Adrenergic Receptor 

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  • ||||||||||  epinephrine / Generic mfg.
    Multicenter evaluation of light transmission platelet aggregation reagents: communication from the ISTH SSC Subcommittee on Platelet Physiology (Room 300) -  May 9, 2024 - Abstract #ISLH2024ISLH_3;    
    we assess whether sources of activators (mainly adenosine diphosphate [ADP], collagen, arachidonic acid, epinephrine, and thrombin receptor activating peptide6) and ristocetin contribute to poor LTA reproducibility...The observation of huge interindividual variability for certain concentrations of activators should lead to a cautious interpretation before reporting a result as abnormal. Confidence can be taken from the fact that difference between sources is not exacerbated in patients treated with antiplatelet agents.
  • ||||||||||  dextroamphetamine immediate release / Generic mfg.
    Journal:  Effective-connectivity of thalamocortical interactions following d-amphetamine, LSD, and MDMA administration. (Pubmed Central) -  May 8, 2024   
    In conclusion, we propose a fast and cost-efficient pipeline to explore the underlying molecular mechanisms of ADHD drug treatment in Drosophila brain at single-cell resolution, which may further facilitate drug repurposing applications. The results advance our knowledge about the action of psychedelics on the brain and refine current models aiming to explain the underlying neurobiological processes.
  • ||||||||||  verapamil modified release / Generic mfg., epinephrine / Generic mfg., trandolapril/verapamil / Generic mfg.
    Journal:  Use of Intravenous Lipid Emulsion Therapy and Insulin in a Case of Tarka Intoxication. (Pubmed Central) -  May 8, 2024   
    The results advance our knowledge about the action of psychedelics on the brain and refine current models aiming to explain the underlying neurobiological processes. ILE is an alternative treatment method for acute lipophilic drug intoxications, such as Tarka.
  • ||||||||||  Sunosi (solriamfetol) / Axsome Therap, Pharmanovia
    New P2 trial:  RECOVER-SLEEP: Platform Protocol (clinicaltrials.gov) -  May 8, 2024   
    P2,  N=1074, Not yet recruiting, 
  • ||||||||||  epinephrine / Generic mfg.
    Journal:  Effect of terahertz waves on the aggregation behavior of neurotransmitters. (Pubmed Central) -  May 8, 2024   
    Furthermore, similar investigations on epinephrine (EPI), 5-hydroxytryptamine (5-HT), and ?-aminobutyric acid (GABA) corroborated these findings...However, 5-HT and GABA, with charged or hydrophilic functional groups, exhibited minimal aggregation under THz stimulation. The present study sheds some light on neurotransmitter responses to THz waves, offering implications for neuroscience and interdisciplinary applications.
  • ||||||||||  Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
    Trial primary completion date:  POTS Adrenergic Ab (CIHR Aims #1&2) (clinicaltrials.gov) -  May 8, 2024   
    P=N/A,  N=125, Recruiting, 
    Further research with larger sample sizes and longer treatment durations is recommended to explore modafinil's potential benefits in managing altered consciousness in COVID-19 patients. Trial primary completion date: Jan 2024 --> Dec 2024
  • ||||||||||  Deep learning for 177Lu-PSMA dose prediction from pre-therapeutic 68Ga-PSMA PET/CT radiomics features (717AB (Convention Center); In-Person) -  May 8, 2024 - Abstract #SNMMI2024SNMMI_1643;    
    Our findings suggest that AI models, particularly those with higher capacities like the fully connected NN, can effectively utilize pre-therapy radiomic features to predict TIA and dose. In future works, we aim to implement predictive models that can be interpreted to identify the subset of features used to accurately predict TIA and dose.
  • ||||||||||  dobutamine / Generic mfg.
    Revolutionizing Cardiac Imaging: A Success Story with IQ SPECT and SMARTZOOM Technology (709 (Convention Center); In-Person) -  May 8, 2024 - Abstract #SNMMI2024SNMMI_1328;    
    This success story underscores the significance of these advancements in overcoming challenges associated with patients with larger body mass indices, contributing to more confident and efficient cardiac scans. Addressing these challenges becomes crucial in cardiac imaging, where precise anatomical and functional information is essential for accurate diagnosis and treatment planning.
  • ||||||||||  dobutamine / Generic mfg.
    Advancements in Myocardial Viability Assessment and Its Impact on Treatment Strategies for Post-Revascularization Recovery (Exhibit Hall D - Science Pavilion (Convention Center); Screen 12; In-Person Only) -  May 8, 2024 - Abstract #SNMMI2024SNMMI_667;    
    Identifying viable tissue within dysfunctional LV segments is crucial, as it aids in patient stratification and treatment guidance. While large randomized trials are lacking, numerous studies involving thousands of cases have provided strong evidence that revascularizing dysfunctional but viable myocardium can reverse LV remodeling, offering prognostic benefits in preventing left ventricular failure.
  • ||||||||||  dobutamine / Generic mfg.
