- |||||||||| vardenafil / Generic mfg., papaverine / Generic mfg., L-citrulline / Generic mfg.
Clinical, Journal: Comparison of PDE-5 inhibitors used in erectile dysfunction with some candidate molecules: A study involving molecular docking, ADMET, DFT, biological target, and activity. (Pubmed Central) - Mar 12, 2025
Additionally, NO donors such as L-arginine, L-citrulline, and ?-lipoic acid provide effective alternatives when used in combination with PDE5 inhibitors...It is important to learn more about these compounds or conduct research to improve their therapeutic efficacy. Although computer-based calculations play an important role in toxicity predictions, drug interactions, pharmacokinetics and toxicity properties should be carefully evaluated.
- |||||||||| CBT-1 (tetrandrine) / CBA Pharma
Journal: Tetrandrine alleviates macrophage activation syndrome after CAR-T cell therapy. (Pubmed Central) - Mar 12, 2025
This study identified tetrandrine as a promising therapeutic candidate for attenuating macrophage activation associated with CAR-T cell therapy and LPS/Poly I:C-induced stimulation. These findings underscore the potential of tetrandrine to mitigate toxicities after CAR-T cell therapy while ensuring its therapeutic efficacy.
- |||||||||| levosimendan oral (TNX-103) / Orion Corp, Tenax Therap
Enrollment change, Trial completion date, Trial primary completion date: LEVosimendan to Improve Exercise Limitation in Patients with PH-HFpEF (clinicaltrials.gov) - Mar 11, 2025
P3, N=230, Recruiting,
These findings underscore the potential of tetrandrine to mitigate toxicities after CAR-T cell therapy while ensuring its therapeutic efficacy. N=152 --> 230 | Trial completion date: Jul 2027 --> May 2028 | Trial primary completion date: Mar 2027 --> May 2026
- |||||||||| isradipine / Generic mfg.
GENETIC SIGNATURE STRATIFIES PD PATIENTSINTO 3 SUBGROUPS WITH DIFFERING RESPONSES IN TWO PHASE 3 TRIALS AND INDICATE MULTIPLE DISEASE BIOLOGY PATHWAYS TO PD. (Hall F2) - Mar 10, 2025 - Abstract #ADPD2025ADPD_650;
WGS and pharmacokinetic data from two disease-modifying PhaseIII trials, where testing of isradipine (STEADY-PD3) or inosine/urate (SURE-PD3) did not show efficacy in early-stage PD, were modelled for treatment and exposure effects for multiple clinical outcomes in each of the 3 subgroups...We have identified a genetic signature, relevant to PD, that stratifies PwP into three subgroups. When applied to clinical data from two previously conducted Phase 3 clinical trials, it was evident that participants with differing genetic signatures responded differently to the trial therapeutic both within and between trials.
- |||||||||| ketorolac / Generic mfg.
SINGLE-MICROGLIA TRANSCRIPTOMIC TRANSITION NETWORK-BASED PREDICTION AND REAL-WORLD PATIENT DATA VALIDATION IDENTIFIES KETOROLAC AS A REPURPOSABLE DRUG FOR ALZHEIMER (Hall B) - Mar 10, 2025 - Abstract #ADPD2025ADPD_543;
Using two independent real-world patient databases (MarketScan [172 million insured individuals] and INSIGHT Clinical Research Network [15 million patients]), we identified that usage of Ketorolac was associated with reduced AD incidence in both MarketScan (hazard ratio [HR] = 0.89) and INSIGHT (HR = 0.83) Clinical Research Network databases, mechanistically supported by Ketorolac-treated transcriptomic data from AD patient iPSC-derived microglia. Conclusions This study offers insights into the pathobiology of AD-relevant microglial subtypes and identifies Ketorolac as a potential anti-inflammatory treatment for AD.
- |||||||||| Elayta (zervimesine) / Cognition Therap
TREATMENT OF DLB AND PDD: STATUS AND NEW DEVELOPMENTS (Hall A) - Mar 10, 2025 - Abstract #ADPD2025ADPD_291;
There is however, Level 1 evidence for the use of cholinesterase inhibitors and mixed evidence for memantine for cognition in both conditions,, and for zonisamide for parkinsonism in DLB...Examples of drugs in ongoing trials based on ClinicalTrials.Gov are neflampimod, CT1812, and ambroxol, and memantine as add-on to cholinesterase inhibitor...There are currently no widely accepted DLB-specific outcome measures available, but development of such instruments is ongoing. These and other design elements will be discussed.
- |||||||||| Clinical, Journal: Persistent aura without infarction. (Pubmed Central) - Mar 10, 2025
However, an approach using zonisamide and ketamine might be beneficial. Randomized and controlled clinical trials are required for a better comprehension of the aetiopathogenesis and therapeutic approach.
- |||||||||| nifedipine immediate release / Generic mfg., labetalol / Generic mfg.
