- |||||||||| ivermectin oral / Generic mfg.
Journal: Effective Treatment of COVID-19 Infection with Repurposed Drugs: Case Reports. (Pubmed Central) - Aug 4, 2024
Multidrug therapy is effective because of the differing mechanisms of action of these drugs, and it may also mitigate the emergence of drug-resistant SARS-CoV-2 strains. The medicines were lopinavir/ritonavir (Kaletra), bamlanivimab (monoclonal antibody), glycopyrrolate-formoterol (Bevespi), ciclesonide (Alvesco), famotidine (Pepcid), and diphenhydramine (Benadryl).
- |||||||||| Maxidex (dexamethasone eye drops, suspension) / Novartis
Journal: Oculomotor nerve palsy caused by imidacloprid at initial diagnosis: A case report. (Pubmed Central) - Aug 2, 2024
Following therapeutic intervention, the patient showed marked improvement and was discharged from the hospital, providing a point of reference for the treatment of analogous cases in future clinical practice. It also serves as a reminder for the public to take appropriate precautions when using imidacloprid.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Does dexamethasone therapy affect intimal hyperplasia after injury in rat abdominal aorta models? (Pubmed Central) - Aug 2, 2024
This report focuses on relevant treatment plans, which provide value for the examination and comprehensive management of patients with LM infection in the future. After vascular interventions, dexamethasone treatment may reduce intimal hyperplasia and increase patency by providing vascular remodeling.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Retrospective data, Journal: Clinical pattern, neuroimaging findings and outcome of Acute Disseminated Encephalomyelitis in children: A retrospective study. (Pubmed Central) - Aug 2, 2024
Treatment included IV methylprednisolone (22; 73%), IVIG (9; 30%), or both (6; 20%)...The clinical presentation of ADEM is variable, but the most common symptoms are fever, headache, and altered consciousness. Despite generally favorable outcome, long-term monitoring revealed that patients may experience motor deficits, seizures, cognitive impairment, and academic difficulties.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Non Typical Type 1 Diabetes Mellitus Onset in a Child With Salt-Wasting Congenital Adrenal Hyperplasia. (Pubmed Central) - Aug 2, 2024
Although he only started with rapid-acting insulin analogue before meals, he presented spontaneous episodes of hypoglycemia just before the morning hydrocortisone dose, due to an underdosed glucocorticoid intake...HbA1c and CGM can help recognize T1DM onset and evaluate the correct dosage of corticosteroid therapy in CAH patients. New studies are needed to understand the therapeutic approach for a more specific treatment in case of coexistence of these diseases.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal: Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes. (Pubmed Central) - Aug 2, 2024
Male Wistar rats were divided into two groups: (1) Control sham and (2) GC group that was administered dexamethasone 6.25?mg/200??L via osmotic pump implantation over 28 days...In human brown cells, inhibition of miR-21-5p increased brown adipocyte differentiation and prevented GC-induced glucose uptake, resulting in a lower glycolysis rate. In conclusion, high-dose GC therapy significantly impacts brown adipose tissue function, with a notable association between glucose uptake and miR-21-5p.
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg., Epkinly (epcoritamab-bysp) / Genmab, AbbVie
P2 data, Journal, Monotherapy: Epcoritamab monotherapy in patients with relapsed or refractory follicular lymphoma (EPCORE NHL-1): a phase 2 cohort of a single-arm, multicentre study. (Pubmed Central) - Aug 1, 2024
P1/2
In conclusion, high-dose GC therapy significantly impacts brown adipose tissue function, with a notable association between glucose uptake and miR-21-5p. Epcoritamab monotherapy showed clinically meaningful activity in patients with multiply relapsed or refractory follicular lymphoma, and had a manageable safety profile.
- |||||||||| Journal: Trends in Outcomes After Upfront Autologous Transplant for Multiple Myeloma over Three Decades. (Pubmed Central) - Aug 1, 2024
Our results confirm D-VTd induction and consolidation as a standard of care, and support the option of subsequent daratumumab monotherapy maintenance, for transplant-eligible patients with newly diagnosed multiple myeloma. Despite increasing patient age and comorbidity burden, this large real-world study demonstrated significant improvements in the depth of response and survival outcomes in patients with NDMM undergoing upfront auto-SCT over the past three decades, including those with high-risk disease.
