Adrenergic Receptor 

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  • ||||||||||  lithium carbonate ER / Generic mfg.
    Review, Journal:  Management of Bipolar Disorder in Pregnancy and Postpartum: A Clinicians' Guide. (Pubmed Central) -  Jul 2, 2025   
    Women with bipolar disorder are at very high risk of relapse after delivery, but this risk is more than twofold lower with adequate pharmacological prophylaxis. We advise to make a written perinatal bipolar relapse prevention plan in collaboration with the patient, family, and healthcare professionals, which includes a description of: (1) maintenance treatment during pregnancy, (2) preferred mode of delivery, (3) medication immediately after delivery and the first months postpartum for relapse prevention, (4) preferred plan for feeding (breast-feeding versus bottle-feeding), (5) strategies to assist women in ensuring adequate sleep and stable circadian rhythm in the first weeks after delivery, and (6) how to recognize the first symptoms of relapse and which intervention strategies to take.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Standardization of Clinician Outcomes for Croup Using a Clinical Pathway. (Pubmed Central) -  Jul 1, 2025   
    There were differences by patient race in admissions and PED return visits, but no differences by language for care. With a change in the pathway, admissions were reduced without a change in balancing measures.
  • ||||||||||  Journal:  Evaluating the Sensitivity, Selectivity, and Cross-Reactivity of Lateral Flow Immunoassay Xylazine Test Strips. (Pubmed Central) -  Jul 1, 2025   
    While XTS are capable of detecting xylazine at low concentrations, the potential for false-positive results due to cross-reactivity with other drugs necessitates caution in their interpretation. Hence, XTS may serve as a viable harm reduction tool, provided that their cross-reactivity limitations are thoroughly documented and they are incorporated as part of a broader harm reduction strategy.
  • ||||||||||  aripiprazole / Generic mfg., escitalopram / Generic mfg.
    Journal:  Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des r (Pubmed Central) -  Jul 1, 2025   
    Nonresponders at week 8 received augmentation with aripiprazole (ARI), while responders continued ESC until week 16...No significant associations were observed in the ESC?+?ARI group.ConclusionsThese findings suggest that PRSs may influence treatment outcomes, particularly in ESC monotherapy. Replication in larger studies is needed to validate these observations.
  • ||||||||||  Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
    Enrollment change:  SGLTi, Hepatic Glucose Production and Ketogenesis (clinicaltrials.gov) -  Jul 1, 2025   
    P1,  N=30, Recruiting, 
    Not yet recruiting --> Recruiting | Trial completion date: Feb 2025 --> Dec 2025 | Trial primary completion date: Feb 2025 --> Dec 2025 N=169 --> 30
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  Characteristics and toxicology of adult deaths due to quetiapine toxicity in Australia, 2000-2024. (Pubmed Central) -  Jul 1, 2025   
    Given these findings, screening patients prescribed quetiapine for suicide histories and ideation is prudent, as is monitoring cardiovascular disease. For forensic pathologists, the extent and nature of cardiovascular disease appear important for the formulation of death, and suicide should be borne in mind.
  • ||||||||||  doxazosin mesylate / Generic mfg.
    Journal:  Sex differences in management and outcomes in pheochromocytomas and paragangliomas. (Pubmed Central) -  Jul 1, 2025   
    For forensic pathologists, the extent and nature of cardiovascular disease appear important for the formulation of death, and suicide should be borne in mind. Females required a lower final dose of preoperative phenoxybenzamine (50.8
  • ||||||||||  aripiprazole / Generic mfg., risperidone / Generic mfg.
    Review, Journal:  Global autism prevalence, and exploring Montessori as a practical educational solution: a systematic review. (Pubmed Central) -  Jul 1, 2025   
    Montessori education, a sensory-focused, individualized, and play-based learning approach, aligns well with the individual learning needs of ASD and shows considerable potential in improving communication and social skills in children with ASD. This systematic review underscores geographic disparities and risk factors associated with autism while uniquely assessing Montessori education as a promising intervention, paving the way for further research in low-resource settings.
  • ||||||||||  albendazole / Generic mfg., epinephrine / Generic mfg.
    Journal:  Rupture of Echinococcus granulosus leading to severe hypoxia: preoperative and postoperative management. (Pubmed Central) -  Jul 1, 2025   
    Albendazole was administered 5?days prior to the surgical intervention.Surgical intervention consisted of endocystectomy and capitonnage, conserving the parenchyma. Spillage during the rupture, which caused bronchial obstruction from degrading scolexes of the contralateral side, was managed through flexible bronchoscopy.The patient experienced a favourable outcome with full clinical and radiological resolution after a 6-month course with albendazole and supportive therapy.
  • ||||||||||  Riarify (beclometasone/formoterol/glycopyrrolate) / Chiesi
    Enrollment closed, Trial completion date, Trial primary completion date, Real-world evidence:  TRIMAXIMIZE: Observational Study on Therapy Pathways of Asthamics Treated With ICS/LABA/LAMA Therapy in a Real-world Setting (clinicaltrials.gov) -  Jul 1, 2025   
    P=N/A,  N=200, Active, not recruiting, 
    Our findings do not support the use of propranolol for prolonged latent labor in nulliparous patients undergoing IOL at term. Recruiting --> Active, not recruiting | Trial completion date: Oct 2025 --> Jun 2026 | Trial primary completion date: Oct 2025 --> Jun 2026
  • ||||||||||  atenolol / Generic mfg.
