- |||||||||| Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma
Is It Asthma?: A Rare Case of an Endobronchial Hamartoma (Walter E. Washington Convention Center, Area D, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4853;
The patient
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Small Airways Deposition of Two Fixed-dose Triple Therapy Combinations Assessed With Functional Respiratory Imaging (FRI) (Walter E. Washington Convention Center, Area D, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4817;
Importantly, there was a 4-fold difference in small airways deposition with the respective ICS components, with only a small percentage of the ICS dose from FF/UM/VI reaching the small airways. Further research is needed to understand if this more effective drug delivery could translate to clinical benefits, such as reduced mortality.
- |||||||||| dexamethasone / Generic mfg.
Obstructive Fibrinous Tracheal Pseudomembrane Managed By Flexible Bronchoscopy With Cryoprobe (Walter E. Washington Convention Center, Area D, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4805;
This could not be dislodged, and the patient was temporized with Heliox, dexamethasone, and broad-spectrum antimicrobials in the ICU...The safety and efficacy of flexible bronchoscopy for foreign body is attested in both adults and children.6,7 Cryoprobe was useful given the composition of the pseudo-membrane and the friable underlying tissue.8OFTP is a rare, potentially fatal complication of endotracheal intubation that presents with stridor and dyspnea. While rigid bronchoscopy is the gold standard, flexible bronchoscopy with cryoprobe is a safe and effective alternative.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Rapid Onset of Diffuse Alveolar Hemorrhage in Newly Diagnosed Granulomatosis With Polyangiitis: A Case Report (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4719;
He was started on pulse dose solumedrol and intermittent hemodialysis...He also received a dose of cyclophosphamide...This trial did not include patients on a ventilator like our patient here but fortunately he did well on rituximab and steroid combination. This combination could be promising for severe or refractory GPA however we need more RCTs to conclude this.
- |||||||||| REGEN-COV (casirivimab/imdevimab) / Regeneron, Roche, Actemra IV (tocilizumab) / Roche, JW Pharma
Diffuse Alveolar Hemorrhage Associated With Anti-synthetase Syndrome and COVID-19 (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4716;
He tested positive for SARS-CoV-2 (COVID-19) infection and received casirivimab and imdevimab as outpatient...His immunosuppression was held, and he was started on treatment with Remdesivir, dexamethasone and tocilizumab for severe COVID-19...He was started on pulse dose intravenous methylprednisolone 1 gram daily for 3 days followed by a prednisone taper...Tacrolimus and mycophenolate mofetil were cautiously reintroduced with improvement in his clinical status and tapering of prednisone prior to being discharged to acute rehab...COVID-19 infection likely acted as a triggering event leading to capillaritis manifesting as DAH. COVID-19 infection has shown to uncover underlying autoimmune processes in patients presenting with DAH.[3,4] Thus, evaluation of underlying etiology must be considered in such patients to guide long-term treatment.
- |||||||||| cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
A Rare Presentation of Atypical Anti-Glomerular Basement Membrane Disease (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4714;
There are numerous studies regarding the typical presentation of Anti-GBM however this case presentation highlights an extremely rare scenario with serology negative anti-GBM, yet with positive P-Anca, MPO with tissue positive staining for linear IgG staining along the glomerular basement membrane. Current literature discusses the classic anti-GBM presentation and it
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
Acute Exacerbation of Interstitial Lung Disease in the Setting of COVID-19 (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4702;
She was started on high dose IV solumedrol 250 mg Q6H and oral baricitinib. An understanding of the basic pathogenesis and high mortality rate in COVID AE-ILD can assist clinicians in making the appropriate goal-directed treatments for their patients.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A Case of COVID-19 Infection in a Patient With Advanced Rheumatic Lung Disease (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4699;
To our knowledge, such extensive rheumatologic lung disease and surgical history has been rarely described. This case highlights the importance of growing research on the treatment of COVID-19 in patient with advanced rheumatic disease.