- |||||||||| TAKAYASU ARTERITIS IN A YOUNG HISPANIC MALE (Convention Center Exhibit Hall: Poster Area 5) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5644;
Treatment involves GC and non-GC immunosuppressive agents. A multidisciplinary team is often required for the management and prevention of complications, including vascular stenosis, aneurysm, and arterial occlusion, leading to ischemia and end-organ damage.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD), Vyvgart (efgartigimod alfa-fcab) / argenx, Broteio
IMMUNE CHECKPOINT INHIBITOR-RELATED MYASTHENIA GRAVIS, MYOSITIS, HEPATITIS, AND MYOCARDITIS (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5578;
ICI therapy can cause a spectrum of adverse autoimmune effects. Treatment for cases requiring intensive care includes holding ICI therapy at least temporarily, high-dose corticosteroids, and plasmapheresis or IVIG if symptoms are rapidly progressive or refractory.
- |||||||||| Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
INSIGHTS INTO SURFACTANT PROTEIN C DEFICIENCY: A CASE STUDY OF AN INFANT WITH THE C.565T>G (P.CYS189GLY) MUTATION (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5557;
Budesonide, albuterol, and hypertonic saline treatments were prescribed prior to discharge...The patient was treated with steroids and azithromycin for anti-inflammatory effect prior to obtaining open lung biopsy...Current clinical considerations are long-term treatment with steroids and/or hydroxychloroquine... While c.565T>G (p.Cys189Gly) is reported as a variant of uncertain significance, our patient has clinical and pathological findings consistent with a surfactant protein deficiency leading us to conclude that this variant likely has clinical significance.
- |||||||||| cefepime hydrochloride / Generic mfg., vancomycin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
HIDDEN DIAGNOSIS: TRACHEOBRONCHIAL PAPILLOMATOSIS MASQUERADING AS ASTHMA (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5536;
The presentation of severe asthma-like symptoms can be deceptive, potentially resulting in overlooked management strategies. This case underscores the critical need to differentiate tracheobronchial papillomatosis from other respiratory pathologies such as asthma to facilitate tailored and timely interventions.
- |||||||||| montelukast / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
CORN KERNEL ASPIRATION MIMICKING SEVERE PERSISTENT ASTHMA (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5535;
CASE PRESENTATION: A 57-year-old female with a medical history pertinent for mild intermittent asthma that was previously well controlled on fluticasone/salmeterol and as-needed albuterol inhalers was seen in the office a week after being hospitalized for an asthma exacerbation...Tiotropium inhaler and Montelukast were added to her treatment regimen, and she was scheduled for a bronchoscopic evaluation of the endobronchial lesion... Our case highlights the importance of broadening differential diagnosis when a patient's asthma symptoms abruptly worsen, especially when bronchodilator and anti-inflammatory therapy fails.
- |||||||||| ceftriaxone / Generic mfg., azithromycin / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
ALL THAT GLITTERS IS NOT G.O.L.D.: EVALUATION OF PERSISTENT HYPOXIA IN A PATIENT WITH A COPD EXACERBATION (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5533;
He initially required BiPAP for oxygenation and work of breathing and was managed with antibiotic therapy (azithromycin and ceftriaxone) in addition to IV methylprednisolone and inhaled therapy. In patients with persistent severe hypoxia who have a known history of COPD and especially those with concomitant polycythemia, further evaluation and workup for PE should be strongly considered.
- |||||||||| prednisone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
TACKLING THE DIFFICULTIES IN DIAGNOSING ASTHMA-COPD OVERLAP (ACO): EXPLORING THE DISTINCTIVE FEATURES OF ASTHMA-COPD OVERLAP (ACO) (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5529;
ACOS poses challenges due to its varied clinical manifestations arising from multiple underlying factors, further exacerbated by the limited research data. Nonetheless, precise identification of ACOS in patients is essential for devising personalized treatment plans focused on alleviating symptoms and minimizing exacerbations, ultimately enhancing the clinical management of individuals with Asthma-COPD Overlap.
