Glucocorticoid Receptor 

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  • ||||||||||  topiramate / Generic mfg.
    Preclinical, Journal:  Protective effects of topiramate on acetic acid-induced colitis in rats through the inhibition of oxidative stress. (Pubmed Central) -  Aug 27, 2023   
    Topiramate also effectively decreased the levels of malondialdehyde and upregulated the activity of anti-oxidative enzymes, including catalase, superoxide dismutase, and glutathione peroxidase. Our results reveal that the administration of topiramate ameliorates acetic acid-induced colitis in rats via anti-oxidative properties, and further studies may introduce it as an effective therapeutic candidate to decrease ulcerative colitis severity.
  • ||||||||||  dexamethasone / Generic mfg., aspirin / Generic mfg.
    Preclinical, Journal:  A combination treatment of low-dose dexamethasone and aspirin-triggered resolvin D1 reduces Sj (Pubmed Central) -  Aug 25, 2023   
    A combined treatment of low-dose DEX with AT-RvD1 significantly decreased mast cell degranulation and lymphocytic infiltration, increased saliva secretion, and restored apical aquaporin-5 expression in submandibular glands of NOD/ShiLtJ mice. Low-dose DEX combined with AT-RvD1 reduces the severity of SS-like manifestation and prevents the development of advanced and potentially irreversible damage, all in a form that can reasonably be administered indefinitely without the need to cease treatment because of secondary effects.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Review, Journal:  Enigma of Intramuscular Triamcinolone Acetonide (Kenalog) Efficacy. (Pubmed Central) -  Aug 25, 2023   
    Possible reasons for this may be binding differences at the intramuscular site, low solubility due to acetonide esters, a slow rate of absorption from the injected site, and a low renal clearance rate. There is still much to be learned about its mechanism of action, which may be of clinical and therapeutic significance.
  • ||||||||||  dexamethasone injection / Generic mfg.
    Journal:  Primary versus salvage intratympanic steroid treatment for idiopathic sudden sensorineural hearing loss. (Pubmed Central) -  Aug 25, 2023   
    The primary group also received IT dexamethasone injection three times during the treatment period, whereas the salvage group received IT dexamethasone injection only if no or slight recovery was noted at the 2-week follow-up...In summary, salvage IT steroid injection is recommended for patients with ISSNHL patients to prevent unnecessary IT injection. 2.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model. (Pubmed Central) -  Aug 25, 2023   
    No significant change in histologic evidence of epithelial ulceration or fibrosis was noted, while an increased degree of inflammation was noted in the dexamethasone group (p?=?.04). Local dexamethasone delivery increases VF stiffness and degree of inflammation compared to uncoated ETTs in an acute laryngeal burn model, reflected in early biomechanical and histologic changes in an inhalational burn model.
  • ||||||||||  Besponsa (inotuzumab ozogamicin) / Pfizer, UCB
    Trial primary completion date:  Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO) (clinicaltrials.gov) -  Aug 25, 2023   
    P2,  N=25, Recruiting, 
    Local dexamethasone delivery increases VF stiffness and degree of inflammation compared to uncoated ETTs in an acute laryngeal burn model, reflected in early biomechanical and histologic changes in an inhalational burn model. Trial primary completion date: Jun 2023 --> Jun 2024
  • ||||||||||  dexamethasone / Generic mfg., dexmedetomidine / Generic mfg.
    Enrollment open, Combination therapy, Surgery:  Any: Dexmedetomidine in Postoperative Analgesia (clinicaltrials.gov) -  Aug 25, 2023   
    P2/3,  N=100, Recruiting, 
    Trial primary completion date: Nov 2022 --> Sep 2024 Not yet recruiting --> Recruiting
  • ||||||||||  dexamethasone / Generic mfg., clonidine / Generic mfg., epinephrine / Generic mfg.
    Enrollment closed, Surgery:  RCT Comparing ESPB Solutions in Breast Surgery (clinicaltrials.gov) -  Aug 25, 2023   
    P2,  N=75, Active, not recruiting, 
    Not yet recruiting --> Recruiting Recruiting --> Active, not recruiting
  • ||||||||||  dexamethasone / Generic mfg., ropivacaine / Generic mfg.
    New P2 trial:  BLOCK-SAH - PPF-Block for Post-SAH Headache (clinicaltrials.gov) -  Aug 24, 2023   
    P2,  N=195, Not yet recruiting, 
  • ||||||||||  dexamethasone / Generic mfg.
    Pediatric Regional Anesthetic Management of Femur Fracture with Single Shot Fascia Iliaca Plane Block (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6200;    
    In order to minimize opioids and facilitate serial neurological examination, a single shot fascia iliaca plane block with a mix of 40mL of 0.25% ropivicaine and 4mg dexamethasone spread upward to cover the femoral, lateral femoral cutaneous, and obturator nerves. Patient remained opioid free for two days after surgery.
  • ||||||||||  Flu Unresponsive to Steroids . . . Or is It? (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6194;    
    It is common that diagnosis of SGS is delayed due to similar presentation with URI. Fortunately, a quick diagnosis of SGS was made based on previous intubation history and failure to pass decreasing ETT size.
