- |||||||||| Imfinzi (durvalumab) / AstraZeneca
Cerebellar Degeneration Causing Saccadic Dysmetria and Ocular Flutter: A Seronegative Paraneoplastic Syndrome (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1932;
Her metastatic small cell lung cancer was in remission, and she no longer showed bilateral cerebellar metastases on brain MRI, following treatment with chemotherapy, durvalumab, and whole brain radiation...She was treated with high dose intravenous methylprednisolone and plasmapheresis, with resolution of eye movement abnormalities, and improvement of ataxia...Even in the absence of relevant antibodies and in the setting of confounders such as prior cerebellar metastases, use of checkpoint inhibitors, clinical presentation and CSF findings should raise concern for a paraneoplastic disorder. Cerebellar paraneoplastic syndromes may respond to Immunotherapy with methylprednisolone and plasmapheresis.
- |||||||||| prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
A Case of Seropositive Autoimmune Glial Fibrillary Acidic Protein Encephalitis with Renal Cell Carcinoma (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1927;
Cerebellar paraneoplastic syndromes may respond to Immunotherapy with methylprednisolone and plasmapheresis. Mayo autoimmune panel detected GFAP IgG (1:16, reference <1:2), with follow up imaging showing RCC confirmed on nephrectomy.Patient was treated with daily intravenous methylprednisolone 1000mg for 5 days and showed improvement...Long term steroid treatment with 1mg/kg/day prednisone and steroid sparing agent, mycophenolate 500mg BID were started...Results NA Conclusions Although there is no specific diagnostic criteria, the identification of GFAP-IgG in serum or CSF is a marker of disease and the patient
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Pseudo-bulbar affect and Tremors in GFAP Astrocytopathy: A Case Report (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1922;
Meanwhile, the patient was started on IV methylprednisolone (IVMP) 1 g x 5 days followed by PLEX x 5 days with significant clinical improvement in mentation, tremors and ataxia...Patient was restarted on IVMP with plan for maintenance with a steroid sparing agent Rituxan with addition of mood stabilizers...Conclusions Anti-GFAP astrocytopathy should be included in the differential diagnosis of patients who present with a relapsing-remitting, steroid responsive subacute encephalitis. Pseudo-bulbar affect and tremors may an atypical neurological manifestation associated with possible loss of somatosensory inhibition to cerebellum in GFAP astrocytopathy.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
S for Seizure? A Case of SMART syndrome (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1708;
Due to ongoing seizures, he received 5 days of high dose intravenous methylprednisolone...He remains seizure-free 4 months later on levetiracetam and lacosamide...This exhibits a possible benefit of steroid treatment for seizure control in these patients. Further studies are warranted to delineate the pathophysiology and standardize the management of SMART syndrome.
- |||||||||| dexamethasone / Generic mfg., leucovorin calcium / Generic mfg.
Transmission of Behavioral Deficits in Rats Exposed to Folate Receptor Alpha Antibody In Utero. (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1545;
We hypothesize that treatment of the directly exposed generation with folinic acid prior to mating may prevent transmission of behavioral deficits to a subsequent generation by altering the epigenome. This may be a strategy to decrease the risk in families with a history of ASD.
- |||||||||| methylprednisolone sodium succinate / Generic mfg., azathioprine / Generic mfg.
