- |||||||||| dexamethasone / Generic mfg.
Observational data, Journal: Dexamethasone in adults with viral meningitis: an observational cohort study. (Pubmed Central) - Aug 26, 2024
In enteroviral meningitis, ?5 doses were associated with an increased risk of an unfavourable outcome. However, a sensitivity analysis indicated that the association was affected by unmeasured or residual confounding by severity.
- |||||||||| dexamethasone / Generic mfg.
Journal: Loss of BACH1 improves osteogenic differentiation in glucocorticoid-induced hBMSCs through restoring autophagy. (Pubmed Central) - Aug 26, 2024
However, a sensitivity analysis indicated that the association was affected by unmeasured or residual confounding by severity. Taken together, our results demonstrated that silencing of BACH1 mitigated Dex-triggered osteogenic differentiation inhibition by transcriptionally activating ATG7-mediated autophagy, suggesting that BACH1 may be a therapeutic target for GIOP treatment.
- |||||||||| triamcinolone acetonide / Generic mfg.
Trial completion date, Trial primary completion date: Short-Term Efficacy of Triamcinolone Acetonide (Aristocort (clinicaltrials.gov) - Aug 26, 2024
P4, N=20, Recruiting,
Taken together, our results demonstrated that silencing of BACH1 mitigated Dex-triggered osteogenic differentiation inhibition by transcriptionally activating ATG7-mediated autophagy, suggesting that BACH1 may be a therapeutic target for GIOP treatment. Trial completion date: May 2024 --> Nov 2024 | Trial primary completion date: Apr 2024 --> Oct 2024
- |||||||||| dexamethasone / Generic mfg., acetazolamide / Generic mfg., furosemide / Generic mfg.
Preclinical, Journal: Glucocorticoid-induced acute diuresis in rats in relation to the reduced renal expression of sodium-dependent cotransporter genes. (Pubmed Central) - Aug 24, 2024
Free water clearance values were negative after Dex or PSL treatment, similar to those observed after treatment with osmotic diuretics (furosemide and acetazolamide)...Dex did not affect renal expression of the natriuretic peptide receptor 1 (Npr1) gene, or the expression, localization, and phosphorylation of aquaporin-2 (AQP2), a water channel protein. These findings suggest that the acute diuretic effects of glucocorticoids might be mediated by reduced expression of sodium-dependent cotransporter genes.
- |||||||||| dexamethasone / Generic mfg.
Journal: Panaxadiol Saponin alleviates LPS-induced cardiomyopathy similar to dexamethasone via improving mitochondrial quality control. (Pubmed Central) - Aug 23, 2024
and fusion protein OPA1, Mfn1, Mfn2 expression, inhibit phosphorylation of mitochondrial fission protein Drp1, aiming to maintain normal structure and function of mitochondrial, thereby preserving oxidative phosphorylation capacity. In summary, our findings highlighted that the protective efficacy of PDS and DEX in maintaining mitochondrial in LPS-induced cardiomyopathy, and mechanism improving mitochondrial quality control at least in part by promoting Nrf2 activation.
- |||||||||| Jorveza (budesonide orodispersible tablets) / Dr Falk
Journal: Budesonide Orodispersible Tablet for the Treatment of Refractory Esophageal Lichen Planus. (Pubmed Central) - Aug 23, 2024
We describe a severe case of esophageal lichen planus and recurrent esophageal stricture that was refractory to acid suppression, local and systemic steroid formulations, and dilatation. We present the first reported use of budesonide orodispersible tablet for this condition, including the excellent clinical, endoscopic, and histopathological response.
- |||||||||| Enerzair Breezhaler (glycopyrrolate/indacaterol/mometasone) / Novartis
Journal: Digitally monitored inhaled therapy: A 'Smart' way to manage severe asthma? (Pubmed Central) - Aug 23, 2024
Consecutive consenting patients meeting criteria for biologics had their existing high-dose ICS/LABA//LAMA combination inhaler/s switched to mometasone/indacaterol/glycopyrronium (114/46/136)...Both groups demonstrated a significant reduction in ACQ6 score at follow-up (2.81 vs 1.92, p?<?0.001 and 3.05 vs 2.60, p?<?0.001, respectively), but there was no statistically significant difference in improvement between groups. Patients with optimal adherence also demonstrated a significant reduction in median FeNO at follow-up (47ppb vs 40ppb, p?=?0.003).In severe asthma patients, 'smart' inhalers may represent an effective management tool to improve adherence and asthma control, therefore avoiding the need for patients to commence biological therapies.
- |||||||||| hydrocortisone / Generic mfg.
