Glucocorticoid Receptor 

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  • ||||||||||  Mifeprex (mifepristone) / Danco Laboratories
    Review:  Pharmacological memory modulation to augment trauma-focused psychotherapy for PTSD: a systematic review of randomised controlled trials. (Pubmed Central) -  Jun 20, 2023   
    Seven studies showed no significant effect of pharmacological augmentation compared to placebo (D-cycloserine, rapamycin, mifepristone, propranolol, mifepristone combined with D-cycloserine, methylene blue)...Results of pharmacological augmentation were mixed overall and heterogenous for the pharmacological agents tested in more than one study. Additional studies and replications are needed to identify which pharmacological agents work, in which combination and to identify patient groups that benefit most to tailor PTSD treatment.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Long-Term Activity and Safety of a Low-Dose Hydrocortisone Tear Substitute in Patients with Dry Eye Disease. (Pubmed Central) -  Jun 20, 2023   
    Intraocular pressure did not change at the end of the treatment period and was maintained within the normal range, sustaining the product's safety. Our findings support the prolonged use of the new eye drop with low-dose hydrocortisone, also in the DED initial stages, to prevent the degenerating towards a chronic condition (http://www.isrctn.com/ISRCTN16288419).
  • ||||||||||  dexamethasone / Generic mfg., azithromycin / Generic mfg.
    Journal:  Identification of antimicrobial and glucocorticoid compounds in wastewater effluents with effect-directed analysis. (Pubmed Central) -  Jun 19, 2023   
    Novel Bud liposomes complex in thermosensitive Gel effectively mitigated symptoms, alleviated macroscopic and microscopic colon damage, and reduced inflammatory reaction in UC mice, which might be a potential strategy for UC treatment. The antimicrobial activity of the effluents was determined with an antibiotics assay and ranged from 298 to 711
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
    Journal:  Report of consensus panel 7 from the 11th international workshop on Waldenstr (Pubmed Central) -  Jun 19, 2023   
    The common chemoimmunotherapy backbones, bendamustine-rituximab (BR) and dexamethasone, rituximab and cyclophosphamide (DRC), may be considered standard-of-care for the frontline comparative studies. Key unanswered questions include the definition of frailty in WM; the importance of attaining a very good partial response or better (?VGPR), within stipulated time frame, in determining survival outcomes; and the optimal treatment of WM populations with special needs.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Observational data, Retrospective data, Journal:  Factors influencing prognosis and relapse in patients with anti-N-methyl-D-aspartate receptor encephalitis. (Pubmed Central) -  Jun 19, 2023   
    Motor disorders or involuntary movement, abnormal brain magnetic resonance imaging, electroencephalogram slow wave activity >50%, and elevated white blood cell counts in cerebrospinal fluid were associated with poor prognosis in patients with NMDAR encephalitis. First-line immunotherapy less than 3 months after first onset may be a risk factor for relapse.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Risk Factor for Superimposed Nosocomial Bloodstream Infections in Hospitalized Patients with COVID-19. (Pubmed Central) -  Jun 19, 2023   
    Unmodified risk variables for nosocomial bloodstream infections included male sex and leukocytosis at admission. Using methylprednisolone and obtaining a cumulative dosage of dexamethasone were adjusted risk variables associated with superimposed nosocomial bloodstream infections in hospitalized patients with COVID-19.
  • ||||||||||  hydrocortisone / Generic mfg.
    Observational data, Journal:  Depressive-Like Effects of Foreclosing: A Cross-Sectional Study of Hair Cortisol Concentration. (Pubmed Central) -  Jun 18, 2023   
    The findings show that foreclosure and home eviction are associated with increased cumulative hair cortisol and with depressive-like symptoms. Foreclosing procedures yielded to maintain high levels of cortisol which may increase the risk to develop major depression.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Marrubium persicum ?mproved the Biological Parameters Associated with Angiogenesis and ?nflammation in Mice. (Pubmed Central) -  Jun 18, 2023   
    The mice were divided into four groups, including; negative control (normal saline into the pouch), control (carrageenan), treatment and positive control (dexamethasone)...Compared to the control group, the optimum dose (3.5 mg/kg) lessened the myeloperoxidase (MPO) and angiogenesis activity, as well as haemoglobin levels. In sum, the methanol extract of M. persicum exhibited anti-inflammatory effects against carrageenan-induced inflammation, which could be related to its antioxidant and inhibitory effects on neutrophils' infiltration.
  • ||||||||||  Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
    Enrollment change, Trial completion date, Trial primary completion date, Real-world evidence, Patient reported outcomes, Real-world:  RECORD: REported Outcomes in COPD With Trixeo in Real worlD (clinicaltrials.gov) -  Jun 18, 2023   
    P=N/A,  N=150, Recruiting, 
    In sum, the methanol extract of M. persicum exhibited anti-inflammatory effects against carrageenan-induced inflammation, which could be related to its antioxidant and inhibitory effects on neutrophils' infiltration. N=500 --> 150 | Trial completion date: Mar 2024 --> Jun 2024 | Trial primary completion date: Mar 2024 --> Jun 2024
  • ||||||||||  Pinorubin (pirarubicin) / Sanofi, Oncaspar liquid (pegaspargase) / Servier
    Enrollment open, Trial completion date, Trial primary completion date:  Modified BFM-95 Regimen as First-Line Chemotherapy in Adults With T- Lymphoblastic Lymphoma (clinicaltrials.gov) -  Jun 18, 2023   
    P2,  N=50, Recruiting, 
    Active, not recruiting --> Recruiting Unknown status --> Recruiting | Trial completion date: Mar 2021 --> Mar 2025 | Trial primary completion date: Mar 2021 --> Mar 2025
  • ||||||||||  5-fluorouracil / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  Treatment of Keloids With Fractional Erbium Laser-Assisted 5-Fluorouracil Versus Laser-Assisted Corticosteroid (clinicaltrials.gov) -  Jun 18, 2023   
    P4,  N=20, Completed, 
    Unknown status --> Recruiting | Trial completion date: Mar 2021 --> Mar 2025 | Trial primary completion date: Mar 2021 --> Mar 2025 Active, not recruiting --> Completed | Trial completion date: Apr 2023 --> Dec 2022 | Trial primary completion date: Apr 2023 --> Dec 2022
  • ||||||||||  Airsupra (budesonide/salbutamol) / AstraZeneca, Avillion
    Albuterol (PS-5 in poster area) -  Jun 17, 2023 - Abstract #ERS2023ERS_4929;    
    However, in terms of reducing edema and ecchymosis, no significant differences were noted among dexamethasone, methylprednisolone, and betamethasone. General respiratory patient care; Physiology; Cell and molecular biology; Epidemiology; Public health; Pulmonary function testing