- |||||||||| dexamethasone injection / Generic mfg.
APPARENT CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATIONS MASKING DIAGNOSIS OF LARYNGEAL CANCER (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5526;
Recurrent COPD exacerbations, particularly in a setting of inadequate response to the usual treatment should raise the suspicion for alternate diagnosis. Clinicians should always be aware of all other possible differential diagnosis during every patient assessment for accurate diagnosis and timely management of respiratory conditions.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
BRONCHODILATOR BETRAYAL: A CASE OF ALBUTEROL- AND IPRATROPIUM-INDUCED PARADOXICAL BRONCHOSPASM (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5523;
Paradoxical bronchospasm is an under-documented adverse reaction to inhaled bronchodilators that can lead to worsening respiratory failure (2). It is essential for clinicians to be aware and recognize this unexpected adverse event, especially in patients that are progressively getting worsening, to minimize harm and improve outcomes.
- |||||||||| dexamethasone / Generic mfg.
ENDOBRONCHIAL ULTRASOUND-GUIDED TRANSBRONCHIAL NEEDLE ASPIRATION: A NOVEL WAY TO DIAGNOSE PULMONARY EMBOLISM (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5458;
To date, there remains a paucity of data, only anecdotal reports, regarding the true incidence of acute pulmonary embolisms diagnosed with EBUS prior to CTA. This case highlights the need for further research on this topic, and if a protocolized observance of the pulmonary arteries during EBUS would be warranted, especially those at high risk for PE.
- |||||||||| hydrocortisone / Generic mfg.
PNES OR INSULINOMA: A MASKING DIAGNOSIS (Convention Center Exhibit Hall: Rapid Fire Area 2C) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5429;
Admitted to the ICU for persistent hypoglycemia and seizure activity, she received dextrose 10% and intravenous hydrocortisone... Keeping an open mind for differential diagnoses in patients with neuroglycopenic patients can be crucial in identifying insulinomas.
- |||||||||| hydrocortisone / Generic mfg.
ROLE OF EARLY ADMINISTRATION OF GLUCOCORTICOIDS IN INSULIN OVERDOSE (Convention Center Exhibit Hall: Rapid Fire Area 2C) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5428;
Early recognition and use may decrease fluid requirements and potentially contribute to faster overall resolution of insulin overdose when used in conjunction with traditional treatment modalities. So far within the critical care literature, only case studies are present, however based on the multiple cases reporting adequate resolution, further research studies should be warranted and applied to such patient populations.
- |||||||||| ACUTE RESPIRATORY DISTRESS SYNDROME: A RARE FIRST MANIFESTATION OF ANTISYNTHETASE SYNDROME (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5380;
While rare, ARDS can be the presenting clinical manifestation of AS, and can occur in the absence of extrapulmonary symptoms. While there are no guidelines for AS testing in patients with ARDS, the diagnosis can be considered in patients with idiopathic ARDS, negative microbiologic workup and elevated inflammatory markers.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg.
THE RAPID PROGRESSION OF EMPHYSEMA IN A PATIENT RECOVERING FROM COVID-19 (Convention Center Exhibit Hall: Poster Area 3) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5355;
Patient was found to be COVID-19 positive and he was treated with dexamethasone 6mg daily for 10 days, Remdesivir for 5 days, and was managed with supplemental oxygen via high flow nasal cannula and intermittent BiPAP. This case serves as an important reminder of the devastating effects of COVID-19 infection and should cue providers to consider progressive pulmonary parenchymal disease in COVID-19 patients who require long term ventilatory support.
- |||||||||| Rituxan (rituximab) / Roche
RITUXIMAB FOR THE MANAGEMENT OF REFRACTORY THROMBOTIC THROMBOCYTOPENIC PURPURA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5336;
CASE PRESENTATION: 33-year-old female with a significant PMH of systemic lupus erythematous on chronic prednisone therapy 20mg/day presents to ED with a six-day history of chills, shortness of breath, and pleuritic chest pain. Refractory TTP to pulse dose IV methylprednisolone and plasmapheresis requires once a week Rituximab for four weeks.
