|
186 Products |
| 186 Products |
|
1696 Diseases |  |
95004 News |  |
| «12...174175176177178179180181182183184...10651066» |
- |||| mometasone fuorate (LYR-210) / Lyra Therap
Enrollment open: Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults (ENLIGHTEN 2) (clinicaltrials.gov) - Apr 26, 2023
P3, N=180, Recruiting, Sponsor: Lyra Therapeutics
Active, not recruiting --> Recruiting
- | dexamethasone / Generic mfg., dexmedetomidine / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: AADDCToR: Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain (clinicaltrials.gov) - Apr 26, 2023
P4, N=252, Active, not recruiting, Sponsor: Women's College Hospital
Active, not recruiting --> Recruiting Suspended --> Active, not recruiting | Trial completion date: Dec 2022 --> Feb 2025 | Trial primary completion date: Dec 2022 --> Dec 2024
- | Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
Enrollment closed, Trial completion date, Trial primary completion date: ScanCLAD: Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD. (clinicaltrials.gov) - Apr 26, 2023
P=N/A, N=249, Active, not recruiting, Sponsor: Vastra Gotaland Region
Suspended --> Active, not recruiting | Trial completion date: Dec 2022 --> Feb 2025 | Trial primary completion date: Dec 2022 --> Dec 2024 Completed --> Active, not recruiting | Trial completion date: Oct 2022 --> Oct 2026 | Trial primary completion date: Oct 2022 --> Oct 2025
- || budesonide / Generic mfg.
Lol yes, you can buy a 🚒and fill it with budesonide, and then maybe it'll be close. (Twitter) - Apr 25, 2023
- | dexamethasone / Generic mfg.
Journal: Dexamethasone: 3 things the general dentist needs to know. (Pubmed Central) - Apr 25, 2023
Completed --> Active, not recruiting | Trial completion date: Oct 2022 --> Oct 2026 | Trial primary completion date: Oct 2022 --> Oct 2025 No abstract available
- ||| prednisone delayed-release tablet / Generic mfg.
La molécula del ADN fue descubierta en 1869 por Friedrich Miescher, el 25 de abril de 1953 James Watson y Francis Crick publican su artículo donde describen la estructura de esta molécula, gracias a la fotografía 51 tomada por Rosalind Franklin mediante difracción de rayos X (Twitter) - Apr 25, 2023
- | methylprednisolone acetate / Generic mfg.
Journal: Ultrasound-Guided Glenohumeral Corticosteroid Injection for the Treatment of Adhesive Capsulitis of the Shoulder: The Role of Clinical Stage in Response to Treatment. (Pubmed Central) - Apr 25, 2023
All patients were treated with an USGI of local anesthetic and depomedrol...USGI for early adhesive capsulitis allows patients to recover ROM more rapidly if performed early after onset of pain and stiffness. These results stress the importance of recognition of idiopathic adhesive capsulitis in its early stages and subsequent intervention with an intra-articular glenohumeral corticosteroid injection.
- |||| fluvoxamine / Generic mfg., budesonide / Generic mfg.
Clinical, Adverse events, Combination therapy, Serious adverse event: TOGETHER trial @AnnalsofIM fluvoxamine+budesonide Can't square sentence in discussion with Table 2: "The absolute number of serious adverse events associated with this combination therapy was lower than in the placebo group." Surely higher? @boulware_dr https://t.co/eM3qwBJy1i (Twitter) - Apr 25, 2023
- | dexamethasone / Generic mfg., olanzapine / Generic mfg.
Preclinical, Journal: Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats. (Pubmed Central) - Apr 25, 2023
Coadministration of olanzapine does not exacerbate any diabetogenic dexamethasone effect on glucose metabolism and exerts a minor impact on the lipid homeostasis of rats. Our data favor the addition of olanzapine in the antiemetic cocktail considering the low incidence of metabolic adverse effects for the period and dosage analyzed in male and female rats.
- | dexamethasone / Generic mfg.
