- |||||||||| propranolol / Generic mfg.
Review, Journal: A Case of Superficial Kaposiform Hemangioendothelioma Treated with Oral Propranolol Combined with Topical Sirolimus. (Pubmed Central) - Jun 17, 2024 Kaposiform hemangioendothelioma(KHE) without Kasabach-Merritt phenomenon is a rare tumor primarily observed in pediatric patients; however, its documentation in the literature remains limited. We reported about a 1-year-old boy diagnosed with superficial KHE who received oral propranolol in combination with topical sirolimus and reviewed relevant reports and treatment of superficial KHE.
- |||||||||| Silverzine Tulle (Silver Sulfadiazine) / MinaPharm
Retrospective data, Review, Journal: The effect of various interventions on the prevention of radiation dermatitis: a network meta-analysis. (Pubmed Central) - Jun 17, 2024 The study reveals that Hyaluronan_cream and OOCH are two promising treatments for the prevention of RD in patients undergoing radiotherapy. Future research might focus on validating the efficacy of these two therapies with large sample sizes and on identifying an optimal intervention strategy.
- |||||||||| epinephrine / Generic mfg.
Review, Journal: Laryngotracheitis and Coronavirus Disease 2019 (COVID-19) in a Three-Year-Old Child: A Case Report and Literature Review. (Pubmed Central) - Jun 17, 2024 Unlike typical croup cases, the patient required hospitalization and multiple administrations of racemic epinephrine for respiratory distress...This distinction is crucial as such cases may necessitate more intensive medical intervention and prolonged monitoring compared to standard croup treatment protocols. The patient reported here did not require intensive care admission or respiratory support.
- |||||||||| Mekinist (trametinib) / Novartis, BeiGene, Cotellic (cobimetinib) / Exelixis, Roche
Journal: MEK Inhibitor-Associated Ocular Hypertension. (Pubmed Central) - Jun 17, 2024 All 3 patients' IOP returned to normal following dorzolamide/timolol administration and continued their cancer therapy...All 3 patients had a satisfactory response to topical pressure-lowering drops while continuing their life-preserving MEK inhibitor drug dose, indicating that discontinuation of therapy may not be necessary. Due to the increasing use of MEK inhibitors, it is important that ophthalmologists familiarize themselves with the broad range of potential adverse ocular effects of MEK inhibitors.
- |||||||||| Bystolic (nebivolol) / Menarini, AbbVie
Journal: Physicians' attitudes toward beta-blockers for the treatment of hypertension in Italy, Poland, and Turkey. (Pubmed Central) - Jun 17, 2024 In all three countries, nebivolol is the only ?-blocker among the ones analyzed which is consistently prescribed to 20% or more of patients and is overall the most prescribed one for the population with comorbid diabetes. In terms of specific ?-blockers' features, this study revealed knowledge gaps that underline the need for educational activities focused on the differences among ?-blockers, which are important in choosing the most suitable agent for individualized antihypertensive therapy.
- |||||||||| primidone / Generic mfg., propranolol / Generic mfg.
Review, Journal: Essential Tremor: Update of Therapeutic Strategies. (Pubmed Central) - Jun 16, 2024 In cases with severe tremor we will consider a surgical option, the method of choice being thalamotomy using high-intensity focused ultrasound. In the future we must continue to study the pathophysiology of TE, develop drugs specifically designed for TE and improve the technology of available invasive techniques.
- |||||||||| Myrbetriq (mirabegron) / Astellas
Journal, PD(L)-1 Biomarker, IO biomarker: Brown adipose tissue activation in humans increases plasma levels of lipid mediators. (Pubmed Central) - Jun 16, 2024 LB interscalene brachial plexus block before total shoulder arthroplasty did not reduce 120-hour postoperative opioid consumption but significantly reduced postoperative pain between 24 and 96 hours and at postoperative day These results indicate that selected lipid mediators may serve as biomarkers of BAT activation.
- |||||||||| lithium carbonate ER / Generic mfg.
Biomarker, Review, Journal: Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review. (Pubmed Central) - Jun 16, 2024 These results indicate that selected lipid mediators may serve as biomarkers of BAT activation. Inflammation in BD requires further investigation to understand the underlying immunologic mechanism, to identify predictors of treatment response, and to make informed decisions about the use and development of more effective pharmacological interventions for BD.
- |||||||||| methamphetamine / Generic mfg.
Journal: Enhanced brain-targeting and efficacy of cannabidiol via RVG-Exo/CBD nanodelivery system. (Pubmed Central) - Jun 16, 2024 The efficacy of this delivery system was assessed using a behavioral sensitization model in mice, where RVG-Exo/CBD notably suppressed methamphetamine-induced hyperactivity more effectively than CBD alone, indicating a reduction in effective dose and enhanced bioavailability. Overall, the RVG-Exo/CBD system emerges as a promising strategy for enhancing the therapeutic efficacy and safety of CBD, particularly for neurological applications, highlighting its potential for addressing the limitations associated with traditional CBD administration in clinical settings.
- |||||||||| epinephrine / Generic mfg.
