Glucocorticoid Receptor 

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  • ||||||||||  Rituxan (rituximab) / Roche
    Burkitt's Lymphoma Responding to Rituximab-Cyclophosphamide-Vincristine-Dexamethasone-Lenalidomide: Time for a Paradigm Shift? (LEVEL 3, HALL B3) -  Aug 30, 2024 - Abstract #SOHO2024SOHO_772;    
    Due to his cardiac condition, the patient received anthracycline-free chemoimmunotherapy, developed at our hospital for elderly patients with DLBCL (rituximab 375 mg/ m 2, cyclophosphamide 750 mg/m2, vincristine capped at 1 mg, dexamethasone 40 mg IV daily for 4 days, lenalidomide 10 mg daily for 21 days; R2-COP). We will explore rituximab-COP with lenalidomide in elderly patients with BL and in patients ineligible for dose-intensive therapy, given that a non-intensive regimen has been proven of therapeutic value.
  • ||||||||||  dexamethasone / Generic mfg.
    Incidental Mixed Corticomedullar Tumor of the Adrenal Gland (Exhibit Hall, Cristal Ballroom) -  Aug 28, 2024 - Abstract #CAP2024CAP_576;    
    A dexamethasone suppression test was deferred because of the patient's chronic corticosteroid use...This case highlights the very rare entity of MCMT and demonstrates its varied clinical presentation, including incidental discovery with no overt symptoms. Given that most reported cases had steroidogenic symptoms, this may suggest a higher prevalence of asymptomatic MCMTs in the general populace.
  • ||||||||||  dexamethasone / Generic mfg.
    Fatal Pediatric Post-COVID Multi-Inflammatory Syndrome Presenting With Hypothermia (Exhibit Hall, Cristal Ballroom) -  Aug 28, 2024 - Abstract #CAP2024CAP_505;    
    She was treated with broad-spectrum antibiotics, fluids, and dexamethasone; however, she ultimately had a fatal cardiac arrest...Overall, the changes detected were indicative of a disseminated microthrombotic diathesis post-COVID that led to pneumonia and cardiac arrest. Cases of hypothermia in infection with SARS-CoV-2 have been only rarely reported in the medical literature, and it is critical to better understand their etiopathogenesis.
  • ||||||||||  Undisclosed YAP/TAZ-TEAD inhibitor / Hanmi
    Journal:  Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. (Pubmed Central) -  Aug 28, 2024   
    On the molecular level, activation of VGLL4 inhibited the PI3K-AKT pathway, and disrupting VGLL4 and TEAD interaction abolished this inhibition. In conclusion, our data suggest that VGLL4 suppresses CM maturational hypertrophy by inhibiting the YAP/TAZ-TEAD complex and its downstream activation of the PI3K-AKT pathway.
  • ||||||||||  dexamethasone / Generic mfg., indomethacin / Generic mfg., rosiglitazone / Generic mfg.
    Journal:  Optimized Adipogenic Differentiation and Delivery of Bovine Umbilical Cord Stem Cells for Cultivated Meat. (Pubmed Central) -  Aug 28, 2024   
    Consequently, the overall lipid production is higher when BUSCs are delivered via GelMA-MPs rather than encapsulation. This study not only systematically evaluated the impact of common adipogenic inducers on BUSCs, but also identified GelMA-MPs as a promising carrier for delivering bovine adipocytes for cultivated meat production.
  • ||||||||||  triamcinolone acetonide / Generic mfg.
    Journal:  Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids. (Pubmed Central) -  Aug 28, 2024   
    By examining the VSS scale in each of the groups, this scale decreased significantly in both groups after the intervention (P=0.001), which was greater in the group receiving triamcinolone (P=0.001). It seems that the injection of vitamin D at the site of the lesion helps to treat it, but the effectiveness of the usual triamcinolone treatment was still higher, it is suggested to use vitamin D as an adjunctive treatment in these patients.
  • ||||||||||  dexamethasone / Generic mfg.
