Glucocorticoid Receptor 

 186 Products   186 Products   1696 Diseases   94663 News 


«12...910111213141516171819...10631064»
  • ||||||||||  hydrocortisone / Generic mfg., azathioprine / Generic mfg.
    Journal:  Dyspnea Due to Laryngeal Cicatricial Pemphigoid: A Case Report. (Pubmed Central) -  Aug 15, 2024   
    To avoid tracheostomy, we were able to utilize infraglottic high-frequency jet ventilation under total intravenous anesthesia to perform a CO2 laser supraglottoplasty with sectioning of the aryepiglottic folds. Post-operatively, her dyspnea at rest resolved; there was no progression at the six- and 12-month follow-up, and she was satisfied with the result.
  • ||||||||||  Jorveza (budesonide orodispersible tablets) / Dr Falk
    Journal:  Cohort Profile Update: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS). (Pubmed Central) -  Aug 15, 2024   
    Post-operatively, her dyspnea at rest resolved; there was no progression at the six- and 12-month follow-up, and she was satisfied with the result. At inclusion, 686 (95.8%) of EoE patients were on ongoing treatment (orodispersible budesonide tablet [Jorveza
  • ||||||||||  Kesimpta (ofatumumab subcutaneous) / Novartis, Genmab
    Journal:  Successful treatment of relapsed and refractory CIDP with ofatumumab: a first case report. (Pubmed Central) -  Aug 15, 2024   
    The patient, a 46-year-old man diagnosed with CIDP, received high-dose intravenous methylprednisolone, intravenous immunoglobulin (IVIG), and plasma exchange(PE) during the acute phase of the disease, and long-term oral administration of prednisone, azathioprine (AZA), and mycophenolate mofetil (MMF) during the remission phase...This case demonstrates the effectiveness and good tolerability of OFA in the treatment of relapsed and refractory CIDP. Further studies are needed to investigate the efficacy and safety of OFA in patients with relapsed and refractory CIDP, especially in those who have shown an ineffective response to conventional immunotherapy and are intolerant to RTX.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    Journal:  Diverse effects of synthetic glucocorticoid species on cell viability and stress response of neuroblastoma cells. (Pubmed Central) -  Aug 14, 2024   
    In this report, we have compared the neurotoxicity induced by dexamethasone, prednisolone, betamethasone, and hydrocortisone in cultured neuroblastoma cells, through the analysis of several parameters such as cell viability, ER stress, oxidative stress, and mitochondrial fusion and fission markers. Interestingly, we have found that synthetic glucocorticoids may impact neuronal viability by affecting different cellular responses, suggesting that their therapeutic use should be consciously decided after careful consideration of benefits and detrimental effects.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Embryonic dexamethasone exposure exacerbates hepatic steatosis and APAP-mediated liver injury in zebrafish. (Pubmed Central) -  Aug 14, 2024   
    In addition, we showed that embryonic DXMS exposure worsened liver injury induced by paracetamol (N-acetyl-p-aminophenol, APAP), increased the infiltration of macrophages and neutrophils, and promoted the expression of inflammatory factors, leading to impeded liver regeneration. Taken together, our results provide new evidence that embryonic DXMS exposure exacerbates hepatic steatosis by activating glycolytic pathway, aggravates APAP-induced liver damage and impeded regeneration under a persistent inflammation, calling attention to DXMS administration during pregnancy with probable clinical implications for offspring.
  • ||||||||||  cisplatin / Generic mfg.
    Review, Journal:  Cisplatin and ototoxicity in childhood: the perspective of supporting otoprotective agentes. (Pubmed Central) -  Aug 14, 2024   
    The biochemical effects of these substances are relevant to their potential otoprotective properties, including the inactivation of oxygen free radicals and electrophilic platinum species. The use of these substances can reduce ototoxicity, decreasing cisplatin-induced hearing loss and improving the confort of life, especially for children.
  • ||||||||||  Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol) / GSK, Innoviva, Theravance Biopharma
    Clinical, Retrospective data, Journal, Adherence:  Evaluation of Adherence and Persistence to Triple Therapy in Patients with COPD: A German Claims Data Study. (Pubmed Central) -  Aug 14, 2024   
    Patients initiating SITT in Germany had significantly higher adherence and persistence compared with patients initiating MITT over 6 to 18 months following treatment initiation. Among SITT, FF/UMEC/VI users had the highest proportion of adherence and persistence.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Heterogeneity:  Cartilage-derived cells display heterogeneous pericellular matrix synthesis in agarose microgels. (Pubmed Central) -  Aug 14, 2024   
    ACs were stimulated with TGF-?1 and dexamethasone and ACPCs were sequentially stimulated with BMP-9 followed by TGF-?1 and dexamethasone...Both cell types showed variations between individual cells and donors. On one hand, this was more prominent in ACPCs, but also a subset of ACPCs showed superior PCM and ECM regeneration, suggesting that isolating these cells may potentially improve cartilage repair strategies.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study. (Pubmed Central) -  Aug 14, 2024   
    To compare the efficacy of intralesional vitamin D3 injection versus that of intralesional triamcinolone acetonide in the treatment of patchy alopecia areata...Also a statistically significant difference was found between both groups regarding the reported adverse effects with a significant better patient satisfaction encountered toward the intralesional vitamin D3 injection. Intralesional vitamin D3 is a promising effective, simple, safe, and inexpensive, therapeutic modality for patchy AA.
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
    Trial primary completion date, Combination therapy:  Venetoclax Plus Inotuzumab for B-ALL (clinicaltrials.gov) -  Aug 14, 2024   
    P1,  N=26, Recruiting, 
    The trial has a primary efficacy end point (oral morphine equivalent/day use within 24 Trial primary completion date: Jul 2024 --> Dec 2024
  • ||||||||||  prednisolone / Generic mfg.
