- |||||||||| methamphetamine / Generic mfg.
Daily Smartphone Assessments for Substance Use Measurement in a Methamphetamine Clinical Trial (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_427;
While survey completion rates were low, further investigation is needed to understand the variability of survey completion between participants. Importantly, remuneration was provided to people attending visits to complete the TLFB but 1 nothing was provided to incentivise survey completion.
- |||||||||| methamphetamine / Generic mfg.
Psychostimulant-Driven Epigenetic Alterations: Decoding Dna Damage and Repair Protein Functions (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_423;
Collectively, our data reveal that acute exposure to cocaine and METH activates protective DNA repair responses, whereas chronic exposure impairs DNA repair proteins, exacerbating DNA damage in microglia. These disruptions, coupled with altered epigenetic patterns, highlight the detrimental effects of drug abuse on DNA integrity and repair mechanisms in microglia, potentially driving neurodegeneration.
- |||||||||| methamphetamine / Generic mfg.
Integrating Substance Use Screening in 5 Rural HIV Clinics in Alabama (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_421;
Integrating screening into HIV clinics can identify patient and population level opportunities for both addiction and HIV treatment. This type of data can be used to implement tailored interventions for specific vulnerable groups, such as transgender youth.
- |||||||||| methamphetamine / Generic mfg.
Effect of Selective Adenosine 2A Receptor Antagonist on Dopamine D2 Receptor Availability in Methamphetamine Use Disorder (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_409;
This type of data can be used to implement tailored interventions for specific vulnerable groups, such as transgender youth. Subjects with methamphetamine use disorder underwent one MRI scan to define region of interest, and two PET scans with [11C]raclopride to evaluate a change of D2R availability in striatum after 2-week pharmacological intervention with istradefylline, which is selective A2AR antagonist and used as a treatment for Parkinson
- |||||||||| methamphetamine / Generic mfg.
Pre-Post Evaluation of a Toolkit to Increase Engagement in Post-Overdose Outreach Among People who Use Cocaine and Methamphetamine (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_349;
After the implementation of a post-overdose outreach toolkit for people using stimulants, the proportion of stimulant using overdose survivors identified increased moderately, whereas successful engagement) of stimulant-using overdose survivors improved substantially. Future work will investigate the impact of increased engagement on overdose prevention risk behaviors and referral to harm reduction and treatment among this population.
- |||||||||| methamphetamine / Generic mfg.
Estimating the Effective Daily Dose Ingested Among Illicit Methamphetamine Consumers in Los Angeles (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_346;
This may help explain the limited 1 efficacy of prescription stimulant treatment for methamphetamine use disorder, which typically employ considerably lower doses. These findings may also shed light on the rising incidence of methamphetamine-related sequalae, such as psychosis, cardiovascular complications, and sudden death, given the extremely high doses being ingested in practice by many consumers.
- |||||||||| methamphetamine / Generic mfg.
Prenatal Substance Use Patterns and Correlates Among People With Opioid Use Disorder (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_305;
Among pregnant individuals with OUD, those with prenatal polysubstance use exhibit more pronounced psychosocial concerns than those with primarily opioid use or no PSU. Addressing these complexities may require tailored clinical assessments and interventions to meet their unique needs.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
The Effects Buprenorphine on Fentanyl and Methamphetamine Self-Administration in Rhesus Monkeys (Napoleon Ballroom B3, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_273;
These data demonstrate that buprenorphine, particularly larger doses, attenuates the reinforcing effects of FENT and METH, suggesting that larger buprenorphine doses might be necessary to effectively treat FENT and METH co-users. Future studies will examine the effects of buprenorphine administered acutely and chronically on self-administration of FENT and METH mixtures.
- |||||||||| methamphetamine / Generic mfg.
PDE4B Inhibition and Psilocybin as Promising Approaches for Treating Methamphetamine Use Disorder: Preclinical Evidence from Rat Models (Napoleon Ballroom B3, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_272;
Using preclinical models, we evaluated the effects of 11H, a selective PDE4B inhibitor, and the prototypical PDE4 inhibitors rolipram and ibudilast on remifentanil and MA self-administration and reinstatement behaviors in male and female Sprague-Dawley rats. These findings suggest that PDE4 plays an essential role in mediating drug-seeking behavior and that PDE4 inhibitors, particularly selective PDE4B inhibitors like 11h, may be a promising approach for treating stimulant and opioid use disorders.
