Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   95004 News 


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  • ||||||||||  hydrocortisone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Management of mad honey intoxication with suspected anaphylaxis in Nepal: a case report. (Pubmed Central) -  Jun 26, 2023   
    This is especially important in a pandemic situation in which many doctors were redeployed outside of their usual specialties. He again developed hypotension and bradycardia in a few hours, for which hydrocortisone was administered, following which his heart rate was normalized in 2
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Effects of R-salbutamol on the inflammatory response and acute lung injury in endotoxemic mice. (Pubmed Central) -  Jun 26, 2023   
    Dexamethasone (Dex) was used for comparison...In addition, R-sal pre-treatment showed a better improvement in prognostic pulmonary function on day 4 compared to that by Rac-sal. Collectively, our results indicate the potential benefits of R-sal in regulating inflammatory responses to endotoxemia and endotoxin-induced lung injury.
  • ||||||||||  prednisolone / Generic mfg., cyclophosphamide / Generic mfg.
    Journal:  Splenic Small Cell Lymphoma with Presumed Secondary Immune-Mediated Hemolytic Anemia in an African Penguin (Spheniscus demersus). (Pubmed Central) -  Jun 26, 2023   
    The penguin was treated with oral prednisolone as an immunomodulatory agent; however, it did not result in a positive treatment response...Additional therapy with cyclophosphamide was initiated, and the penguin improved clinically, but then declined...Microscopic review of submitted postmortem tissue samples demonstrated a monomorphic population of neoplastic small lymphocytes infiltrating the spleen, consistent with splenic small cell lymphoma. The neoplastic cells did not label with the T-cell marker CD3 or B-cell markers CD20, CD79a, and Pax-5.
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    Trial primary completion date:  Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM (clinicaltrials.gov) -  Jun 26, 2023   
    P2,  N=43, Recruiting, 
    Larger studies are needed to further explore this regimen. Trial primary completion date: Mar 2023 --> Dec 2023
  • ||||||||||  Polivy (polatuzumab vedotin-piiq) / Roche
    Enrollment open, Trial initiation date:  Polatuzumab Vedotin With R-GDP in Relapsed/Refractory Diffuse Large B-cell Lymphoma (clinicaltrials.gov) -  Jun 26, 2023   
    P2,  N=44, Recruiting, 
    Trial primary completion date: Mar 2023 --> Dec 2023 Not yet recruiting --> Recruiting | Initiation date: May 2023 --> Feb 2023
  • ||||||||||  prednisone delayed-release tablet / Generic mfg.
    Qué son rayos C (Twitter) -  Jun 25, 2023   
  • ||||||||||  dexamethasone / Generic mfg.
    Review, Journal:  Strongyloides coinfection in COVID-19 patients treated with corticosteroids: A systematic review. (Pubmed Central) -  Jun 24, 2023   
    Most of cases (53.8%) were treated with dexamethasone, followed by methylprednisolone (26.9%)...Two of the 26 patients (7.7%) had fatal outcomes. Most of the SARS-CoV-2-Strongyloides coinfected cases were immigrants living in developed countries, emphasising the need for clinicians in these countries to be aware of clinical and laboratory parameters associated with such co-infections, as well as the key importance of rapid and accurate diagnostic tests for timely and effective diagnosis and patient management.
  • ||||||||||  dexamethasone / Generic mfg., prednisone / Generic mfg., cytarabine / Generic mfg.
    Journal:  Rosai-Dorfman disease involving the entire esophagus. (Pubmed Central) -  Jun 23, 2023   
    1F-1G). The child is presently undergoing six cycles of VCR+Ara-c+Dex chemotherapy and the treatment is going well.
  • ||||||||||  Rinvoq (upadacitinib) / AbbVie
    Trial initiation date:  A Trial for Acute Severe Ulcerative Colitis (clinicaltrials.gov) -  Jun 23, 2023   
    P4,  N=162, Not yet recruiting, 
    The child is presently undergoing six cycles of VCR+Ara-c+Dex chemotherapy and the treatment is going well. Initiation date: May 2023 --> Aug 2023
  • ||||||||||  Sarclisa (isatuximab-irfc) / Sanofi
    New P2 trial:  Isa-Pom-Dex in Elderly/Frail Subjects With RRMM (clinicaltrials.gov) -  Jun 22, 2023   
    P2,  N=49, Not yet recruiting, 
  • ||||||||||  budesonide ER / Generic mfg.
    New P2 trial:  Efficacy and Safety of Budesonide MMX (clinicaltrials.gov) -  Jun 22, 2023   
    P2,  N=80, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg., lenalidomide / Generic mfg.