    Review, Journal:  IgG4-Related Dacryoadenitis With Fibrous Mass in a 19-Month-Old Child: Case Report and Literature Review. (Pubmed Central) -  Aug 13, 2024   
    The patient received oral prednisolone for 4 months postoperatively and remained relapse-free for 27 months...IgG4-related dacryoadenitis with a fibrous mass may occur in very young children, responding well to surgical excision and steroids. Although pediatric IgG4-related orbital disease is not well-characterized yet, it may manifest differently from its adult variant.
  • ||||||||||  methylprednisolone sodium succinate / Generic mfg.
    Review, Journal:  Acute Cerebellar Manifestations without Limbic Involvement in GABAB Receptor Autoimmune Encephalitis: Case Report and Literature Review. (Pubmed Central) -  Aug 13, 2024   
    Despite receiving initial empirical antiviral treatment, his symptoms worsened, prompting the administration of intravenous methylprednisolone and immunoglobulin...Our case underscores the importance of increased clinical awareness and consideration of autoimmune causes, even when neuroimaging appears normal. Early and appropriate immunosuppressive therapy may help change the course of the disease and enhance patient outcomes.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Rhythms in lipid droplet content driven by a metabolic oscillator are conserved throughout evolution. (Pubmed Central) -  Aug 13, 2024   
    Moreover, in synchronized T98G cells, LD oscillations were altered by glycogen synthase kinase-3 (GSK-3) inhibition that affects the cytosolic activity of the metabolic oscillator or by knocking down LIPIN-1, a key GL synthesizing enzyme. Overall, our findings reveal the existence of metabolic oscillations in terms of LD content highly conserved across evolutionary scales notwithstanding variations in complexity, regulation, and cell organization.
  • ||||||||||  Xpovio (selinexor) / Karyopharm
    Enrollment closed:  Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) -  Aug 13, 2024   
    P2,  N=18, Active, not recruiting, 
    This could contribute to the patient's stratification and personalized treatment approach. Recruiting --> Active, not recruiting
  • ||||||||||  budesonide/formoterol / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  U-LABA/ICS Effects on Exercise Performance, Formoterol (clinicaltrials.gov) -  Aug 13, 2024   
    P=N/A,  N=20, Completed, 
    Recruiting --> Active, not recruiting Not yet recruiting --> Completed | Trial completion date: Dec 2025 --> Jul 2024 | Trial primary completion date: Dec 2025 --> Jul 2024
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  Cortisol, Stress, and Disease-Bidirectional Associations; Role for Corticosteroid-Binding Globulin? (Pubmed Central) -  Aug 12, 2024   
    We propose some stress system disorders result from constitutional stress system variants rather than stressors themselves. Altered CBG:cortisol buffering may influence interstitial cortisol ultradian surges leading to pathological tissue effects, an example of stress system variants contributing to stress-related disorders.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Suprachoroidal triamcinolone for alexandrite laser-induced macular burn. (Pubmed Central) -  Aug 12, 2024   
    She was treated immediately with a suprachoroidal injection of triamcinolone acetonide delivered with a custom-made needle. This resulted in the improvement of visual acuity and restoration of foveal anatomy over 1-year period.
  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Journal:  A Case of COVID-19-Triggered Polymyositis Leading to Rhabdomyolysis. (Pubmed Central) -  Aug 12, 2024   
    She was then started on high-dose intravenous methylprednisolone for presumed immune-mediated polymyositis...The patient was discharged with a prednisone taper and completely recovered at a follow-up six months later...Some proposed mechanisms include direct infection of the muscle or an environmental event triggering autoimmunity. Treatment generally involves corticosteroids that are gradually tapered.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Clinical prediction nomogram for steroid-induced ocular hypertension risk in patients with intravitreal dexamethasone implant. (Pubmed Central) -  Aug 12, 2024   
    Recognizing the risk factors and understanding the mechanisms underlying steroid-induced ocular hypertension (SIOH) are vital to prevent potent vision loss and ensure the safety and effectiveness of dexamethasone (DEX) injections...We established cutoff values to ensure different levels of sensitivity and specificity within the safety zone following DEX implantation. Our improved nomogram incorporating TM height as a newly identified risk factor, established a safety threshold for intravitreal DEX implantation, helping identify safe individuals from those who require caution.
  • ||||||||||  dexamethasone / Generic mfg., cisplatin / Generic mfg.
    Journal:  Comparison of Intratympanic Oxytocin and Dexamethasone in Cisplatin Ototoxicity: An Experimental Study. (Pubmed Central) -  Aug 12, 2024   
    There was no significant decrease in the frequencies of 2832 and 4004 after treatment in the oxytocin and dexamethasone group compared to pre-treatment in Distortion Product Otoacoustic Emission. As a result, it has been shown that intratympanic oxytocin may be an option that can be used in the treatment, although it is not as effective as dexamethasone in preventing cisplatin ototoxicity.
  • ||||||||||  Review, Journal:  Pain management after laparoscopic cholecystectomy: A systematic review and procedure-specific postoperative pain management (PROSPECT) recommendations. (Pubmed Central) -  Aug 12, 2024   
    The following interventions are not recommended due to limited or no evidence on improved pain scores: single port or mini-port techniques, routine drainage, low flow insufflation, natural orifice transluminal endoscopic surgery (NOTES), infra-umbilical incision, i.v. clonidine, nefopam and regional techniques such as quadratus lumborum block or rectus sheath block. Several interventions provided better pain scores but are not recommended due to risk of side effects: spinal or epidural anaesthesia, gabapentinoids, i.v. lidocaine, i.v. ketamine and i.v. dexmedetomidine.