- |||||||||| dexamethasone injection / Generic mfg.
Intraoperative Development of Severe Euglycemic Ketoacidosis in a Non-diabetic Patient (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8049;
Intraoperatively she received dexamethasone 10 mg IV x 2 (first dose early in case), 5% albumin 100g, lactated ringers 1L, normal saline 1L, and sodium bicarbonate 50 mEq (one ampule) without significant improvement (repeat ABG 7.16/23)...Though surgery is known to trigger euDKA, to our knowledge such severe perioperative acidosis from euDKA in a non-diabetic patient has not been previously reported. Intensivists and anesthesiologists should recognize euDKA as a potential cause of severe perioperative acidosis in non-diabetics with risk factors.
- |||||||||| prednisone / Generic mfg., thyroxine / Generic mfg., hydrocortisone / Generic mfg.
Bilateral Pleural Effusion Secondary to Myxedema (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8045;
The mainstay of treatment is correction of the hormonal imbalance with intravenous thyroid hormone and hydrocortisone in an ICU setting. Studies have reported a mortality rate of as high as 60% therefore making an early diagnosis crucial for a positive patient outcome.
- |||||||||| Pituitary Apoplexy, A Rare But Life Threatening Complication of Pituitary Adenoma (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8042;
Pituitary apoplexy is a rare but serious complication of pituitary adenoma associated with significant mortality and morbidity...Transsphenoidal resection of the pituitary gland is the surgical intervention of choice for patients presenting with neuro-ophthalmological findings. Rapid diagnosis, medical stabilization, and early surgical decompression will be lifesaving and will result in better neurological outcomes.
- |||||||||| methimazole / Generic mfg., hydrocortisone / Generic mfg., amiodarone / Generic mfg.
Thyrotoxic Periodic Paralysis: A Grave Disease (Walter E. Washington Convention Center, Area K, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8041;
CRRT was initiated due to low urine output and Patient was started on Methimazole due to elevated liver enzymes due to shock liver and Hydrocortisone...Slow potassium replacement is considered to be the mainstay of treatment with the danger of rebound hyperkalemia. Definitive treatment includes anti-thyroid medications, surgical thyroidectomy or radioiodine therapy until euthyroid state is achieved.
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
A Bug Problem: Increased Incidence of Infections With Baricitinib Administration in Critically Ill Patients With COVID-19 (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8034;
In our institution we switched the immunomodulatory treatment of COVID from Tocilizumab to Baricitinib when the former became unavailable in late 2021...All studied patients received at least 10 days of steroids (most commonly dexamethasone), with half of the patients receiving additional doses for treatment of suspected organizing pneumonia...Which the two seminal large trials of the medication for this indication show both a low, and no added risk for infection, our experience suggests that the actual risk of infection in a real-world setting may be much higher. Confirmation of these findings requires an adequate case-controlled study (in progress) and expansion to multiple sites.
- |||||||||| Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech, Actemra IV (tocilizumab) / Roche, JW Pharma
A Healthy 27-year-old Multiparous Patient at 27 Weeks (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8031;
Three weeks following her diagnosis she received her first dose of the BNT162b2 mRNA vaccination...Her echocardiogram showed a newly reduced left ventricular ejection fraction to 40% and clinical evidence of cardiogenic shock requiring initiation of dobutamine...She was recovered in the ICU with diuresis, 162 mg of aspirin, 1 mg/kg of methylprednisolone following dexamethasone for fetal lung maturity, one 400 mg dose of tocilizumab, and intravenous immunoglobulin 1mg/kg for two doses with guidance from our interdisciplinary MIS-A team. This case highlights clinical features of MIS-A in a healthy pregnant woman at 27 weeks
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Peripartum Pneumoperitoneum and Pneumoretroperitoneum in COVID-19 (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8030;
Patients with COVID-19 are at increased risk of barotrauma and should be monitored for such complication. For patients in respiratory distress requiring mechanical intubation, ECMO should be considered as an intervention for lung rest strategy to reduce further barotrauma.
- |||||||||| Acute Epiglottitis Due to Serratia Marcescens in the Setting of SARS-CoV-2 Infection in an Immunocompetent Patient (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8027;
Although the incidence of AE is decreasing, a high suspicion index is required in patients presenting with high-grade fever, drooling, and voice hoarseness. Early management initiation with broad antibiotics coverage, decreasing intubation threshold, and possibly adding pulse steroids and Racemic Epinephrine might decrease mortality and morbidity.
