Glucocorticoid Receptor 

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  • ||||||||||  prednisone / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
    Epidemiology and Predictors of Relapse in Giant Cell Arteritis: Results of the ARTESER Register (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_4369;    
    Between 8 and 18% of patients had multiple relapses. Despite the relevance of this problem, we do not yet have any predictive factors to identify patients with a higher risk of flare.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly, Rinvoq (upadacitinib) / AbbVie
    Safety and Effectiveness in Cycling Between Non-Selective and Selective JAKi in a Multi-Center Registry of Rheumatoid Arthritis in the Middle East (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_4119;    
    We evaluated the overall safety of JAKis in the Middle Eastern population, as well as the clinical efficacy of cycling from Tofacitinib (Tofa) or Baricitinib (Bari) to Upadacitinib (Upa)...All patients had previously received csDMARD, however 56% received bDMARD and 59% received oral prednisolone... Our findings show that switching from non-selective JAKi to selective JAKi is feasible and safe, and that it may improve disease activity outcomes in patients who have failed to achieve low disease activity or remission with a previous JAKi.
  • ||||||||||  Olumiant (baricitinib) / Incyte, Eli Lilly
    Safety of Baricitinib for COVID-19 Related Hyperinflammation in Pediatric Patients: A Large Tertiary Care Center Experience (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_4018;    
    Children with Delta-variant associated hyperinflammation tolerated adjunctive treatment with baricitinib with a lower-than-expected adverse event and cessation rate. Additional data from other centers may be necessary to understand the role of JAK inhibition in enhancing the survival of children with severe COVID pneumonias and inflammation.
  • ||||||||||  dexamethasone / Generic mfg.
    Generation of a Human 3D in Vitro Bone Model That Mimics Glucocorticoid-induced Osteoporosis (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3985;    
    Additional data from other centers may be necessary to understand the role of JAK inhibition in enhancing the survival of children with severe COVID pneumonias and inflammation. Ultimately, we will obtain an in vitro 3D co-culture of osteoblasts/osteoclasts simulating human native bone, which will be treated with dexamethasone to mimic key aspects of GIOP in vitro .
  • ||||||||||  dexamethasone / Generic mfg.
    Therapeutic Effect of ICAM-1 Mimic on Experimental Axial Spondyloarthritis (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3709;    
    Follow-up studies will examine pharmacokinetics and pharmacodynamics of the compound. This is promising data for application of this ICAM-1 mimic as a new therapeutic option for axSpA.
  • ||||||||||  dexamethasone / Generic mfg., bleomycin / Generic mfg.
    Macrophages Regulate Adipocyte Differentiation and Proliferation in Skin Fibrosis (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_3071;    
    Our findings suggest that cenerimod can effectively disrupt multiple nodes of a vicious circle of pathogenesis associated with rheumatic diseases like RA. To assess the effect of M
  • ||||||||||  RCI002 / RudaCure
    The Analgesic Effect of RC-0165, a TRPV1 Antagonist, for Osteoarthritis Pain (Poster Hall; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_2969;    
    In vivo, pain-related behavioral effects were compared to RC-0165 and triamcinolone acetonide (TA)as positive control in a MIA-induced OA rat model, which was assessed using Von Frey, Hargreaves, open field, and rotarod tests. The results of our study suggest that RC-0165 may be a promising approach to significantly reduce OA pain compared to TA by suppressing pain signals mediated by TRPV1 effects of RCI002 compare to TA for OA
  • ||||||||||  Tavneos (avacopan) / Kissei, Amgen, Otsuka
    Real-world Experience with Avacopan in ANCA Vasculitis: A Multi-center Retrospective Cohort Analysis (Ballroom 20D; in person) -  Sep 23, 2023 - Abstract #ACRConvergence2023ACR_Convergence_1757;    
    Acknowledgements: Intramural Research Program of NIAMS and NIEHS of the NIH. Rituximab plus cyclophosphamide was the most common induction regimen (49%), followed by rituximab only (46%)...The cumulative dose of IV methylprednisolone was 2.4 g (
  • ||||||||||  Venclexta (venetoclax) / Roche, AbbVie, Walter and Eliza Hall Institute
    Biomarker, Journal, IO biomarker:  Venetoclax in biomarker-selected multiple myeloma patients: Impact of exposure on clinical efficacy and safety. (Pubmed Central) -  Sep 23, 2023   
    P1/2
    Evaluation of the exposure-safety relationships demonstrated a lack of a relationship between venetoclax exposures (AUC ) and grade ?3 infections, grade ?3 neutropenia, grade ?3 treatment-emergent adverse events or any grade serious treatment-emergent adverse events. These findings support further study of venetoclax at 800
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Green synthesis of metal-organic framework loaded dexamethasone on wood aerogels for enhanced cranial bone regeneration. (Pubmed Central) -  Sep 23, 2023   
    In this study, for the first time, a simple but effective one-pot method for developing a novel zeolitic imidazolate framework-8 with different concentrations of dexamethasone was developed. These findings illustrate that the novel scaffold has a significant positive impact on osteogenic differentiation in vitro and repairs defects in vivo, suggesting that it can be used in bone tissue engineering.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal:  Increased risk of vertebral fractures in patients with mild autonomous cortisol secretion. (Pubmed Central) -  Sep 22, 2023   
    These findings illustrate that the novel scaffold has a significant positive impact on osteogenic differentiation in vitro and repairs defects in vivo, suggesting that it can be used in bone tissue engineering. Women and men with AI and MACS are at higher risk of VFx.
