Glucocorticoid Receptor 

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  • ||||||||||  Decadron (dexamethasone) / Merck (MSD)
    Trial completion, Trial completion date:  MUA to Treat Postoperative Stiffness After Total Knee Arthroplasty (clinicaltrials.gov) -  Sep 21, 2023   
    P=N/A,  N=130, Completed, 
    Active, not recruiting --> Completed Active, not recruiting --> Completed | Trial completion date: Dec 2024 --> Dec 2022
  • ||||||||||  Trial completion, Trial completion date:  Allo HSCT Using RIC for Hematological Diseases (clinicaltrials.gov) -  Sep 21, 2023   
    P2,  N=156, Completed, 
    Active, not recruiting --> Completed | Trial completion date: Dec 2024 --> Dec 2022 Active, not recruiting --> Completed | Trial completion date: Mar 2024 --> May 2023
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Suppression of mir-150-5p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis. (Pubmed Central) -  Sep 20, 2023   
    The results showed that mir-150-5p suppression with antagomirs did not significantly interfere with or enhance the induction of ulcerative colitis symptoms by dextran sulfate sodium, but it did attenuate the inflammation inhibitory effect of dexamethasone by abnormally regulating the expression of IL-17a, IL-10, IL-2 and IL-6 levels and myeloperoxidase activity...Our results indicate that mir-150-5p suppression attenuates the anti-inflammatory effect of glucocorticoids and may function as a driver element in ulcerative colitis glucocorticoid resistance. AVAILABILITY OF DATA AND MATERIALS: All data and figures analyzed in this study are available from the corresponding author by request.
  • ||||||||||  dexamethasone / Generic mfg.
    Observational data, Journal:  Endoluminal treatment for Zenker's diverticulum - a population-based observational study. (Pubmed Central) -  Sep 20, 2023   
    of Gastrointestinal Surgery (p?<?0.001), administered more frequently intraoperative dexamethasone (p?<?0.001), and had significantly more postoperative infections (19.6% vs 3.4%, p?=?0.01)...Although no standardized follow-up took place, at a median of 119?months elapsed, observed clinical recurrence was 35% for the endostapler treatment and 51% for the laser treatment procedure. Both rigid endoscopic stapled oesophago-diverticulostomy and laser diverticulostomy are safe treatments for Zenker's diverticulum, however with a substantial risk of recurrence.
  • ||||||||||  hydrocortisone / Generic mfg., propylthiouracil / Generic mfg., labetalol / Generic mfg.
    THYROTOXICOSIS IN PARTIAL MOLAR PREGNANCY, DIAGNOSTIC CHALLENGES AND THERAPEUTIC IMPLICATIONS () -  Sep 20, 2023 - Abstract #ATA2023ATA_683;    
    Partial moles have a triploid karyotype resulting from fertilization of an ovum and two sperms, and their intact fetal tissue with focal hydropic villi, leads to delayed diagnosis (3). Therefore, in thyrotoxicosis and first?trimester bleeding with known triploid fetus, consideration of partial molar pregnancy is crucial for prompt medical intervention and dilation and curettage as definitive management.
  • ||||||||||  PTU?INDUCED ANCA?ASSOCIATED VASCULITIS; A CASE REPORT OF A RARE SIDE EFFECT TWO YEARS AFTER PTU INITIATION FOR GRAVES' DISEASE TREATMENT () -  Sep 20, 2023 - Abstract #ATA2023ATA_611;    
    Propylthiouracil (PTU) has been associated with autoimmune syndromes, particularly anti?neutrophil cytoplasmic antibody (ANCA)?associated vasculitis...Next, she was given Methimazole but developed arthralgias, became non?compliant and developed thyroid storm...She was treated for three days with 500?mg intravenous methylprednisolone followed by a tapering dose of prednisone starting at 60?mg daily which halted the disease progression promptly...When triggered, ANCA activates the complement cascade resulting in low C4 complement and activation of the coagulation system leading to vasculitis. In conclusion, PTU?induced ANCA vasculitis is a rare adverse event that needs intensive treatment with corticosteroids for at least one year.
  • ||||||||||  dexamethasone / Generic mfg., hydrocortisone / Generic mfg.
    TIME IS OF THE ESSENCE: MEDULLARY THYROID CANCER WITH ECTOPIC CUSHING'S SYNDROME: A CASE REPORT () -  Sep 20, 2023 - Abstract #ATA2023ATA_573;    
    He received stress dose of steroids in OR and was placed on maintenance hydrocortisone therapy following his surgery which resulted a significant improvement in his symptoms.Time is of the essence in the management of ectopic ACTH syndrome with overt hypercortisolism. Due to the rarity of this disease, and lack of established guidelines, one should maintain high index of suspicion to ensure timely diagnosis and involvement of experienced multidisciplinary team to adapt the best therapeutic approach and prevent complications(1).
  • ||||||||||  RIDING THE STORM? A CASE OF THYROTOXICOSIS ENCEPHALOPATHY SECONDARY TO SOLITARY TOXIC ADENOMA () -  Sep 20, 2023 - Abstract #ATA2023ATA_568;    
    The incidence of thyroid storm ranges from 0.56 to 0.76/100,000 persons per year and is lower when associated with subclinical hyperthyroidism secondary to a solitary toxic adenoma...However, all evidence pointed towards solitary toxic adenoma as causative. This case highlights the necessity of close follow?up of subclinical hyperthyroidism and early management with thionamides, radioactive iodine or surgery.
