Adrenergic Receptor 

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  • ||||||||||  fentanyl citrate / Generic mfg.
    Journal:  Innovation and adaptation: The rise of a fentanyl smoking culture in San Francisco. (Pubmed Central) -  May 22, 2024   
    However, SF overdose mortality hit a record high in 2023. Recommendations to reduce fentanyl smoking overdose risks through pacing, greater awareness of dosages consumed and checking tolerance of residue recipients are potentially viable interventions deserving further exploration.
  • ||||||||||  Atimos (formoterol hydrofluoroalkane inhaler) / Chiesi
    Journal:  Parameterization of H2SO4 and organic contributions to volatile PM in aircraft plumes at ground idle. (Pubmed Central) -  May 22, 2024   
    While vPM is not currently a part of engine emissions certificationregulations, vPM is used in aviation environmental impact assessments and forair quality modeling in and around airports...These estimatescan be used to develop inventories and provide a better estimate of total PMemission for most aviation engines. Its use in international regulatory toolscan inform possible future regulatory actions regarding vPM.
  • ||||||||||  propranolol / Generic mfg.
    Journal:  The burden of treatment of propranolol for infantile hemangiomas: A mixed methods study. (Pubmed Central) -  May 22, 2024   
    Out of 80 caregivers, the overall burden score was very low at 1.2 out of 10; thematic analysis of interviews grouped themes into administration, monitoring, financial, and associated anomalies. The BOT of propranolol for IH is very low but could be reduced further by offering age-based risk stratification related to feeding frequency and risk of hypoglycemia, pragmatic advice around timing of doses before sleep, and reducing frequency of vital sign monitoring.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Chiral analysis of amphetamine, methamphetamine, MDMA and MDA enantiomers in human hair samples. (Pubmed Central) -  May 22, 2024   
    Additionally, the method detected co-use of methamphetamine, MDA or MDMA in some samples, highlighting its applicability in drug monitoring and real-life case scenarios within a forensic institute. This innovative analytical approach offers a sensitive and selective method for enantiomeric differentiation of amphetamine, methamphetamine, MDA and MDMA in human hair samples, providing a valuable tool for forensic and clinical investigations.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Latinx Sexual Minority Adolescent Substance Use: State of the Science and Call for Intersectional Minority Stressors and Protective Factors. (Pubmed Central) -  May 22, 2024   
    In terms of resilience, less is known, but there may be some protective factors that have not been measured that could explain lower rates in some substances (i.e., club drugs and methamphetamine)...Future research should assess the temporal relationship of multilevel (i.e., intrapersonal, relational, and system), intersectional (i.e., ethnicity and SM status) minority stressors and protective factors unique to LSMA on substance use. We propose that the findings from these future studies will help to create socioculturally appropriate behavioral health treatments that consider the intersectional risks and strengths within the LSMA population.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine. (Pubmed Central) -  May 21, 2024   
    These data inform relationships between neural complexity, spectral power, and subjective states, demonstrating that increased neural complexity is not necessary or sufficient for altered states of consciousness. Future studies should address whether greater complexity after low doses of LSD is related to cognitive, behavioral, or therapeutic outcomes, and further examine the role of alpha desynchronization in mediating altered states of consciousness.
  • ||||||||||  dobutamine / Generic mfg.
    Journal:  Association of Hypertensive Disorders of Pregnancy With Coronary Microvascular Dysfunction 8 to 10 Years After Delivery. (Pubmed Central) -  May 21, 2024   
    Individuals with pregnancies delivered from 2008 to 2010 underwent burst-replenishment myocardial contrast echocardiography (2017-2020) to quantify myocardial perfusion at rest and during dobutamine stress...In this small study, HDP history is associated with coronary microvascular dysfunction 1 decade after delivery, findings that may, in part, be driven by metabolic factors including obesity and diabetes. Microvascular dysfunction may contribute to cardiovascular disease among individuals with a history of HDP.