    Enrollment closed, Enrollment change, Trial completion date, Trial primary completion date:  LENDER: Study to Demonstrate Clinical Benefit of Lenalidomide and Dexamethasone (clinicaltrials.gov) -  Jun 22, 2023   
    P2,  N=70, Active, not recruiting, 
    Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting | N=102 --> 70 | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
  • ||||||||||  Dextenza (dexamethasone punctal plug) / Ocular Therap
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date, Surgery:  DEXTENZA Compared to Topical Steroid Therapy Prior to Cataract Surgery in Patients Who Receive Premium Intraocular Lenses (clinicaltrials.gov) -  Jun 22, 2023   
    P4,  N=13, Completed, 
    Recruiting --> Active, not recruiting | N=102 --> 70 | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024 Recruiting --> Completed | N=30 --> 13 | Trial completion date: Sep 2022 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022
  • ||||||||||  Farydak (panobinostat) / Secura Bio
    Trial completion, Trial completion date, Combination therapy, Immunomodulating:  PANORAMA_3: Panobinostat/Bortezomib/Dexamethasone in Relapsed or Relapsed-and-refractory Multiple Myeloma (clinicaltrials.gov) -  Jun 22, 2023   
    P2,  N=249, Completed, 
    Recruiting --> Completed | N=30 --> 13 | Trial completion date: Sep 2022 --> Dec 2022 | Trial primary completion date: Sep 2021 --> Dec 2022 Active, not recruiting --> Completed | Trial completion date: May 2024 --> Aug 2022
  • ||||||||||  QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva
    Journal:  An application of QVAR dynamic connectedness between geopolitical risk and renewable energy volatility during the COVID-19 pandemic and Russia-Ukraine conflicts. (Pubmed Central) -  Jun 22, 2023   
    Dynamic net pairwise directional connectedness over a quantile suggests that uncertain events like the COVID-19 epidemic or the Russia-Ukraine conflict influence the dynamic interlinkages between geopolitical risks and renewable energy volatility and change their roles in the designed system. These findings are critical since they help authorities develop effective policies to lessen the vulnerabilities of these indicators and minimize how widely the renewable and non-renewable energy market is exposed to risk or uncertainty.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Severe osteoporosis in a young man with bilateral Cushing's syndrome: a case report. (Pubmed Central) -  Jun 21, 2023   
    The early identification of Cushing's syndrome, with measures based on the assessment of risks and benefits, remains the best way to prevent its progression and reduce the morbidity of the condition. Despite the unavailability of genetic analysis for a precise etiological definition, it is possible to take efficient measures to avoid future damage.
  • ||||||||||  Empliciti (elotuzumab) / AbbVie, BMS
    Journal:  Determining Optimal Combination Regimens for Patients with Multiple Myeloma. (Pubmed Central) -  Jun 21, 2023   
    We find that optimal control combined with approximation outperforms other methods, in that it can quickly produce a combination regimen that is clinically-feasible and near-optimal. Implications of this work can be used to optimize doses and advance the scheduling of drugs.
  • ||||||||||  mycophenolate mofetil / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  A case of systemic lupus erythematosus having concurrent Evans syndrome and acquired thrombotic thrombocytopenic purpura. (Pubmed Central) -  Jun 21, 2023   
    The patient had been diagnosed with systemic lupus erythematosus and secondary immune thrombocytopenia 8 years before and treated with high-dose prednisolone and mycophenolate mofetil...The patient was treated with pulse intravenous methylprednisolone followed by 45?mg/day prednisolone; however, the patient's platelet count did not normalise...After undergoing therapeutic plasma exchange for six consecutive days, the patient's platelet count recovered rapidly. Although concurrent acquired TTP and ES have not been reported previously, the findings from this case highlight the importance of measuring ADAMTS-13 activity and inhibitors to rule out acquired TTP, especially when ES is refractory to glucocorticoids.
  • ||||||||||  Xolair (omalizumab) / Roche, Novartis
    Journal:  Pulmonary aspergillus infection with abnormal imaging successfully treated with omalizumab: A case report. (Pubmed Central) -  Jun 20, 2023   
    This study found high rates of behaviour problems at 2?years' CA following very preterm birth, but these problems were not associated with hydrocortisone treatment initiated between 7 and 14 days after birth in ventilated preterm infants. We reported the case of a patient with pulmonary Aspergillus infection who was treated with omalizumab and showed significant improvement in clinical symptoms and imaging abnormalities, which provides a new option for patients with pulmonary Aspergillus infection who show unsatisfactory response with first-line drugs.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Effects of antenatal dexamethasone on postnatal serum cortisol levels in late preterm infants. (Pubmed Central) -  Jun 20, 2023   
    Antenatal dexamethasone administered 14?days prior to delivery did not affect serum cortisol levels and short-term hospital outcomes in stable LPT infants. Exposure to low cumulative doses of dexamethasone resulted in transient low serum cortisol levels compared to 4 or more doses only at 24-hours.