- |||||||||| labetalol / Generic mfg.
(126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1072;
The maternal-fetal medicine attending meets you on arrival in OB Triage, and orders IV magnesium and labetalol for the patient.Key Question: What is your list of possible causes for an acute seizure in a pregnant patient?The patient receives IV magnesium and labetalol, and is admitted to OB for observation...The imaging demonstrates features consistent with posterior reversible encephalopathy syndrome or PRES.Key Question: What is PRES, and is it likely to change the OB management or your anesthetic plan?The patient is stable on OB for 24 hours, and she is transferred to the inpatient antepartum unit for continued blood pressure control and observation. Following unsuccessful induction of labor at 35 weeks, the patient has a nonemergent primary cesarean delivery with spinal anesthesia and excellent outcomes for the mother and baby.
- |||||||||| epinephrine / Generic mfg.
CSF Drain During OHT: Just Another Monitor? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1070;
Aortic root pressure?The allograft functions immediately and she separates successfully from CPB on iNO, epinephrine, vasopressin, and liothyronine...Can she undergo MRI (for meningeal enhancement) while still on iNO? With EVD?
- |||||||||| fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
Intrathecal Catheter in Labor? Leave It and Love It! (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_669;
Will you remove the catheter postoperatively? What are the risks and benefits of leaving the catheter in versus removing it?19.What postpartum follow up will you provide for this patient?
- |||||||||| Clotinab (abciximab) / ISU Abxis, Integrilin (eptifibatide) / Takeda, NovoLog (insulin aspart) / Novo Nordisk
Keeping Coronary Stents Patent in Patients (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_481;
(ASA, Clopidogrel (Plavix), Eptifibatide (Integrelin), Abciximab (Reopro), prasugrel (Effient), ticagrelor (Brilinta) Intra operatively, the patient develops hypotension, ST elevation and T wave inversion on EKG.16. What are the therapeutic options available in this scenario?
- |||||||||| Rybelsus (semaglutide oral) / Novo Nordisk
Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_479;
Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Impella Standby and Pharmacologic Support During Mitral Clip Procedure in an Unstable Cardiac Patient (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_471;
Preoperative medications included: Sacubitril-valsartan (Entresto), Metoprolol, Empagliflozin, Furosemide, Protonix, Sertraline and Digoxin...He then received 150 mg of IV amiodarone load followed by continuous infusion and was taken to the hybrid Cath Lab to undergo a TEE followed by cardioversion and mitral clip application...Anesthesia was induced with etomidate, fentanyl, rocuronium and esmolol...Inotropic support was provided pharmacologically with milrinone and norepinephrine infusions...How can the Impella flow adjustments facilitate mitral clipping. 10-How would you manage new onset hypotension in PACU after extubation.
- |||||||||| Betadine (povidone iodine) / Egis
Everything You Ever Wanted to Know About Perioperative Hypersensitivity Reactions Before It's Too Late (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_469;
Maintenance included sevoflurane...Preoperatively, betadine skin prep was used, and he was pretreated with corticosteroids and antihistamines...An awake arterial line was placed, and he was then induced with dexmedetomidine, etomidate, and methadone...He was stable for 18 minutes and then hypotensive and tachycardic but responded very rapidly to boluses of epinephrine, vasopressin, phenylephrine and fluid resuscitation...Table 1 summarizes the anesthetics used and the tryptase levels. What is the significance of these results?
- |||||||||| ketamine / Generic mfg., epinephrine / Generic mfg., dexmedetomidine / Generic mfg.
Woody Neck! What in the World Is That? Anesthetic Considerations for a Radiated Neck (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_114;
He is treated with racemic epinephrine, steroid, and antihistamine before being brought to the operating room (OR) for emergent intubation...Following induction with ketamine, dexmedetomidine, and midazolam an airway is established by placing a nasotracheal tube with a fiber optic scope...Key questions 19.) What postoperative complications would you anticipate in the ICU? 20.) What would you do differently in the overall management of this patient?
