- |||||||||| Zolgensma (onasemnogene abeparvovec-xioi) / Novartis, Kineret (anakinra) / SOBI
Subacute Liver Injury in Two Young Infants Following Gene Replacement Therapy for Spinal Muscular Atrophy (Petree Hall D) - May 3, 2023 - Abstract #ASGCT2023ASGCT_2264; Onset of liver injury at 4 weeks post gene transfer with laboratory evidence of systemic inflammation and biopsy reflective of T cell mediated inflammation is consistent with prior case reports. Safety of OA administration in young infants (<1 month of age) has not been characterized separately from other pediatric patient populations, and established standards of care for management of immune response as manifested by liver injury refractory to protocol steroids is an area of clinical need.
- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Journal: Mixed autoimmune haemolytic anaemia in a COVID-19 patient. (Pubmed Central) - May 3, 2023 She was treated with intravenous methylprednisolone, before being changed to high dose oral prednisolone. A total of 3 units packed cells were transfused.
- |||||||||| Decadron (dexamethasone) / Merck (MSD), Hemady (dexamethasone tablets) / Dexcel Pharma
Trial completion date, Trial primary completion date, Surgery: Radiosurgery Before Surgery for the Treatment of Brain Metastases (clinicaltrials.gov) - May 3, 2023 P1, N=20, Recruiting, Trial completion date: Sep 2029 --> Apr 2029 Trial completion date: Jan 2023 --> Jan 2025 | Trial primary completion date: Jan 2023 --> Jan 2024
- |||||||||| Venclexta (venetoclax) / Roche, AbbVie, Rituxan (rituximab) / Roche, Imbruvica (ibrutinib) / AbbVie, J&J
Trial completion date, Trial primary completion date: Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib and Rituximab) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma (clinicaltrials.gov) - May 3, 2023 P2, N=71, Suspended, Trial completion date: Jan 2023 --> Jan 2025 | Trial primary completion date: Jan 2023 --> Jan 2024 Trial completion date: Apr 2023 --> Apr 2024 | Trial primary completion date: Apr 2023 --> Apr 2024
- |||||||||| dexamethasone / Generic mfg., prazosin / Generic mfg.
Preclinical, Journal: Chronic intermittent ethanol exposure disrupts stress-related tripartite communication to impact affect-related behavioral selection in male rats. (Pubmed Central) - May 3, 2023 Ca signals were evaluated in response to norepinephrine (NE) with or without selective ?-adrenergic receptor (?AR) or GluN2B-containing N-methyl-D-aspartate receptor (NMDAR) antagonists, followed by dexamethasone (DEX) to mock a pharmacological stress response...Administration of the selective ?1AR antagonist, prazosin, reversed this CIE-induced dysfunction in both cell types...Signaling changes in astrocytes in response to NE were correlated with anxiety-like behaviors, such as the grooming:rearing ratio, suggesting tripartite synaptic function plays a role in switching between exploratory and stress-coping behavior. These data show how CIE exposure causes persistent changes to PVN neuro-glial function and provides the groundwork for how these physiological changes manifest in behavioral selection.
- |||||||||| hydrocortisone / Generic mfg.
Journal, HEOR: Comparative Effectiveness of Fludrocortisone and Hydrocortisone vs Hydrocortisone Alone Among Patients With Septic Shock. (Pubmed Central) - May 3, 2023 The primary composite outcome of death in hospital or discharge to hospice occurred among 1076 (47.2%) patients treated with hydrocortisone-fludrocortisone vs 43?669 (50.8%) treated with hydrocortisone alone (adjusted absolute risk difference, -3.7%; 95% CI, -4.2% to -3.1%; P?<?.001). In this comparative effectiveness cohort study among adult patients with septic shock who began hydrocortisone treatment, the addition of fludrocortisone was superior to hydrocortisone alone.
- |||||||||| methylprednisolone oral / Generic mfg.
Journal: Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans. (Pubmed Central) - May 2, 2023 In contrast, HMMC was not detectable at any time interval after each dose. Sweat proved to be a suitable matrix for methylone and its metabolites' determination in clinical and toxicological studies, providing a concentration that reveals recent drug consumption.
- |||||||||| hydrocortisone / Generic mfg.
Review, Journal: Nelson syndrome and perinatal challenges: A case report and systematic review of the literature. (Pubmed Central) - May 2, 2023 Five studies report the use of parenteral hydrocortisone at the time of delivery...Multidisciplinary review in a combined obstetric-endocrine prenatal clinic is ideal. Awareness about potential complications during pregnancy and the postnatal period is crucial in providing optimal care to the mother and baby.
- |||||||||| Review, Journal, Cytokine storm, Immunomodulating: Fighting cytokine storm and immunomodulatory deficiency: By using natural products therapy up to now. (Pubmed Central) - May 1, 2023
However, these synthetic medications and therapies have several side effects, including heart failure, permanent retinal damage in the case of hydroxyl-chloroquine, and liver destruction in the case of remdesivir. This review summarizes four strategies for fighting cytokine storms and immunomodulatory deficiency induced by COVID-19 using natural product therapy as a potential therapeutic measure to control cytokine storms.
- |||||||||| dexamethasone / Generic mfg.
Preclinical, Journal, Metastases: Aconicumines A-D, an advanced class of norditerpenoid alkaloids with an unprecedented N,O-diacetal motif from Aconitum taipeicum Hand.-Mazz., exhibit anti-inflammatory properties in vitro. (Pubmed Central) - May 1, 2023 Aconitine, hypaconitine, and aconicumine A showed significant inhibition of nitric oxide production in RAW 264.7 macrophages induced by lipopolysaccharide with IC values ranging from 4.1 to 19.7??M compared to positive control (dexamethasone, IC?=?12.5??M). Furthermore, the primary structure-activity relationships for aconicumines A-D were also represented.
- |||||||||| morphine sulphate / Generic mfg., dexamethasone injection / Generic mfg., paracetamol / Generic mfg.
Journal: Analgesia after cesarean section - what is new? (Pubmed Central) - May 1, 2023 Neuraxial morphine should be used whenever possible. If it cannot be used, abdominal wall blocks or surgical wound infiltration are good alternatives.
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