- |||||||||| atomoxetine / Generic mfg.
Effect of catecholaminergic neuromodulation on slow brain travelling waves (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_2113;
Our results suggest that neuromodulatory tone affects travelling wave propagation, and that this arousal-modulated propagation shapes integrated functional connectivity features, highlighting specific effects of prolonged and transient neuromodulatory influences on slow brain dynamics. Novel Imaging Acquisition BOLD fMRI 1 Physiology, Metabolism and Neurotransmission: Pharmacology and Neurotransmission 2
- |||||||||| methamphetamine / Generic mfg.
Brain mGlu5 receptor linked to self-reported impulsivity (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_2012;
The mGlu5 may be a useful therapeutic target for neuropsychiatric disorders associated with deficits in impulse control. Higher Cognitive Functions: Executive Function, Cognitive Control and Decision Making 2 Neuroanatomy, Physiology, Metabolism and Neurotransmission: Transmitter Receptors 1
- |||||||||| methamphetamine / Generic mfg.
Prediction of Persistent Drug-seeking Behavior by Brain-Wide Network (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_846;
Our preliminary results indicate that while many previously identified regions contained information regarding drug-seeking behavior, individual behavior across longitudinal timescales was only successfully decoded at the network level. Our findings suggest that for brain
- |||||||||| methamphetamine / Generic mfg.
Inhibitory Control Brain Patterns in Depression vs. Psychostimulant Users: A Meta-Analysis (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_837;
The results revealed disorder-specific hypoactivation in the MCG in MDD and bilateral IPL in PUD, as well as common neurofunctional alterations in the right IFG/MFG which is engaged in top-down cognitive control. These findings provide new insights into the neurobiology of IC in MDD and PUD and may have implications for differential diagnosis and treatment.
- |||||||||| methamphetamine / Generic mfg.
The impact of methamphetamine dependence on reward learning: neural mechanisms and the potential of (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_482;
The results indicate that the impairment in reward learning associated with MA dependency is reflected in the compulsive behaviors exhibited by severely addicted individuals under positive conditions. Enhanced theta band activity in the prefrontal cortex serves as the neural basis for these behaviors, and theta-gamma coupled tACS has the potential to ameliorate these characteristic impairments.
- |||||||||| methamphetamine / Generic mfg.
Intervention on Cue Reactivity in Methamphetamine Addicts Using Closed-Loop tACS (Exhibition Hall 1) - Jun 30, 2025 - Abstract #OHBM2025OHBM_478;
Results indicate that MA addicts exhibit abnormal neural responses to drug cues, characterized by increased theta band activity in the parieto-occipital region. Closed-loop tACS effectively reduces cue reactivity in MA addicts while improving inhibitory control.
- |||||||||| modafinil / Generic mfg.
The neuroreceptors and transporters underlying spontaneous brain activity (Room: Great Hall (Mezzanine Level) Doors 6, 7 & 8) - Jun 30, 2025 - Abstract #OHBM2025OHBM_343;
This neuroreceptor-based framework provides is non-invasive approach to understanding neuromodulatory mechanisms across brain states and conditions, advancing insights into cognition and behavior. Disorders of the Nervous System: Psychiatric (eg. Depression, Anxiety, Schizophrenia) Modeling and Analysis fMRI Connectivity and Network Modeling 1 PET Modeling and Analysis Neuroanatomy, Physiology, Metabolism and Neurotransmission: Transmitter Receptors 2 Physiology, Metabolism and Neurotransmission: Pharmacology and Neurotransmission
- |||||||||| methylphenidate tablet / Generic mfg., modafinil / Generic mfg.
How brain network architecture, disease, and neurotransmitter systems control transitions between cognitive states (Room: M2 (Mezzanine Level)) - Jun 30, 2025 - Abstract #OHBM2025OHBM_161;
We anticipate that future work will combine different facets of our computational framework to evaluate in silico which potential pharmacological treatments may best address the specific cognitive difficulties associated with a given disorder or brain tissue lesion. Altogether, we established a principled foundation for interrogating transitions between specific configurations of brain activity, and designing interventions that promote selective transitions between cognitive states.
- |||||||||| methamphetamine / Generic mfg.
Unraveling the Impact of Methamphetamine (Room: M2 (Mezzanine Level)) - Jun 30, 2025 - Abstract #OHBM2025OHBM_127;
Wendy extensive experience in drug management and monitoring systems. She has facilitated and tailored drug and education programmes and workshops for the past 7 years in the Tair?whiti and Wairoa district, including in workplaces and secondary schools.
- |||||||||| methamphetamine / Generic mfg.
DIC Symposium: First Nations People in Neuroimaging Research (Room: M2 (Mezzanine Level)) - Jun 30, 2025 - Abstract #OHBM2025OHBM_123;
Methamphetamine addiction is a serious problem that can harm both the brain and heart...To understand the importance of building relationships with First Nations Peoples and community before research is undertaken and how this can be maintained into the future. Target Audience All mainstream researchers who seek to build strong reciprocal relationships and work with First Nations Peoples and communities.
- |||||||||| atomoxetine / Generic mfg.
Neuromodulatory effects on brain traveling waves: Insights from combined pharmacology, pupillometry and fMRI (Room: M4 (Mezzanine Level)) - Jun 30, 2025 - Abstract #OHBM2025OHBM_109;
Specifically, I assessed the effect of atomoxetine, which increases the levels of noradrenaline and dopamine in the brain (N = 36), and the effect of lysergic acid diethylamide (LSD), a serotoninergic agonist (N = 15)...Furthermore, pupil signatures indicated that instantaneous changes in neuromodulatory activity may act as time-specific regulators of travelling wave activity. The findings highlight specific effects of both prolonged and transient neuromodulatory influences on slow brain dynamics, suggesting a finely tuned regulation of brain communication at the slow time scales.