  • ||||||||||  Review, Journal:  Drugs for hypertension. (Pubmed Central) -  May 21, 2024   
    Microvascular dysfunction may contribute to cardiovascular disease among individuals with a history of HDP. No abstract available
  • ||||||||||  Terlivaz (terlipressin) / Mallinckrodt
    Journal:  Safety and efficacy of continuous terlipressin infusion in HRS-AKI in a transplant population. (Pubmed Central) -  May 21, 2024   
    With continuous terlipressin infusion, a CR rate of 64% was observed with a favorable safety profile. Terlipressin use was associated with lower EOT MELD and SCr than the historical M&O/NorEpi cohort; LT-alone was accomplished in a high proportion of complete terlipressin responders.
  • ||||||||||  methamphetamine / Generic mfg.
    Trial completion date, Trial primary completion date:  PRevention Of Methamphetamine Use Among Postpartum Women Trial (PROMPT) (clinicaltrials.gov) -  May 21, 2024   
    P1,  N=40, Recruiting, 
    No abstract available Trial completion date: Apr 2025 --> Apr 2027 | Trial primary completion date: Apr 2024 --> Apr 2026
  • ||||||||||  aspirin / Generic mfg., epinephrine / Generic mfg.
    Journal:  PFA-100 System: A New Method for Assessment of Platelet Dysfunction. (Pubmed Central) -  May 20, 2024   
    Previous experience has shown that CEPI cartridges detect qualitative platelet defects, including acetylsalicylic acid (ASA)-induced abnormalities, while CADP cartridges detect only thrombocytopathies and not ASA use...The data suggest that the PFA-100 system is highly accurate in discriminating normal from abnormal platelet function. The ease of operation of the instrument makes it a useful tool to use in screening patients for platelet-related hemostasis defects.
  • ||||||||||  ATR-258 / Atrogi
    ATR-258 Is a Precision Modulator of  (Poster Hall (West A4-B2); 1883) -  May 20, 2024 - Abstract #ADA2024ADA_1531;    
    ATR-258 is a ?2-AR agonist with a preferential signaling and safety profile resulting in beneficial effects on glucose homeostasis in preclinical models and a promising safety profile in humans. ATR-258 could lead the way of a new class of adrenergic agonists totreat T2D.
  • ||||||||||  quetiapine / Generic mfg.
    Journal:  Daily quetiapine after severe TBI improves learning and memory. (Pubmed Central) -  May 20, 2024   
    Post-TBI QTP reduces brain edema and improves spatial learning and memory with a potential dose dependence impact benefiting memory up to 14 days. These data suggest an unanticipated QTP benefit following brain injury that should be specifically explored.
  • ||||||||||  esmolol / Generic mfg.
    Trial completion:  Clinical Investigation of Galnobax (clinicaltrials.gov) -  May 20, 2024   
    P1/2,  N=44, Completed, 
    AAD prescription requires a multifaceted approach with a key consideration to prioritise safety over efficacy, being mindful of challenges in delivering optimal healthcare in a rural setting. Unknown status --> Completed
  • ||||||||||  methamphetamine / Generic mfg.
    Review, Journal:  Crystal methamphetamine and its effects on mental and oral health: A narrative review. (Pubmed Central) -  May 20, 2024   
    For this purpose, PubMed and Google Scholar electronic databases were searched for relevant articles, yielding 115 search results, which were further scrutinized for their relevance, leaving 55 for a detailed review. The analysis of the gathered data indicates that a comprehensive patient-centered approach that takes into consideration the physical, mental, and social aspects is crucial for mitigating the detrimental effects of increasing methamphetamine use.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Risk of Relapse Assessment Scale for Metamphetamine Abusers: Reliability and Validity Study of the Turkish Version. (Pubmed Central) -  May 20, 2024   
    2/df =2.13, P < .001, goodness of fit index?=?0.88, comparative fit index?=?0.92, normed fit index?=?0.86, Trucker-Lewis index?=?0.90, root mean square error of approximation?=?0.08, and standardized root mean squared residual?=?0.06. Our findings demonstrate that Risk of Relapse Assessment Scale is a valid and reliable measurement tool for assessing the risk of methamphetamine relapse in Turkish.