- |||||||||| A Life-Threatening Combination: A Case of Burkholderia Gladioli Pneumonia in a Patient With Coronavirus Disease 2019 (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8022;
Non-invasive positive pressure ventilation was initiated and he was treated with remdesivir, convalescent plasma, dexamethasone as well as empiric ceftriaxone and azithromycin...Antibiotics were broadened to cefepime and vancomycin at that time...Antibiotic therapy was adjusted to empiric piperacillin/tazobactam and nebulized tobramycin, however, the patient's family elected to proceed with hospice care prior to the availability of the B gladioli sensitivity report...In one other case, the patient succumbed to this illness. We believe that this case adds to the existing literature to shed light on the significant morbidity and mortality this infection can have on patients with COVID-19.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Patient With COVID-19 Pneumonia Treated With Steroids and Tocilizumab is Diagnosed With AIDS (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8020;
The early phase of the COVID-19 pandemic included research to guide treatment, and the literature showed dexamethasone decreased mortality...He tested positive for HIV with a CD4 count of 16 and was started on TMP-SMX, steroids, and fluconazole...The patient received beyond the recommended course of steroids, which may have contributed to his clinical decline given his underlying immunocompromised state. At the case site, order guidance has been reviewed to optimize steroid stewardship, especially in complex cases like these.
- |||||||||| remdesivir / Generic mfg., hydrocortisone / Generic mfg.
A Case Series of Persistent SARS-CoV-2 Infection in Immunocompromised Pediatric Patients (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8017;
Multiple therapeutic agents were used in their COVID-19 management, including corticosteroids, remdesivir, and monoclonal antibodies. All three patients whom have received concurrent therapy with Remdesivir, Hydrocortisone and Monoclonal Antibodies has survived, only one patient has died as a direct complication of COVID-19 ARDS with secondary pulmonary Mucormycosis; Our outcomes suggests the potential benefit of Remdesivir use in combination with Hydrocortisone and Monoclonal Antibodies in the management of severe COVID-19 ARDS in this group, as well as the importance of early administration of broad empirical antimicrobial coverage, including antifungal coverage, given the higher risk of secondary bacterial and fungal infections.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Soliris (eculizumab) / AstraZeneca
Pressure Ulcers in the Prone Ventilated Critically Ill Patient With COVID-19 (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8010;
These case series illustrate and hypothesize that patients with COVID-19 requiring mechanical ventilation in a prone position are at an increased risk for pressure ulcer development from the positioning changes process and the hyperinflammatory state intrinsic to the infection and require frequent skin surveillance. Preventative solutions to decrease shearing forces between the skin and devices should be considered and specific guidelines for prone positioning implemented.
- |||||||||| Post COVID Pneumonia Complicated by Secondary MRSA Empyema (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8009;
Sputum culture grew MRSA, and the patient was started on vancomycin...Secondary bacterial infections lead to higher morbidity and mortality rate. Early recognition with appropriate surgical and medical intervention in our patient resulted in successful recovery.
- |||||||||| Kineret (anakinra) / SOBI
Early Recognition of Idiopathic Hemophagocytic Lymphohistiocytosis Complicated by Intracranial Hemorrhage, A Case Report (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_8004;
In our case, this led to the unfortunate outcome of terminal intracranial hemorrhage, a complication that has been mentioned in only a few case reports but is a deadly sequelae of disease. Our case suggests the importance of more rigorous monitoring and aggressive correction of coagulopathies to prevent secondary sequelae of HLH which remain life threatening despite an improvement in the underlying disease process.
- |||||||||| A Rare Case of Herpes Simplex Virus Type1 Induced Hemophagocytic Lymphohistiocytosis in Adult Patient (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7993;
We present an additional case of HSV-1 as an etiology of HLH.Case description: 66-year-old male with a past medical history of gastric adenocarcinoma status post total gastrectomy, on fluorouracil, leucovorin, oxaliplatin, docetaxel and trastuszumab recent diagnosis of typhilitis treated with levofloxacin and metronidazole presented with abdominal pain, diarrhea, and poor intake...He was started on antibiotics which included cefepime, vancomycin, and doxycycline...The patient was started on IV acyclovir and continuous renal replacement therapy given continued decompensation of renal function...Treatment would consist of etoposide, dexamethasone or methotrexate in addition to supportive care via blood product transfusions and treatment of underlying etiology. Literature review showed mostly pediatric case reports of HSV-1 induced HLH but rarely was it described in the adult population.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Dilemma: Ehrlichiosis or EBV? (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7992;
Rituximab was also added given the concomitant concern for HLH secondary to EBV...EBV-driven HLH, however, warrants steroids and chemotherapy agents that are not well-tolerated in the ICU. Thus, it is imperative to identify the preliminary cause of HLH, keeping in mind that EBV could be reactivated in an HLH patient and act as a confusing diagnostic decoy.