    Preclinical, Journal:  Impact of Photobiomodulation and Melatonin on Periodontal Healing of Periodontitis in Immunosuppressed Rats. (Pubmed Central) -  Aug 28, 2024   
    Subcutaneous administration of dexamethasone was performed in the immunosuppressant groups for immunosuppression...The combined application of melatonin and PBM resulted in a best histological response presented by lower inflammatory response and better periodontal healing, when compared with all other treated groups (P<0.001). After considering the circumstances of this research, the combination of melatonin and PBM by a 650 nm diode laser with output power of 100 mw for one minute for three sessions appeared to be a beneficial adjunct in periodontal healing in immunosuppressed rats with periodontitis.
  • ||||||||||  desoximetasone cream/gel/ointment / Generic mfg.
    Review, Journal:  Familial Reactive Perforating Collagenosis with Adolescence-Onset: A Rare Case Report and Literature Review. (Pubmed Central) -  Aug 28, 2024   
    Unlike the majority of FRPC patients who had their disease onsets during infancy or early childhood, FRPC skin manifestations in our patient started during the adolescence period. The resolution of skin manifestations after daily application of topical desoximetasone suggests that topical corticosteroids are a potential treatment option for FRPC patients.
  • ||||||||||  dexamethasone / Generic mfg.
    HYPEREOSINOPHILIC SYNDROME WITH TRANSUDATIVE BILATERAL PLEURAL EFFUSION () -  Aug 27, 2024 - Abstract #MTS2024MTS_286;    
    HES is a rare myeloproliferative disorder with hypereosinophilia (>1500cell/mm3) and evidence of at least 1 organ dysfunction. HES responded well with steroid and close follow up is essential as unusual evolution to malignancy is common in persistent hypereosinophilia.
  • ||||||||||  Rybrevant (amivantamab-vmjw) / J&J, Lazcluze (lazertinib) / J&J
    INTERSTITIAL PNEUMONITIS IN NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH LAZERTINIB, AMIVANTAMAB AND MINOCYCLINE () -  Aug 27, 2024 - Abstract #MTS2024MTS_281;    
    He received intravenous methylprednisolone and broad-spectrum antibiotics but passed away on day 6 of hospitalization due to severe pneumonia with unresolved fast atrial fibrillation...In the MARIPOSA study, the incidence of pneumonitis did not differ between the Lazertinib- Amivantamab group and the Osimertinib group...It remains unknown at this point as to whether minocycline use alone and/or a 3-drug combination is responsible for severe pneumonitis in our patients. Further observation and studies are eagerly needed to ensure a better clinical outcome.
  • ||||||||||  budesonide/formoterol / Generic mfg.
    A RARE CAUSE OF CHEST PAIN: SPONTANEOUS PNEUMOMEDIASTINUM () -  Aug 27, 2024 - Abstract #MTS2024MTS_255;    
    It is potentially life-threatening, fortunately most cases are managed conservatively. Although it is rare incidence, it should be an important differential diagnosis must be excluded among young adults with chest pain and dyspnea.
  • ||||||||||  dexamethasone / Generic mfg.
    RARE PRESENTATION OF SVC OBSTRUCTION AND AIRWAY INVOLVEMENT IN MALIGNANT MESOTHELIOMA AT YOUNG AGE () -  Aug 27, 2024 - Abstract #MTS2024MTS_240;    
    His symptoms were slightly improved with dexamethasone...This young patient presented with superior vena cava obstruction as the initial symptom, which is exceptionally rare. This underscores the importance of good clinical judgement, as malignant mesothelioma has a slow progression but is highly aggressive, with a high mortality rate and less than 12 months of survival time.
  • ||||||||||  Ultibro (glycopyrronium/indacaterol) / Novartis
    18 ADMISSIONS WEREN () -  Aug 27, 2024 - Abstract #MTS2024MTS_233;    
    Despite comprehensive treatment with Ultibro Breezehaler and Fluticasone, his symptoms remained uncontrolled. This case report underscores the challenges involved in diagnosing and managing ACOS, particularly in the context of a patient with a history of COPD and persistent peripheral blood eosinophilia which emphasises the need for heightened clinical awareness and a deep understanding of ACOS to provide optimal care for patients with overlapping respiratory disorders.
  • ||||||||||  triamcinolone acetonide / Generic mfg., prednisolone / Generic mfg., prednisone / Generic mfg.