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, Gold standard: Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies. (Pubmed Central) - Jun 25, 2024
Lithium was superior to aripiprazole, valproic acid, and quetiapine in terms of improving manic symptoms...Only the add-on therapy with sertraline led to a higher rate of study discontinuations than lithium-monotherapy...However, risperidone and quetiapine were superior to lithium in some aspects, which is why these drugs should be considered as an alternative treatment option for children. Collectively, current clinical studies highlight the relevance of lithium in the treatment of bipolar disorder.
- |||||||||| Review, Journal: Pharmacological treatment of posttraumatic stress disorder (Pubmed Central) - Jun 25, 2024
Venlafaxine, in particular, has shown good effectiveness in studies, whereas risperidone has shown lower effectiveness in augmentation...Treatment of trauma-related nightmares can be attempted with doxazosin or clonidine. In contrast, there are limited empirical data available for sleep disorders associated with PTSD, but the pharmacological treatment of insomnia can provide some guidance.
- |||||||||| Qelbree (viloxazine) / Supernus Pharma, Knight Therap
Review, Journal: Current nonstimulant medications for adults with attention-deficit/hyperactivity disorder. (Pubmed Central) - Jun 25, 2024
While according to clinical guidelines, atomoxetine may serve as the only second-line option in adults with ADHD, several other nonstimulant compounds may be effectively used in order to personalize treatment based on comorbid conditions and ADHD features. Nevertheless, further research is needed to identify and test more personalized treatment strategies for adults with ADHD.
- |||||||||| Phenylephrine topical gel (PSD503) / Regent Pacific Group
Review, Journal: Pharmacotherapy in Stress Urinary Incontinence; A Literature Review. (Pubmed Central) - Jun 24, 2024
Currently, trials are evaluating novel targets. Systemic adverse effects such as gastrointestinal upset with duloxetine and orthostatic hypotension with ?-adrenoceptor agonists have hampered the efficacy of drugs used to treat SUI in women and men.
- |||||||||| epinephrine / Generic mfg.
Journal: Examining the association between ethnicity and out-of-hospital cardiac arrest interventions in Salt Lake City, Utah. (Pubmed Central) - Jun 24, 2024
Our multivariable analysis found no statistically significant association between race/ethnicity and EMS response time, epinephrine administration, antiarrhythmic medication use, bystander CPR, AED intervention, or intra-arrest transport. These results imply regional variations in ethnic disparities in OHCA may not be consistent across all areas, warranting further research into disparities in other regions and additional influential factors like neighborhood conditions and socioeconomic status.
- |||||||||| methamphetamine / Generic mfg.
Retrospective data, Journal: Sex differences in houselessness, injection drug use, and mental health conditions among people newly diagnosed with HIV in Manitoba, Canada from 2018 to 2021: a retrospective cohort study. (Pubmed Central) - Jun 24, 2024
Main exposures evaluated: methamphetamine use, injection drug use, houselessness, and mental health conditions...These findings highlight the need for syndemic and gender-specific approaches, simultaneously addressing social and health conditions, to treat HIV. This work was supported by the Canadian Institutes of Health Research, The Manitoba Medical Service Foundation, The James Farley Memorial Fund and the Canada Research Chairs Program.
- |||||||||| doxazosin mesylate / Generic mfg., labetalol / Generic mfg.
Journal: An Unusual Case of Pheochromocytoma Associated with von Hippel-Lindau Disease and Lynch Syndrome During Pregnancy. (Pubmed Central) - Jun 24, 2024
DOTATATE positron emission tomography/computed tomography scan showed a small hepatic focus of a maximum standard uptake value of 12.1. Altogether, this case illustrates the importance of prompt diagnosis and proper management of PCCs/PGLs during pregnancy and incorporating genetic information during surveillance to lower morbidity and mortality.