Trial completion date, Trial primary completion date: Steroid, Thiamine and Ascorbic Acid for Comatose Out-of-hospital Cardiac Arrest Survivors (clinicaltrials.gov) - Aug 23, 2024
P2, N=160, Recruiting,
Patients with optimal adherence also demonstrated a significant reduction in median FeNO at follow-up (47ppb vs 40ppb, p?=?0.003).In severe asthma patients, 'smart' inhalers may represent an effective management tool to improve adherence and asthma control, therefore avoiding the need for patients to commence biological therapies. Trial completion date: Dec 2023 --> Nov 2025 | Trial primary completion date: Dec 2023 --> Nov 2024
- |||||||||| dexamethasone / Generic mfg., prednisone / Generic mfg.
Journal: Facial nerve palsy after ethylene vinyl alcohol arterial embolization of glomus tympanicum in a 57 (Pubmed Central) - Aug 22, 2024
There is a possible relationship between the choice of embolic agent and this complication. Though facial palsy is of sufficient rarity that no standard treatment pathway exists, due to the impact on a patient's quality of life, we recommend aggressive therapy to salvage nerve function.
- |||||||||| dexamethasone / Generic mfg.
Journal: A SIRT1-independent mechanism mediates protection against steroid-induced senescence by resveralogues in equine tenocytes. (Pubmed Central) - Aug 22, 2024
Exposure to clinically reflective levels of dexamethasone for 48 hours drove equine tenocytes into steroid induced senescence (SIS)...SIS also induced a distinctive equine senescence associated secretory phenotype (eSASP) characterised by enhanced secretion of IL-8 and MCP-1. Preincubation with resveratrol or the potent SIRT1 activator SRT1720 prevented SIS in equine tenocytes, while treatment with the non-SIRT1 activating resveratrol analogue V29 was equally protective against SIS, consistent with a novel, as yet uncharacterised SIRT1-indendent mechanism which has relevance for the development of future preventative and therapeutic strategies.
- |||||||||| dexamethasone injection / Generic mfg.
Preclinical, Journal: Exercise-activated hepatic autophagy combined with silymarin is associated with suppression of apoptosis in rats subjected to dexamethasone induced- fatty liver damage. (Pubmed Central) - Aug 22, 2024
Preincubation with resveratrol or the potent SIRT1 activator SRT1720 prevented SIS in equine tenocytes, while treatment with the non-SIRT1 activating resveratrol analogue V29 was equally protective against SIS, consistent with a novel, as yet uncharacterised SIRT1-indendent mechanism which has relevance for the development of future preventative and therapeutic strategies. Silymarin supplementation combined with interval or continuous training substantially improves DEX-induced hepatic steatosis and hepatocyte injury mostly through suppressing liver apoptosis and upregulating autophagy, which may provide a novel perspective for NAFLD treatment.
- |||||||||| dexamethasone / Generic mfg., levetiracetam / Generic mfg.
Journal, Metastases: Atypical Cutaneous Presentation and Diagnostic Challenges in Advanced Metastatic Testicular Cancer. (Pubmed Central) - Aug 22, 2024
The patient responded well to the treatment, showing significant improvement in neurological function and stabilization of his condition. This case underscores the diagnostic and therapeutic challenges of metastatic testicular cancer, particularly with rare presentations such as cutaneous involvement, and highlights the importance of comprehensive diagnostic evaluations and multidisciplinary care.
- |||||||||| hydrocortisone / Generic mfg.
Enrollment closed, Trial completion date, Trial primary completion date: Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty) (clinicaltrials.gov) - Aug 22, 2024
P4, N=132, Active, not recruiting,
Suspended --> Recruiting Recruiting --> Active, not recruiting | Trial completion date: May 2024 --> May 2025 | Trial primary completion date: May 2024 --> May 2025
- |||||||||| Activase (alteplase) / Roche, Boehringer Ingelheim, Kyowa Kirin, Mitsubishi Tanabe
Case series of acute porto mesenteric vessel thrombosis () - Aug 22, 2024 - Abstract #IDDF2024IDDF_431;
Injection Alteplase, injection. Acute portomesenteric vein thrombosis is manageable with conservative care, but acute mesenteric artery thrombosis has a very poor prognosis.
- |||||||||| cardiotoxin (CB-6) / Celtic Biotech
Journal: Down-regulation of TGF-?1 in Fibro-adipogenic Progenitors Initiates Muscle Ectopic Mineralization. (Pubmed Central) - Aug 21, 2024
In previous studies, we have demonstrated that stress response-induced high glucocorticoid levels could be the underlying cause of traumatic heterotopic ossification (HO), and we have developed a glucocorticoid-induced ectopic mineralization (EM) mouse model by systemic administration of a high dose of dexamethasone (DEX) to animals with muscle injury induced by cardiotoxin injection...On the contrary, therapeutics that enhanced TGF-?1 signaling in FAPs inhibited the inflammatory response and attenuated muscle EM. In summary, these results indicate that FAPs-derived TGF-?1 is a key molecule in regulating muscle inflammatory response and subsequent EM, and that glucocorticoids exert their effect via down-regulating TGF-?1 in FAPs.