- |||||||||| Hemophagocytic Lymphohistiocytosis Secondary to Infected Staghorn Renal Calculus (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7991;
High degree of suspicion of HLH is required because of variable clinical presentations, lack of specificity of clinical and laboratory findings, and diversity of causes. In the case presented prompt recognition of HLH syndrome secondary to underlying pyelonephritis was critical to start appropriate treatment with etoposide and dexamethasone following which the patient had significant clinical improvement.
- |||||||||| Postpartum Hemophagocytic Lymphohistiocytosis (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7990;
Pregnancy has only rarely been associated with HLH in case reports with the overwhelming majority occurring prior to delivery. This case highlights that while pregnancy may be a trigger for HLH, delivery does not resolve this risk and HLH should be considered in the immediate postpartum period.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
An Unusual Cause of Thrombocytopenia By Commonly Used Over the Counter Phenazopyridine (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7981;
Phenazopyridine was discontinued, patient received platelets and was started on IVIG with decadron 40 mg for 4 days.DITP can be a result of three different processes including direct injury to the bone-marrow consequently affecting its thrombopoietic function, immune-mediated process with the antibody production and formation of Hapten...Systemic corticosteroids are highly efficacious with response in up-to 90% of cases given their anti-inflammatory and thrombopoietic effects. Our patient required platelets, systemic corticosteroids and IVIG administration with good response.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A Rare Case of Evans Syndrome With Antiphospholipid Antibodies and RSV Infection (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7975;
Secondary ES has been reported to be associated with non-Hodgkin lymphoma, autoimmune disease, infections, primary immunodeficiencies and pregnancy...Also, RSV with antiphospholipid antibodies is very rare. Our patient presentation is probably because of viral antigenic mimicry and cross-reactivity with host phospholipid-binding protein b2 glycoprotein I?.
- |||||||||| gemcitabine / Generic mfg.
Intraperitoneal Absorption of Intravesical Gemcitabine Resulting in ARDS and Pancytopenia (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7952;
The patient received 5 units of platelets, 1 unit of packed red blood cells, filgrastim, methylprednisolone, and intravenous immunoglobulin (IVIG) for thrombocytopenia down to a nadir of 4 K/mcL. Although IVC gemcitabine is considered to have a favorable safety profile in the treatment of urothelial carcinoma, potential intraperitoneal absorption was the likely cause of this patient
- |||||||||| An Adverse Reaction to Coral Snake Antivenom (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7941;
Patients should be closely monitored in an ICU setting for adverse reactions including anaphylaxis during and after antivenom administration. Timely identification and management of adverse reactions is crucial in order to administer the complete and effective antivenom dose.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron
The Role of Dupilumab in Refractory Anaphylaxis Secondary to Food Allergy (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7937;
IL4 and IL13 inhibition may have played a role in the resolution of this patient laryngeal edema. CONCLUSION This highlights a rare case of refractory anaphylaxis improvement with Dupilumab.
- |||||||||| Mycamine (micafungin) / Astellas
Acute Hypoxic Respiratory Failure and Septic Shock Secondary to Mycetoma (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7926;
Adrenal insufficiency: PO fludrocortisone 0.05mg, dexamethasone 4mg IV x1, IV Hydrocortisone 100mg q8h...Depite of all measures pt didn't resopded to the therapy. Due to poor prognosis family decided for DNR and comfort meassure only.
- |||||||||| Tragic Consequences : Mycoplasma Pneumoniae Septic Shock (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7921;
Patient was admitted for suspected meningitis versus gastroenteritis and was started on vancomycin, acyclovir, ceftriaxone and dexamethasone...Patient completed seven days of azithromycin, improved significantly and discharged home in stable condition.We describe sever form of infection with MP, septic shock in a healthy young adult woman, without initial pulmonary symptoms...Current antibiotic therapy guidelines for severe sepsis do not include MP infection. Hence, high suspicion should be considered for patients with atypical presentations.