Journal, Metabolomic study: Targeted metabolomics revealed the seasonal plasticity of skin color and pigment metabolites in ornamental koi carp. (Pubmed Central) - Jun 16, 2024 A correlation analysis suggested that the seasonal changes in white skin color occurred through the epinephrine-cAMP pathway; melanin-dependent and carotenoid-dependent skin color changes occurred through melatonin in koi carp. This study demonstrated the seasonal plasticity of skin color in koi carp regulated by melatonin and epinephrine, associating with variety and color specificity.
- |||||||||| asenapine / Generic mfg., iloperidone / Generic mfg., lurasidone / Generic mfg.
Preclinical, Journal: The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver. (Pubmed Central) - Jun 15, 2024 The changes in the expression of AhR, CAR, and PXR mostly correlate with alterations in the expression and activity of respective CYP enzymes found in our previous studies. Since these transcription factors are also engaged in the expression of phase II drug metabolism and drug transporters, changes in their expression may affect the metabolism of endogenous substrates and pharmacokinetics of concomitantly used drugs.
- |||||||||| Braftovi (encorafenib) / Ono Pharma, Pierre Fabre, Pfizer, Mektovi (binimetinib) / Ono Pharma, Pierre Fabre, Pfizer
PK/PD data, Journal, Metastases: Evaluation of the effect of modafinil on the pharmacokinetics of encorafenib and binimetinib in patients with BRAF V600-mutant advanced solid tumors. (Pubmed Central) - Jun 15, 2024 P1 Common DDIs involved anticoagulants, cardiovascular and antimicrobial drugs, which should be targeted for medicine optimisation. The results from this clinical study indicate modafinil 400
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Journal: A multi-analyte assay of opioids in API and drug products using HPLC and HRMS. (Pubmed Central) - Jun 15, 2024 For all samples tested in the study, their identities were confirmed, and assays met specifications. Overall, there was no evidence of illegal substitution or adulteration in any of the ingredients and products tested from the legitimate commercial marketed US supply chain.
- |||||||||| methamphetamine / Generic mfg.
Review, Journal: Transcranial magnetic stimulation for methamphetamine use disorder: A scoping review within the neurocircuitry model of addiction. (Pubmed Central) - Jun 15, 2024 We propose the use of the Koob and Volkow's neurocircuitry model of addiction as a frame to explain the brain effects of TMS in patients with MUD. We will finally discuss new venues that could lead to a more individualized and effective treatment of this complex disorder including the use of neuroimaging, the exploration of different areas of the brain such as the frontopolar cortex or the salience network and the use of biomarkers.
- |||||||||| Journal: Synthesis and Biological Evaluation of Novel MB327 Analogs as Resensitizers for Desensitized Nicotinic Acetylcholine Receptors after Intoxication with Nerve Agents. (Pubmed Central) - Jun 15, 2024
By means of in silico studies based on our recently presented allosteric binding pocket at the nAChR, i.e. the MB327-PAM-1 binding site, three promising MB327 analogs with a 4-aminopyridinium ion partial structure (PTM0056, PTM0062, and PTM0063) were identified...More potent compounds were identified compared to MB327, as some of them showed a higher affinity towards MB327-PAM-1 and also a higher recovery of neuromuscular transmission at lower compound concentrations. To improve the treatment of organophosphate poisoning, direct targeting of nAChRs with appropriate compounds is a key step, and this study is an important contribution to this research.
- |||||||||| dobutamine / Generic mfg.
Observational data, Retrospective data, Journal: Isoproterenol Improves Hemodynamics And Right Ventricle-Pulmonary Artery Coupling After Heart Transplantation. (Pubmed Central) - Jun 15, 2024 To improve the treatment of organophosphate poisoning, direct targeting of nAChRs with appropriate compounds is a key step, and this study is an important contribution to this research. In post-HT RVF, isoproterenol exhibits chronotropic and inotropic effects, thereby improving RV-PA coupling and resulting in a clinically relevant increase in the cardiac index.
- |||||||||| methamphetamine / Generic mfg.
Journal: Toxicology findings from drivers suspected of drug-impaired driving in Ontario (2008-2019). (Pubmed Central) - Jun 14, 2024 Over the 12-year period of this study, cannabis was the most frequently detected substance in drivers (52.8% of cases), followed by cocaine (44.3%) and methamphetamine (24.8%)...Examining the characteristics of suspected drug-impaired drivers, the temporal circumstances, and the drug findings throughout the large geographic area of Ontario and over the extended period of this study enhances our understanding of drug-impaired driving behavior. These characteristics can assist in the development and/or evaluation of enforcement strategies and enhanced countermeasure activities.
- |||||||||| tamsulosin / Generic mfg., tadalafil / Generic mfg.
Retrospective data, Review, Journal: Pooled-analysis of tadalafil and tamsulosin for ureteral calculi. (Pubmed Central) - Jun 14, 2024 Collectively, this study demonstrates the potential of the scalable fabrication strategy and the resultant BM/BX SDNs for improving glaucoma management through eyedrops. But patients receiving 5
- |||||||||| imipramine / Generic mfg., mirtazapine / Generic mfg., escitalopram / Generic mfg.
Observational data, Journal: Antidepressant prescription patterns and polypharmacy in outpatient psychiatry: a cross-sectional study. (Pubmed Central) - Jun 14, 2024 Selective serotonin reuptake inhibitors were the most commonly prescribed antidepressants, monotherapy, and combination therapy. A substantial amount of patients received concomitant administration of antidepressants or psychotropic drugs, warranting careful monitoring.
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