- |||||||||| methylprednisolone sodium succinate / Generic mfg.
Trial completion date, Trial primary completion date: MYTHS - MYocarditis THerapy With Steroids (clinicaltrials.gov) - Sep 15, 2023
P3, N=288, Recruiting,
Trial completion date: Jan 2025 --> Dec 2028 | Trial primary completion date: Oct 2024 --> Mar 2028
- |||||||||| Sarclisa (isatuximab-irfc) / Sanofi
Trial completion date, Trial primary completion date, Combination therapy: Isatuximab in Combination With Novel Agents in RRMM - Master Protocol (clinicaltrials.gov) - Sep 15, 2023
P1/2, N=123, Recruiting,
Trial completion date: Jan 2025 --> Dec 2028 | Trial primary completion date: Oct 2024 --> Mar 2028 Trial completion date: Feb 2026 --> Nov 2028 | Trial primary completion date: Feb 2026 --> Nov 2028
- |||||||||| mezigdomide (CC-92480) / BMS
Journal: Mezigdomide plus Dexamethasone in Relapsed and Refractory Multiple Myeloma. (Pubmed Central) - Sep 15, 2023
P1/2
The all-oral combination of mezigdomide plus dexamethasone showed promising efficacy in patients with heavily pretreated multiple myeloma, with treatment-related adverse events consisting mainly of myelotoxic effects. (Funded by Celgene, a Bristol-Myers Squibb Company; CC-92480-MM-001 ClinicalTrials.gov number, NCT03374085; EudraCT number, 2017-001236-19.).
- |||||||||| pavurutamab (AMG 701) / Amgen
Trial termination, Combination therapy, Monotherapy: A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma (clinicaltrials.gov) - Sep 14, 2023
P1/2, N=174, Terminated,
(Funded by Celgene, a Bristol-Myers Squibb Company; CC-92480-MM-001 ClinicalTrials.gov number, NCT03374085; EudraCT number, 2017-001236-19.). Completed --> Terminated; business decision, not safety reasons.
- |||||||||| fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Digihaler System Use By Healthcare Professionals And App Connectivity In Asthma Patients: A Pragmatic Study (Monitor 15) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_923;
P4
In this DS, the Digihaler integrated inhalers (fluticasone propionate/salmeterol and albuterol Digihalers) transmit data wirelessly to a patient-facing application (App), and from a cloud-based solution to a healthcare professional (HCP)-facing Dashboard...Conclusion In this pragmatic study, patients and HCPs used the Digihaler System in a manner consistent with GINA recommendations for continuous adherence and technique assessment. The DS provides objective data, supporting guideline-based care and allowing for timely as-needed adjustments to clinical asthma management based on individuals
- |||||||||| hydrocortisone / Generic mfg.
A Case of Aquagenic Palmoplantar Keratoderma In A School-Aged Male (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_848;
He was initially evaluated by Pediatric Dermatology, diagnosed with atopic dermatitis(AD), and prescribed hydrocortisone which alleviated his AD symptoms...Discussion APK pathophysiology is not well known and is thought to be related to aberrant sweat ducts. It can occur sporadically or in families and should be considered in refractory hand and food dermatitis that worsens with water exposure.
- |||||||||| hydrocortisone / Generic mfg.
DAVID Syndrome Associated With Common Variable Immunodeficiency (Monitor 05) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_823;
She was started on hydrocortisone replacement with physiologic doses for life...There is variable severity and manifestations including recurrent respiratory infections, asthma, nephrotic syndrome, hypoplastic anterior pituitary, central adrenal insufficiency, recurrent infections, hypogammaglobulinemia, low memory B cells, and autoimmune diseases. In this case, initial immunological abnormalities were thought to be due to prolonged use of steroids, however further investigation revealed genetic cause, that ultimately changed management of the disease.
- |||||||||| dexamethasone / Generic mfg., epinephrine / Generic mfg.
Severe, life-threatening hereditary angioedema of the larynx induced by ingestion of cold foods (Monitor 04) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_818;
He received racemic epinephrine and steroids with little effect...He was started on high dose dexamethasone and extubated 2 days later...The strong family history of similar cold-induced symptoms indicates a strong hereditary component and supports our working diagnosis of HAE with normal C1-INH. Future genetic testing may reveal a novel cause for this patient's symptoms.