- |||||||||| Decadron (dexamethasone) / Merck (MSD)
Maternal and Fetal Outcomes in Pregnant Women With Severe SARS-CoV-2 Infection (Walter E. Washington Convention Center, Area B, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7871;
Our findings are most likely due to the limited size ofthe study, with only 34 patients. In addition, multivariate analysis could not be performed due to the small sample size.To better assess if there is an association with BMI and medical interventions for severe SARS-CoV-2 infection in pregnant patients, a larger sample size is needed.
- |||||||||| dexamethasone / Generic mfg.
Post Covid-19 ARDS Persistent Air Leak Treated With Endobronchial Valve Placement (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7829;
Management of PAL remains challenging with lack of standard guidelines to define a systematic approach, Endobronchial valve (EBV) has proven to be an efficacious intervention in the management of PAL.Case: 29-year-old female non-smoker without significant past medical history was transferred to our hospital for VV ECMO cannulation secondary to acute hypoxemic respiratory failure due to SARS-CoV-2 pneumonia.Her hospital course was complicated by PE, Pseudomonas/Proteus bacteremia, acute renal failure requiring dialysis, and subsequently left-sided pneumothorax requiring chest tube insertion while on mechanical ventilation.The patient received treatment with dexamethasone for her SARS-CoV-2 and eventually had a tracheostomy placement...Different less invasive options have been tested, such as autologous blood patch, Heimlich valve, and albumin-glutaraldehyde tissue adhesives. EBV placement remains a more definitive and minimally invasive way to treat PAL and its utility in critically ill patients should be studied in prospective trials.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
An Irony Behind the Bronchus: A Case Report (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7824;
We present a case of airway inflammation and necrosis secondary to iron pill aspiration, treated with intraluminal methylprednisolone injection during bronchoscopy with demonstrated improvement of initial necrosis and granulation.A 70-year-old woman presented with 5-days of non-exertional, intermittent, and self-resolving chest pain accompanied by dyspnea...Routine follow-up bronchoscopy can provide ongoing evaluation and possible treatment after initial aspiration event. Steroid injections demonstrate promise in halting progression of pulmonary insult but require further research for its efficacy and utility in the treatment protocol.
- |||||||||| prednisone / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Spontaneous Pneumomediastinum in a Young Man (Walter E. Washington Convention Center, Area L, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7725;
Most cases are self-limited and resolve with expectant management without complications and have a low risk of recurrence. However, due to its rarity and often subtle presentation, a high index of suspicion is needed for prompt diagnosis and management of SPM.
- |||||||||| Jakafi (ruxolitinib) / Novartis, Incyte
Hemophagocytic Lymphohistiocytosis Secondary to Sarcoidosis (Walter E. Washington Convention Center, Area E, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7665;
Our case is also unusual, though not unique, with regard to the positive outcome. The majority of reported cases, despite high-dose steroids and in some instances etoposide, resulted in death.
- |||||||||| Atectura Breezhaler (indacaterol/mometasone furoate) / Novartis, Merck (MSD), Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
Once Daily Versus Twice Daily Inhaled Corticosteroids Plus Long Acting Beta2-agonists in Patients With Moderate-to-severe Asthma - a Meta-analysis and Systematic Review (Walter E. Washington Convention Center, Area J, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7245;
In the last decade, two new controller combinations of inhaled corticosteroids (ICS)/ long-acting ?2-adrenoceptor agonists (LABA) administered once daily have been proposed to improve adherence to asthma treatment: fluticasone furoate/vilanterol (FF/VI) and mometasone furoate/indacaterol (MF/IND). Once daily ICS/LABA combinations were associated with a reduction in exacerbations, improvement in lung function, and similar control of asthma symptoms and safety profile compared to twice daily ICS/LABA combinations in adults with moderate-to-severe asthma.
- |||||||||| dexamethasone / Generic mfg.
Aberrant KRas Activation in HRas/NRas-devoid Mice Distorts Lung Alveologenesis (Walter E. Washington Convention Center, Area J, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7238;
This phenotype is partially mitigated after NAC treatment and completely reversed with a MEK inhibitor. This study suggests that a physiological modulation of KRas signaling is critical for the control of murine late lung maturation.