    Polygenic risk score association with bone density in postmenopausal women of diverse race and ethnicity (Discovery Hall, Hall 4B (Seattle Convention Center)) -  Jul 1, 2025 - Abstract #ASBMR2025ASBMR_862;    
    P2
    The Atenolol for Prevention of Osteoporosis (APO) study (NCT04905277) is a multi-site randomized controlled trial to assess the ability of atenolol to prevent BMD loss in postmenopausal women...The small Hispanic and NH Black subgroup sizes limited the precision of these estimates and should be explored further in larger populations. In conclusion, the association between PRS and BMD may vary by race and ethnicity, highlighting a potential limitation to implementing personalized medicine for bone outcomes in non-white individuals.
  • ||||||||||  ondansetron / Generic mfg., propranolol / Generic mfg., clozapine / Generic mfg.
    Integrative Multi-Omics and Network Medicine Strategy for Drug Repurposing in Osteoporosis (Discovery Hall, Hall 4B (Seattle Convention Center)) -  Jul 1, 2025 - Abstract #ASBMR2025ASBMR_730;    
    In conclusion, the association between PRS and BMD may vary by race and ethnicity, highlighting a potential limitation to implementing personalized medicine for bone outcomes in non-white individuals. Network proximity analysis identified five top-ranked candidate drugs
  • ||||||||||  atenolol / Generic mfg.
    Osteoclast beta-1 adrenergic receptor contributes to age-related trabecular bone loss in female mice (Room 606 - 609 (Seattle Convention Center)) -  Jul 1, 2025 - Abstract #ASBMR2025ASBMR_317;    
    Our findings support the clinical utility of beta-blockers as a treatment for bone loss, especially in females. Future work will test whether ?1AR is required for the beneficial effects of ?1-selective antagonist atenolol, and leverage these findings for novel osteoporosis treatment strategies.
  • ||||||||||  Spravato (esketamine intranasal) / J&J, quetiapine extended-release / Generic mfg., quetiapine / Generic mfg.
    Journal:  Cost-per-remitter for esketamine nasal spray versus quetiapine for treatment-resistant depression. (Pubmed Central) -  Jun 30, 2025   
    Evidence was firm in favor of a robust pro-neurogenic effect of selective serotonin reuptake inhibitor fluoxetine, in both species, making updates of this review probably redundant. Aim: Estimate the cost-per-remitter with esketamine nasal spray plus an oral antidepressant (ESK NS
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Isoprenaline shows unique kinase dependencies in stimulating ?1AR-?-arrestin2 interaction compared to endogenous catecholamines. (Pubmed Central) -  Jun 30, 2025   
    Although ?-arrestin2 translocation to the PM occurred to similar extents with isoprenaline, epinephrine, and norepinephrine, kinase involvement was crucial only upon Iso stimulation of ?1-adrenergic receptor. By elucidating these ligand-specific pathways, this study advances our understanding of ?1-adrenergic receptor signaling and regulation while additionally highlighting the importance of considering these differences when translating molecular insights into pathophysiological contexts.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Preference for Abstinence-Based Recovery and Public Stigma Toward Substance Use. (Pubmed Central) -  Jun 30, 2025   
    The results indicate that the general public has greater stigmatizing attitudes toward methamphetamine use disorder than it does toward cocaine use disorder, opioid use disorder, and alcohol use disorder...The perceived dangerousness of a substance did not moderate the relationship between preference for abstinence-based recovery and stigmatizing attitudes toward SUDs. Results have implications for creating public stigma interventions for the general public, which can be adapted for abstinence-based settings.
  • ||||||||||  tamoxifen / Generic mfg., propranolol / Generic mfg.
    Journal, Metabolomic study:  Evaluating inkjet dispenser/liquid vortex capture-mass spectrometry for single-cell metabolomics in Hep G2 steatosis caused by tamoxifen. (Pubmed Central) -  Jun 30, 2025   
    Triglycerides were upregulated in the tamoxifen-treated cells and the results indicated two distinct cell populations, differing in tamoxifen and phosphatidylcholines levels, suggesting heterogeneity within the treated population. These findings highlight the D100/LVC-MS system as a cost-effective, high-throughput platform for single-cell metabolomics and lipidomics, with significant potential for evaluating metabolic alterations.
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Development of a Validated, Updated North American Pediatric Food Allergy Anaphylaxis Management Plan. (Pubmed Central) -  Jun 30, 2025   
    Further high-quality RCTs with larger sample sizes are needed to confirm these findings. This is the first validated AAP incorporating preference-sensitive post-epinephrine management options consistent with updated North American guidelines, newly approved nasal epinephrine, and age-specific anaphylaxis presentation.
  • ||||||||||  sotalol / Generic mfg., flecainide / Generic mfg., amiodarone / Generic mfg.
    Review, Journal:  Arrhythmogenic Right Ventricular Cardiomyopathy: Diagnosis, Risk Stratification, and Treatment. (Pubmed Central) -  Jun 30, 2025   
    ARVC is associated with an increased risk of sudden cardiac death. Risk assessment remains challenging in the absence of randomized controlled trials, particularly with regard to the primary prophylactic implantation of a defibrillator.