  • ||||||||||  dexamethasone / Generic mfg.
    Intrathecal Space Violation By Epidural Catheter (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6166;    
    The catheter was then withdrew till no CSF aspirated then 10 mg of dexamethasone was then given. The patient reported no complication and excellent pain relief 60-70% for more than 3 months.
  • ||||||||||  dexamethasone injection / Generic mfg., dexmedetomidine / Generic mfg.
    Extended Duration of Femoral and Sciatic Blocks as Primary Anesthetic for Complex Ankle Surgery (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6159;    
    Propofol and dexmedetomidine infusions were given for sedation...Afterwards, the block started to wear off. Small propofol boluses were given to compensate until the surgery concluded at the ninth hour, and no conversion to general anesthesia was needed.
  • ||||||||||  ketamine / Generic mfg., dexamethasone injection / Generic mfg., dexmedetomidine / Generic mfg.
    Combined Regional Approach for Lower Extremity I&D in Setting of Super-Morbid Obesity and Sleep Apnea (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_6144;    
    The patient was placed prone for a deep popliteal approach to the sciatic nerve and supine for femoral nerve blocks with perineural dexmedetomidine and dexamethasone. Intravenous dexmedetomidine and ketamine were used for intraoperative sedation with application of high-flow nasal cannula for CPAP, and arterial waveform analysis for hemodynamic monitoring was utilized.
  • ||||||||||  dexamethasone / Generic mfg.
    Parasternal Nerve Blocks as Novel Treatment for Complex Xiphodynia (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_6040;    
    A third treatment of 20cc 0.5% bupivacaine and 10mg dexamethasone for 85% relief. This case report represents a novel treatment for a challenging clinical presentation of xiphodynia.
  • ||||||||||  hydrocortisone / Generic mfg., ipratropium bromide / Generic mfg., epinephrine / Generic mfg.
    Intraoperative Management of Acutely Rising EtCO2 (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_6032;    
    We continued therapy for severe bronchospasm which included magnesium, ipratropium, epinephrine, and hydrocortisone administration. Upon head and neck palpation, crepitus was discovered, and a diagnosis of iatrogenic subcutaneous emphysema was made secondary to accidental CO2 subcutaneous insufflation.
  • ||||||||||  Tavegil (clemastine) / GSK
    Post general anesthesia induction anaphylaxis - Caught off guard no more (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5914;    
    We administered fentanyl, lidocaine, propofol and rocuronium...We administered O2 100%, epinephrin, hydrocortisone, clemastine and crystalloids...Tryptase blood levels were measured within the first hour and 24h after. The allergologic investigation revealed alllergies to rocuronium and latex.
  • ||||||||||  dexamethasone / Generic mfg., ondansetron / Generic mfg.
    PONV Prophylaxis as an Adjunct to CSF Leak Prevention in a Neurosurgical Patient Population (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5599;    
    None of the 5 patients received a preoperative antiemetic, 3 of the 5 did not receive intraoperative ondansetron and/or dexamethasone, and 2 received IV acetaminophen. To minimize PONV, a three-phase (pre-, intra-, and post-op), evidence-based protocol was developed.
  • ||||||||||  dexamethasone / Generic mfg.
    Perioperative QI Project: Administration of Dexamethasone for PONV Prophylaxis (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5508;    
    The goal is to improve the compliance percentage of dosing and timing. Through three interventions, it was shown in pre- and post-intervention data analysis, the percentage of overall compliance increased from 21% to 54%.
  • ||||||||||  Vecuron (vecuronium) / Sun Pharma
    Intraoperative Anaphylaxis and Bronchospasm Triggered by Vecuronium Administration (South: Hall F) -  Aug 23, 2023 - Abstract #ASA2023ASA_5424;    
    Interestingly, diagnosis and management of anaphylaxis and bronchospasm were complicated by lack of anaphylaxis and bronchospasm to rocuronium on induction. Neuromuscular blockers are the most common cause of intra-operative anaphylaxis and clinicians should be prepared to recognize and manage these complications rapidly.
  • ||||||||||  hydrocortisone / Generic mfg., epinephrine / Generic mfg.
    Anaphylaxis from de-novo allergy to Gelfoam in a pediatric liver transplant patient (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5348;    
    Notably, he received Gelfoam twice in the past year without adverse reaction. This case underscores the significance of risk factor awareness for de-novo post-transplant allergies to prevent pediatric perioperative anaphylaxis.
  • ||||||||||  Difficult Airway Management in the Setting of Angioedema (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_5238;    
    71-year-old female with hypertension presented to ED with suspected new onset lisinopril-induced angioedema reaction...IV diphenhydramine, hydrocortisone, and epinephrine were administered without clinical improvement, so airway team was called for emergent airway management...After sufficient bag mask ventilation, a successful fiberoptic intubation was achieved on second attempt with a grade 1 view and appropriate tube positioning confirmation. Patient tolerated interventions without complications and was admitted to MICU for closer respiratory monitoring and allergy evaluation.