- |||||||||| bictegravir (GS-9883) / Gilead
Disseminated Histoplasmosis in a Patient With Acquired Immunodeficiency Syndrome in a Non-Endemic Region (California) (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7076;
He was started on liposomal amphotericin B with IV methylprednisolone for treatment of PDH...was also initiated with daily oral bictegravir/emtricitabine/tenofovir...AIDS patients with histoplasmosis present with a myriad of non-specific infectious symptoms and failure to consider histoplasmosis in the differential diagnosis may lead to delays in care for this vulnerable population. Consequently, it is important for clinicians to recognize manifestations of non-endemic mycoses and obtain a full infectious work-up in immunocompromised patients, as histoplasmosis is a treatable condition.
- |||||||||| Cortone (cortisone acetate) / Merck (MSD)
Determine the Extent and Type of Tissue Injury Caused by Mucorales in Lungs Using Pneumonia Mouse Model (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7054;
CD-1 male mice were immunosuppressed with cyclophosphamide (200?mg/kg) and cortisone acetate (500?mg/kg) on days ?2 and +3, relative to infection. Rhizopus infection causes lung tissue injury characterized by decreased AT2 cell markers and compromised endothelial cells during early infection consistent with clinical angioinvasion which likely contribute to bad prognosis.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg.
Steroid-Related Pneumocystis Pneumonia: A Devastating Toll (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7051;
Through examination of 96 cases of srPJP, we have been able to identify more specific steroid dose thresholds and underlying conditions that increase the risk of developing this iatrogenic and often fatal infection. In particular, the use of dexamethasone in cancer patients and the presence of a sulfa allergy may be previously unrecognized barriers to prophylaxis.
- |||||||||| Dupixent (dupilumab) / Sanofi, Regeneron, Duoneb (ipratropium bromide/albuterol sulfate) / Viatris, Nucala (mepolizumab) / GSK
Blastomycosis Induced Circumferential Tracheobronchial Thickening: A Case Report (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7038;
He is scheduled for a follow-up CT after a few months. This case represents a very rare presentation of blastomycosis characterized by tracheobronchial thickening.
- |||||||||| dexamethasone / Generic mfg.
Thymic Hyperplasia After Severe SARS-CoV-2 Pneumonia (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7013;
The exact nature of the relationship between thymic hyperplasia and SARS-CoV-2 infection has yet to be determined. In the meantime, tCT examination of the thymic area should be included in the initial and follow-up evaluation of COVID-19 patients with severe disease.
- |||||||||| prednisolone / Generic mfg.
A Case of Immune Thrombocytopenic Purpura Secondary to COVID-19 Infection (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7006;
The patient was started on a pulse dose of oral prednisolone...Our case highlights the importance of vigilance regarding the hematologic manifestation of COVID-19 infection. Early recognition of rare complications like ITP will help prevent a fatal outcome.
- |||||||||| Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
When Humoral Immunity Fails Due to Rituximab in COVID-19 Pneumonia (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7004;
She had mild hypoxemia and received remdesivir and dexamethasone without improvement...She was readmitted, prednisone was continued, remdesivir was started, and she received bebtolivumab...Relapse versus reinfection could not be determined. A second round of passive immunity with monoclonal antibody was again temporally associated with sustained recovery in a woman in whom steroids did not result in immediate benefit.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma
Fatal COVID 19 Infection in an Adult Patient With Previous Miliary Tuberculosis: A Case Report (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6990;
This case highlights the challenges in caring for patients with previous miliary infection presenting with a new respiratory infection. The presence of structural changes due to the previous tuberculosis infection led to diagnostic challenges as well portended a poorer prognosis in the patient.
- |||||||||| dexamethasone / Generic mfg.
Radiographic and Clinical Correlations in Survivors With Post -ARDS Related to COVID-19 Two Years After Discharge From Hospitals (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6970;
The presence of structural changes due to the previous tuberculosis infection led to diagnostic challenges as well portended a poorer prognosis in the patient. There wer several risk factors found for development of more severe residual pulmonary functional and radiological abnormalities 2 yeras after discharge from hospitals: older age ,obesity,kidney failure ,DM were associated with more extend severe residual lung abnormalities.Extend IMV and lack of use dexamethasone at the time of ICU admission and first 3 -months after discharge were associated extend fibrotic-like lung abnormalities with more severe pulmonary functional impairment.
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