- |||||||||| carvedilol / Generic mfg.
Journal: Drug solubilization in dog intestinal fluids with and without administration of lipid-based formulations. (Pubmed Central) - Jun 26, 2024
In this study we used molecular dynamics simulations to investigate solubilization patterns for three model drugs (carvedilol, felodipine and probucol) in dog intestinal fluid, a lipid-based formulation, and a mixture of both...Hence, a simplified dissolution medium suitable for in vitro studies provided physiologically relevant data for the systems explored. The computational protocol used in this study, coupled with in vitro studies using simulated intestinal fluids, can serve as a useful prescreening tool in the process of drug delivery strategies development.
- |||||||||| dobutamine / Generic mfg.
Journal: Perioperative dobutamine infusion in an African lion (Panthera leo). (Pubmed Central) - Jun 26, 2024
The computational protocol used in this study, coupled with in vitro studies using simulated intestinal fluids, can serve as a useful prescreening tool in the process of drug delivery strategies development. The lion was immobilized via intramuscular darts containing midazolam (0.033 mg/kg), medetomidine (50
- |||||||||| epinephrine / Generic mfg.
Clinical guideline, Journal: 2024 RECOVER Guidelines: Updated treatment recommendations for CPR in dogs and cats. (Pubmed Central) - Jun 26, 2024
Very low quality of evidence due to absence of clinical data in dogs and cats continues to compromise the certainty with which recommendations can be made. While the majority of the BLS and ALS recommendations remain unchanged, some noteworthy changes were made due to new evidence that emerged over the past 10
- |||||||||| atenolol / Generic mfg., methamphetamine / Generic mfg.
Journal: The Impact of Combined Sewer Overflows on Pharmaceutical and Illicit Drug Levels in New York/New Jersey Waterways. (Pubmed Central) - Jun 26, 2024
The most frequently detected analytes in 2021 were metoprolol (n?=?206, 92%), benzoylecgonine (n?=?151, 67%), atenolol (n?=?142, 63%), and methamphetamine (n?=?118, 53%), and in 2022 the most frequently detected were methamphetamine (n?=?194, 84%), atenolol (n?=?177, 76%), metoprolol (n?=?177, 76%), and 2-ethylene-1,5-dimethyl-3,3-diphenylpyrrolidine (n?=?159, 69%). Environ Toxicol Chem 2024;00:1-12.
- |||||||||| methamphetamine / Generic mfg.
Journal: Methamphetamine Removal from Aquatic Environments by Magnetic Microrobots with Cyclodextrin Chiral Recognition Elements. (Pubmed Central) - Jun 26, 2024
A dramatically enhanced capture of MA from water with active magnetically powered microrobots when compared with static passive CD-modified particles is demonstrated. This work shows the advantages of enhanced mass transfer provided by the externally controlled magnetic navigation in microrobots that together with the versatility of their design is an efficient strategy to clean polluted waters.
- |||||||||| timolol maleate ophthalmic solution / Generic mfg., propranolol / Generic mfg.
Journal: Beta-blockers for the treatment of infantile haemangiomas in premature infants. (Pubmed Central) - Jun 26, 2024
A retrospective study was performed to review the safety of oral propranolol and topical timolol in the treatment of IH in a cohort of preterm infants treated at our tertiary paediatric hospital. It was observed that there was an increased risk of adverse events amongst the preterm infants with chronic lung disease, retinopathy of prematurity and gastroesophageal reflux, when treated with oral propranolol.
- |||||||||| Journal: Treating Benzodiazepine Withdrawal in a Bridge Clinic. (Pubmed Central) - Jun 26, 2024
Managing benzodiazepine withdrawal with a 4- to 6-week intensive outpatient taper in patients with benzodiazepine and opioid use disorders is challenging. More work is needed to refine patient selection, balance safety risks with feasibility, and study long-term, patient-centered outcomes.
- |||||||||| olanzapine / Generic mfg., quetiapine / Generic mfg., clozapine / Generic mfg.