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
COVID-19 Leading to Accelerated Rapidly Progressive Interstitial Lung Disease in Anti-MDA5 Dermatomyositis (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4691;
Our patient initially presented with asymptomatic pulmonary findings with positive anti-MDA5 antibodies and negative COVID-19 test but then tested positive for COVID after which she started deteriorating rapidly. This is likely due to the fact that RNA viruses including COVID-19 induce MDA5 production in infected cells to fight the virus with IFN pathway which leads to the production of more anti-MDA5 antibodies leading to more severe disease and faster progression as higher titers are linked to worse survival.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Granulomatosis With Polyangiitis Presenting as Diffuse Alveolar Hemorrhage (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4582;
Additionally, GPA presenting in an 85-year-old is atypical (incidence usually peaks in older adults). This underlines the importance of high index of suspicion in the appropriate clinical settings and early initiation of therapy.
- |||||||||| Don't Breathe: It's a Trap (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4580;
Vancomycin and Unasyn were initiated until cultures proved negative...Intravenous Methylprednisolone along with Naproxen were initiated resulting in significant clinical improvement...Glucose levels below 20 mg/dL with pleural fluid:serum glucose ratio < 0.5, or RF in the fluid is diagnostic. Management lacks universal consensus but may include NSAIDs or glucocorticoids early in the disease, repeated thoracenteses, intrapleural glucocorticoids, surgical evacuation, and escalating immunosuppressive medications such as Methotrexate and disease modifying rheumatic drugs.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg.
Not All Hoofbeats Are Horses: A Case of Antisynthetase Syndrome Masquerading as Community-Acquired Pneumonia (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4574;
The patient was admitted to the hospitalist service and treated with dexamethasone until a repeat COVID-19 test returned negative, as well as a one-week course of Levaquin with improvement in symptoms...The patient established care with Rheumatology who recommended initiation of mycophenolate with prednisone...When evaluating patients who fail to respond to conventional treatments of pneumonia, organizing pneumonia should be heavily considered as a differential. Moreover, it is important to consider rheumatologic conditions as many manifest primarily as pulmonary complaints such as the case outlined above.
- |||||||||| A Case of Secondary HLH in Setting of RMSF (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4557;
Definitive treatment is an allogenic hematopoietic cell transplantation. Overall, sHLH is a rapidly fatal disorder that requires prompt work-up including workup such as serum ferritin, fibrinogen, triglycerides, complete blood count, IL-2 receptor levels and, if indicated, a bone marrow biopsy.
- |||||||||| dexamethasone / Generic mfg., etoposide IV / Generic mfg.
Secondary Hemophagocytic Lymphohistiocytosis After Mild Covid-19 Infection: A Case Report (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4554;
As reports continue to recognize novel and rare sequelae of SARS-CoV-2, clinicians should consider a broad differential in evaluating patients presenting after COVID-19. High clinical suspicion for sHLH in patients with cytopenias and elevated inflammatory markers, even in vaccinated patients with resolved mild disease is warranted as morbidity and mortality for HLH is high and management for this condition is unique.
- |||||||||| dexamethasone / Generic mfg.
Corticosteroid Changes Mast Cell Receptor Expression and Responses to Asthma-associated Cytokines (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4528;
We showed here that unlike other inflammatory immune cells in asthma, corticosteroid treatment did not suppress or eliminate mast cells, instead making them more responsive to epithelial cytokines. In this way, mast cells may play a role in steroid resistance in asthma.
- |||||||||| Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
Modulating the Level of ICS in Triple ICS/LABA/LAMA FDC: Effect Against Airway Hyperresponsiveness in a Human Ex Vivo Model of Severe Eosinophilic Asthma (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4527;
After that, concentration-response curves (CRCs) to medium-dose (MD) and high-dose (HD) BDP/FF/GB administered respectively at 100/6/12.5 and 200/6/12.5 concentration-ratios were constructed on the submaximal contractile tone elicited by histamine 30 uM, a concentration eliciting 70% of maximal contractility (EC70)...CONCLUSIONS The findings of this study provide the evidence that higher BDP concentrations significantly improved the bronchorelaxant potency by ?0.3 logarithms and increased the bronchorelaxant effect by ?0%, when compared to FDC in which BDP was combined at lower concentrations. Indeed, adding a LAMA to ICS/LABA improves the bronchorelaxant profile of the FDC, and the possibility of modulating the dose of the ICS may help to prevent AHR and further optimize the bronchorelaxant response to triple ICS/LABA/LAMA FDC in severe asthmatic patients.
