PD model enabled quantitative assessment of in vivo potency of DEX and, upon translation to humans, may help optimize dosing regimens of DEX for the treatment of immune-related conditions associated with exaggerated immune response.
- | dexamethasone / Generic mfg.
Journal: Serum 25-hydroxycholesterol levels are increased in patients with coronavirus disease 2019. (Pubmed Central) - Mar 2, 2023
The mPBPK/PD model enabled quantitative assessment of in vivo potency of DEX and, upon translation to humans, may help optimize dosing regimens of DEX for the treatment of immune-related conditions associated with exaggerated immune response. Our results highlighted that 25HC could be used as a unique biomarker in severe COVID-19 and a potential therapeutic candidate for detecting the severity of COVID-19 and other infectious diseases.
- | remdesivir / Generic mfg., dexamethasone / Generic mfg.
Journal: Cardiac Characteristics of the First Two Waves of COVID-19 in Denmark and the Prognostic Value of Echocardiography: The ECHOVID-19 Study. (Pubmed Central) - Mar 2, 2023
Reduced GLS was associated with covid-related mortality independently of wave, treatment, and SARS-CoV-2 variant. LV function was significantly impaired in patients hospitalised during the second wave.
- ||| Review, Journal, Adverse events: Anti-programmed death-1 inhibitor nivolumab-induced immune-related adverse events: hepatitis, renal insufficiency, myositis, vitiligo, and hypothyroidism: a case-based review. (Pubmed Central) - Mar 2, 2023
LV function was significantly impaired in patients hospitalised during the second wave. A 68-year-old male patient with metastatic renal cell carcinoma and right-sided nephrectomy received NIVO after pazopanib and sunitinib treatment...Due to hepatitis, he has been treated with dexamethasone 16
- | azelastine intranasal / Generic mfg., fluticasone / Generic mfg.
Journal: Eustachian Tube Dysfunction in Children with Adenoid Hypertrophy: The Effect of Intranasal Azelastine-Fluticasone Spray Treatment on Middle Ear Ventilation and Adenoid Tissue. (Pubmed Central) - Mar 2, 2023
In this study, it was observed that Aze-Flu treatment was significantly effective in both regression of the adenoid tissue and Eustachian tube dysfunction. We believe that it can be applied as an initial therapy in children with AH and associated ETD.
- | triamcinolone acetonide / Generic mfg.
Journal, Monotherapy: Combination cryotherapy and intralesional corticosteroid versus steroid monotherapy in the treatment of keloids. (Pubmed Central) - Mar 2, 2023
We believe that it can be applied as an initial therapy in children with AH and associated ETD. While both IL TAC and IL TAC with cryotherapy were effective at reducing pruritus and pain, combination therapy was more effective in reducing keloid size, specifically for pubic keloids.