Journal: Pneumonia Risk, Antipsychotic Dosing, and Anticholinergic Burden in Schizophrenia. (Pubmed Central) - Jun 26, 2024
Moreover, monotherapy antipsychotics and antipsychotics with high anticholinergic burden are associated with increased pneumonia risk in a dose-dependent manner. These findings call for prevention strategies aimed at patients with schizophrenia requiring high-risk antipsychotics.
- |||||||||| methamphetamine / Generic mfg.
Preclinical, Journal: Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration. (Pubmed Central) - Jun 26, 2024
Lactobacillus changes were significantly negatively correlated with total MA uptake in rats (Pearson R?=??-?0.666, p?=?0.035; Spearman R?=??-?0.721, p?=?0.023), whereas its change was also highly negatively correlated with total MA uptake in rhesus monkeys (Pearson R?=??-?0.882, p?=?0.118; Spearman R?=??-?1.000, p?=?0.083), although this was not significant. These findings suggest that MA causes significant alterations in GM in both rhesus monkeys and rats and that the genus Lactobacillus might be a common therapeutic target for MA uptake prevention across the species.
- |||||||||| propranolol / Generic mfg.
Review, Journal: Diagnosis and Management of Fetal Arrhythmias in the Current Era. (Pubmed Central) - Jun 26, 2024
Diagnosis and management of fetal arrhythmias have changed over the past 40-50 years since propranolol was first used to treat fetal tachycardia in 1975 and when first attempts were made at in utero pacing for complete heart block in 1986...Pharmacologic management of fetal arrhythmias remains one of the most successful achievements of fetal intervention. Patience, vigilance, and multidisciplinary collaboration are key to successful diagnosis and treatment.
- |||||||||| propranolol / Generic mfg.
Journal: Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study. (Pubmed Central) - Jun 26, 2024
Treatment options included propranolol (39.8%), nadolol (22.2%), inderal (11.1%), metoprolol (11.1%), and no treatment (16.7%)...(4) This screening approach has demonstrated effectiveness in the early identification of LQTS and other cardiac rhythm anomalies, with additional identification of mutations and/or prolonged QTc intervals in family members. Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening.
- |||||||||| epinephrine / Generic mfg.
Preclinical, Journal: Ischemic Post-Conditioning in a Rat Model of Asphyxial Cardiac Arrest. (Pubmed Central) - Jun 26, 2024
Identifying other ECG abnormalities and congenital heart malformations further enhances the benefits of the screening. IPoC demonstrated no harm in a model of short arrest using a new arrest etiology for CPR based IPoC intervention in a rat model.
- |||||||||| methamphetamine / Generic mfg.
Review, Journal: Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-Based Review. (Pubmed Central) - Jun 26, 2024
However, the mechanisms underlying these toxic effects have not yet been fully described. This study reviews the evidence concerning the impact of METH on male and female reproduction in the context of the testis, sperm, ovaries, oocytes, reproductive hormones, embryo development, and newborns, discussing the potential pathophysiological mechanisms in the reproductive toxicity induced by METH.
- |||||||||| epinephrine / Generic mfg.
Journal: Proteomic and transcriptomic analyses of Cutibacterium acnes biofilms and planktonic cultures in presence of epinephrine. (Pubmed Central) - Jun 26, 2024
According to the proteomic profiling, epinephrine itself was more effective in the case of C. acnes biofilms and potentially affected the tricarboxylic acid cycle (as well as alpha-ketoglutarate decarboxylase Kgd), biotin synthesis, cell division, and transport of different compounds in C. acnes cells. These findings are consistent with recent research on Micrococcus luteus, suggesting that the effects of epinephrine on actinobacteria may be universal.
- |||||||||| epinephrine / Generic mfg.
Retrospective data, Journal: Endoscopic management of giant colonic polyps: a retrospective Italian study. (Pubmed Central) - Jun 26, 2024
Eighteen polypectomies were performed using the epinephrine volume reduction (EVR) method, nine polypectomies utilized endo-looping or clipping methods, and 11 patients underwent surgery...We propose EVR as an alternative technique for giant polyp resection due to its safety, effectiveness, cost-efficiency, and the advantage of avoiding the need to postpone polypectomy to a later time. Further prospective studies might help improve this experience and enhance the technique.