Retrospective data, Journal, Adverse events: Is there a relationship between visit-to-visit blood pressure variability and adverse perinatal outcomes? (Pubmed Central) - Mar 9, 2025
The difference in BP variability between antihypertensives may reflect varying effectiveness or factors influencing antihypertensive choice. Prospective research is needed to investigate any potential link between antihypertensive medications, BP variability and perinatal outcome.
- |||||||||| nifedipine immediate release / Generic mfg.
Review, Journal: Systematic Review of the Impact of Calcium Channel Blockers on Sperm Function. (Pubmed Central) - Mar 9, 2025
Supporting these findings, animal studies indicated that CCBs impair spermatogenesis and sperm function without necessarily affecting hormonal levels. The research suggests that the impact of CCBs on male fertility might be reversible, emphasizing the need for more extensive in vivo studies to further understand these effects and their clinical significance for patients on CCB therapy.
- |||||||||| nifedipine extended release / Generic mfg.
Journal: Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor. (Pubmed Central) - Mar 7, 2025
P=N/A
At clinical doses, cinnarizine did not reduce plasma ARR in patients with PA, and, as in vitro, was inferior to nifedipine. The limited efficacy of high-dose nifedipine may be due to incomplete Cav1.3 blockade, or to a role for non-L-type calcium channels in aldosterone secretion.
- |||||||||| verapamil / Generic mfg.
Journal: Real-time cardiomyocyte contraction sensing via a neo-flexible magnetic sensor. (Pubmed Central) - Mar 6, 2025
It also enables the quantitative assessment of cardiovascular dynamics, such as in response to drugs like isoproterenol and verapamil. Offering a uniquely simple, stable, and efficient method for evaluating drug-induced cardiotoxicity, this novel detection platform underscores the transformative potential of flexible magnetic sensors in real-time cellular detection applications.
- |||||||||| Review, Journal: From barbiturates to ganaxolone: The importance of chirality in drug development and in understanding the actions of old and new antiseizure medications. (Pubmed Central) - Mar 6, 2025
Of the 17 chiral ASMs, six (ethosuximide, fenfluramine, methsuximide, mephobarbital, stiripentol and vigabatrin) are marketed as racemates, and the remainder are licensed as enantiomerically pure medicines...We identified a number of critical knowledge gaps that are relevant to the use of chiral drugs in epilepsy, including a remarkable lack of published information on the comparative pharmacokinetics, toxicity and antiseizure activity of the enantiomers of most racemic ASMs. The importance of chirality aspects in understanding the clinical actions of racemic ASMs is discussed, together with the rationale for the development of enantiomerically pure follow-up compounds with potentially improved efficacy, safety and commercial viability.
- |||||||||| nifedipine immediate release / Generic mfg.
Journal: Alcohol consumption and ambulatory blood pressure-lowering effect in male patients on clinic blood pressure-guided antihypertensive treatment. (Pubmed Central) - Mar 4, 2025
The study participants were hypertensive (clinic systolic/diastolic BP of 140-179/90-109?mmHg and 24-hour ambulatory systolic/diastolic BP???130/80?mmHg) patients enrolled in a randomized controlled trial and treated with amlodipine 5-10?mg or nifedipine gastrointestinal therapeutic system (GITS) 30-60?mg once daily...Alcohol drinkers had higher nighttime systolic and diastolic blood pressure than non-drinkers at baseline. Clinic blood pressure-guided antihypertensive treatment was insufficient in changing the non-dipping to dipping pattern in alcohol drinkers with sustained clinic and ambulatory hypertension.
- |||||||||| nifedipine immediate release / Generic mfg.
Retrospective data, Review, Journal: Polyphenols for the Prevention or Management of Preeclampsia: A Systematic Review and Meta-Analysis. (Pubmed Central) - Mar 3, 2025
As a noninvasive therapy, auricular point acupressure has the potential to be an adjuvant therapy for noise-induced tinnitus. ECGC and resveratrol supplements have been investigated for potential effects in managing clinical signs and symptoms of preeclampsia; however, evidence on the clinical and adverse effects of polyphenols is limited and uncertain.
- |||||||||| nifedipine immediate release / Generic mfg.
Preclinical, Journal: Synaptic plasticity deficits in a mouse model of Timothy syndrome: LTP saturation and its pharmacological rescue by nifedipine. (Pubmed Central) - Mar 2, 2025
Nifedipine blocked LTP-related phosphorylation in WT mice, but normalized baseline phosphorylation of ERK, CREB and GluR1 in TS2-neo mice, allowing their subsequent activity-dependent induction. Thus, while nifedipine inhibits LTP in WT mice, the drug reinstates LTP and normal synaptic plasticity in a TS model, suggesting potential therapeutic approaches for synaptic deficits in channelopathies such as TS.
