Glucocorticoid Receptor 

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  • ||||||||||  prednisolone / Generic mfg.
    Retrospective data, Review, Journal:  Relapsing polychondritis - A single Centre study in the United Kingdom. (Pubmed Central) -  Jul 28, 2023   
    Pulmonary involvement in RP may cause significant morbidity and mortality due to organ damage. Disease modifying anti rheumatic drugs and biologics should be considered early in the disease course to minimise adverse effects of long-term corticosteroid therapy and organ damage.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  Methylprednisolone sodium succinate retroauricular injection combined with acupuncture in the treatment of Bell's Palsy. (Pubmed Central) -  Jul 28, 2023   
    The adverse reaction rate was lower in the experimental group (15.00%) than in the control group (21.66%). Although the dose of steroid hormone injected into the bone surface of retroauricula in the treatment of Bell's Palsy is lower than the administered dose of oral hormones, it has the same curative effect; however, it has a better effect regarding to the duration of postauricular pain and adverse reactions.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Enrollment open:  Efficacy of Nerve Blocks for Episodic Migraine (clinicaltrials.gov) -  Jul 27, 2023   
    P2,  N=60, Recruiting, 
    Not yet recruiting --> Recruiting Not yet recruiting --> Recruiting
  • ||||||||||  Dulera (mometasone/formoterol) / Merck (MSD), Novartis
    Trial completion:  Replication of the P04334 Asthma Trial in Healthcare Claims Data (clinicaltrials.gov) -  Jul 27, 2023   
    P=N/A,  N=10288, Completed, 
    Not yet recruiting --> Recruiting Active, not recruiting --> Completed
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Dexamethasone improves thymoma-associated myasthenia gravis via the AKT-mTOR pathway. (Pubmed Central) -  Jul 27, 2023   
    This study demonstrates that dexamethasone can promote apoptosis through the AKT-mTOR pathway for the treatment of thymoma-associated MG, as validated by network pharmacology predictions and clinical specimen experiments, and can be verified by large-scale clinical trials in the future. This study also provides theoretical support and new research perspectives for this disease.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Acute Effects of Systemic Glucocorticoids on the Vocal Folds in a Pre-Clinical Model. (Pubmed Central) -  Jul 27, 2023   
    Methylprednisolone decreased body weight 7?days following injections compared to controls (P?=?.004). Systemic dexamethasone may more efficiently activate GR in the VF epithelium with a lower risk of body weight loss, suggesting a role for more refined approaches to GC selection for laryngeal pathology.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  The Use of Herbal Medicine in Sudden Sensorineural Hearing Loss in Diabetic Patients. (Pubmed Central) -  Jul 27, 2023   
    Moreover, all patients had an injection of dexamethasone in the middle ear...The chance of recovery reduced with increased time between the onset of symptoms and treatment (delayed visitation) in group 1; however, this finding was not seen in groups 2 and 3. Doluperine
  • ||||||||||  hydrocortisone / Generic mfg.
    Clinical:  Pulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal Insufficiency. (Pubmed Central) -  Jul 27, 2023   
    It was superior to both continuous pump and oral therapy in maintaining normal ACTH levels throughout the 24-hours cycle. Our results demonstrate a low free cortisol bioavailability on thrice daily oral replacement therapy compared to both types of subcutaneous infusion.
  • ||||||||||  amiodarone / Generic mfg.
    Review, Journal:  Amiodarone-Induced Myxedema Coma in Elderly Patients: A Systematic Review of Case Reports. (Pubmed Central) -  Jul 26, 2023   
    Despite the myriad potential causes of myxedema coma complicating the diagnosis, it was found that through a combination of clinical symptoms and serum TSH measurements, a confirmed diagnosis could be reached. Furthermore, it was observed that amiodarone-induced myxedema coma responded favorably to treatment with levothyroxine and glucocorticoids.
  • ||||||||||  dexamethasone / Generic mfg., alendronate / Generic mfg.
    Preclinical, Journal:  Effects of Eleutherine bulbosa (mill.) urb. bulb extract on mice glucocorticoid-induced osteoporosis models. (Pubmed Central) -  Jul 26, 2023   
    Glucocorticoid (Dexamethasone) 0.1015 mg/kg BW/day induction was given to all groups except the healthy group to create osteoporosis rats for approximately four weeks...The result showed that E. bulbosa bulbs extract could raise blood calcium levels and bone density percentage at doses of 60 and 120 mg/kg BW, as well as raise osteoblast cell levels at doses of 120 mg/kg BW. The findings indicate that E.bulbosa bulb extract is a potential complementary medicine for osteoporosis.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Simultaneous Presentation of Dexamethasone and Nerve Growth Factor via Layered Carbon Nanotubes and Polypyrrole to Interface Neural Cells. (Pubmed Central) -  Jul 25, 2023   
    Dex released from the functional coating under controlled electrochemical stimulation was able to inhibit the lipopolysaccharide-induced secretion or mRNA transcription of inflammatory cytokines, including nitric oxide, TNF-?, and IL-6 in RAW264.7 cells, and control the activation of cultured astrocytes. In addition, the functional coatings did not show a toxic effect on PC12 cells and primary neural cells but exhibited promoted activities on the adhesion, growth, and neurite extension of neural cells.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Preoperative Steroid Pulse Therapy for Invasive Thymoma (Exhibit Hall) -  Jul 25, 2023 - Abstract #IASLCWCLC2023IASLC_WCLC_1861;    
    Thymoma shrinkage made it easier to remove it surgically, was gentler for the patient (with intracostal surgical access instead of sternotomy) and thus reduced the risk of metastases perioperatively. It is known that the contact areas between the thymoma and other mediastinal structures are the last to disappear.
