- |||||||||| fentanyl citrate / Generic mfg.
Journal: Innovation and adaptation: The rise of a fentanyl smoking culture in San Francisco. (Pubmed Central) - May 22, 2024 However, SF overdose mortality hit a record high in 2023. Recommendations to reduce fentanyl smoking overdose risks through pacing, greater awareness of dosages consumed and checking tolerance of residue recipients are potentially viable interventions deserving further exploration.
- |||||||||| Atimos (formoterol hydrofluoroalkane inhaler) / Chiesi
Journal: Parameterization of H2SO4 and organic contributions to volatile PM in aircraft plumes at ground idle. (Pubmed Central) - May 22, 2024 While vPM is not currently a part of engine emissions certificationregulations, vPM is used in aviation environmental impact assessments and forair quality modeling in and around airports...These estimatescan be used to develop inventories and provide a better estimate of total PMemission for most aviation engines. Its use in international regulatory toolscan inform possible future regulatory actions regarding vPM.
- |||||||||| propranolol / Generic mfg.
Journal: The burden of treatment of propranolol for infantile hemangiomas: A mixed methods study. (Pubmed Central) - May 22, 2024 Out of 80 caregivers, the overall burden score was very low at 1.2 out of 10; thematic analysis of interviews grouped themes into administration, monitoring, financial, and associated anomalies. The BOT of propranolol for IH is very low but could be reduced further by offering age-based risk stratification related to feeding frequency and risk of hypoglycemia, pragmatic advice around timing of doses before sleep, and reducing frequency of vital sign monitoring.
- |||||||||| methamphetamine / Generic mfg.
Journal: Chiral analysis of amphetamine, methamphetamine, MDMA and MDA enantiomers in human hair samples. (Pubmed Central) - May 22, 2024 Additionally, the method detected co-use of methamphetamine, MDA or MDMA in some samples, highlighting its applicability in drug monitoring and real-life case scenarios within a forensic institute. This innovative analytical approach offers a sensitive and selective method for enantiomeric differentiation of amphetamine, methamphetamine, MDA and MDMA in human hair samples, providing a valuable tool for forensic and clinical investigations.
- |||||||||| Breztri Aerosphere (budesonide/formoterol fumarate/glycopyrronium) / AstraZeneca
Trial completion date, Trial initiation date: A Study to Assess the Lung Exposure Bioequivalence of Budesonide, Glycopyrronium, & Formoterol (BGF) Metered Dose Inhaler (MDI) Hydrofluoroolefin (HFO) With a Spacer (Treatment B), BGF MDI Hydrofluoroalkane (HFA) With a Spacer (Treatment A), as Well as BGF MDI HFO Without a Spacer (Treatment C) (clinicaltrials.gov) - May 22, 2024 P1, N=132, Not yet recruiting, This innovative analytical approach offers a sensitive and selective method for enantiomeric differentiation of amphetamine, methamphetamine, MDA and MDMA in human hair samples, providing a valuable tool for forensic and clinical investigations. Trial completion date: Oct 2024 --> Feb 2025 | Initiation date: Jun 2024 --> Oct 2024
- |||||||||| methamphetamine / Generic mfg.
Journal: Latinx Sexual Minority Adolescent Substance Use: State of the Science and Call for Intersectional Minority Stressors and Protective Factors. (Pubmed Central) - May 22, 2024 In terms of resilience, less is known, but there may be some protective factors that have not been measured that could explain lower rates in some substances (i.e., club drugs and methamphetamine)...Future research should assess the temporal relationship of multilevel (i.e., intrapersonal, relational, and system), intersectional (i.e., ethnicity and SM status) minority stressors and protective factors unique to LSMA on substance use. We propose that the findings from these future studies will help to create socioculturally appropriate behavioral health treatments that consider the intersectional risks and strengths within the LSMA population.
- |||||||||| methamphetamine / Generic mfg.
Journal: Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine. (Pubmed Central) - May 21, 2024 These data inform relationships between neural complexity, spectral power, and subjective states, demonstrating that increased neural complexity is not necessary or sufficient for altered states of consciousness. Future studies should address whether greater complexity after low doses of LSD is related to cognitive, behavioral, or therapeutic outcomes, and further examine the role of alpha desynchronization in mediating altered states of consciousness.
- |||||||||| dobutamine / Generic mfg.
Journal: Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery. (Pubmed Central) - May 21, 2024 Individuals with pregnancies delivered from 2008 to 2010 underwent burst-replenishment myocardial contrast echocardiography (2017-2020) to quantify myocardial perfusion at rest and during dobutamine stress...In this small study, HDP history is associated with coronary microvascular dysfunction 1 decade after delivery, findings that may, in part, be driven by metabolic factors including obesity and diabetes. Microvascular dysfunction may contribute to cardiovascular disease among individuals with a history of HDP.
- |||||||||| Review, Journal: Drugs for hypertension. (Pubmed Central) - May 21, 2024
Microvascular dysfunction may contribute to cardiovascular disease among individuals with a history of HDP. No abstract available
- |||||||||| aspirin / Generic mfg., epinephrine / Generic mfg.