Peripheral T-Cell Lymphoma Manifesting as Multifocal Central Nervous System Disease with Prominent Spinal Cord Involvement (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1489;
This may be a strategy to decrease the risk in families with a history of ASD. Design/Methods N/A Results A 53-year-old male with Celiac disease on azathioprine presented with one-week of vertigo, diplopia, and dysarthria upon one-year of malaise and cachexia...He was empirically treated with intravenous methylprednisolone and immunoglobulin without benefit.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Wernicke (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1429;
Design/Methods N/A Results A 53-year-old male with Celiac disease on azathioprine presented with one-week of vertigo, diplopia, and dysarthria upon one-year of malaise and cachexia...He was empirically treated with intravenous methylprednisolone and immunoglobulin without benefit. Electroencephalogram showed slowing with frequent generalized periodic discharges.Patient
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Cryptococcal Meningoencephalitis and Immune Reconstitution Inflammatory Syndrome in a patient on Tocilizumab Therapy: A Case Report (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1298;
A 71-year-old female with giant cell arteritis on daily prednisone and monthly Tocilizumab infusions presented with worsening headaches for 2 weeks and new-onset confusion for 3 days...She was started on empiric liposomal amphotericin B and flucytosine before the cryptococcal antigen and cultures resulted...She was continued on antifungal therapy and received IV methylprednisolone for IRIS...Despite early and appropriate treatment, she continued to worsen with multiple complications including IRIS, a dysfunctional inflammatory response to infection precipitated by immune recovery. In patients treated appropriately for cryptococcal meningoencephalitis, a failure to respond should raise concern for complicating conditions.
- |||||||||| amifostine / Generic mfg.
Preclinical, Journal: Effects of amifostine against blunt chest trauma-induced cardiac injury in rats. (Pubmed Central) - Mar 12, 2023
According to evaluation based on histological, biochemical, and electrocardiographic examinations, we believe that only 400 mg/kg dose of AMI or DXM can be effective in the treatment of myocardial contusion in rats. Evaluation based on histological findings.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Association Between Multiple Sclerosis and the Symptoms of Vertigo and Facial Nerve Palsy. (Pubmed Central) - Mar 11, 2023
Otolaryngologists often suspect Hunt's syndrome in patients who present with facial nerve palsy combined with vertigo. However, herein, we report our experience with an extremely rare case of a patient with atypical nystagmus symptoms, eye movement disorder, and diplopia secondary to facial palsy and vertigo, who presented with a clinical course different from that of Hunt's syndrome.
- |||||||||| dexamethasone / Generic mfg.
Journal: MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy. (Pubmed Central) - Mar 11, 2023
Herein, mesoporous polydopamine nanoparticles (DAMM NPs) doped with arginine and manganese (Mn) ions were prepared to load dexamethasone (DEX) for OA intervention...Importantly, the T1-T2 magnetic contrast capabilities of DAMM NPs allowed an MRI-trackable delivery, manifesting a distinct feature widely regarded to boost the potential of nanomedicines for clinical applications. Together, our developed antioxidant-enhanced DAMM NPs with MRI-visible signals may serve as a novel multifunctional nanocarriers for prevention of OA progression.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Cannabis Use and Its Association With Thirty- and Ninety-Day Hospital Readmissions for Patients Admitted for an Inflammatory Bowel Disease Exacerbation. (Pubmed Central) - Mar 10, 2023
Patients with an IBD exacerbation were identified by primary or secondary ICD10 code (K50.xx or K51.xx) and administration of intravenous (IV) solumedrol and/or biologic therapy...Cannabis use was not found to be associated with 90-day readmission on univariable analysis (OR: 1.11, 95% CI: 0.65 - 1.87) nor in the final multivariable model after adjusting for other factors (OR: 1.19, 95% CI: 0.68 - 2.05). Pre-admission cannabis use was found to be associated with 30-day readmission among patients with UC, but not with 30-day readmission for patients with CD nor with 90-day readmission, following an IBD exacerbation.