  • ||||||||||  epinephrine / Generic mfg., dexmedetomidine / Generic mfg.
    New P4 trial:  Intrathecal Dexmedetomidine vs Epinephrine (clinicaltrials.gov) -  May 20, 2024   
    P4,  N=90, Not yet recruiting, 
  • ||||||||||  Hensify (crystalline hafnium oxide) / Nanobiotix, J&J, epinephrine / Generic mfg.
    Review, Journal, IO biomarker:  Intratumoral therapies in head and neck squamous cell carcinoma: A systematic review and future perspectives. (Pubmed Central) -  May 19, 2024   
    As of today, IT therapies lack sufficient evidence to recommend their use in clinical practice. Continuing research on potential molecules, patient selection, safe administration of injections and controlled randomized trials are needed to assess their added benefit.
  • ||||||||||  Journal:  Antipsychotic medications and sleep problems in patients with schizophrenia. (Pubmed Central) -  May 19, 2024   
    Prevalence of sleep problems is markedly related to the antipsychotic medication the patient uses. These findings underline the importance of considering and assessing sleep problems when treating schizophrenia patients with antipsychotics.
  • ||||||||||  methamphetamine / Generic mfg.
    Journal:  Methamphetamine Poisoning After "Plugging" Intentional Recreational Rectal Use. (Pubmed Central) -  May 19, 2024   
    There is the potential for mesenteric ischemia and bowel injury after rectal methamphetamine. Close clinical monitoring for bowel and rectal ischemia or injury are recommended, in addition to management of the sympathomimetic toxidrome.
  • ||||||||||  sotalol / Generic mfg.
    Journal:  Safety and feasibility of intravenous sotalol loading for the prevention of ventricular arrhythmias. (Pubmed Central) -  May 18, 2024   
    IV sotalol loading appears feasible and safe for use in ventricular arrhythmias and results in a decreased length of stay. Despite increased comorbidities and greater increase in QTc interval following IV sotalol infusion in the ventricular arrhythmias group, there were no significant differences in successful completion of loading or adverse outcomes when compared to PO sotalol initiation for ventricular arrhythmias and IV loading for atrial arrhythmias.
  • ||||||||||  Myrbetriq (mirabegron) / Astellas
    Biomarker, Journal:  Nerve Growth Factor and Brain-Derived Neurotrophic Factor as Potential Biomarkers of Mirabegron Efficacy in Patients with Overactive Bladder Syndrome. (Pubmed Central) -  May 18, 2024   
    Despite increased comorbidities and greater increase in QTc interval following IV sotalol infusion in the ventricular arrhythmias group, there were no significant differences in successful completion of loading or adverse outcomes when compared to PO sotalol initiation for ventricular arrhythmias and IV loading for atrial arrhythmias. Although both NGF/Cre and BDNF/Cre levels were significantly decreased after mirabegron treatment, only NGF/Cre levels were associated with treatment response.
  • ||||||||||  Review, Journal:  Evidence for Therapeutic Drug Monitoring of Atypical Antipsychotics. (Pubmed Central) -  May 18, 2024   
    Non-response to therapeutic doses, uncertain adherence to medication, suboptimal tolerability, or pharmacokinetic drug-drug interactions are typical indications for TDM of SGAs. This review aims to summarize an overview of the current knowledge and evidence of the possibilities to tailor the dosage of selected SGAs using TDM, including the necessary pharmacokinetic parameters for personalised pharmacotherapy.
  • ||||||||||  epinephrine / Generic mfg.
    GRK3 regulates platelet function through general G protein-coupled receptor desensitization (208 A-D) -  May 17, 2024 - Abstract #ISTH2024ISTH_2236;    
    Conversely, platelet aggregation and secretion induced by the non-GPCR agonist collagen were unaffected, suggesting that GRK3 regulates GPCR-mediated platelet function. We have demonstrated earlier that ?-arrestin2 plays a central role in the regulation of GPCR-mediated platelet function.