Adrenergic Receptor 

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  • ||||||||||  dobutamine / Generic mfg.
    Review, Journal:  Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment. (Pubmed Central) -  Jun 13, 2024   
    Modifiable risk factors for psychiatric impairment post-sepsis include the number of experienced traumatic memories, the length of ICU stay, level of albumin, the use of vasopressors or inotropes, daily activity function after sepsis, and the cumulative dose of dobutamine...Nevertheless, non-pharmacological approaches, such as comprehensive nursing care, may provide a promising avenue for treating psychiatric disorder following sepsis. In addition, although several therapeutic drugs have shown preliminary efficacy in animal models, further confirmation of their potential is required through follow-up clinical studies.
  • ||||||||||  Journal:  The Incorporated Drug Affects the Properties of Hydrophilic Nanofibers. (Pubmed Central) -  Jun 13, 2024   
    This study emphasizes the importance of considering specific drug properties, such as solubility, hydrophilicity, and compatibility with the solvent used for electrospinning, when designing hydrophilic nanofibers for drug delivery. Such considerations are crucial for optimizing the properties of the drug delivery system, which is essential for achieving therapeutic efficacy and safety.
  • ||||||||||  Review, Journal:  Emerging trends in antipsychotic and antidepressant drug development: Targeting nonmonoamine receptors and innovative mechanisms. (Pubmed Central) -  Jun 13, 2024   
    Additionally, TAK-653 (NBI-1065845) and MJI821 (Onfasprodil) have emerged as potential antidepressants targeting AMPA receptors and NMDA receptor 2B (NR2B) negative allosteric modulation, respectively...By focusing on nonmonoamine receptors and introducing innovative mechanisms, these drugs offer a promising prospect of improved outcomes for individuals suffering from schizophrenia and MDD. Thus, sustained attention and dedication to the development of such drugs are essential to augmenting the therapeutic options available for psychiatric patients.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  A novel copper ion enhanced electrochemical DNA biosensor for the determination of epinephrine. (Pubmed Central) -  Jun 13, 2024   
    These findings indicated excellent electrocatalytic activity of the modified electrode towards oxidation of EP. The developed biosensor successfully detected EP in spiked mouse serum as well as epinephrine hydrochloride injection with high selectivity, sensitivity, stability, and accuracy.
  • ||||||||||  aripiprazole / Generic mfg.
    Review, Journal:  Aripiprazole for treating delirium: A systematic review-Is it a valid yet understudied treatment? (Pubmed Central) -  Jun 13, 2024   
    Considering the limited data currently available, we can assert that aripiprazole is at least as efficient as haloperidol, the true point is that it has a far better tolerability and safety profile. Nonetheless, further studies are necessary to provide more compelling data, together with a more precise indication regarding minimum efficient dose, as the main limitations of our review are the very small sample size, the small percentage of subjects with preexisting dementia, and the fact that most studies used scales with low specificity for the examined condition.
  • ||||||||||  modafinil / Generic mfg.
    Journal:  Expanding the Use of Benzothioxanthene Imides to Photochemistry: Eco-Friendly Aerobic Oxidation of Sulfides to Sulfoxides. (Pubmed Central) -  Jun 13, 2024   
    In this context, we report herein a sustainable, aerobic and environmentally friendly photochemical protocol based on the use of a benzothioxathene imide as the photocatalyst to selectively oxidise sulfides under mild irradiation (456 nm), in very low catalyst loading (0.01 mol%) and on water. In addition, to demonstrate the compatibility of our protocol with wide scope of substrates, the latter was successfully applied to the synthesis of the biologically-active Sulforaphane and Modafinil.
  • ||||||||||  atomoxetine / Generic mfg.
    Review, Journal:  Norepinephrine Reuptake Inhibition, an Emergent Treatment for Neurogenic Orthostatic Hypotension. (Pubmed Central) -  Jun 12, 2024   
    Previous studies found that patients with neurogenic orthostatic hypotension can improve standing blood pressure and reduce symptoms of neurogenic orthostatic hypotension after a single administration of the selective NRI atomoxetine...The long-term efficacy of NRIs for the treatment of neurogenic orthostatic hypotension-related symptoms is currently under investigation. In summary, an in-depth understanding of the pathophysiology of neurogenic orthostatic hypotension resulted in the discovery of a new therapeutic pathway targeted by NRI.