Biomarker, Journal, Metabolomic study: Spatial metabolomics reveal mechanisms of dexamethasone against pediatric pneumonia. (Pubmed Central) - Apr 25, 2023
The above data were illustrated using a Lipopolysaccharides-induced lung injury juvenile rat model. This work will provide evidence for the precise treatment of pediatric pneumonia.
- | hydrocortisone / Generic mfg.
Preclinical, Journal: Immunoregulatory actions of calf thymus extract (TFX (Pubmed Central) - Apr 25, 2023
This work will provide evidence for the precise treatment of pediatric pneumonia. TFX
- | Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
Retrospective data, Journal: Efficacy of once-daily, single-inhaler, fixed-dose combination of mometasone/indacaterol/glycopyrronium in patients with asthma with or without persistent airflow limitation: Post hoc analysis from the IRIDIUM study. (Pubmed Central) - Apr 25, 2023
TFX Once-daily fixed-dose MF/IND/GLY was efficacious in asthma patients with and without persistent airflow limitation.
- | dexamethasone / Generic mfg.
Journal: Short- and long-term T cell and antibody responses following Dexamethasone treatment in COVID-19. (Pubmed Central) - Apr 25, 2023
Dexamethasone treatment is associated with short-term reduction of T cell and antibody response in severe COVID-19 when compared to the non-treated group, but this difference evens out six months after infection. We confirm higher cellular and humoral immune responses in patients after severe versus mild COVID-19 infection and the concept of improved hybrid immunity upon immunization.
- | hydrocortisone / Generic mfg.
Journal: Evaluation of hydrocortisone as a strain-dependent growth-regulator of Porphyromonasgingivalis. (Pubmed Central) - Apr 25, 2023
We confirm higher cellular and humoral immune responses in patients after severe versus mild COVID-19 infection and the concept of improved hybrid immunity upon immunization. HC could reduce the incubation time when isolating P.
- ||| dexamethasone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
Me too!!! I think there also might be some role by adding linezolid so.I have done this too, specially if kidney function or allergy prevents the use of TMP-SMX. I am still skeptical about the use of dexamethasone. I don't know if it increases mortality, maybe don't help (Twitter) - Apr 25, 2023
- || budesonide / Generic mfg.
I don’t know that there are any true analyses but before q8weeks is gonna cost mid to high 5 figures and I can’t imagine that’d be true for Budesonide. (Twitter) - Apr 25, 2023
- | dexamethasone injection / Generic mfg.
Trial primary completion date: Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) (clinicaltrials.gov) - Apr 25, 2023
P3, N=520, Active, not recruiting, Sponsor: Oxford University Clinical Research Unit, Vietnam
HC could reduce the incubation time when isolating P. Trial primary completion date: Dec 2022 --> Apr 2022
- | Akeega (abiraterone/niraparib) / J&J, Zejula (niraparib) / GSK, J&J
Trial initiation date, Metastases: CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations (clinicaltrials.gov) - Apr 25, 2023
P2, N=30, Not yet recruiting, Sponsor: Mayo Clinic
Trial primary completion date: Dec 2022 --> Apr 2022 Initiation date: Mar 2023 --> Jun 2023
- | Venclexta (venetoclax) / Roche, AbbVie, Ninlaro (ixazomib) / Takeda
Trial completion date, Combination therapy: Venetoclax, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple Myeloma (clinicaltrials.gov) - Apr 25, 2023
P1, N=7, Active, not recruiting, Sponsor: Mayo Clinic
Initiation date: Mar 2023 --> Jun 2023 Trial completion date: Mar 2023 --> Dec 2023
- | Enrollment open, Trial completion date, Trial primary completion date: AlloRelapseMM: Allogeneic Stem Cell Transplantation vs. Conventional Therapy as Salvage Therapy for Relapsed / Progressive Patients With Multiple Myeloma After First-line Therapy (clinicaltrials.gov) - Apr 25, 2023
P3, N=482, Recruiting, Sponsor: Universit
Trial completion date: Mar 2023 --> Dec 2023 Not yet recruiting --> Recruiting | Trial completion date: May 2028 --> Mar 2033 | Trial primary completion date: Jul 2027 --> Mar 2028
- | fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Enrollment open, Trial completion date, Trial primary completion date, Adverse events: MAELABA: Mechanisms of Adverse Effects of Long-Acting Beta-Agonists in Asthma (clinicaltrials.gov) - Apr 25, 2023
P4, N=24, Recruiting, Sponsor: Imperial College London
Not yet recruiting --> Recruiting | Trial completion date: May 2028 --> Mar 2033 | Trial primary completion date: Jul 2027 --> Mar 2028 Unknown status --> Recruiting | Trial completion date: Dec 2021 --> Sep 2024 | Trial primary completion date: Mar 2021 --> Sep 2024
- | Keytruda (pembrolizumab) / Merck (MSD), Anktiva (nogapendekin alfa inbakicept-pmln) / ImmunityBio
Enrollment closed, Enrollment change, Metastases: Lung-MAP Non-Match Sub-Study: Testing the Use of Combination Immunotherapy Treatment (N-803 [ALT-803] Plus Pembrolizumab) Against the Usual Treatment for Advanced Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial) (clinicaltrials.gov) - Apr 25, 2023
P2/3, N=82, Active, not recruiting, Sponsor: SWOG Cancer Research Network
Unknown status --> Recruiting | Trial completion date: Dec 2021 --> Sep 2024 | Trial primary completion date: Mar 2021 --> Sep 2024 Recruiting --> Active, not recruiting | N=478 --> 82
- ||| budesonide / Generic mfg.
Clinical: Interesting @DCharabaty - like the idea I usually try to get to lowest possible budesonide dose and refer frequently to this study of 6mg/3mg alt regimen and safety -- but still not ideal for indefinite trx https://t.co/LXSsx32JMn (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg.
So appreciate the convo. I just don’t think our field has embraced that we are recommending per guidelines lifelong steroid therapy since relapses are common, since we essentially have no rct data for maint tx except budesonide. (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg.
Really nice paper. And thoughtful. I agree that these risks are low esp at 4.5mg qd. This cohort was a bit younger and f/u only 1 year. I just think about my 80Yo on chronic budesonide while I quote this paper and refill their steroids. (Twitter) - Apr 24, 2023
- ||| budesonide / Generic mfg.
There is no cortisol suppression with chronic budesonide doses of <6mg https://t.co/L82Hi4Xlzb low cortisol: in 3.7% budesonide vs 5.6% pbo https://t.co/tI9praadyO mean morning cortisol of budesonide group within normal range at week 52. Shouldn’t be osteoporosis if cortisol N (Twitter) - Apr 24, 2023
- |||| budesonide / Generic mfg.
Clinical: Entirely agree, we need more data on alternatives for budesonide maintenance in #microscopic #colitis. Experience with biologicals/small molecules and interested to collaborate ? PM for ongoing @Y_ECCO_IBD #CONFER series! @JulsgaardMette @yzabanaa @my_ueg @AmerGastroAssn (Twitter) - Apr 24, 2023
- ||| budesonide / Generic mfg.
Adverse events: Agree! Will consider VDZ if budesonide tx refractory (rare) vs. steroid side effects (more common, mostly irritability/sleep). We do see them w/ budesonide. (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg.
But we see an increasing need over the years. Long term might be safer than continuing (low dose) budesonide ? (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg., loperamide / Generic mfg., cholestyramine / Generic mfg.
I have never tried every other day before. I have seen loperamide or lomotil for augmentation so cholestyramine makes sense. Obviously it’s a steroid, but I haven’t read much about the data re: chronic budesonide and if it is really a concern? @EugeneYenMD (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg.
In our MC registry, our average budesonide dose was <3mg qd (many taking q2-3d). I think that's such a low dose and completely reasonable. (Twitter) - Apr 24, 2023
- ||| budesonide / Generic mfg.
Clinical: Yes, if you look at most of the RCTs for budesonide maintenance (usu 1 yr), relapse rates for placebo ~80%. (Twitter) - Apr 24, 2023
- |||| budesonide / Generic mfg.