- |||||||||| Review, Journal: Attention-Deficit / Hyperactivity Disorder in pregnancy and the postpartum period. (Pubmed Central) - Jun 23, 2024
Specifically, providers should work collaboratively with patients and their support networks to balance the risks of perinatal ADHD medication with the risks of inadequately treated ADHD in pregnancy. The risks and impacts of ADHD in pregnancy can be successfully managed through preconception counselling and appropriate perinatal planning, management, and support.
- |||||||||| PK/PD data, Review, Journal: Central Nervous System Medications: Pharmacokinetic and Pharmacodynamic Considerations for Older Adults. (Pubmed Central) - Jun 22, 2024
Important pharmacodynamic changes in older adults include an increased sedative effect of benzodiazepines at a given drug exposure, and a higher sensitivity to mu opiate receptor agonists and to opioid adverse effects. Artificial intelligence, physiologically based pharmacokinetic modeling and simulation, and concentration-effect modeling enabling a differentiation between the pharmacokinetic and the pharmacodynamic effects of aging might help to close some of the gaps in knowledge.
- |||||||||| epinephrine / Generic mfg.
Retrospective data, Review, Journal: From Skin to Solution: Exploring Epicutaneous Immunotherapy for Peanut Allergy-A Systematic Review and Meta-Analysis. (Pubmed Central) - Jun 22, 2024
Additionally, individuals administered EPIT have an increased probability of requiring rescue medications like epinephrine (RR: 1.91 (95% C.I: 1.12, 3.28), P?=?0.02, I2?=?0%) and topical corticosteroids (RR: 1.49 (95% C.I: 1.29, 1.73), P?<?0.01, I2?=?0%) to treat adverse events...EPIT, although effective in desensitization, is linked to an increased risk of adverse events. PROSPERO registration: CRD42023466600.
- |||||||||| Journal, Surgery: Perioperative effects of different hypotensive anesthesia techniques in orthognathic surgery. (Pubmed Central) - Jun 22, 2024
Based on this study's results, it was concluded that infusing remifentanil, esmolol, or nitroglycerin with sevoflurane during orthognathic surgery successfully achieved the targeted hypotensive anesthesia and can be considered alternative methods. The decision on which method to use should consider the patient's overall health status and additional medical conditions.
- |||||||||| methamphetamine / Generic mfg.
Journal: Involuntary discharge from drug or alcohol treatment programs in Vancouver, Canada. (Pubmed Central) - Jun 22, 2024
While involuntary discharge was a relatively rare occurrence, those who were discharged due to active substance use possessed several markers of risk, including high-intensity injection drug use, homelessness, and recent non-fatal overdose. Our findings highlight the need for increased flexibility within treatment programs to account for those who re-initiate or continue to use substances during treatment.
- |||||||||| epinephrine / Generic mfg.
Review, Journal: EXPLORING THE INTERPLAY BETWEEN STRESS MEDIATORS AND SKIN MICROBITA IN SHAPING AGE-RELATED HALLMARKS: A REVIEW. (Pubmed Central) - Jun 22, 2024
Physiologically, stress manifests through neuroendocrine pathways (Hypothalamic-Pituitary-Adrenal (HPA) axis and Sympathetic-Adrenal-Medullary (SAM) system) which culminate in the production of stress mediators like cortisol, epinephrine and norepinephrine...From a different perspective, since it is not a "traditional" stress mediator, oxytocin, a cortisol antagonist, has been related to glucorticoids inhibition and to display positive effects on cellular aging. This hormone dysregulation has been associated to psychological issues such as depression, whereas its upregulation has been linked to positive social interaction.
- |||||||||| atenolol / Generic mfg.
Journal: Matching periodate peak absorbance by far UVC at 222 (Pubmed Central) - Jun 22, 2024
The effectiveness and the underlying mechanisms of UV222/PI for the remediation of micropollutants were studied by selecting atenolol (ATL) as a representative...The high energy efficiency of the UV222/PI process was also confirmed. This study provides a cost-effective and convenient approach to enhance PI light-response activity for the treatment of micropollutants.
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