  • ||||||||||  dexamethasone / Generic mfg., epinephrine / Generic mfg.
    Journal:  Laryngeal Foreign Body Aspiration in Infancy: A Diagnostic Challenge. (Pubmed Central) -  Jun 12, 2024   
    More research on brexpiprazole is needed to delineate its relative role in the management of adolescent schizophrenia. He was suspected of having croup and treated with dexamethasone and racemic nebulized epinephrine, which led to temporary clinical improvement.
  • ||||||||||  terazosin / Generic mfg., diltiazem / Generic mfg., captopril / Generic mfg.
    Journal:  Report on three cases of familial primary aldosteronism type IV. (Pubmed Central) -  Jun 11, 2024   
    As the three patients were blood-related immediate family members, gene screening was performed, diagnosing them with FH-IV. This article reports the clinical characteristics of the three cases in combination with related literature to improve the understanding of FH-IV.
  • ||||||||||  propafenone / Generic mfg., flecainide / Generic mfg., propranolol / Generic mfg.
    Journal:  Clinical characteristics and follow-up of complex arrhythmias associated with RYR2 gene mutations in children. (Pubmed Central) -  Jun 11, 2024   
    If arrhythmias persisted, flecainide or propafenone was added as adjunctive therapy...Complex arrhythmias associated with RYR2 gene mutations in children can present with various clinical manifestations. Atrial arrhythmias combined with sinoatrial node dysfunction are commonly observed in younger children, and the combination of pharmacological therapy and cardiac pacemaker treatment yields favourable treatment outcomes.
  • ||||||||||  methamphetamine / Generic mfg.
    Review, Journal:  Understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health. (Pubmed Central) -  Jun 10, 2024   
    Methiopropamine or 1-(thiophen-2-yl)-2-methylaminopropane (MPA) is a thiophene ring-based structural analogue of methamphetamine, first synthesized in 1942 but become popular when it started to be available for purchase on websites selling 'legal highs' since 2010...Additionally, it discusses the drug's effects on the central nervous system, its potential for addiction, and its adverse physical and mental health effects. Improving the understanding of safety aspects of MPA and how it imposes health threats for public health will guide the development of therapeutic approach of its intoxication and guide the authorities in deciding its legal status.
  • ||||||||||  naltrexone / Generic mfg., bupropion / Generic mfg., methamphetamine / Generic mfg.
    Journal:  Extended observation of reduced methamphetamine use with combined naltrexone plus bupropion in the ADAPT-2 trial. (Pubmed Central) -  Jun 10, 2024   
    This study also indicates that psychosocial stress might be a risk factor which weakens the efficacy of anti-angiogenic therapy. For people with methamphetamine (MA) use disorder receiving treatment with extended-release injectable naltrexone plus extended-release oral bupropion (NTX?+?BUPN), continued treatment with NTX + BUPN after 6
  • ||||||||||  Lonasen tape (blonanserin transdermal patch) / Nitto Denko, Sumitomo Pharma
    Review, Journal, Metastases:  Novel therapies for nausea and vomiting in advanced illness and supportive cancer care. (Pubmed Central) -  Jun 10, 2024   
    Isopropyl alcohol aromatherapy has been successfully used in the emergency department for nausea and vomiting with an onset to benefit more rapidly than standard antiemetics. Isopropyl alcohol prep pads can be used for home-going antiemetic therapy and as a bridge to treating acute nausea until standard antiemetics take effect.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Sialic Acid-Functionalized Gold Nanoparticles for Sensitive and Selective Colorimetric Determination of Serotonin. (Pubmed Central) -  Jun 10, 2024   
    The proposed method effectively eliminates interventions from potential interfering species such as dopamine, epinephrine, l-tyrosine, glucosamine, galactose, mannose, and oxalic acid...The possible use of the proposed method in biological sample analysis was evaluated by employing a serotonin recovery assay in processed human plasma. The recoveries ranged from 90.5 to 104.2%, showing promising potential for clinical applications.
  • ||||||||||  clobazam / Generic mfg., quetiapine / Generic mfg.
    Journal, Adverse events:  Central Pontine Myelinolysis: A Rare and Life-Threatening Adverse Effect of Clobazam and Quetiapine. (Pubmed Central) -  Jun 10, 2024   
    Despite normal serum sodium levels, discontinuation of clobazam and quetiapine, medications taken by the patient, led to clinical improvement. This case underscores the importance of considering medication-induced CPM in the differential diagnosis of patients presenting with neurological symptoms, even in the absence of electrolyte abnormalities.