- |||||||||| oxaliplatin / Generic mfg.
Targeting Fascin as a Therapeutic Approach to Overcome Oxaliplatin Resistance in Colorectal Cancer (Poster and Exhibition Hall; Poster Board No EACR25-1307) - Jun 29, 2025 - Abstract #EACR2025EACR_1239;
Although the anti-fascin compounds NP-G2-044 and imipramine in monotherapy could be viable therapeutic options, higher concentrations would be required to achieve inhibitory effects comparable to oxaliplatin in resistant cells. However, the combination of fascin inhibitors with oxaliplatin exhibited a great ability to reverse drug resistance, showing promising therapeutic potential to overcome chemoresistance.
- |||||||||| isotretinoin / Generic mfg.
Alpha-1 adrenergic antagonists to sensitize neuroblastoma over isotretinoin theraphy (Poster and Exhibition Hall; Poster Board No EACR25-1416) - Jun 29, 2025 - Abstract #EACR2025EACR_1031;
Our findings suggest that ?1-AR antagonism sensitizes NB cells to 13cRA by facilitating the pro-differentiative and pro-apoptotic effects, potentially disrupting an autocrine catecholamine-driven pro-survival circuit. Given the druggable nature of ARs, ?1-AR inhibition emerges as new a promising pharmacological therapeutic strategy for neuroblastoma treatment.
- |||||||||| Avastin (bevacizumab) / Roche
Repurposing Tricyclic Antidepressants for Glioblastoma Treatment (Poster and Exhibition Hall; Poster Board No EACR25-1784) - Jun 29, 2025 - Abstract #EACR2025EACR_426;
This study aims to delve deeper into TCA mechanisms of action, assess potential synergies with VEGF pathway inhibitors and immune checkpoint blockade, and ultimately provide critical insights to optimize the proposed triple combination regimen. By leveraging drug repurposing and simultaneously targeting multiple tumor hallmarks, this approach holds significant promise for improving GBM therapeutic outcomes.
- |||||||||| Tivicay (dolutegravir) / ViiV Healthcare
Clinical data, Preclinical, Journal: Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor. (Pubmed Central) - Jun 27, 2025
However, the extent of variability differed among metformin, N1-methylnicotinamide, atenolol, frovatriptan, and sumatriptan, likely reflecting differences in cellular kinetics...DDI predictions using in vitro IC50 values suggested repeated dolutegravir administration could raise the area under the curve of OCT substrates, such as atenolol, nadolol, and sulpiride beyond regulatory thresholds...SIGNIFICANCE STATEMENT: This study identified experimental conditions affecting the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor. These findings offer valuable insights for improving in vitro to in vivo drug-drug interaction predictions and optimizing inhibition experiments for transporter-mediated drug-drug interactions.
- |||||||||| epinephrine / Generic mfg.
Journal: Anaesthesia for mandibular premolars with symptomatic irreversible pulpitis - which nerve block is best? (Pubmed Central) - Jun 27, 2025
It would be beneficial to use the MNB technique for anaesthesia of First Premolars, compared to Second Premolars, as a statistically significant difference was recorded, with higher success rates observed for anaesthesia of First Premolars by the MNB technique. Irrespective of Nerve Block technique and Premolar tooth type, it was identified that for 1 in 3 Premolars with SIP supplementary anaesthesia was required to ensure adequate anaesthesia and patient comfort.
- |||||||||| beclometasone/formoterol / Generic mfg.
Retrospective data, Journal: Impact of smoking on asthma control with extrafine beclomethasone/formoterol: post hoc analysis of a prospective cohort study. (Pubmed Central) - Jun 27, 2025
Uncontrolled asthma remained infrequent but was more prevalent in current (10%) and former (8.9%) smokers than in nonsmokers (5.7%) (p?=?0.002 and p?=?0.033, respectively).ConclusionsAsthma patients, regardless of smoking status, demonstrate a similar response to treatment. Uncontrolled asthma, though rare under treatment, is more common among smokers, due to their higher baseline severity.
- |||||||||| timolol maleate ophthalmic solution / Generic mfg.
Journal: Bronchospasm after timolol administration. (Pubmed Central) - Jun 27, 2025
Pulse oximetry screening had the potential to identify newborn infants in the delivery room who appeared healthy but required early medical attention. No abstract available
- |||||||||| nifedipine immediate release / Generic mfg., labetalol / Generic mfg.
Review, Journal: Anxiety and hypertensive disorders of pregnancy: Epidemiology, mechanisms, and management strategies. (Pubmed Central) - Jun 27, 2025
Additionally, multidisciplinary collaboration and long-term postpartum follow-up are crucial for reducing the long-term risk of cardiovascular diseases. Despite significant progress in research on anxiety and HDP, many issues still require further exploration, including in-depth mechanism studies, optimization of clinical interventions, improvement of multidisciplinary collaboration models, long-term follow-up studies, and the impact of cultural and social factors.
- |||||||||| propranolol / Generic mfg.
Journal: Bioadhesive Eudragit RL (Pubmed Central) - Jun 27, 2025
These findings underscore the importance of optimizing laboratory-scale processes to ensure the quality and safety of pharmaceutical suspensions. The nanoencapsulation of PROP in Eudragit RL
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