Journal: PFA-100 System: A New Method for Assessment of Platelet Dysfunction. (Pubmed Central) - May 20, 2024 Previous experience has shown that CEPI cartridges detect qualitative platelet defects, including acetylsalicylic acid (ASA)-induced abnormalities, while CADP cartridges detect only thrombocytopathies and not ASA use...The data suggest that the PFA-100 system is highly accurate in discriminating normal from abnormal platelet function. The ease of operation of the instrument makes it a useful tool to use in screening patients for platelet-related hemostasis defects.
- |||||||||| ATR-258 / Atrogi
ATR-258 Is a Precision Modulator of (Poster Hall (West A4-B2); 1883) - May 20, 2024 - Abstract #ADA2024ADA_1531; ATR-258 is a ?2-AR agonist with a preferential signaling and safety profile resulting in beneficial effects on glucose homeostasis in preclinical models and a promising safety profile in humans. ATR-258 could lead the way of a new class of adrenergic agonists totreat T2D.
- |||||||||| quetiapine / Generic mfg.
Journal: Daily quetiapine after severe TBI improves learning and memory. (Pubmed Central) - May 20, 2024 Post-TBI QTP reduces brain edema and improves spatial learning and memory with a potential dose dependence impact benefiting memory up to 14 days. These data suggest an unanticipated QTP benefit following brain injury that should be specifically explored.
- |||||||||| esmolol / Generic mfg.
Trial completion: Clinical Investigation of Galnobax (clinicaltrials.gov) - May 20, 2024 P1/2, N=44, Completed, AAD prescription requires a multifaceted approach with a key consideration to prioritise safety over efficacy, being mindful of challenges in delivering optimal healthcare in a rural setting. Unknown status --> Completed
- |||||||||| methamphetamine / Generic mfg.
Review, Journal: Crystal methamphetamine and its effects on mental and oral health: A narrative review. (Pubmed Central) - May 20, 2024 For this purpose, PubMed and Google Scholar electronic databases were searched for relevant articles, yielding 115 search results, which were further scrutinized for their relevance, leaving 55 for a detailed review. The analysis of the gathered data indicates that a comprehensive patient-centered approach that takes into consideration the physical, mental, and social aspects is crucial for mitigating the detrimental effects of increasing methamphetamine use.
- |||||||||| methamphetamine / Generic mfg.
Journal: Risk of Relapse Assessment Scale for Metamphetamine Abusers: Reliability and Validity Study of the Turkish Version. (Pubmed Central) - May 20, 2024 2/df =2.13, P < .001, goodness of fit index?=?0.88, comparative fit index?=?0.92, normed fit index?=?0.86, Trucker-Lewis index?=?0.90, root mean square error of approximation?=?0.08, and standardized root mean squared residual?=?0.06. Our findings demonstrate that Risk of Relapse Assessment Scale is a valid and reliable measurement tool for assessing the risk of methamphetamine relapse in Turkish.
- |||||||||| Alenia (budesonide/formoterol) / Ache Lab
Trial completion date, Trial primary completion date, Head-to-Head: ESPIRE: A Multicenter, Randomized, Parallel, Two-Period, Non-Inferiority Study of EurofarmavsAlenia in Asthma and COPD Treatment (clinicaltrials.gov) - May 20, 2024 P3, N=472, Recruiting, Our findings demonstrate that Risk of Relapse Assessment Scale is a valid and reliable measurement tool for assessing the risk of methamphetamine relapse in Turkish. Trial completion date: Jul 2025 --> Nov 2025 | Trial primary completion date: Sep 2024 --> Mar 2025
- |||||||||| methamphetamine / Generic mfg.
Journal: Methamphetamine Poisoning After "Plugging" Intentional Recreational Rectal Use. (Pubmed Central) - May 19, 2024 There is the potential for mesenteric ischemia and bowel injury after rectal methamphetamine. Close clinical monitoring for bowel and rectal ischemia or injury are recommended, in addition to management of the sympathomimetic toxidrome.
- |||||||||| sotalol / Generic mfg.
Journal: Safety and feasibility of intravenous sotalol loading for the prevention of ventricular arrhythmias. (Pubmed Central) - May 18, 2024 IV sotalol loading appears feasible and safe for use in ventricular arrhythmias and results in a decreased length of stay. Despite increased comorbidities and greater increase in QTc interval following IV sotalol infusion in the ventricular arrhythmias group, there were no significant differences in successful completion of loading or adverse outcomes when compared to PO sotalol initiation for ventricular arrhythmias and IV loading for atrial arrhythmias.
- |||||||||| Review, Journal: Evidence for Therapeutic Drug Monitoring of Atypical Antipsychotics. (Pubmed Central) - May 18, 2024
Non-response to therapeutic doses, uncertain adherence to medication, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM of SGAs. This review aims to summarize an overview of the current knowledge and evidence of the possibilities to tailor the dosage of selected SGAs using TDM, including the necessary pharmacokinetic parameters for personalised pharmacotherapy.
- |||||||||| epinephrine / Generic mfg.
GRK3 regulates platelet function through general G protein-coupled receptor desensitization (208 A-D) - May 17, 2024 - Abstract #ISTH2024ISTH_2236; Conversely, platelet aggregation and secretion induced by the non-GPCR agonist collagen were unaffected, suggesting that GRK3 regulates GPCR-mediated platelet function. We have demonstrated earlier that ?-arrestin2 plays a central role in the regulation of GPCR-mediated platelet function.
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