- |||||||||| Carvykti (ciltacabtagene autoleucel) / J&J
FIRST PHASE 3 RESULTS FROM CARTITUDE-4: CILTA-CEL VERSUS STANDARD OF CARE (PVD OR DPD) IN LENALIDOMIDE-REFRACTORY MULTIPLE MYELOMA (festival hall) - Mar 10, 2023 - Abstract #EHA2023EHA_303;
P3
Background: CARTITUDE-4 is a global, phase 3, randomized, controlled trial (NCT04181827) of ciltacabtagene autoleucel (cilta-cel), a dual-binding, B-cell maturation antigen-targeting chimeric antigen receptor (CAR)-T cell therapy, versus (vs)standard of care (SOC; pomalidomide, bortezomib, and dexamethasone [PVd] or daratumumab, pomalidomide,and dexamethasone [DPd]) in lenalidomide-refractory patients.Aims:To report results of the first phase 3 study evaluating efficacy and safety of cilta-cel vs SOC in lenalidomide-refractory patients treated with 1-3 prior lines of therapy (LOT). A single cilta-cel infusion significantly improved PFS vs SOC in lenalidomide-refractory patients with 1
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
Immunosuppression minimization during COVID infection: is it safe? (Grand Georgian) - Mar 10, 2023 - Abstract #ITS2023ITS_79;
Reduction of the anti-metabolic immunosuppressive therapy for a short period of time did not seem to correlate with the development of de-novo DSA or increased rates of acute rejection in our expanded cohort. Studies on larger cohorts will help further determine the impact of IS reduction on transplant outcomes following COVID-19 infection in renal transplant recipients.
- |||||||||| dexamethasone / Generic mfg., sirolimus / Generic mfg.
Journal: Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization. (Pubmed Central) - Mar 9, 2023
By dissecting the respective role of each of these components during immunization, we have further shown why immunosuppressive and immunogenic agents are both needed for forming true adjuvants for Treg cells. This finding may guide the design of additional, and potentially more potent, complete tolerogenic adjuvants with which we may form numerous novel vaccines for treating immune diseases.
- |||||||||| P3 data, Journal: Overall Survival With Daratumumab, Lenalidomide, and Dexamethasone in Previously Treated Multiple Myeloma (POLLUX): A Randomized, Open-Label, Phase III Trial. (Pubmed Central) - Mar 9, 2023
P3
D-Rd significantly extended OS versus Rd alone in patients with RRMM. To our knowledge, for the first time, our findings, together with the OS benefit observed with daratumumab plus bortezomib and dexamethasone in the phase III CASTOR trial, demonstrate OS improvement with daratumumab-containing regimens in RRMM (ClinicalTrials.gov identifier: NCT02076009 [POLLUX]).
- |||||||||| dobutamine / Generic mfg., hydrocortisone / Generic mfg.
Journal: Fluid and vasopressor therapy in sepsis (Pubmed Central) - Mar 9, 2023
With increasing norepinephrine dose, addition of hydrocortisone or vasopressin may contribute to maintaining the hemodynamic state, although the prognostic advantage of these drugs has not been demonstrated. While dobutamine may be considered in patients with septic cardiomyopathy, the evidence for inotropic therapy in sepsis is limited.
- |||||||||| P3 data, Journal: Overall Survival With Daratumumab, Bortezomib, and Dexamethasone in Previously Treated Multiple Myeloma (CASTOR): A Randomized, Open-Label, Phase III Trial. (Pubmed Central) - Mar 9, 2023
P3
D-Vd significantly prolonged OS in patients with RRMM, with the greatest OS benefit observed in patients with one prior line of therapy. To our knowledge, our results, together with the OS benefit observed with daratumumab plus lenalidomide and dexamethasone in the phase III POLLUX study, demonstrate for the first time an OS benefit with daratumumab-containing regimens in RRMM (ClinicalTrials.gov identifier: NCT02136134 [CASTOR]).
- |||||||||| triamcinolone acetonide / Generic mfg., 5-fluorouracil / Generic mfg., bleomycin / Generic mfg.
Review, Journal: Efficacy and safety of needle-free jet injector-assisted intralesional treatments in dermatology-a systematic review. (Pubmed Central) - Mar 9, 2023
Limited evidence suggests that needle-free jet injector-assisted intralesional treatment is efficacious and safe for hypertrophic and atrophic acne scars. More well-powered RCTs investigating the efficacy and safety of jet injector treatment in dermatology are warranted to make further evidence-based recommendations.
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