  • ||||||||||  Review, Journal, IO biomarker:  Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway. (Pubmed Central) -  Sep 22, 2023   
    This study summarizes the latest scientific data about the bile acid signaling pathway, the neutrophil chemotaxis recruitment process during cholestasis, and the role of NO in cholestasis liver diseases. Literature review directed us to propose that suppression of NO and its related pathways could be a therapeutic option for preventing or treating cholestatic liver diseases.
  • ||||||||||  Korlym (mifepristone) / Corcept Therap, miricorilant (CORT118335) / Corcept Therap, Mifeprex (mifepristone) / Danco Laboratories
    Preclinical, Journal:  Glucocorticoid receptor modulator CORT125385 alleviates diet-induced hepatosteatosis in male and female mice. (Pubmed Central) -  Sep 22, 2023   
    In this study, we set out to evaluate the novel glucocorticoid receptor modulator CORT125385, an analogue of the previously studied miricorilant but without mineralocorticoid receptor binding activity...In vivo, CORT125385 treatment did not influence PR-responsive gene expression in the oviduct, while mifepristone treatment strongly influenced these genes in the oviduct, thus excluding in vivo PR cross-reactivity of CORT125385 at a therapeutically active dose. We conclude that CORT125385 is a promising glucocorticoid receptor modulator that effectively reduces liver steatosis in male and female mice without affecting other steroid receptors at doses that lower hepatic lipid content.
  • ||||||||||  Rizaben (tranilast) / Kissei, Nuon Therapeutics
    Biomarker, Review, Journal, Tumor microenvironment:  Strategy of targeting the tumor microenvironment via inhibition of fibroblast/fibrosis remodeling new era to cancer chemo-immunotherapy resistance. (Pubmed Central) -  Sep 22, 2023   
    Consistent to many repurposing drugs such as pirfenidone, metformin, losartan, tranilast, dexamethasone and pentoxifylline are used to decrease immune-suppression by abrogation of TME inhibitory signal that stimulates the immune system and increases efficiency and reduces resistance to chemotherapy drugs. To overcome immunosuppression based on fibroblast/fibrosis remodeling, in this review, we focus on inhibitory signal transduction, which is the physical barrier, alleviates mechanical stress and prevents mechano-metabolic activation.
  • ||||||||||  dexamethasone / Generic mfg.
    Clinical, Journal, Surgery:  CORR Insights (Pubmed Central) -  Sep 22, 2023   
    To overcome immunosuppression based on fibroblast/fibrosis remodeling, in this review, we focus on inhibitory signal transduction, which is the physical barrier, alleviates mechanical stress and prevents mechano-metabolic activation. No abstract available
  • ||||||||||  dexamethasone / Generic mfg.
    Targeting Lipid Nanoparticles to the Blood Brain Barrier to Ameliorate Acute Ischemic Stroke (Zone 4, Science and Technology Hall, Level 2) -  Sep 21, 2023 - Abstract #AHA2023AHA_6834;    
    VCAM/IL-10 mRNA LNP also achieved a 100% survival rate (E) and elevated plasma levels of IL-10. In conclusion, VCAM-targeted lipid nanoparticles provide a novel platform for effectively concentrating drugs within the compromised BBB of the penumbra, thereby improving the outcomes of AIS.
  • ||||||||||  hydrocortisone / Generic mfg.
    Trial completion date, Trial primary completion date:  HYVAPRESS: HYdrocortisone and VAsopressin in Post-RESuscitation Syndrome (clinicaltrials.gov) -  Sep 21, 2023   
    P3,  N=380, Recruiting, 
    Trial primary completion date: Sep 2023 --> Dec 2023 Trial completion date: May 2023 --> Aug 2024 | Trial primary completion date: May 2023 --> Jul 2024
  • ||||||||||  Yonsa (abiraterone acetate) / Churchill Pharma, Sun Pharma, Erleada (apalutamide) / J&J
    Trial completion date, Trial primary completion date, Metastases:  Abiraterone Acetate, Prednisone, and Apalutamide in Treating Patients With Hormone-Naive Metastatic Prostate Cancer (clinicaltrials.gov) -  Sep 21, 2023   
    P2,  N=60, Active, not recruiting, 
    Trial completion date: May 2023 --> Aug 2024 | Trial primary completion date: May 2023 --> Jul 2024 Trial completion date: Oct 2023 --> Oct 2024 | Trial primary completion date: Oct 2023 --> Oct 2024
  • ||||||||||  budesonide / Generic mfg.
    Trial completion, Enrollment change, Trial primary completion date:  Acupuncture Therapy for COVID-Related Olfactory Loss (clinicaltrials.gov) -  Sep 21, 2023   
    P=N/A,  N=32, Completed, 
    Recruiting --> Completed Active, not recruiting --> Completed | N=100 --> 32 | Trial primary completion date: Aug 2023 --> Apr 2023