    Journal:  Suprachoroidal Triamcinolone Injection in Posterior Scleritis: A Case Report. (Pubmed Central) -  Aug 27, 2024   
    Suprachoroidal triamcinolone acetonide (SCS-TA) injections were recently approved to treat macular edema secondary to noninfectious uveitis...She was previously prescribed topical prednisolone and oral prednisone with minimal improvement...Via its novel delivery method, SCS-TA may be an effective treatment for posterior scleritis. Further studies are needed to establish long-term efficacy and safety of this treatment modality.
  • ||||||||||  prednisolone / Generic mfg., valacyclovir / Generic mfg.
    Journal:  Focal Posterior Herpetic Retinitis. (Pubmed Central) -  Aug 27, 2024   
    A vitreous tap confirmed a positive result for HSV-1, and the patient was prescribed oral valacyclovir 3?g. This treatment led to a resolution of the retinitis and a restoration of the patient's vision to 20/25.
  • ||||||||||  Journal:  Maternal puerperal infection caused by Parabacteroides goldsteinii: a case report. (Pubmed Central) -  Aug 26, 2024   
    We administered broad-spectrum antibiotics, including meropenem/nalidixic acid and piperacillin tazobactam, intravenously, but the antimicrobial effect was not satisfactory...Subsequently, uterine curettage was performed, followed by uterine cavity irrigation with metronidazole and intramuscular injection of gentamicin and dexamethasone...Parabacteroides goldsteinii bacteraemia is extremely rare, and clinically, the postinfection toxicity of this bacterium appears to be significant. In this report, we review the research history of P. goldsteinii and relevant infection cases, aiming to enhance awareness among clinical practitioners, particularly obstetricians and gynecologists, regarding P. goldsteinii bloodstream infections, facilitating early diagnosis and timely treatment.
  • ||||||||||  dexamethasone / Generic mfg.
    Journal, Immunomodulating:  Deciphering 3D periodontal fibroblast-macrophage crosstalk in bioactive nanoparticle-guided immunomodulation for treating traumatic dental avulsion. (Pubmed Central) -  Aug 26, 2024   
    The objective of the study was to investigate the impact of an engineered chitosan nanoparticles (CSNP), photosensitizer Rose Bengal (RB) functionalized CSNP (CSRB) and sustained dexamethasone (CSDEX) releasing CSNP for application in management of delayed replantation of avulsed teeth...CSDEX demonstrated higher anti-inflammatory activity by downregulating TNF?, while CSNP upregulated TGF?1, periostin, and downregulated MMP9. The combination of matrix stabilization with CSRB with periostin upregulation and sustained releasing CSDEX showed potential for hampering root resorption and ankylosis in dental avulsion.
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Journal:  The Efficacy of Thumb Spica Casting With or Without Corticosteroid Injection for De Quervain's Tenosynovitis. (Pubmed Central) -  Aug 26, 2024   
    Conclusions This study supports the superiority of thumb spica casting along with local corticosteroid injection over casting alone for treating De Quervain's tenosynovitis. The combined approach led to significantly better pain relief and functional outcomes, highlighting its effectiveness as a treatment option despite the positive outcomes observed with casting alone.
  • ||||||||||  methylprednisolone oral / Generic mfg.
    Journal:  Molecular Structural Characteristics and 3D Model Reconstruction of Organic Matter in Longmaxi Formation Shale. (Pubmed Central) -  Aug 26, 2024   
    The C skeleton types were 93 protonated arylons, 39 bridged arylons, 6 carboxylons, 5 alkyl-substituted carbons, 2 oxygen-substituted carbons, 4 methylene carbons, and 3 methylons...Finally, the adsorption results showed that the experimental adsorption of CO2 adsorption was less than the simulated adsorption, completing the validation of the model. The above study provides a method for determining the molecular structure of kerogen in the Longmaxi Formation shale, which can guide the study of the pore structure characteristics of the Longmaxi Formation shale.
  • ||||||||||  dexamethasone / Generic mfg., midodrine hydrochloride / Generic mfg.
    Journal:  Severe hypotension requiring resuscitation in tumour-related carotid sinus syndrome: a case report. (Pubmed Central) -  Aug 26, 2024   
    As a result, the patient was started on neoadjuvant chemotherapy and midodrine, after which she experienced multiple complications and died. To the best of our knowledge, this is the first case report that shows an IHCA due to severe hypotension related to a carotid sinus syndrome.