- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Acute contact urticaria to ammonium persulfate () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1864;
The latency period between the exposure to AP and the appearance of symptoms, positive SPT and rubbing test, suggest an IgE-mediated mechanism despite of the negative result of specific IgE to AP. The patient remains asymptomatic after avoiding AP self- application although she tolerate professional use of AP with glove protection.
- |||||||||| prednisolone / Generic mfg., prednisone / Generic mfg.
A Case Of Trimethoprim/Sulfamethoxazole Induced Bullous Pemphigoid In Old Aged Egyptian Female () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1848;
The patient was admitted to the ward and intravenous pulse steroid methyl-prednisone 1gm/day for 3 days was initiated. Drug hypersensitivity is an emerging condition with heterogenicity in endotypes and phenotypes, which could be related to HLA allogenicity or environmental triggers.
- |||||||||| chlorpheniramine / Generic mfg., hydrocortisone / Generic mfg.
Drug Induced Enterocolitis Syndrome: a diagnosis not to be missed () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1810;
DIES to AMX/CL diagnosis is highly probable in our patient because the child was previously sensitized, he did not had an IgE mediated reaction and one major and four minor criteria were fulfilled. Other differential diagnoses were ruled out by the subsequent clinical observation in the Pediatric Department.
- |||||||||| chlorpheniramine / Generic mfg., dexamethasone / Generic mfg., epinephrine / Generic mfg.
A peculiar case of recurrent facial edema and laryngeal obstruction () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1803;
Patient was considered as anaphylaxis before and treated with dexamethasone, chlorpheniramine maleate, and epinephrine, without significant improvement. Serum complement test showed C1q 2U/ml (0
- |||||||||| hydrocortisone / Generic mfg.
Anaphylaxis to constrast material: a rare case (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1768;
We highlight the need for an allergologic referral and workup. Skin testing (and basophil activation testing, if available) with a panel of different contrast materials appears to be useful for identifying alternative contrast material that can be used safely, specially with prophylactic pretreatment drug regimens.
- |||||||||| epinephrine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Anaphylaxis following intravenous sodium fluorescein (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1736;
Conclusion Although uncommon, anaphylaxis to sodium fluorescein may occur. Patients with drug allergy history may have an increased risk of hypersensitivity reaction to sodium fluorescein, including anaphylaxis.
- |||||||||| Anaphylaxis to methylprednisolone succinate in a child (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1733;
Both reactions were successfully treated with epinephrine i.v. Treatment with dexamethasone, prednisone and prednisolone were well tolerated thereafter...A positive IDT to hydrocortisone hemissucinate at 1 mg/ml and negative IDTs to methylprednisolone acetate up to 4 mg/ml proved the responsibility of sodium succinate...Conclusion This case emphasizes the importance for awareness of corticosteroid-induced reactions, especially in asthmatic patients in whom the symptoms may be mistakenly interpreted as an exacerbation of their primary illness. Allergologic follow-up with search for sodium succinate hypersensitivity is essential to guide the choice of systemic corticosteroids allowed for the patient.
- |||||||||| prednisolone / Generic mfg.
Drug Reaction with Eosinophilia and Systemic Symptoms (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1638;
Allergologic follow-up with search for sodium succinate hypersensitivity is essential to guide the choice of systemic corticosteroids allowed for the patient. Suspected antibiotics were suspended and oral prednisolone was initiated...
- |||||||||| Thymoglobulin (anti-thymocyte globulin (rabbit)) / Sanofi
A successful desensitization protocol for horse-derived anti-thymocyte globulin in paediatric age (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1631;
Due to the lack of blood marrow HLA matched donor, in June 2022, he started a five-day immunosuppression protocol with rabbit-derived ATG, cyclosporine and corticosteroids...The infusion was stopped and i.m epinephrine, hydrocortisone and clemastine were administered, with total recovery...The patient was then desensitized to horse-derived ATG with a 10-step protocol (adapted 12-step protocol from Mariana Castells) for a cumulative dose of 850mg (40mg/Kg), with premedication with clemastine and montelukast...He started oral desloratadine every 12 hours in a quadruple dose...A continuous infusion of 850mg/day of ATG was successfully maintained at a rate of 36cc/hour for 4 days in order to complete the planned treatment, with no further reactions. This case demonstrates the safety and efficacy of this desensitization protocol in paediatric patients, allowing the completion of the ATG cycle, at the recommended doses.