- |||||||||| Clotinab (abciximab) / ISU Abxis, Integrilin (eptifibatide) / Takeda, NovoLog (insulin aspart) / Novo Nordisk
Keeping Coronary Stents Patent in Patients (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3263;
(ASA, Clopidogrel (Plavix), Eptifibatide (Integrelin), Abciximab (Reopro), prasugrel (Effient), ticagrelor (Brilinta) Intra operatively, the patient develops hypotension, ST elevation and T wave inversion on EKG.16. What are the therapeutic options available in this scenario?
- |||||||||| epinephrine / Generic mfg.
Regional Anesthesia Options and Perioperative Management for Prone Spine Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3159;
A negative test dose of 3 milliliters 1.5% lidocaine with 1:200,000 epinephrine is given after aspiration from the catheter is negative for heme and cerebrospinal fluid...She is unresponsive to verbal and painful stimuli and you hear audible obstruction during spontaneous ventilation.What devices can you use for airway rescue and to improve oxygenation?Which modalities are easiest to successfully use with the patient remaining prone?Do you need to place an endotracheal tube, and if so how do you position the patient?Consider now, the patient had wished to pursue a general anesthetic. What peripheral regional options exist for postoperative analgesia in this patient?What are some benefits and drawbacks of a peripheral regional technique relative to a neuraxial technique?What medication and dose will you use for your peripheral regional technique?
- |||||||||| Rybelsus (semaglutide oral) / Novo Nordisk
Anesthesia, Your Patient Is Almost Coded in the PACU After a Pituitary Surgery! Crisis Preparation and Management for Transsphenoidal Pituitary Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_3036;
Oral hydrocortisone was prescribed during last hospitalization for surgery but weaned off in the following months...Would you routinely give dexamethasone for post-op nausea and vomiting (PONV) in TSS?Case Continued: During surgical exploration, the surgeon informs you that there is profuse bleeding on the field, and they might injure the carotid artery.8.What is your blood pressure management target now?...11.What are your differential diagnoses and treatment?12.If the patient wakes up slow, is there a cognitive aid to help troubleshoot? How does the cognitive aid help during neuroanesthetic crises?$$graphic_{9CA3D4AD-3357-477A-921A-4E0D00A82435}$$$$graphic_{1D86D868-9821-42AC-A5FF-6985D06287C1}$$
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., epinephrine / Generic mfg.
Labor Epidural Struggles Lead to C-Section Troubles (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2855;
How the you will break the bad news to the patient family? A test dose of lidocaine 1.5% with 1:200,000 epinephrine was administered and no increases in heart rate or profound lower extremity weakness was noted...What medications can be given?After administration of fentanyl 100 mcg, ketamine 20 mg, and inhaled nitrous oxide 50%, the patient is still uncomfortable and asks if she can
- |||||||||| tranexamic acid oral / Generic mfg., esmolol / Generic mfg., levetiracetam / Generic mfg.
Just Another Subarachnoid Hemorrhage? Or Am I Really Up-to-Date on What to Do? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2677;
The patient was given 1gm of Levetiracetam and 1gm of Tranexamic acid and transferred to a specialized hospital with around-the-clock interventional neuroradiology and vascular neurosurgical services.What are the clinical severity scales of SAH?...Esmolol was then given...How is the diagnosis made? What are the treatments available?
- |||||||||| labetalol / Generic mfg.
(126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2665;
The maternal-fetal medicine attending meets you on arrival in OB Triage, and orders IV magnesium and labetalol for the patient.Key Question: What is your list of possible causes for an acute seizure in a pregnant patient?The patient receives IV magnesium and labetalol, and is admitted to OB for observation...The imaging demonstrates features consistent with posterior reversible encephalopathy syndrome or PRES.Key Question: What is PRES, and is it likely to change the OB management or your anesthetic plan?The patient is stable on OB for 24 hours, and she is transferred to the inpatient antepartum unit for continued blood pressure control and observation. Following unsuccessful induction of labor at 35 weeks, the patient has a nonemergent primary cesarean delivery with spinal anesthesia and excellent outcomes for the mother and baby.