- |||||||||| diphenhydramine / Generic mfg., hydrocortisone / Generic mfg.
Allergic Reaction to PEG Asparaginase with Successful Desensitization (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_809;
Hypersensitivity reactions are associated with neutralizing antibody formation, and lower asparaginase levels and therefore worse outcomes. Though desensitization to PEG-asparaginase includes risk of serious allergic reaction, the benefit of improved outcome often outweighs this risk when desensitization is performed in a closely observed and controlled environment.
- |||||||||| Corticosteroid As The Cause Of Unforeseen Anaphylaxis Following A Joint Injection (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_806;
She was discharged the following day on cetirizine for lingering cutaneous symptoms...Cross-reactivity between corticosteroids is possible, but evidence on this topic is lacking. Conducting extra skin testing to assess the suitability of alternative corticosteroids can be vital for ensuring patient safety.
- |||||||||| prednisone / Generic mfg.
Fixed Drug Reaction to Methylprednisolone and Prednisone (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_803;
Drug allergy testing was performed with intralesional intradermal injections on her left buttocks with methylprednisolone sodium succinate, hydrocortisone sodium succinate, triamcinolone acetonide, and dexamethasone sodium phosphate at 1:100 and 1:10 dilations...Discussion FDE is a cutaneous reaction that occurs in the same location when exposed to an offending drug. We report a unique case of FDE to methylprednisolone and prednisone.
- |||||||||| Solu-Cortef (hydrocortisone sodium succinate injection) / Pfizer
Sodium Succinate: The Guilty Bystander in a Case of Suspected Corticosteroid Hypersensitivity (Monitor 01) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_800;
Skin-prick and intradermal testing to CS and excipients were positive to methylprednisolone sodium succinate and negative to methylprednisolone acetate and dexamethasone, suggesting sensitization to the sodium succinate component...This case highlights the importance of a thorough workup scrutinizing CS molecules and associated excipients in a medically complex patient. By identifying a culprit allergenic agent to CS, we can provide patients with safe and appropriate therapeutic options.
- |||||||||| ketorolac / Generic mfg.
A case of anaphylaxis to Ketorolac in a pediatric patient (Monitor 01) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_799;
He regained consciousness, had an episode of emesis, then received intramuscular epinephrine, IV dexamethasone, and fluids...Patient denies history of nasal polyps, or drug hypersensitivity, and he previously tolerated ibuprofen...It is important to distinguish between common pseudo-allergic NSAID reactions and hypersensitivity reactions. The correct diagnosis impacts potential management in the future.
- |||||||||| ethambutol / Generic mfg.
Long Induction Of Drug Tolerance To Ethambutol In Treatment Of Mycobacterium Avium Complex Lung Disease (Monitor 01) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_796;
The rash erupted 18 days and 4 days after initiation of MAC-LD treatment with ethambutol and azithromycin, respectively...Antibiotics were discontinued and the rash was treated with triamcinolone acetonide injection and topical clobetasol with improvement within 7 days...Alternative agents for MAC were contraindicated due to CKD (inhaled amikacin) or concern for decreased efficacy, limited supply and greater side effects (clofazimine)...Discussion HSRs to ethambutol can impact clinical outcomes in treatment of MAC-LD, particularly for those without alternate drug options. We adapted a previous long IDT protocol that enabled continued use of ethambutol for the most efficacious treatment.
- |||||||||| budesonide/formoterol / Generic mfg.
Reversibility of Dyspnea in An Asthmatic Patient: Thinking Beyond Asthma (Monitor 10) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_791;
She was prescribed Symbicort BID, but did not start the therapy...Discussion Though the patient's history was indicative of a decline in asthma status, physical exam and spirometry were not entirely consistent with this diagnosis. This case of a large ovarian cyst causing respiratory symptoms due to mass effect, though rare, highlights the importance of including abdominal and pelvic masses in the differential diagnosis of atypical presentations of new-onset persistent asthma.