- |||||||||| methamphetamine / Generic mfg.
Effects of Environmental and Pharmacological Variables on Methamphetamine-Vs-Food Choice in Sprague-Dawley and Long-Evans Rats (Napoleon Ballroom B1-2, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_224;
These findings suggest that PDE4 plays an essential role in mediating drug-seeking behavior and that PDE4 inhibitors, particularly selective PDE4B inhibitors like 11h, may be a promising approach for treating stimulant and opioid use disorders. These findings provide an empirical foundation to study the pharmacology and neurobiology of methamphetamine reinforcement in a drug choice context.
- |||||||||| Chantix (varenicline) / Pfizer
Co-Use of Alcohol and Nicotine with Cocaine Reduces the Efficacy of Behavioral and Pharmacological Interventions in Nonhuman Primates (Napoleon Ballroom B3, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_210;
Our results indicate that polysubstance exposure differentially impacts drug-induced locomotor sensitization and social interaction compared to single-substance exposure in a sex-dependent manner and that treatment with DOI can reduce deficits induced by polysubstance exposure. Together, these data suggest that cocaine users who engage in polysubstance use should be viewed as a distinct and more prevalent population that requires differential behavioral and pharmacological approaches to reduce cocaine use.
- |||||||||| methamphetamine / Generic mfg.
Perceived Burden of Care in Families of Patients with Methamphetamine Use Disorder (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_189;
In conclusion, this study showed that several factors, including unemployment, are 1 significantly associated with perceived burden by the family caregiver of patients with MUD. Addressing these factors is crucial to ensure the general well-being of these family members is maintained in the process of caring for and supporting patients with MUD.
- |||||||||| methamphetamine / Generic mfg.
Comparison of Substance Use Disorder Patients (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_173;
The group of dihydrocodeine showed this tendency more markedly, and it may be related to alexithymia. However, gender and age differences may also influence these results, further investigation is required.
- |||||||||| methamphetamine / Generic mfg.
Beat Meth: Using Care Navigation to Improve Treatment Entry for Individuals with Methamphetamine Use Disorder (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_125;
Despite significant social determinant barriers, a large proportion of the intervention participants engaged with the care navigator. Preliminary findings suggest a flexible patient-centered intervention that addresses motivation, supports connection to care, and incorporates contingency management aids in supporting patients
- |||||||||| methamphetamine / Generic mfg.
Overdose Witnessing and (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_122;
Preliminary findings suggest a flexible patient-centered intervention that addresses motivation, supports connection to care, and incorporates contingency management aids in supporting patients Mental symptoms (feeling like having a panic attack, or manic or psychotic episode) 1 were commonly experienced and were associated with methamphetamine use, indicating these are common symptoms of
- |||||||||| methamphetamine / Generic mfg., methadone / Generic mfg.
Trends and Correlates of Non-Fatal Overdose and Substance Use Treatment Participation Among People who Inject Drugs in Hai Phong, Vietnam From 2016 to 2023 (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_115;
Peer-education groups participation increased but was interrupted during the COVID-19 pandemic. Despite promising trends, substance use programs should prioritize marginalized PWID, particularly those with histories of homelessness, incarceration, long-term drug use, frequent injection, and lack of insurance, in care planning and resource allocation in Vietnam.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
Risk Factors for Stimulant-And-Opioid-Involved Overdoses among People Who Use Cocaine and Other Stimulants in the Northeastern United States (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_107;
Despite promising trends, substance use programs should prioritize marginalized PWID, particularly those with histories of homelessness, incarceration, long-term drug use, frequent injection, and lack of insurance, in care planning and resource allocation in Vietnam. Aims: Despite increases in US stimulant-and-opioid-involved overdoses driven by the widespread proliferation of illicitly-manufactured fentanyl, limited research has explored people who use stimulants
- |||||||||| methamphetamine / Generic mfg.
High Variability in Methamphetamine Purity: Findings From A Community-Based Drug Checking Program in Los Angeles (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_105;
Given the cardiovascular effects of chronic methamphetamine use, future research should investigate how variability in purity may impact health outcomes. Methamphetamine was also frequently found to be an adulterant in other substances rather than a substance being adulterated, which may indicate unwitting exposure among people intending to use other drugs.
- |||||||||| fentanyl citrate / Generic mfg.
(Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_93;
Our findings highlight how shifts in drug policy and law enforcement shape the ways individuals understand the consequences of their substance use. These findings underscore the role of law enforcement as a public health tool alongside other public health and medical messaging, influencing use and treatment patterns for people who co-use.
- |||||||||| methamphetamine / Generic mfg.
Substance Use Patterns among US Adults with HIV: Identifying Priorities for Screening and Interventions (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_91;
Targeted interventions should prioritize these substances and address specific subpopulations, such as 1 middle-aged adults for methamphetamine prevention and young adults for broader substance use. Sociodemographic factors, including urban residence, gender, and racial/ethnic differences, should guide tailored prevention and treatment strategies to reduce substance use-related harms in PWH.
- |||||||||| CS-1103 / Clear Scientific
Development of CS-1103 as a First-In-Class Treatment for Methamphetamine Intoxication (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_74;
P1
Sequestration by CS-1103 represents a novel pathway for removing harmful substances from the human body. Successful completion of nonclinical efficacy and clinical safety studies of our therapeutic candidate, CS-1103, clears a significant hurdle toward conducting Phase 2 efficacy trials in humans.
- |||||||||| fentanyl citrate / Generic mfg.
Trends in Nonfatal Fentanyl Poisonings Involving Stimulants in the United States, 2015 (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_66;
Although most cocaine co-use cases were from the Northeast and the plurality of methamphetamine co-use cases were from the Midwest, significant increases were 1 identified in all regions but the West for cocaine co-use and all regions but the Northeast for methamphetamine co-use. Findings regarding the odds of experiencing a major adverse effect may suggest stimulant-specific differences in outcomes.
- |||||||||| fentanyl citrate / Generic mfg., methamphetamine / Generic mfg.
The Promise and Pitfalls of Harm Reduction Vending Machines: A Qualitative Exploration (Napoleon Ballroom CD, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_65;
However, this study demonstrates that HRVMs have their own set of unique barriers that must be taken into consideration to have the greatest impact. These findings underscore the importance of collaborating with people who use drugs when implementing novel service delivery models in the US.
- |||||||||| methamphetamine / Generic mfg.
Binge Drinkers Exhibit Blunted Rewarding Effects of Methamphetamine (Napoleon Ballroom B3, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_19;
Together, the 1 evidence suggests that a history of alcohol exposure may confer cross-tolerance to stimulant drugs, though whether this increases a propensity to stimulant use disorder e.g., via dose escalation, is unclear. Studies using self-administration protocols will provide insight and may resolve the apparent discrepancy between separate subjective response items considered analogous to
- |||||||||| methamphetamine / Generic mfg.
Novel VMAT2 Inhibitor UKY-86 Decreases Methamphetamine Self-Administration in Rats (Napoleon Ballroom B3, Third Floor) - Jun 8, 2025 - Abstract #CPDD2025CPDD_18;
With repeated dosing, UKY-86 decreased only methamphetamine SA, not cocaine SA, and tolerance did not develop to its efficacy. Additionally, UKY-86 did not serve as a reinforcer, suggesting no abuse liability.
- |||||||||| epinephrine / Generic mfg.
Journal: Real-Time Hemodynamic Responses to Epinephrine and Their Association with ROSC in Out-of-Hospital Cardiac Arrest. (Pubmed Central) - Jun 7, 2025
Further studies are required to determine if NQO2 expression levels and activity are protective mechanisms against clozapine-induced agranulocytosis or if NQO2 levels are a prognostic risk factor for clozapine-induced agranulocytosis. Greater delta DBP and delta MAP following epinephrine administration during cardiopulmonary resuscitation were associated with higher likelihood of achieving sustained ROSC in patients with OHCA.
- |||||||||| Journal: Emerging therapeutics in the management of food allergy. (Pubmed Central) - Jun 7, 2025
In this review, we outline the clinical management of food allergy, including mainstream non-pharmaceutical therapies, such as food oral immunotherapy (OIT), as well as three FDA-approved therapies: Palforzia (pharmaceutical peanut oral immunotherapy), omalizumab (anti-IgE monoclonal antibody), and Neffy (intranasal epinephrine). We also discuss emerging therapies, including novel routes of immunotherapy administration (epicutaneous, subcutaneous, sublingual, oral mucosal) and existing immunomodulatory therapies undergoing trials for use in food allergy, including dupilumab (anti-IL-4 and IL-13 monoclonal antibody), abrocitinib (oral JAK inhibitor) and abatacept (IgG-CTLA-4 fusion protein).
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