- |||||||||| digoxin / Generic mfg.
NOT SO TOXIC: A CASE REPORT OF MILD DIGOXIN TOXICITY MASKING SEVERE HYPOTHYROIDISM (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5335;
Endocrine emergencies including myxedema coma must not be overlooked and can be masked by symptom overlap with sepsis, adrenal insufficiency or other forms of distributive shock, obstructive shock, psychosis, or other types of metabolic encephalopathies. Care should be taken to check TSH levels on admission for patients treated for these similar critical care pathologies that may mask severe hypothyroidism and myxedema coma.
- |||||||||| hydrocortisone / Generic mfg.
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS SECONDARY TO ENTEROPATHOGENIC E. COLI AND HEPATITS A INFECTION (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5333;
There are other features supporting an HLH diagnosis that are not part of the HLH-2004 criteria which include hyperbilirubinemia, hepatomegaly, transaminitis, elevated lactate dehydrogenase and D-dimer levels. While these findings cannot give a definite diagnosis, in patients fulfilling many of the criteria for HLH while waiting for results from labs and bone marrow biopsies, these findings may help to discriminate HLH from other similarly presenting conditions.
- |||||||||| A RARE AUGMENTIN DRUG REACTION WITH EOSINOPHILIA AND SYSTEMIC SYMPTOMS (DRESS) SYNDROME: A DIFFERENTIAL TO CONSIDER (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5331;
A case of rarely reported Augmentin induced DRESS syndrome resulting in severe cellulitis with desquamating rash leading to septic shock with severe renal failure exacerbated by eosinophilia and synergistic DRESS involvement that responded to steroids. This is an atypical differential that needs to be considered when patients experience drug rashes after penicillin drugs.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
IMMUNE CHECKPOINT INHIBITOR-ASSOCIATED ACUTE LIVER FAILURE (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5303;
Steroids and immunosuppressant are mainstay therapies for severe immune-related adverse events. However, management may involve additional therapies such as plasma exchange to mitigate innate immune response that is rampant in acute liver failure.
- |||||||||| dexamethasone / Generic mfg., hydroxyurea / Generic mfg., cytarabine / Generic mfg.
DEVASTATING LEUKEMIA! RAVAGING ARTERIAL AND VENOUS THROMBOSIS COMPLICATIONS OF ACUTE MYELOID LEUKEMIA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5288;
AML, when accompanied by severe arterial thrombotic complications, is rare. Our case highlights the recognition of this complication in a disease primarily associated with bleeding risk is crucial to mitigate adverse outcomes.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg., loperamide / Generic mfg.
OVERCOMING THE ANCHORING BIAS: A CASE OF MICROSCOPIC COLITIS INITIALLY PERCEIVED AS MESENTERIC ISCHEMIA (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5278;
Antidiarrheal agents including loperamide can be utilized for symptom management... Given the significant overlap of symptoms, any patient with diarrhea should be approached with a broad differential and appropriate diagnostics should be performed in a timely manner to provide patient-centered and evidence-based care.
- |||||||||| remdesivir / Generic mfg., dexamethasone / Generic mfg., fludrocortisone / Generic mfg.
RESTORING EQUILIBRIUM: A CASE OF COVID-19-ASSOCIATED CAPILLARY LEAK SYNDROME AND CLINICAL RESPONSE TO MINERALOCORTICOIDS (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5272;
Capillary leak syndrome has been linked to other medical conditions and represents significant clinical challenges in its management. The patient's clinical response may suggest that fludrocortisone can be beneficial when CLS is associated with COVID-19 however dose and timing are unclear.
- |||||||||| Jaypirca (pirtobrutinib) / Eli Lilly, Elitek (rasburicase) / Sanofi
WHEN BLOOD IS THICKER THAN WATER: A RARE CASE OF THERAPEUTIC LEUKAPHERESIS IN CLL (Convention Center Exhibit Hall: Poster Area 2) - Jul 31, 2024 - Abstract #CHEST2024CHEST_5249;
Leukostasis is an exceedingly rare complication of CLL. Prompt identification of end organ damage with urgent measures such as leukapheresis can be lifesaving.
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