  • ||||||||||  propranolol / Generic mfg.
    Trial completion date, Trial primary completion date, Checkpoint inhibition, IO biomarker:  Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma (clinicaltrials.gov) -  Jun 9, 2024   
    P2,  N=24, Recruiting, 
    Thus, our results provide a novel model for BD in outbred rats and suggest that female binging is more sensitive to adrenergic modulation than males, perhaps providing a novel sex-related therapy. Trial completion date: Jan 2025 --> Jan 2027 | Trial primary completion date: Jan 2024 --> Jan 2026
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Model compounds for evaluating the reactivity of amphetamine-type stimulants. (Pubmed Central) -  Jun 9, 2024   
    Herein, two model compounds resembling norephedrine and ephedrine were selected based on their (i) structural similarity (i.e., presence of key functional groups) and (ii) availability from multiple suppliers without restriction. Model compounds 2-amino-1-phenylethanol and 2-(methylamino)-1-phenylethanol (halostachine), were compared to norephedrine and pseudoephedrine by firstly subjecting them to transformations known in the synthesis of amphetamines, and secondly, comparing the compounds using colourimetric spot tests, FTIR and NMR.
  • ||||||||||  Journal:  Determination of 13 potential anti-obesity agents in hair by dispersive liquid-liquid microextraction-assisted UHPLC-MS/MS. (Pubmed Central) -  Jun 9, 2024   
    The validated method was successfully applied to 369 real cases and detected six analytes, including bambuterol, salbutamol, terbutaline, sibutramine, desmethyl sibutramine, and N,N-didesmethyl sibutramine. This method offers several advantages, including simple pretreatment, high extraction efficiency, rapid extraction, solvent economy, and pollution mitigation, making it highly suitable for large-scale surveillance of usage of added anti-obesity agents.
  • ||||||||||  dextroamphetamine immediate release / Generic mfg., haloperidol / Generic mfg.
    Review, Journal:  Behaviorally conditioned effects of psychoactive drugs in experimental animals: What we have learned from nearly a century of research and what remains to be learned. (Pubmed Central) -  Jun 9, 2024   
    In each section, the drug under discussion is briefly introduced, followed by a detailed examination of conditioning features, including doses and dosing regimens, characteristics of the conditioning process such as test environments or specific conditioned stimuli, testing and conditioned response characteristics, possible extinction or reconditioning or reversal training, neural mechanisms, and finally, the potential clinical relevance of the research area related to the drug. We focus on key outcomes, delve into methodical issues, identify gaps in current knowledge, and suggest future research directions.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Methamphetamine effects in zebrafish (Danio rerio) depend on behavioral endpoint, dose and test session duration. (Pubmed Central) -  Jun 9, 2024   
    The results also suggest that anxiety-like responses associated with various procedural aspects (netting, isolation, novel test apparatus) likely interfere with the ability to observe many behavioral effects of methamphetamine in zebrafish. Based on the current results, habituation to testing procedures to reduce anxiety-like behaviors is recommended in determining the effects of methamphetamine in zebrafish.
  • ||||||||||  methamphetamine / Generic mfg.
    Review, Journal:  Overview of Methamphetamine-Associated Pulmonary Arterial Hypertension. (Pubmed Central) -  Jun 9, 2024   
    This review consolidates our understanding of MA-PAH, pinpointing knowledge gaps for future studies. Addressing these gaps is crucial for advancing diagnostic accuracy, unraveling mechanisms, and optimizing treatment for MA-PAH, thereby addressing the evolving landscape of this complex health concern.
  • ||||||||||  prazosin / Generic mfg.
    Journal:  Prazosin Potentiates Mast Cell-Stabilizing Property of Adrenaline. (Pubmed Central) -  Jun 9, 2024   
    This study provided electrophysiological evidence for the first time that adrenaline dose-dependently inhibited the process of exocytosis, confirming its usefulness as a potent mast cell-stabilizer. The pharmacological blockade of ?1-adrenergic receptor by prazosin synergistically potentiated such mast cell-stabilizing property of adrenaline, which is primarily mediated by ?2-adrenergic receptors.