Clinical: However, to answer your question, yes, much like in other forms of IBD, you know who is most likely to relapse (>10BMs, incontinence, noc BMs), so I may discuss maintenance strategy immediately. However, should expect a relapse if you are only doing 6-8 wk budesonide induction. (Twitter) - Apr 24, 2023
- || budesonide / Generic mfg.
I don’t always have a say 😂. Typically we just see how people do off it but it almost always returns. The few times I’ve seen this I’ve re-initiated budesonide and done extended tapers to the lowest possible effective dose and kept them there. (Twitter) - Apr 24, 2023
- ||| budesonide / Generic mfg., cholestyramine / Generic mfg.
Clinical: We published this a few years ago. Cholestyramine allowed us to decrease budesonide dosing in 50%, stop budesonide completely in 20% of our bud-dep patients.https://t.co/U48pvn7Bsn (Twitter) - Apr 24, 2023
- | Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
Journal: New Combination Asthma Drug. (Pubmed Central) - Apr 24, 2023
Recruiting --> Active, not recruiting | N=478 --> 82 A new asthma drug, Airsupra, combines the short-acting ?2-adrenergic agonist albuterol with the corticosteroid budesonide to treat acute asthma attacks.Patients should not stop their asthma maintenance therapy when albuterol-budesonide is prescribed.
- triamcinolone acetonide / Generic mfg.
A comparative study on the efficacy of intralesional radiofrequency ablation combined with triamcenalone versus intralesional triamcenalone alone in treatment of keloid (Level 3 - Room 331) - Apr 24, 2023 - Abstract #WCD2023WCD_2702;
Triamcinolone acetonide suspension 10 to 40 mg per mL is injected intralesionally, will eventually flatten 50 to 100 percent of keloids... Both the modalities of treatment produced equal efficacy, safety and adverse effect but with less recurrence in group B. LIMITATION-Sample Size could have been larger
- tranexamic acid oral / Generic mfg., fluticasone / Generic mfg., hydroquinone / Generic mfg.
Cosmetic issues and its nuances in dark skin (Level 3 - Nicoll 1) - Apr 24, 2023 - Abstract #WCD2023WCD_1621;
KEY MESSAGE: In overall treatment of pigmentary disorders, various combinations of oral vitamin C, tranexamic acid, glutathione can be incorporated into daily regime along with sunscreens, topical agents containing combinations of kojic acid, arbutin, vitamin C, niacinamide, glycolic acid and lactic acid. As a multipronged approach 1064 Nano, Pico Nd:Yag, Erbium Yag laser will further reduce the intensity of hyper pigmentation in skin of color
- dexamethasone / Generic mfg., tacrolimus topical / Generic mfg.
Repigmentation of a stubborn vitiligo (Level 3 - Nicoll 1) - Apr 24, 2023 - Abstract #WCD2023WCD_1315;
KEY MESSAGE: Vitiligo is most disfiguring in darker skin types, given the contrast between normal skin and vitiligo patches. However, when well approached, repigmentation responses are easily achievable in skin of color
- Tri-Luma (fluocinolone acetonide/hydroquinone/tretinoin) / Galderma
Thiamidol as an Adjunctive with Triluma for melasma treatment in Asian (Level 3 - Room 310+311) - Apr 24, 2023 - Abstract #WCD2023WCD_1244;
However, when well approached, repigmentation responses are easily achievable in skin of color Sponsored by Beiersdorf
- triamcinolone acetonide / Generic mfg., 5-fluorouracil / Generic mfg.
A comparative study of efficacy of intradermal injection of hyaluronidase in combination with triamcinolone acetonide and 5-fluorouracil in keloids and hypertrophic scars (Level 3 - Room 323) - Apr 24, 2023 - Abstract #WCD2023WCD_1000;
Both regimens were effective in treatment of keloids; triple-combination showed significant reduction of height. Hyaluronidase degrades acidic mucopolysaccharides and extracellular matrix present in keloids/hypertrophic scars and also helps in spreading of triamcinolone acetonide and 5-fluorouracil into the lesion and thereby augmenting their effect
- triamcinolone acetonide / Generic mfg.