- |||||||||| Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
The MiSTIC Study Design: Medium Strength Triple Therapy Vs High Strength ICS/LABA for Adult Patients With Asthma Uncontrolled on Medium Strength ICS/LABA (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4526;
P4
Indeed, adding a LAMA to ICS/LABA improves the bronchorelaxant profile of the FDC, and the possibility of modulating the dose of the ICS may help to prevent AHR and further optimize the bronchorelaxant response to triple ICS/LABA/LAMA FDC in severe asthmatic patients. The MiSTIC study addresses an important gap in evidence about the use of triple therapy in asthma that can help optimize treatment strategies for GINA Steps 4-5.
- |||||||||| Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
Effect of Albuterol-budesonide As-needed on Asthma-related Systemic Corticosteroid Use in Mandala (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4509;
P3
Of those patients with SCS exposure, those in the albuterol-budesonide 180/160 ?g group had a decreased annualized total SCS dose per patient of 74 mg (425 mg vs 499 mg/patient/year) compared with those in the albuterol group.Conclusions As-needed albuterol-budesonide 180/160 ?g reduced mean annualized SCS exposure compared with as-needed albuterol for patients with moderate-to-severe asthma who received SCS for severe exacerbations in the MANDALA study. These findings are of clinical importance, as limiting cumulative lifetime SCS exposure will decrease the risk of developing long-term adverse health conditions.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Actemra IV (tocilizumab) / Roche, JW Pharma
Mitochondrial DNA Is an Early Predictor of COVID19 Severity of Disease: Validation Cohort and Response to Targeted COVID19 Treatments (Walter E. Washington Convention Center, Ballroom B (Level 3)) - Mar 25, 2023 - Abstract #ATS2023ATS_4416;
In this validation cohort, we demonstrate significantly higher plasma MT-DNA levels at the time of initial hospital presentation in patients who ultimately develop more severe COVID19 disease. This supports this measure as an early predictor of severity of disease during initial presentation that perhaps should be adopted into clinical use.
- |||||||||| Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma, Stiolto Respimat (olodaterol/tiotropium FDC) / Boehringer Ingelheim
COPD Exacerbations, Resource Use, and Costs Among COPD Patients With Eosinophil Count ?300 Cells/ (Walter E. Washington Convention Center, Room 146 A-C (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_4148;
This supports this measure as an early predictor of severity of disease during initial presentation that perhaps should be adopted into clinical use. Among COPD patients with BEC ?300 cells/
- |||||||||| dexamethasone / Generic mfg.
Distinct Epithelial-Innate Immune Cell Transcriptional Circuits Underlie Airway Hyperresponsiveness in Asthma (Walter E. Washington Convention Center, West Salon G-I (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3879;
Immunopathological mechanisms implicated include IL-33-enhanced sustained T2 inflammatory responses in MCs that are partially resistant to corticosteroids and novel T1 and T2 responses in EOS. These studies reveal new pathways through which the airway epithelium supports airway inflammation in asthma through distinct populations of intraepithelial MCs and EOS.
- |||||||||| fluticasone / Generic mfg.
FeNO, Biomarkers of High Th2 Immunity, and Response to Inhaled Corticosteroids in African American Children With Asthma (Walter E. Washington Convention Center, West Salon G-I (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3875;
All participants completed a six-week course of inhaled fluticasone MDI at age-appropriate doses... In this prospective study of African American children with asthma, a biomarker of high Th2 immunity incorporating data for allergen-specific IgEs, total IgE, and eosinophil count was better at predicting ICS responsiveness than a high FeNO.