- |||||||||| Breo Ellipta (fluticasone furoate / vilanterol) / GSK, Innoviva
Fixed Extrathoracic Obstruction Masquerading As Poorly Controlled Asthma (Monitor 10) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_788;
Case Description A 27-year-old female was referred by her primary doctor for worsening wheezing and dyspnea, presumed due to uncontrolled asthma without response to increased dose of daily maintenance inhaler (fluticasone furoate/vilanterol)...PFT can be crucial for proper diagnosis. Attentiveness to risk factors for compromised airways and patient response to inhalers is important to discern the true etiology of chronic respiratory symptoms.
- |||||||||| fluocinolone acetonide / Generic mfg.
Peanut Allergy Puzzle: Unexpected Response To Topical Fluocinolone (Monitor 08) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_782;
Case Description A 17-month-old female with atopic dermatitis and multiple food allergies including egg, peanut, and tree nuts developed a diffusely erythematous, pruritic morbilliform rash across the trunk, extremities, hands, and groin about 5-7 hours after applying Fluocinolone acetonide 0.01% oil for the first time on the hands, arms, and legs...Hence, when treating patients with food allergies, the food content of topical treatments should be considered as possible triggers for reactions. Further investigation into non-oral exposure to food allergens is warranted.
- |||||||||| budesonide / Generic mfg.
Reactive Hypereosinophilia in a Toddler with Very Early Onset Inflammatory Bowel Disease (Monitor 10) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_712;
Discussion This patient's hypereosinophilia was secondary to underlying gastrointestinal inflammation, likely from developing inflammatory bowel disease. This case demonstrates the importance of maintaining a broad differential in evaluating patients with HE and tailoring treatment to the underlying cause, rather than specifically targeting the eosinophils themselves.
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg., clindamycin phosphate / Generic mfg.
Systemic Dermatitis With An Uncommon Cause (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_699;
These are largely removed during processing. Previous cases of ACD to cashews have been from raw or partially processed cashews, making this case unique.
- |||||||||| diphenhydramine / Generic mfg., epinephrine / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Respiratory Distress And Failure To Thrive In An 11-Year-Old Girl With Hypopharyngeal Polyp (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_692;
Our patient had a rare finding of hypopharyngeal polyp, which was repeatedly missed. This case illustrates the need for providers to maintain an index of suspicion for upper airway obstruction in children presenting with respiratory distress with oropharyngeal swelling refractory to first-line treatments for anaphylaxis.
- |||||||||| prednisone / Generic mfg., fluticasone / Generic mfg., levocetirizine / Generic mfg.
When A Polyp Is Not A Polyp: Unilateral Nasal Masses And Masqueraders Of Nasal Polyps (Monitor 09) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_691;
She was using Fluticasone 2 sprays/nostril daily and Levocetirizine 5 mg daily...Patient was changed to Fluticasone exhalation therapy and treated with Prednisone for 5 days...Warning signs/red flags for tumors include rapid growth, change in symptom pattern, no response to nasal/systemic steroids or biologics, and crusting/bleeding lesions. A high degree of suspicion, sinus imaging and Otolaryngology referral for biopsy are paramount in these scenarios for accurate diagnosis and treatment.
- |||||||||| Jakafi (ruxolitinib) / Novartis, Incyte, Actemra IV (tocilizumab) / Roche, JW Pharma, Kineret (anakinra) / SOBI
A Patient with Hemophagocytic Lymphohistiocytosis (HLH) Syndrome Due to Natural Killer (NK) Cell Lymphoproliferation (Monitor 07) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_671;
and CXCL-9 levels, and he died due to multifactorial shock...Considerations were made to use emapalumb, however, we were unable to get approval for administration. This case report highlights both the need for more aggressive HLH treatment upfront and further research to better understand the pathogenesis and management of HLH due to LPD-NK.
- |||||||||| hydrocortisone / Generic mfg.
Variable Expression Of The AIRE Gene In Autoimmune Polyglandular Syndrome Type 1 (Monitor 06) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_651;
Subsequently, his father was found to have the same heterozygous pathogenic variant, although he only has chronic cutaneous candidiasis. Discussion Through this case, we highlight that our patients with heterozygous pathogenic variants of the AIRE gene developed significant symptoms with variable expression within the same family.
