Glucocorticoid Receptor 

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  • ||||||||||  dexamethasone / Generic mfg.
    SOME INFECTIONS AND AUTOIMMUNE HEMOLYTIC ANEMIA  () -  May 6, 2023 - Abstract #ESPID2023ESPID_1456;    
    Double infection (Epstein Barr and mycoplasma) or Influenza after covid increases the risk of haemolitic anemia. This cases respond to corticotherapy.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    CORTICOSTEROID ADMINISTRATION AND OUTCOMES FOR COMMUNITY ACQUIRED BACTERIAL MENINGITIS (CABM) IN GREECE (2010-2020). () -  May 6, 2023 - Abstract #ESPID2023ESPID_1356;    
    Among the 263 laboratory confirmed cases, medical records were retrieved in 129 (51.5%). Among those, analysis of 76 patients medical records was carried out, age ranging 2 months to 15 years (median=3 years) as 51 were excluded for factors such as septicemia, age (<2 mo), other infections etc. Neisseria meningitidis was the leading cause (60.5%; 46/76) followed by S. pneumoniae (15,8%; 12/76).
  • ||||||||||  H. INFLUENZA TYPE F VENTRICULITIS AND SUBDURAL EMPYEMA IN AN IMMUNOCOMPETENT 4-YEAR-OLD () -  May 6, 2023 - Abstract #ESPID2023ESPID_1349;    
    A 10ml/kg bolus and dexamethasone were given...Hypertonic saline and levetiracetam were initiated...Meropenem and Rifampicin were commenced on advice from the microbiologist...Learning Points/ The incidence of H.influenza infections in 5 years in the recent UKHSA report (2022). This case highlights the severity of this infection and its impact on long-term morbidity.
  • ||||||||||  LONG-TERM CONSEQUENCES OF PARECHOVIRUS ENCEPHALITIS IN A NEONATE () -  May 6, 2023 - Abstract #ESPID2023ESPID_1338;    
    He received treatment with ampicillin, gentamicin, aciclovir and phenobarbital...Dexamethasone and mannitol were added to the therapy...Normal CSF cytosis does not rule out encephalitis. Patients with neuroinfections may develop long-term complications that cannot be overlooked.
  • ||||||||||  prednisolone / Generic mfg., sulphadiazine / Generic mfg., pyrimethamine / Generic mfg.
    IF IT LOOKS LIKE A DUCK, THAN IT PROBABLY IS A DUCK () -  May 6, 2023 - Abstract #ESPID2023ESPID_1183;    
    Throughout multidisciplinary follow-up, she was also diagnosed with chorioretinitis of the right eye and started oral prednisolone...Learning Points/ Although evidence is limited, the risk of vertical transmission of Toxoplasma gondii among HIV-1 infected women is low and has been associated with maternal immunosuppression and elevated viral load. In this case, it is uncertain whether reinfection or reactivation occurred; nonetheless, a high clinical concern is needed for timely diagnosis and proper approachment, especially before patients with acquired immunodeficiency and social precarity.
  • ||||||||||  dexamethasone injection / Generic mfg., cefotaxime / Generic mfg.
    HAEMOPHAGOCYTIC SYNDROME ASSOCIATED WITH TYPHOID FEVER () -  May 6, 2023 - Abstract #ESPID2023ESPID_1155;    
    He remained febrile despite intravenous cefotaxime, and pancytopenia, increased APR and hypertriglyceridaemia were observed...During the first few days the patient remained febrile and weak, thus intravenous dexamethasone was added with a good clinical response...The difficulty lies in the similarity between advanced phase TF and HLH, both of which may present with persistent fever, hepatosplenomegaly, neurological symptoms or cytopenia. Differential diagnosis is important, especially in severe cases of HLH, which may require immunomodulatory drugs to reverse excessive activation of lymphocytes and macrophages.
  • ||||||||||  dexamethasone injection / Generic mfg.
    TROPICAL FEVER WITH UNEXPECTED TWIST AND TURN () -  May 6, 2023 - Abstract #ESPID2023ESPID_1133;    
    Learning Points/ HLH is rare but fatal complication of dengue leading to multiorgan dysfunction thereby increasing morbidity and mortality. Early suspicion and timely treatment are crucial for uneventful recovery
  • ||||||||||  dexamethasone / Generic mfg., ceftriaxone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg.
    PRIMARY IMUNNODEFICIENCIES AS A PREDISPOSING OR PROTECTIVE FACTOR FOR SEVERE COVID-19 () -  May 6, 2023 - Abstract #ESPID2023ESPID_1090;    
    The main treatment of both cases consists of support oxygen, cephalosporin antibacterial and short course systemic steroid therapy and treatment of PID. Clarification of the predisposing/protective role of primary immunodeficiencies on the severity COVID-19 is currently limited to a small number of observations and requires further accumulation of data.