- |||||||||| dexamethasone / Generic mfg.
Retrospective data, Journal, Metastases: A retrospective assessment of the effectiveness of pulsed radiofrequency ablation in the treatment of chronic pain caused by advanced knee osteoarthritis. (Pubmed Central) - Aug 21, 2024
A diagnostic blockade with total volume of 9 ml of 1% lidocaine (WZF, Poland) combined with 4 mg of dexamethasone with subsequent pRFA with a radio frequency of 300-500 kHz under ultrasound guidance was used during the procedure...The outcome of the treatment may be related to the patient's age (block duration increased with patient age) and sex (in women, the therapeutic effect was more effectively prolonged) in our study group. There was also higher effectiveness of pRFA in high-BMI patients, which was close to statistical significance ( P = 0.053).
- |||||||||| dexamethasone injection / Generic mfg.
Enrollment change, Trial withdrawal, Head-to-Head: Medical Versus Surgical Treatment for Peritonsillar Abscesses (clinicaltrials.gov) - Aug 21, 2024
P=N/A, N=0, Withdrawn,
Trial completion date: Oct 2027 --> Mar 2027 | Trial primary completion date: Apr 2026 --> Sep 2025 N=24 --> 0 | Not yet recruiting --> Withdrawn
- |||||||||| dexamethasone / Generic mfg.
Journal: Development of a drug delivering round window niche implant for cochlear pharmacotherapy. (Pubmed Central) - Aug 21, 2024
The accuracy and precision of printing, distribution of the sample ingredient dexamethasone (DEX), biocompatibility, bio-efficacy, implantability and drug release were tested in vitro...The GP-RNI containing 1% DEX was biocompatible, bio-effective and showed a two-phase and sustained DEX release in vitro, while it reduced fibrous tissue growth around the cochlear implant in vivo. We developed a GP-RNI that can be used for precise inner ear drug delivery in guinea pigs, providing a reliable platform for testing the RNI's safety and efficacy, with potential implications for future clinical translation.
- |||||||||| QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva
Journal: The rise of Soybean in international commodity markets: A quantile investigation. (Pubmed Central) - Aug 21, 2024
Our study leverages the connectedness or risk of spillover based on a Quantile Vector Autoregression (QVAR) model, allowing us to track connectedness over time through the examination of extreme quantiles...We observed a diminution in network complexity, manifested as a decline in network connectedness, in correlation with extreme quantiles. Policymakers can use this information to draft proactive measures, ensuring stability and sustainability in both domestic and international markets.
- |||||||||| dexamethasone / Generic mfg., lenalidomide / Generic mfg.
Trial primary completion date: Len/Dex/DLI in Relapsed Multiple Myeloma After Allogeneic Stem Cell Transplant (clinicaltrials.gov) - Aug 21, 2024
P2, N=10, Active, not recruiting,
Policymakers can use this information to draft proactive measures, ensuring stability and sustainability in both domestic and international markets. Trial primary completion date: Jan 2024 --> Jan 2026
- |||||||||| dexamethasone / Generic mfg.
Clinical, Retrospective data, Review, Journal: Efficacy of corticosteroids in patients with acute respiratory distress syndrome: a meta-analysis. (Pubmed Central) - Aug 21, 2024
Further subgroup analysis indicated that specific variables, such as low-dose (RR = 0.81; 95%CI: 0.67-0.98; p?=?0.034), methylprednisolone (RR = 0.70; 95%CI: 0.49-0.98; p?=?0.035), and dexamethasone (RR = 0.82; 95%CI: 0.69-0.98; p?=?0.029) were associated with mortality among patients receiving corticosteroids...Current data do not support routine use of corticosteroids in ARDS since protective effects were observed in RCTs but increased mortality was found in observational studies. More well designed and large clinical trials are needed to specify the favorable subgroups for corticosteroid therapy.
- |||||||||| dexamethasone injection / Generic mfg.
Trial completion date, Trial primary completion date: DEXA-SEPSIS: Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis (clinicaltrials.gov) - Aug 21, 2024
P1/2, N=102, Recruiting,
More well designed and large clinical trials are needed to specify the favorable subgroups for corticosteroid therapy. Trial completion date: Jun 2024 --> Dec 2024 | Trial primary completion date: Jun 2024 --> Dec 2024
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