    Myocardial Viability  (Exhibit Hall D - Science Pavilion (Convention Center); Screen 8; In-Person Only) -  May 8, 2024 - Abstract #SNMMI2024SNMMI_644;    
    Radiological imaging includes Dobutamine stress echocardiography and Contrast-Enhanced Cardiac Magnetic Resonance (CMR)... In this exhibit, we present the overview of myocardial viability in a simplified manner and demonstrate the key findings of the current imaging modalities as well as their limitations.
  • ||||||||||  methamphetamine / Generic mfg.
    Preclinical, Journal, Machine learning:  Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning. (Pubmed Central) -  May 7, 2024   
    These results indicate that neonatal systemic LPS exposure produces a persistent dopaminergic lesion leading to a long-lasting change in the brain reward system as indicated by the enhanced METH-induced behavioral sensitization and reinstated behavioral sensitization later in life. These findings indicate that early-life brain inflammation may enhance susceptibility to drug addiction development later in life, which provides new insights for developing potential therapeutic treatments for drug addiction.
  • ||||||||||  timolol maleate ophthalmic solution / Generic mfg.
    Retrospective data, Journal:  Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China. (Pubmed Central) -  May 7, 2024   
    These findings indicate that early-life brain inflammation may enhance susceptibility to drug addiction development later in life, which provides new insights for developing potential therapeutic treatments for drug addiction. ?Timolol maleate introduced by nanometer microneedles is an effective and safe treatment for superficial hemangioma in infants with the highest effective and cure rates, lower incidence of adverse reactions, and the shortest effective treatment time.
  • ||||||||||  dasotraline (SEP-225289) / Sumitomo Pharma
    Clinical, Heterogeneity:  Estimating heterogeneity of treatment effect in psychiatric clinical trials. (Pubmed Central) -  May 7, 2024   
    Significant response heterogeneity was detected in other datasets as well, often despite no difference in variance between placebo and drug arms. The implications of eHTE as a clinical trial outcomes independent from central tendency of the group is considered and the important of the eHTE method and results for drug developers, providers, and patients is discussed.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Levels of engagement among office-based opioid treatment (OBOT) patients with concurrent methamphetamine use. (Pubmed Central) -  May 7, 2024   
    The implications of eHTE as a clinical trial outcomes independent from central tendency of the group is considered and the important of the eHTE method and results for drug developers, providers, and patients is discussed. This study demonstrates the ways patients who meet criteria for OUD and MUD engage with providers to receive treatment.
  • ||||||||||  midodrine hydrochloride / Generic mfg.
    Interactive Symposium - Updates in Management of Hepatorenal Syndrome (116, Level 1) -  May 6, 2024 - Abstract #ATC2024ATC_2805;    
    This session will provide a review of the diagnostic criteria for HRS-1 and an evaluation of the literature comparing therapies for the management of HRS-1. In addition, the session will address current challenges that health systems are facing with terlipressin administration and discuss alternative treatment strategies.
  • ||||||||||  carvedilol / Generic mfg., propranolol / Generic mfg.
    Rates of Secondary Prevention of Variceal Bleeding Differ by Race and Ethnicity (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_2242;    
    While still low, Hispanics had the highest rate of NSBB use (47.4%) despite the lowest rates of competing indications for NSBB. More work is needed to understand the barriers to NSBB prescription to decrease the morbidity and mortality associated with recurrent VB.
  • ||||||||||  carvedilol / Generic mfg., propranolol / Generic mfg.
    Prevention of Recurrent Variceal Bleeding is Low among Patients with ALD Cirrhosis (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_2241;    
    While NSBB use after VB is very low overall (38%), only 15.4% of patients with ALD received secondary VB prevention. This highlights the need for aggressive intervention to target patients with cirrhosis at high risk of morbidity and mortality from recurrent VB.
  • ||||||||||  Neo-Synephrine (phenylephrine hydrochloride ophthalmic solution) / Paragon BioTeck, Bausch Health, Akorn
    Streamlined: A Case Study of Organ Donor Optimization (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_873;    
    This case demonstrates that seamless integration of interdisciplinary teams can provide optimal organ function in a brain-dead donor and produce successful outcomes in organ recovery. This streamlined process is evidence that effective communication and preparedness in both the intensive care and perioperative roles yields beneficial outcomes regarding transplant surgery.
  • ||||||||||  midodrine hydrochloride / Generic mfg.
    Pre-Transplant Midodrine Use in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_760;    
    Our findings suggest that pre-transplant midodrine use is associated with higher rates of adverse outcomes prior to kidney transplantation. These results highlight the need for detailed risk stratification during pre-transplant evaluation and optimization of the post-operative care of these KTR.
  • ||||||||||  terbutaline oral / Generic mfg.
    Terbutaline for Chronotropic Incompetence in Orthotopic Heart Transplant Recipients (Poster Hall, Exhibit Hall A, Level 2) -  May 6, 2024 - Abstract #ATC2024ATC_501;    
    Our overall PPM placement rate was low suggesting that early sinus node dysfunction can be treated with pharmacotherapy without committing to a PPM. We conclude that terbutaline can be used safely early post heart transplant.