- |||||||||| nifedipine immediate release / Generic mfg., lercanidipine / Generic mfg., Lacidip (lacidipine) / Incepta Pharma
Journal: UHPLC-MS/MS method for the simultaneous quantification of five calcium channel antagonists' drugs in human plasma. (Pubmed Central) - Mar 2, 2025
Drug concentrations in the patient's serum or urine (also known as therapeutic drug monitoring, or TDM) and blood pressure measurements following supervised medication ingestion are two techniques for assessing treatment adherence. In alignment with guideline from the Food and Drug Administration (FDA) and European Medicines Agency (EMA), this study aims to design, develop, and validate a single UHPLC method for the plasma quantification of five antihypertensive drugs within the calcium channel blocker class: amlodipine, nifedipine, barnidipine, lercanidipine and lacidipine.
- |||||||||| Review, Journal: Cognitive and behavioral impact of antiseizure medications, neuromodulation, ketogenic diet, and surgery in lennox-gastaut syndrome: A comprehensive review. (Pubmed Central) - Mar 2, 2025
Behavioral outcomes also vary: stability is observed with valproate, lamotrigine, rufinamide, cannabidiol, and fenfluramine, whereas medications like levetiracetam, perampanel, brivaracetam, clobazam, and zonisamide can increase aggression or irritability...Consideration of minimizing ASM polytherapy, careful evaluation of drug-drug interactions, pharmacogenomic implications, and the need for therapeutic drug monitoring in cases of cognitive adverse effects is essential. Future research should focus on developing assessment tools tailored to the unique needs of individuals with LGS, utilizing connectivity measures to assess intervention impacts, and advancing precision therapeutics to improve cognitive and behavioral outcomes.
- |||||||||| zonisamide / Generic mfg.
PK/PD data, Journal: A new population pharmacokinetic model for dosing optimization of zonisamide in patients with refractory epilepsy. (Pubmed Central) - Mar 2, 2025
Consequently, patients receiving EIASDs require higher daily doses of zonisamide to achieve therapeutic plasma concentrations compared to those not treated with EIASDs. Model validation, using bootstrap and visual predictive checks, confirmed its stability and robustness, making it a valuable tool for individualized zonisamide dosing in adults with refractory epilepsy.
- |||||||||| amlodipine besilate / Generic mfg.
Journal: Solubility and thermodynamic properties of amlodipine besylate in two binary mixtures of n-methyl pyrrolidone + 1-propanol/2-propanol at different temperatures. (Pubmed Central) - Mar 1, 2025
In this study, the solubility of amlodipine besylate in N-methyl-pyrrolidone/1-propanol and N-methyl-pyrrolidone/2-propanol binary mixture systems were measured using a common shake-flask method followed by spectroscopy analysis at temperature ranges from 298.2 K to 313.2 K. The generated data were fitted to some models, van't Hoff, Jouyban-Acree, Jouyban-Acree-van't Hoff, mixture response surface, and modified Wilson, to mathematical representation the solubility data. Finally, the apparent thermodynamics properties for the saturated mixtures were computed using van't Hoff and Gibbs equations.
- |||||||||| sildenafil / Generic mfg., papaverine / Generic mfg., paroxetine / Generic mfg.
Journal: Investigation of Cissus populnea as a Potential Therapeutic Agent for Erectile Dysfunction. (Pubmed Central) - Mar 1, 2025
PDE5, Nitric oxide synthase (NOS) and androgen receptor (AR) genes were studied using RT-PCR on CP-treated paroxetine-induced ERDF-rats...Five (leading) compounds with induced-fit docking (IFD) scores in kcal/mol, namely, stigmasterol (-638.73), daucosterol (-644.73), furostanol (-639.29), papaverine (-639.03), and capsaicin (-642.88), had better docking scores of -9.936, -9.824, -9.064, -8.863, and -8.736?kcal/mol, respectively, compared with those of sildenafil (-8.611?kcal/mol)...The QSAR model revealed that lead compounds possess good pIC50 values. These results indicate that C. populnea is a more promising possible treatment for controlling EDRF and deserves further research.
- |||||||||| Simdax (levosimendan IV) / AbbVie
Journal: Higher vasoactive usage despite hemodynamic goals is associated with higher mortality in acute myocardial infarction-related cardiogenic shock. (Pubmed Central) - Feb 28, 2025
Further analysis showed that vasopressin was associated with the highest mortality in a time-dependent fashion [HRDay1, 8.77 (6.04-12.75)???HRDay30, 1.23 (0.8-1.87)], and levosimendan had similar behavior [HRDay1, 2.67 (1.82-3.91)???HRDay30, 0.66 (0.42-1.03)]. A significant association between the number of vasoactives and in-hospital mortality was found in AMI-CS, which requires future long-term studies to explore the role of vasoactive drug therapies and early temporary mechanical circulatory support.
- |||||||||| nifedipine immediate release / Generic mfg., losartan / Generic mfg., lisinopril / Generic mfg.
Journal: Trends in antihypertensive use among privately insured hypertensive clients in Ghana. (Pubmed Central) - Feb 27, 2025
Most single medicine products was generic (76.5% in 2016; 79.9% in 2017 and 83.1% in 2018) whiles most fixed combination products were branded (73.0% in 2016; 89.7% in 2017 and 91.3% in 2018). The patterns of AHM use are clinically expected although the Ghana Standard Treatment guidelines are not directive about lines of treatment.
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