- |||||||||| Rupex (rupatadine) / Incepta Pharma, Medexus
Hypersensitivity to erythritol in a 7-year-old boy (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1622;
Conclusions When looking for the causative agents of anaphylactic reactions to food, one should remember food additives, including the commonly used erythritol. This is of particular importance in the developmental age population, as erythritol is sometimes used as a sweetener in syrups.
- |||||||||| dexamethasone / Generic mfg.
Allergy due to Sugammadex (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1612;
Anesthetic induction and maintenance of anesthesia were performed without incident with propofol, midazolam, fentanyl, dexamethasone and rocuronium...We present a case of hypersensitivity suggestive of an IgE-mediated mechanism to sugammadex. This synthetic dextrin derivative is used for selective binding to reserve the action of thesteroid neuromuscular blocking agent molecule (rocuronium or vecuronium).
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Exercise-induced anaphylaxis in a young woman with celiac disease (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1576;
She came to our emergency department and intravenous methylprednisolone and dexchlorpheniramine were administered...Conclusion Although CD and WA are entities mediated by different immune mechanisms, with recognition of different epitopes, there are more and more described cases of patients with CD developing WA, so the combination of the two could increase in the coming years. It has been hypothesized that sensitization to wheat could be due to the lack of exposure to a gluten-free diet.
- |||||||||| dexamethasone / Generic mfg., methylprednisolone sodium succinate / Generic mfg., naproxen / Generic mfg.
A case of irinotecan immediate hypersensitivity reaction and its successful prevention with glucocorticoids () - Apr 30, 2023 - Abstract #EAACI2023EAACI_1245;
In the past, she had urticaria 30 min after penicillin or naproxen treatment...On the next cycle, a prophylactic dose of 80mg methylprednisolone iv (in combination with dexamethasone, an approximate dose equal to 180mg prednisolone), and 10mg of cetirizine preceded irinotecan... We suggest that the casuistic use of methylprednisolone 3-4mg/kg bodyweight together with antihistamines and gastric protectors can prevent the occurrence of any immediate breakthrough adverse reactions to medical agents even in the cases of prior history of severe immediate HSR.
- |||||||||| hydrocortisone / Generic mfg.
Allergy induced by bethamethasone phosphate after intra-articular infiltration (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1224;
We suggest that the casuistic use of methylprednisolone 3-4mg/kg bodyweight together with antihistamines and gastric protectors can prevent the occurrence of any immediate breakthrough adverse reactions to medical agents even in the cases of prior history of severe immediate HSR. Hydrocortisone and methylprednisolone succinate esters are the most frequent substances triggering immediate type adverse reactions, while halogenated corticosteroids are rarely involved...The auscultation and blood oxygen levels (SpO2) were normal.
- |||||||||| methylprednisolone acetate / Generic mfg.
PEG (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1185;
Hydrocortisone and methylprednisolone succinate esters are the most frequent substances triggering immediate type adverse reactions, while halogenated corticosteroids are rarely involved...The auscultation and blood oxygen levels (SpO2) were normal. Intradermal skin tests were positive at 0,4mg/ml for methylprednisolone acetate-Depo-Medrol
- |||||||||| methylprednisolone oral / Generic mfg.
A DRESS syndrome caused by a new medicine: niraparib (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1100;
Intradermal skin tests were positive at 0,4mg/ml for methylprednisolone acetate-Depo-Medrol The patient had
- |||||||||| dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
Perioperative Allergic Reaction to Patent Blue (Hall Y 09+10) - Apr 30, 2023 - Abstract #EAACI2023EAACI_795;
However, its specific mechanisms remain unclear. All patients received intravenous crystalloid, clemastine and hydrocortisone...During diagnostic investigation, negative skin test results were obtained for all specific drugs used in each case (midazolam, fentanyl/remifentanil, rocuronium, propofol, atropine, esomeprazole, ondansetron, dexamethasone, tramadol, metamizole, ketorolac), including latex, iodopovidone and chlorohexidine...For one patient, despite the severe reaction with hypotension and blue wheals suggesting PBV reaction, negative SPT/IDT and negative BAT test for PBV didn
- |||||||||| dexamethasone / Generic mfg.