- |||||||||| Kineret (anakinra) / SOBI
A case of hemophagocytic lymphohistiocytosis (HLH) presenting as a complication of adult-onset Still disease (AOSD) (Monitor 06) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_643;
He was discharged after ferritin decreased with the initiation of prednisone and anakinra...He clinically improved after anakinra was increased and IV methylprednisolone was started...The mortality of HLH is high without treatment. Anakinra is the treatment of choice for new-onset moderate to severe AOSD and IV glucocorticoids are reserved for patients with MAS.
- |||||||||| More Than Just Contact: Intraoperative Anaphylaxis Due To Topical Polymyxin B / Bacitracin (Monitor 03) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_587;
46 minutes after starting intravenous sedation with propofol, midazolam, fentanyl and wound irrigation with polymyxin B / bacitracin, the patient became acutely agitated...The patient's symptoms resolved with dexamethasone, diphenhydramine, albuterol and epinephrine...Discussion Bacitracin and polymyxin B are common causes of contact dermatitis with an estimated prevalence of 0.5% to 9.1% and 2.3% respectively. However, their role in IgE mediated hypersensitivity is lesser known and frequently described through case report only.
- |||||||||| dasatinib / Generic mfg.
A Case of Tyrosine Kinase Inhibitor (Dasatinib)-Induced Angioedema (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_574;
Discussion Angioedema occurring because of dasatinib is rare, with no case reports directly implicating it. This case demonstrates dasatinib as a possible trigger of angioedema in a patient who had never experienced these symptoms previously.
- |||||||||| Auvi-Q (epinephrine auto-injector) / Sanofi, Kaleo
Idiopathic Anaphylaxis: A Medical Dilemma (Monitor 02) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_569;
She was treated as an allergic reaction with ondansetron, dexamethasone, diphenhydramine and was discharged home...Once results obtained, elevated tryptase suggests IA as most likely diagnosis, but during ED management remained a challenge to diagnose clinically. Patient was discharged on cetirizine, prednisone and epinephrine auto-injector with close follow-up with Allergist.
- |||||||||| vancomycin / Generic mfg.
A Rare Case Of Toxic Epidermal Necrolysis Associated With The Use Of Vancomycin. Case Report (Monitor 01) - Sep 14, 2023 - Abstract #ACAAI2023ACAAI_558;
The antibiotics most implicated are erythromycin, cefotaxime, trimethoprim-sulfamethoxazole, cloxacillin, and amoxycillin...Treatment started with intravenous methylprednisolone and intravenous immunoglobin with poor response to therapy...In the literature there are few cases of TEN associated with vancomycin. Due to this, other classes of medications and antibiotics groups not documented in the literature should be suspected as the main causes, and not delay the start of treatment for this pathology, increasing patient's prognosis.
- |||||||||| dexamethasone / Generic mfg.
Journal: Multifunctional polysaccharide composited microneedle for oral ulcers healing. (Pubmed Central) - Sep 14, 2023
Herein, we report a multifunctional polysaccharide composite microneedle patch based on hyaluronic acid (HA) and hydroxypropyl trimethyl ammonium chloride chitosan (HACC) loaded with dexamethasone (DXMS) and basic fibroblast growth factor (bFGF) for oral ulcer healing...More importantly, animal experiments have shown that multifunctional microneedle patches can effectively promote oral ulcer healing. Thus, these novel multifunctional polysaccharide composite microneedle patches have great potential for oral ulcers treatment.
- |||||||||| dexamethasone / Generic mfg., progesterone / Generic mfg.
Retrospective data, Review, Journal: Anorexia Nervosa and Adrenal Hormones: A Systematic Review and Meta-analysis. (Pubmed Central) - Sep 14, 2023
Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa. This finding is important to consider when evaluating low-weight women for disorders involving the adrenal axis, especially Cushing's syndrome.
- |||||||||| Mavenclad (cladribine) / EMD Serono
Journal: Oral cladribine treatment and idiosyncratic drug-induced liver injury in multiple sclerosis. (Pubmed Central) - Sep 14, 2023
A causality assessment of the role of prednisolone and OC was performed using the updated Roussel Uclaf Causality Assessment Method which also included a negative re-exposure test for OC during the second OC treatment cycle 1?year later. Our observations suggest that prednisolone or interactions between prednisolone and OC are more likely to foster development of iDILI rather than OC treatment itself.
|