- |||||||||| Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
A Randomised, Double-Blind, Parallel Group, Multicentre, Stratified Study Evaluating the Efficacy and Safety of Once-Daily Fluticasone Furoate/Vilanterol Compared With Once-Daily Fluticasone Furoate in the Treatment of Asthma in Participants Aged 5-17 Years Old Currently Uncontrolled on Inhaled Corticosteroids (ICS) (Walter E. Washington Convention Center, Ballroom B (Level 3)) - Mar 25, 2023 - Abstract #ATS2023ATS_3686;
In 5-17 year-olds with uncontrolled mild asthma, FF/VI demonstrated significant improvement in weighted mean (0-4 hours) FEV1 versus FF; however, there was no significant difference in AM PEF in 5-11 year-olds. Overall, FF/VI was well tolerated, with no new safety concerns identified.
- |||||||||| dexamethasone / Generic mfg.
Directed Differentiation of Alveolar Basal Cells Towards Surfactant Protein B Expressing Cells (Marriott Marquis Washington, Marquis Ballroom, Salons 3-4 (Level M2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3630;
KF-DCI treatment inhibits alveolar BC differentiation towards ciliated- or secretory airway epithelial cells and directs it towards SP-B expressing cells. Altering alveolar BC differentiation represents an attractive target to reduce pathological bronchiolization and to facilitate normal lung regeneration in IPF lungs.
- |||||||||| hydrocortisone / Generic mfg., furosemide / Generic mfg.
Spontaneous Right Ventricular Rupture Following Drainage of Pericardial Effusion: An Unusual Case of Pericardial Decompression Syndrome (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3546;
He was transferred to the ICU on vasopressor support and hydrocortisone...He was weaned off norepinephrine, pleural effusions gradually reduced with daily furosemide, and chest tubes were removed once output was <100 mL/day.DiscussionPericardiocentesis and pericardial window are lifesaving therapeutic procedures for patients presenting with cardiac tamponade...Also, the acute withdrawal of sympathetic stimulus after removal of effusion likely provoked an autonomic imbalance which unmasked a pre-existing myocardial dysfunction similar to stress-induced cardiomyopathy. This uncommon case of PDS highlights the high morbidity associated with this complication and the importance of close clinical monitoring in patients after drainage of pericardial effusion.
- |||||||||| amiodarone / Generic mfg.
Amiodarone Induced Myxedema Coma Presenting With Cardiogenic Shock and Junctional Rhythm (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3545;
Norepinephrine and dobutamine were initiated...Ten days after starting intravenous levothyroxine and liothyronine in addition to hydrocortisone, TSH and fT4 improved to 7.18 uIU/mL and 0.9 ng/dL, respectively...Treatment was instituted without delay for laboratory confirmation of myxedema coma as this endocrine emergency has a high mortality rate (30-60%), even with treatment. Thyroid function testing prior to initiation of amiodarone and in cases of cardiogenic shock or cardiac dysrhythmias can help to avoid potentially fatal complication of hypothyroidism.
- |||||||||| Thyroid Storm Leading to Cardiogenic Shock: To ECMO or Not to ECMO (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3540;
Given concern for thyroid storm, she was quickly treated with methimazole, hydrocortisone, propranolol, and cholestyramine before admission to a medical-surgical intensive care unit (MSU)...She was treated with clevidipine and dobutamine drips...Although VA-ECMO is becoming increasingly utilized in cases of thyroid storm leading to cardiogenic shock, our case shows an example in which the use of VA-ECMO was deferred due rapid patient stabilization prior to thyroidectomy and improvement post-procedure. Given that VA-ECMO has significant risks and may not be necessary in all cases, more investigation to stratify patients regarding risk, benefits, and comorbidities is needed to achieve optimal outcomes.
- |||||||||| colchicine / Generic mfg.
A Case of Severe Colchicine Associated Vacuolar Myopathy and Respiratory Failure (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3526;
Upon admission, methylprednisolone was transitioned to stress-dose hydrocortisone, all other home medications were held.On hospital day 2, the patient developed hypercapnic respiratory failure requiring intubation and mechanical ventilation...It is possible that co-administration with immunosuppressive medications can precipitate colchicine toxicity, as prior reports have documented increased risk of colchicine induced side effects in patients with concomitant cyclosporine or corticosteroid use. Prescription of colchicine with immunomodulatory medications may require increased pharmacovigilance to prevent serious side effects.