- |||||||||| labetalol / Generic mfg., enoxaparin sodium / Generic mfg.
Baby, You Make My Heart Beat Faster (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2661;
Her blood pressure remains 120s/80s and the fetal heart rate tracings continue to be Category I. The patient is not experiencing any chest pain, dyspnea, abdominal pain, or nausea.PMHx: Chronic hypertension, gestational diabetes requiring insulin, morbid obesity (BMI 58), depressionPSHx: NoneHome medications: Labetalol, insulin NPH, bupropionLabor induction medications: Misoprostol, oxytoxin1...What if the patient was already symptomatic on admission and initiated on enoxaparin, dosed at 1mg/kg daily, before she expressed interest in neuraxial anesthesia.9...The obstetrician is asking for your help to resuscitate the neonate. What is your response?
- |||||||||| epinephrine / Generic mfg.
CSF Drain During OHT: Just Another Monitor? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2557;
Aortic root pressure?The allograft functions immediately and she separates successfully from CPB on iNO, epinephrine, vasopressin, and liothyronine...Can she undergo MRI (for meningeal enhancement) while still on iNO? With EVD?$$graphic_{13EE116A-9473-4F67-8989-B7A8A34C50E8}$$
- |||||||||| fentanyl citrate / Generic mfg., epinephrine / Generic mfg.
Intrathecal Catheter in Labor? Leave It and Love It! (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2379;
Will you remove the catheter postoperatively? What are the risks and benefits of leaving the catheter in versus removing it?19.What postpartum follow up will you provide for this patient?
- |||||||||| Endoscopy and Beyond for a Young Woman With a Left Ventricular Assist Device (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2377;
What are the risks and benefits of leaving the catheter in versus removing it?19.What postpartum follow up will you provide for this patient? Her medications include Lisinopril, Carvedilol, and Spironolactone...If so, should you begin chest compressions?You hear the
- |||||||||| Endoscopy and Beyond for a Young Woman With a Left Ventricular Assist Device (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2137;
Her medications include Lisinopril, Carvedilol, and Spironolactone...If so, should you begin chest compressions?You hear the Her medications include Lisinopril, Carvedilol, and Spironolactone...If so, should you begin chest compressions?You hear the
- |||||||||| tranexamic acid oral / Generic mfg., esmolol / Generic mfg., levetiracetam / Generic mfg.
Just Another Subarachnoid Hemorrhage? Or Am I Really Up-to-Date on What to Do? (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_2123;
The patient was given 1gm of Levetiracetam and 1gm of Tranexamic acid and transferred to a specialized hospital with around-the-clock interventional neuroradiology and vascular neurosurgical services.What are the clinical severity scales of SAH?...Esmolol was then given...How is the diagnosis made? What are the treatments available?
- |||||||||| epinephrine / Generic mfg.
Regional Anesthesia Options and Perioperative Management for Prone Spine Surgery (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1842;
A negative test dose of 3 milliliters 1.5% lidocaine with 1:200,000 epinephrine is given after aspiration from the catheter is negative for heme and cerebrospinal fluid...She is unresponsive to verbal and painful stimuli and you hear audible obstruction during spontaneous ventilation.What devices can you use for airway rescue and to improve oxygenation?Which modalities are easiest to successfully use with the patient remaining prone?Do you need to place an endotracheal tube, and if so how do you position the patient?Consider now, the patient had wished to pursue a general anesthetic. What peripheral regional options exist for postoperative analgesia in this patient?What are some benefits and drawbacks of a peripheral regional technique relative to a neuraxial technique?What medication and dose will you use for your peripheral regional technique?
- |||||||||| labetalol / Generic mfg., enoxaparin sodium / Generic mfg.