  • ||||||||||  ceftriaxone / Generic mfg., trimethoprim/sulfamethoxazole / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    INFANT WITH POST-INFECTIOUS BRONCHIOLITIS OBLITERANS AND INBORN ERROR OF IMMUNITY () -  May 6, 2023 - Abstract #ESPID2023ESPID_1083;    
    Learning Points/ This case highlights the importance of early identification of underlying immunological problems following a severe infection early in life. Immunological follow-up is required and further work up for possible yet not known immunological deficiencies.
  • ||||||||||  relacorilant (CORT125134) / Corcept Therap
    Trial completion date, Trial primary completion date:  GRACE: A Study of the Efficacy and Safety of Relacorilant in Patients With Endogenous Cushing Syndrome (clinicaltrials.gov) -  May 6, 2023   
    P3,  N=130, Recruiting, 
    Following RAMIDCAB surgery, adding an ESP block to a standard multimodal analgesia regimen did not reduce opioid consumption and pain scores. Trial completion date: Dec 2022 --> Mar 2024 | Trial primary completion date: Nov 2022 --> Mar 2024
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  A single dose of hydrocortisone does not alter interhemispheric transfer of information or transcallosal integration. (Pubmed Central) -  May 5, 2023   
    These results suggest that a temporary increase in cortisol alone might not be enough to affect the interhemispheric transfer of information via the corpus callosum. Together with previous results from our group, this suggests that chronically elevated stress hormone levels play a more central role in the relationship between altered hemispheric asymmetries and a variety of mental disorders.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    DEVELOPMENT OF THE JAPANESE VERSION OF THE BASEL ASSESSMENT OF ADHERENCE TO IMMUNOSUPPRESSIVE MEDICATIONS SCALE (Focussed Oral Room 7) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_2011;    
    Using the J-BAASIS to evaluate medication adherence may help clin icians to identify non-adherent transplant patients and institute appropriate corrective measures to improve transplant outcomes. Moreover, this study, which demonstrated the concurrent validity with the MEMS, the gold standard for measuring medication adherence, further strengthens the evidence for the psychometric properties of the original BAASIS.
  • ||||||||||  cyclophosphamide / Generic mfg.
    CYCLOPHOSPHAMIDE INDUCTION TREATMENT IN ANCA-ASSOCIATED VASCULITIS WITH RENAL AND PULMONARY INVOLVEMENT: OUTCOMES AND SIDE EFFECTS. (Focussed Oral Room 2) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1901;    
    When treating c-ANCA vasculitis with corticosteroids and cyclophosphamide, routine evaluation of complete blood count parameters is necessary to prevent bone marrow toxicity. We continued methylprednisolone and cyclophosphamide for six months, obtaining a total clinical remission despite side effects induced by the state of immunosuppression (oral cavity mycosis, bone marrow toxicity and CMV reactivation).
  • ||||||||||  bortezomib / Generic mfg., cyclophosphamide / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    MONOCLONAL GAMMOPATHY IN C3 GLOMERULOPATHY: DOES THE BUCKET STOP THERE? (Focussed Oral Room 9) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1880;    
    Although the association between monoclonal gammopathy and C3G rests on epidemiologic findings, experimental evidence suggests that several monoclonal proteins have complement dysregulation features, which may enhance alternate complement pathway activation. Our patient's response is in line with observational data that have shown improved renal outcomes in patients who achieve a haematological response following clone-directed chemotherapy, which further supports the role of monoclonal gammopathy in C3G pathogenesis [1].
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim, Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca, Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
    SGLT2 INHIBITORS IN IGA NEPHROPATHY: REAL-WORLD CLINICAL PRACTICE. (Focussed Oral Room 9) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1763;    
    Treatment with SGLTi was associated to a decrease in uric acid levels, a better blood pressure control, and to an increase in Hb levels. Thus, in real-world clinical practice, SGLT2i seem to be a promising therapy for modifying the clinical course of IgAn with a favorable safety profile.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg.
    LIGHT CHAIN REMOVAL IN MULTIPLE MYELOMA PATIENTS WITH HFR-SUPRA HEMODIALYSIS: OUR EXPERIENCE (Focussed Oral Room 4) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_1476;    
    After presenting severe AKI (KDIGO 3), almost 43% of patients who received this adyuvant therapy obtained full renal recovery at 1 year and in 75% of patients withdrawal from hemodialysis was possible. 1 year survival was 91,7%.
  • ||||||||||  bortezomib / Generic mfg., dexamethasone / Generic mfg.
    KIDNEY IMPAIRMENT AT DIAGNOSIS IN MULTIPLE MYELOMA: THE NEPHROLOGIST PERSPECTIVE (Focussed Oral Room 5) -  May 4, 2023 - Abstract #ERAEDTA2023ERA_EDTA_952;    
    Patients with MM and kidney impairment at diagnosis are more frequent kappa FLC, present most often as AKI, around one third of them require HD at diagnosis, and half of them progress to CKD5D. Therefore, these patients are a distinct group of MM with a high mortality rate (>60% at five years) who need interdisciplinary care.