Combination approach using laser assisted drug delivery (LADD) and topical treatment for the treatment of keloid and hypertrophic scar: case series (Level 3 - Room 323) - Apr 24, 2023 - Abstract #WCD2023WCD_998;
Treatments include compression therapy, topical silicone, intralesional injections using triamcinolone acetonide (TA) alone or combine with 5-fluorouracil (5-FU), cryotherapy, surgical excision, and laser therapy...This method may be preferrable for patient with low pain tolerance that refuse injection treatment. The efficacy of this method is good as shown in this case series
- Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Management of pemphigus with Rituximab versus Dexamethasone Pulse therapy: a comparative study with special reference to changes in histopathology and direct immunofluorescence (Level 3 - Room 320) - Apr 24, 2023 - Abstract #WCD2023WCD_687;
Rituximab has superior efficacy compared to DCP for the management of pemphigus. Clinical recovery in pemphigus strongly correlated with histopathological and immunological improvement
- ||| dexamethasone / Generic mfg., amoxicillin / Generic mfg.
Clinical: That is an important caveat in my opition: “The antibiotic regimen included amoxicillin for 82 of 83 (99%) patients receiving the standard dexamethasone regimen and for 72 of 78 (92%) in those not receiving dexamethasone according to protocol (p = 0.06; Supplementary Table S2).” (Twitter) - Apr 24, 2023
- ||| dexamethasone / Generic mfg., Paxlovid (nirmatrelvir and ritonavir) / Pfizer
@jeremyfaust @AshishKJha46 @meganranney 71 year old female tested positive for COVD-19 with antigen test, symptoms cough and headache. Asked PCP for Paxlovid. He said it was “too strong” and gave her Dexamethasone instead. does that make any sense? (Twitter) - Apr 24, 2023
- | prednisolone / Generic mfg.
Journal: Different presentation of autoimmune hepatitis in children: Case series. (Pubmed Central) - Apr 24, 2023
All four cases showed high serum Ig G levels and responded to oral prednisolone only. AIH should be excluded for all patients with symptoms or signs of prolonged, relapsing, or severe liver disease so that treatment can be promptly initiated and morbidity can be reduced.
- || dexamethasone injection / Generic mfg.
Clinical, Review: Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review. (Pubmed Central) - Apr 24, 2023
The patient was treated with intravenous dexamethasone for 1 week and with Huangqi-Guizhi-Wuwu and Bu-Yang-Huan-Wu decoctions for 90 days...In conclusion, the case and literature demonstrated that TCM treatment might be a more effective, low-cost, and safe option for treating CIDP. Although these preliminary findings are promising, a larger sample size and higher-quality randomized clinical trials are urgently required to confirm our findings.
- | hydrocortisone / Generic mfg.
Journal: Postnatal corticosteroid exposure in very preterm infants: A French cohort study. (Pubmed Central) - Apr 24, 2023
Hydrocortisone was the more often prescribed molecule...Exposure rate widely varied among centers. Pharmacoepidemiology studies are useful to increase knowledge on corticosteroid utilization patterns in preterm infants.
- | dexamethasone / Generic mfg.
Journal: High-Dose vs. Low-Dose Dexamethasone in Patients With COVID-19: A Cohort Study in Rural Central America. (Pubmed Central) - Apr 24, 2023
We find no significant differences in the Kaplan-Meier analysis regarding the survival (log-rank p -value = 0.315). We did not find significant differences between the use of 24 mg and 8 mg of dexamethasone in hypoxemic COVID-19 patients.
- | dexamethasone / Generic mfg.
Journal: Canine adipose tissue-derived MSCs engineered with mRNA to overexpress TSG-6 and enhance the anti-inflammatory effects in canine macrophages. (Pubmed Central) - Apr 24, 2023
To evaluate the anti-inflammatory effects of MSCs, DH82 cells were co-cultured with MSCs or treated with dexamethasone, and changes in the expression of inflammatory cytokines were analyzed using qPCR...Optimization of the HBA1 UTR improved the translation efficiency of IVT mRNA in canine MSCs. cAT-MSCs engineered with TSG-6 mRNA effectively enhanced the anti-inflammatory effects of the MSCs when co-cultured with LPS-activated DH82 cells.