Baby, You Make My Heart Beat Faster (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1840;
Her blood pressure remains 120s/80s and the fetal heart rate tracings continue to be Category I. The patient is not experiencing any chest pain, dyspnea, abdominal pain, or nausea.PMHx: Chronic hypertension, gestational diabetes requiring insulin, morbid obesity (BMI 58), depressionPSHx: NoneHome medications: Labetalol, insulin NPH, bupropionLabor induction medications: Misoprostol, oxytoxin1...What if the patient was already symptomatic on admission and initiated on enoxaparin, dosed at 1mg/kg daily, before she expressed interest in neuraxial anesthesia.9...The obstetrician is asking for your help to resuscitate the neonate. What is your response?
- |||||||||| ketamine / Generic mfg., epinephrine / Generic mfg., dexmedetomidine / Generic mfg.
Woody Neck! What in the World Is That? Anesthetic Considerations for a Radiated Neck (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1581;
He is treated with racemic epinephrine, steroid, and antihistamine before being brought to the operating room (OR) for emergent intubation...Following induction with ketamine, dexmedetomidine, and midazolam an airway is established by placing a nasotracheal tube with a fiber optic scope...Key questions 19.) What postoperative complications would you anticipate in the ICU? 20.) What would you do differently in the overall management of this patient?
- |||||||||| fentanyl citrate / Generic mfg., ketamine / Generic mfg., epinephrine / Generic mfg.
Labor Epidural Struggles Lead to C-Section Troubles (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1435;
20.) What would you do differently in the overall management of this patient? A test dose of lidocaine 1.5% with 1:200,000 epinephrine was administered and no increases in heart rate or profound lower extremity weakness was noted...What medications can be given?After administration of fentanyl 100 mcg, ketamine 20 mg, and inhaled nitrous oxide 50%, the patient is still uncomfortable and asks if she can
- |||||||||| Entresto (sacubitril/valsartan) / Novartis, ROVI Pharmaceuticals Laboratories, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Impella Standby and Pharmacologic Support During Mitral Clip Procedure in an Unstable Cardiac Patient (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1429;
Preoperative medications included: Sacubitril-valsartan (Entresto), Metoprolol, Empagliflozin, Furosemide, Protonix, Sertraline and Digoxin...He then received 150 mg of IV amiodarone load followed by continuous infusion and was taken to the hybrid Cath Lab to undergo a TEE followed by cardioversion and mitral clip application...Anesthesia was induced with etomidate, fentanyl, rocuronium and esmolol...Inotropic support was provided pharmacologically with milrinone and norepinephrine infusions...How can the Impella flow adjustments facilitate mitral clipping. 10-How would you manage new onset hypotension in PACU after extubation.$$graphic_{0ABD30CA-3234-47A0-BF39-C8A2B62426BB}$$$$graphic_{4A201CBB-4F60-48BB-8303-A453EB511991}$$$$graphic_{9098DA9F-016F-4F1F-8A03-547F0E5ED0EB}$$$$graphic_{5A825C96-1CED-4442-9DFB-AA998C5488EE}$$$$graphic_{DE57C476-94EB-4AE3-AE8C-715C50C45F61}$$
- |||||||||| Betadine (povidone iodine) / Egis
Everything You Ever Wanted to Know About Perioperative Hypersensitivity Reactions Before It's Too Late (126A) - Jun 25, 2024 - Abstract #ASA2024ASA_1425;
Maintenance included sevoflurane...Preoperatively, betadine skin prep was used, and he was pretreated with corticosteroids and antihistamines...An awake arterial line was placed, and he was then induced with dexmedetomidine, etomidate, and methadone...He was stable for 18 minutes and then hypotensive and tachycardic but responded very rapidly to boluses of epinephrine, vasopressin, phenylephrine and fluid resuscitation...Table 1 summarizes the anesthetics used and the tryptase levels. What is the significance of these results?$$graphic_{906E5046-3C50-4A47-9837-748270DA6A29}$$
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