  • ||||||||||  amiodarone / Generic mfg.
    WHEN ALL ELSE FAILS  () -  Sep 20, 2023 - Abstract #ATA2023ATA_533;    
    Severe thyrotoxicosis and thyroid storm refractory to medical therapy are indications for advanced treatment mechanisms such as SPAD. We would like to express in our opinion that SPAD continues to be a highly effective methodology and that it should be utilized more frequently and earlier to limit and avoid morbidity and mortality subsequent to thyroid storm.
  • ||||||||||  CHALLENGES IN THE MANAGEMENT OF GRAVES' DISEASE COINCIDING WITH AML () -  Sep 20, 2023 - Abstract #ATA2023ATA_531;    
    Shortly thereafter, the patient started induction chemotherapy.Methimazole was discontinued in the presence of anticipated neutropenia, however it was restarted at a lower dose with the addition of cholestyramine due to worsening hyperthyroidism and in anticipation of count recovery...With persistent hyperthyroidism, the patient was transitioned to hydrocortisone with continued use of cholestyramine and propranolol...This complex case illustrates the tremendous importance of assessing the anticipated risks and benefits and understanding the unique limitations of treatment in a patient with Graves' disease requiring cytotoxic chemotherapy for AML. We highlight the importance of strict lab monitoring and consideration of second and third?line therapies in these cases.
  • ||||||||||  hydrocortisone / Generic mfg., propylthiouracil / Generic mfg., labetalol / Generic mfg.
    THYROTOXICOSIS IN PARTIAL MOLAR PREGNANCY, DIAGNOSTIC CHALLENGES AND THERAPEUTIC IMPLICATIONS () -  Sep 20, 2023 - Abstract #ATA2023ATA_331;    
    Partial moles have a triploid karyotype resulting from fertilization of an ovum and two sperms, and their intact fetal tissue with focal hydropic villi, leads to delayed diagnosis (3). Therefore, in thyrotoxicosis and first?trimester bleeding with known triploid fetus, consideration of partial molar pregnancy is crucial for prompt medical intervention and dilation and curettage as definitive management.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Intratympanic dexamethasone in Mani (Pubmed Central) -  Sep 20, 2023   
    ITD application shows improvement in controlling vertigo and tinnitus in patients under exacerbation in MD. It is a promising non-destructive addition to the 'stepwise treatment concept' in MD and can be used as a first-line treatment in vertigo control.
  • ||||||||||  hydrocortisone / Generic mfg.
    Preclinical, Journal:  Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo. (Pubmed Central) -  Sep 19, 2023   
    Tilapia were fed with and without CBD (0.001% of feed weight) and with and without hydrocortisone stress hormone (0.01% of body weight) every day for four weeks...Although not significant, the stress reducing effect of CBD on stress biomarkers such as glucose and HSI also seemed promising. Further investigation into the matter may not just be useful in stress mediation in aquatic organisms but may also have implications in human medicine as well.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  The utility of salivary cortisone in the overnight dexamethasone suppression test in adrenal incidentalomas. (Pubmed Central) -  Sep 19, 2023   
    These results indicate that treatment of brain vascular inflammation with low doses of Dex should be advocated, while higher doses promote vascular inflammation. In AI patients, after dexamethasone, salivary cortisone correlates very strongly with serum cortisol in the ONDST and could therefore be used as an alternative sampling method which does not require venepuncture or attendance at hospital.
  • ||||||||||  dexamethasone / Generic mfg., gentamicin sulfate / Generic mfg.
    Preclinical, Journal:  Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice. (Pubmed Central) -  Sep 18, 2023   
    Transtympanic administration is used clinically for the injection of gentamicin and/or corticosteroids...LAB was used to deliver dexamethasone phosphate with thermosensitive hydrogel on the mouse RWM...Auditory function measurements showed no hearing impairment suggesting that bioprinting does not induce significant cochlear damage. Hence, the present proof of concept study introduces a promising approach for inner ear drug delivery.
  • ||||||||||  hydrocortisone / Generic mfg.
    Journal:  The Timing of Initiating Hydrocortisone and Long-term Mortality in Septic Shock. (Pubmed Central) -  Sep 18, 2023   
    This study shows that the two-drug class combination of ISAdm is an effective and well tolerated treatment option for RRMM patients exhibiting only BP. In patients with septic shock, initiating hydrocortisone >12 hours after vasopressor use was associated with an increased risk of both short-term and long-term mortality, and a prolonged length of hospital stay.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Triamcinolone Acetonide Injections in Mild-to-moderate Chronic Plaque Psoriasis With a Novel Needle-free Drug-delivery System (clinicaltrials.gov) -  Sep 18, 2023   
    P1,  N=13, Completed, 
    Recruiting --> Completed | Trial completion date: Oct 2024 --> Sep 2023 | Trial primary completion date: Oct 2024 --> Sep 2023 Recruiting --> Completed | N=30 --> 13 | Trial completion date: Dec 2023 --> May 2023 | Trial primary completion date: Dec 2023 --> May 2023
  • ||||||||||  budesonide / Generic mfg.
    Preclinical, Journal:  Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice. (Pubmed Central) -  Sep 16, 2023   
    Anti-inflammatory drugs including corticosteroid therapy may worsen the incidence and severity of CDI in this mouse model. These studies may have important clinical implications for understanding the role of anti-inflammatory/ corticosteroid therapy in CDI and inflammatory bowel disease management.