  • ||||||||||  fluocinolone acetonide / Generic mfg.
    Journal:  REDD1 (regulated in development and DNA damage (Pubmed Central) -  Jul 24, 2023   
    We found large differences in transcriptome of REDD1 KO and control Cas9 cells in response to glucocorticoid fluocinolone acetonide (FA): both the scope and amplitude of response were significantly decreased in REDD1 KO...We found the increased expression and abnormal nuclear translocation of FKBP51 in both untreated and FA-treated REDD1 KO cells. Overall, our results suggest the existence of a feed-forward loop in GR signalling mediated by its target gene REDD1, which has translational potential for the development of safer GR-targeted therapies.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution. (Pubmed Central) -  Jul 24, 2023   
    Synthetic glucocorticoids, such as dexamethasone, have been used as a treatment for many immune conditions, such as asthma and, more recently, severe COVID-19...Our novel measure of gene expression response dynamics, based on the diagonal linear discriminant analysis, separated individual cells by response status on the basis of their transcriptional profiles and allowed us to identify different dynamic patterns of gene expression along the response pseudotime. We identified genetic variants regulating gene expression mean and variability, including treatment-specific effects, and showed widespread genetic regulation of the transcriptional dynamics of the gene expression response.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Development of 3D printed mini-waffle shapes containing hydrocortisone for children's personalized medicine. (Pubmed Central) -  Jul 24, 2023   
    Mass and content uniformity, hardness and friability tests complied with European Pharmacopeia specifications, despite the considerable challenge of the small dimensions of the forms. This study demonstrates that FDM can be used to produce innovative pediatric-friendly printed shapes of an advanced pharmaceutical quality to practice personalize medicine.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
    Trial primary completion date, Combination therapy:  Venetoclax Plus Inotuzumab for B-ALL (clinicaltrials.gov) -  Jul 22, 2023   
    P1,  N=26, Recruiting, 
    In thermographic analysis, acupuncture, laserpuncture, morphine, and negative control had paw temperature of ?27 Trial primary completion date: Jun 2023 --> Jul 2024
  • ||||||||||  Soliris (eculizumab) / AstraZeneca
    Case series of eculizumab treatment on NMOSD attacks (Gold) -  Jul 21, 2023 - Abstract #MSMilan2023MSMilan_1094;    
    Here we reported 5 cases with NMOSD for whom eculizumab administration immediately after acute phase treatment improved their symptoms. Although the efficacy of IVMP and PE before eculizumab administration cannot be excluded, eculizumab can be an option of acute treatment in severe NMOSD attack to lessen the permanent damage.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
    clinical and theurapeutic features in aquaporin-4 igg seropositive neuromyelitis optica spectrum disorders: a multicenter study of a greek patient cohort (Gold) -  Jul 21, 2023 - Abstract #MSMilan2023MSMilan_379;    
    Regarding acute phase treatments, all patients initially received high doses of intravenous (iv) methylprednisolone, and followingly 9 received iv immunoglobulin (IVIG), 9 plasma exchange (PLEX) and 3 combined treatments with IVIG and PLEX. In our seropositive NMOSD cohort, PLEX in the acute phase, rituximab and the add-on of oral glucocorticoids as prophylaxis were associated with better clinical outcomes and are in line with current literature; however, real-world data including the newly approved therapies for NMOSD should also be evaluated in future studies.
  • ||||||||||  Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
    Profound bilateral ophthalmoplegia and ptosis as a first presentation of NMOSD (Gold) -  Jul 21, 2023 - Abstract #MSMilan2023MSMilan_291;    
    This case report highlights the importance of recognizing less typical brainstem syndromes seen in NMOSD and importance of recognizing ascending and descending fibers that may be affected in a more diffuse brainstem lesion. Early recognition and treatment of NMOSD are critical to prevent disability and improve outcomes.
  • ||||||||||  varnimcabtagene autoleucel (ARI-0001) / August Pi i Sunyer Biomedical Research Institute, Rituxan (rituximab) / Biogen, Zenyaku Holdings, Roche
    Chimeric antigen receptor (CAR) T-cell therapy in refractory MOGAD disease: can it be a reasonable therapeutic option? (Gold) -  Jul 21, 2023 - Abstract #MSMilan2023MSMilan_219;    
    The patient received conditioning with cyclophosphamide and fludarabine followed by the infusions of CAR Tcells in 3 consecutive days... CAR T-cell therapy has been shown to be safe; early recurrence in the setting of a severe recurrent active disease does not rule out that it may be effective in long-term as suggested by the disappearance of MOG-IgG.