- |||||||||| How Harmful Is Cocaine? A Case of Cocaine Induced Constrictive Bronchiolitis (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3522;
Although immunosuppression with corticosteroids is a potential treatment option it typically does not prevent progression of the underlying disease. Further exploration into novel therapeutic options is warranted.
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi, Opsumit (macitentan) / Nippon Shinyaku, J&J
Pulmonary Hypertension in a Patient With Multiple Myeloma (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3518;
Carfilzomib was stopped and replaced with isatuximab...In those with PAH, pulmonary vasodilator therapies can be considered. Although further research is needed, carfilzomib is associated with PAH like dasatinib.
- |||||||||| Blenrep (belantamab mafodotin) / GSK
Belantamab Mafodotin Induced Pneumonitis and Pulmonary Fibrosis (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3516;
Case: An 83-year old man was diagnosed with MM and was started on elotuzumab, lenalidomide, and dexamethasone after disease progression on his previous regimen...Pulmonary Function Tests (PFTs) demonstrated restrictive impairment and he was started on a prednisone taper...His regimen was changed to elotozumab, pomalidomide, and dexamethasone in 2020 due to further disease progression...Patients receiving belamaf should be monitored for and counseled about this adverse reaction. Multiple potential mechanisms for pulmonary injury exist, including hematologic pulmonary infiltration with myeloma cells, target dependent uptake of the ADC, or direct injury from the carried payload with the ADC.
- |||||||||| naltrexone / Generic mfg.
A Case of Naltrexone Induced Acute Eosinophilic Pneumonia (Walter E. Washington Convention Center, Room 103 A-B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3507;
To our knowledge, this is one of the rare cases of Naltrexone induced acute eosinophilic pneumonia. Careful history gathering and prompt evaluation for Acute Eosinophilic Pneumonia (AEP) are important given potential for rapid progression of acute hypoxic respiratory failure and excellent response to steroid treatment.
- |||||||||| fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Generic Vs. Brand-name Fluticasone-Salmeterol in the Prevention of COPD Exacerbations (Walter E. Washington Convention Center, Room 151 B (Street Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_3497;
Careful history gathering and prompt evaluation for Acute Eosinophilic Pneumonia (AEP) are important given potential for rapid progression of acute hypoxic respiratory failure and excellent response to steroid treatment. Use of generic fluticasone-salmeterol was not associated with an increased incidence of first moderate or severe COPD exacerbation compared to use of brand-name fluticasone-salmeterol.
- |||||||||| NovoSeven (eptacog alfa) / Novo Nordisk, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Intrapulmonary Administration of Recombinant Activated Factor VII in a Patient With Diffuse Alveolar Hemorrhage and Microscopic Polyangiitis (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3223;
Treatment often involves high-dose glucocorticoids and other immunosuppressive agents such as cyclophosphamide and plasma exchange...The patient was treated with intravenous methylprednisolone and rituximab for the suspected diagnosis of MPA...4mg/46mL NaCl 0.9% (50cc total) reconstituted rFVIIa (NovoSeven RT) was bronchoscopically instilled into the left mainstem bronchus, the bronchus intermedius, and the right upper lobe bronchus...To our knowledge, among the vasculitides, its use in microscopic polyangiitis (MPA) has only been described systemically. Here we describe a patient
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
The Use of Human Immunoglobulin in the Treatment of COVID-19 Pneumonia in Hematologic Patients a Single-Center Case Series (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3209;
Although broad use of intra-venous Ig treatment for COVID-19 did not show positive results, our findings support their use in patients with HM. Prospective randomized studies are needed to understand the impact of intra-venous Ig in this vulnerable population, characterized by a slower viral clearance and poor prognosis.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
An Unusual Case Presentation of Clinically Amyopathic Dermatomyositis in a 63 Year Old Male (Walter E. Washington Convention Center, Room 209 A-C (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_3205;
He also received 1 gm of rituximab...The predominant feature of worsening dyspnea and rapidly progressive ILD is a rare presentation of CADM, especially in the setting of no muscle and no cutaneous involvement. Given the associated high morbidity and mortality of this condition, it is important for clinicians to consider atypical autoimmune conditions such as CADM as the etiology of ILD since the prompt directed treatment can improve prognosis.
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