Allergy due to Sugammadex (Hall Y 01+02, Channel Y 01+02) - Apr 30, 2023 - Abstract #EAACI2023EAACI_732;
Anesthetic induction and maintenance of anesthesia were performed without incident with propofol, midazolam, fentanyl, dexamethasone and rocuronium...We present a case of hypersensitivity suggestive of an IgE-mediated mechanism to sugammadex. This synthetic dextrin derivative is used for selective binding to reserve the action of thesteroid neuromuscular blocking agent molecule (rocuronium or vecuronium).
- |||||||||| dexamethasone / Generic mfg.
CSN5 is a circulating marker for asthma exacerbation (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_667;
proteins increased at 33 and 80 days in OVA-sensitized/challenged mice compared with control mice, but these changes were reduced by PD-L1 inhibitor treatment. Conclusion The results indicate that CSN5 interacts with PD-L1 in asthma and may be a potential target for asthma treatment.
- |||||||||| phenytoin / Generic mfg.
Phenytoin-induced Toxic Epidermal Necrolysis in a Pediatric Patient (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_619;
Conclusion The results indicate that CSN5 interacts with PD-L1 in asthma and may be a potential target for asthma treatment. LEV was then switched to perampanel (PER) 9 days later...Besides symptomatic treatment, IV dexamethasone and IgG were administered with progressive skin lesion and analytical abnormalities
- |||||||||| dexamethasone / Generic mfg.
Clinical Relevance of Serum CC16 in Adult Asthma (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_527;
Conclusion These results indicate that decreased CC16 in asthmatics may contribute to persistent airway inflammation and reversible airway obstruction, resulting in airway remodeling and lower lung function. Thus, CC16 may be a potential therapeutic target for asthmatics presenting reversible airway obstruction.
- |||||||||| prednisone / Generic mfg., budesonide / Generic mfg.
A case report of cvid associated granulomatous disease (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_490;
Conclusion Based on ESID criteria we diagnosed CVID, associated to chronic granulomatous disease sarcoidosis-like (generalized lymphadenopathy, splenomegaly, erythema nodosum) and microscopic eosinophilic colitis. The patient was treated with prednisone 1 mg/kg on a tapering schedule for the granulomatous disease and replacement therapy for CVID with SCIg (40 ml/week); budesonide and mesalazine for eosinophilic colitis, with benefit.
- |||||||||| dexamethasone / Generic mfg.
Journal: Management of preterm birth using protocols in a low resource setting. (Pubmed Central) - Apr 29, 2023
The patient was treated with prednisone 1 mg/kg on a tapering schedule for the granulomatous disease and replacement therapy for CVID with SCIg (40 ml/week); budesonide and mesalazine for eosinophilic colitis, with benefit. The results of this study have shown that protocols standardize care and improve the quality of care in preterm delivery to optimize outcomes.
- |||||||||| methylprednisolone oral / Generic mfg.
Circuit- And Behavioral- Level Investigation of Plasticity After Administration of Entactogens in Mice (Aqua C) - Apr 29, 2023 - Abstract #SOBP2023SOBP_1154;
Methods Entactogens (2-CB, MBDB, methylone, MDMA) were assessed on head-twitch behavior using an automated magnetometer (n=8/drug/dose)...Identifying different dimensions of functional plasticity induced by psychedelics and entactogens may faciliate targeted PTSD treatments. Subsequent studies may relate these effects to synaptic plasticity and neural coding.
- |||||||||| dexamethasone / Generic mfg.
Trauma Timing Effects on a Brain Multiregional Transcriptomic Study in Posttraumatic Stress Disorder (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_612;
As validation, we studied 15 stress-related genes with qPCR in female human-induced pluripotent stem cells-derived neurons exposed to the synthetic glucocorticoid dexamethasone...Conclusions This is the first time we see transcriptional differences in stratified PTSD subjects based on trauma timing. At the molecular level, trauma timing effect are seen in prefrontal, but not amygdala, regions.
- |||||||||| hydrocortisone / Generic mfg.
Journal: Inflammatory Markers and Brain Volume in Patients with Post-traumatic Stress Disorder. (Pubmed Central) - Apr 29, 2023
Our results indicate that increased cortisol level, even though its average level was lower than that of HC, is associated with smaller volumes of the thalamus, right frontal pole, left occipital pole, and right superior occipital gyrus in patients with PTSD. Cortisol, a major stress hormone, might be a reliable biomarker to brain volumes and pathophysiological pathways in patients with PTSD.
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