Serotonin 

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  • ||||||||||  ketamine / Generic mfg.
    Review, Journal:  A Scoping Review: Ketamine for the Prevention of Perioperative Shivering in Patients Undergoing Spinal Anesthesia. (Pubmed Central) -  Sep 11, 2024   
    When comparing ketamine, ondansetron, and meperidine, all three were effective (p < 0.001) versus saline, with no significant difference between the three...Overall, ketamine is a safe and effective drug for the prevention of perioperative shivering. However, other drugs may be equally or more effective; therefore, patient population, hemodynamic status, patient preferences, and provider familiarity with different agents should be considered.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal:  Insertional Achilles Tendinopathy Treated With Botulinum Toxin: A Case Report. (Pubmed Central) -  Sep 11, 2024   
    Botulinum toxin A (BTX-A) has been used to treat several different musculoskeletal injuries, but there have been no published studies assessing the efficacy of BTX-A injections specifically for Achilles tendinopathy. This is a case of recalcitrant IAT treated with ultrasound-guided BTX-A.
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Integrated Long Noncoding RNA and Messenger RNA Expression Analysis Identifies Molecules Specifically Associated With Resiliency and Susceptibility to Depression and Antidepressant Response. (Pubmed Central) -  Sep 11, 2024   
    The current study explored the global expression regulation of lncRNAs and messenger RNAs (mRNAs) in the hippocampus of rats showing susceptibility (learned helplessness [LH]) or resiliency (non-LH) to depression and fluoxetine response to LH (LH+FLX)...In addition, the machine learning approach predicted lncRNA-regulated Spp2 and Olr25 genes in developing LH behavior, whereas joint analysis of mRNA-lncRNA pairs identified Mboat7, Lmod1, I l 18, and Rfx5 genes in depression-like behavior and Adam6 and Tpra1 in antidepressant response. The study shows a novel role for lncRNAs in the development of specific depression phenotypes and in identifying newer targets for therapeutic development.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Review, Journal:  Are we closer to achieving precision medicine for migraine treatment? A narrative review. (Pubmed Central) -  Sep 11, 2024   
    The published literature suggests that there are clinical and biological features which associate with, and might be useful for predicting, migraine treatment responses. To achieve precision medicine for migraine treatment, further research is needed that validates and expands on existing findings and tests the accuracy and value of migraine treatment prediction models in clinical settings.
  • ||||||||||  colchicine / Generic mfg., sertraline / Generic mfg.
    A PATH LESS TAKEN: INTUBATION TO FACILITATE MULTIDOS-ACTIVATED CHARCOAL IN TOXIC OVERDOSE (Convention Center Exhibit Hall: Poster Area 3) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_7040;    
    A high degree of clinical vigilance and prompt decontamination with MDAC and supportive care mitigates the risk of mortality. Intubation may be sometimes necessary to facilitate administration of MDAC.
  • ||||||||||  sildenafil / Generic mfg.
    SILDENAFIL-INDUCED ACUTE PSYCHOSIS IN A PATIENT WITH PULMONARY HYPERTENSION: A RARE COMPLICATION (Convention Center Exhibit Hall: Rapid Fire Area 4C) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6867;    
    When considering sildenafil, sudden onset neuropsychiatric side effects should be discussed with patients and families. Although extremely rare, psychotic symptoms tend to manifest shortly after initiation, workup is usually unremarkable, and patients gradually return to baseline with cessation of Sildenafil.
  • ||||||||||  citalopram / Generic mfg.
    A RARE CASE OF ATYPICAL SARCOIDOSIS PRESENTING AS AN INTRA-ATRIAL SEPTAL MASS (Convention Center Exhibit Hall: Rapid Fire Area 1B) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6852;    
    This case highlights the need to include CS as an important diagnosis on the differential for a patient presenting with conduction abnormalities, heart block, and dyspnea. It also accentuates the critical role of multimodality imaging in working up this disease.
  • ||||||||||  A TALE OF UNWANTED AFFLICTION: A RARE CASE REPORT (Convention Center Exhibit Hall: Poster Area 2) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6561;    
    Ciprofloxacin-induced delirium, although rare, should be included in the differential diagnosis in elderly patients presenting with delirium. Detailed clinical history, along with current medication, should be reviewed in each case before a treatment plan is made.
  • ||||||||||  Rituxan (rituximab) / Roche
    BEYOND THE NORM: A CASE OF LUPUS PSYCHOSIS (Convention Center Exhibit Hall: Rapid Fire Area 2C) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6486;    
    Our case underscores the need to consider autoimmune conditions like SLE in acute psychosis evaluations, even without apparent systemic symptoms or history. Prompt recognition and treatment of reversible causes can improve outcomes and care.
  • ||||||||||  phentermine / Generic mfg.
    USE OF PHENTERMINE FOR WEIGHT LOSS IN PULMONARY ARTERIAL HYPERTENSION PRIOR TO LUNG TRANSPLANT (Convention Center Exhibit Hall: Rapid Fire Area 4D) -  Sep 11, 2024 - Abstract #CHEST2024CHEST_6452;    
    Given the difficulty of obtaining GLP-1 agonists, alternative pharmacological agents can play a crucial role. We propose that phentermine is a safe and effective pharmacologic agent that should be considered for weight loss in pre lung transplant patients with PAH.
  • ||||||||||  Journal:  A large-scale observational comparison of antidepressants and their effects. (Pubmed Central) -  Sep 9, 2024   
    Our study reveals new insights into the varying SSRI impacts, suggesting distinct symptom profiles. This novel use of large-scale, naturalistic search data contributes to pharmacovigilance efforts, enhancing our understanding of intra-class variation among SSRIs, potentially uncovering previously unidentified drug effects.
  • ||||||||||  clozapine / Generic mfg.
    Review, Journal:  Neurolipidomics in schizophrenia: a not so well-oiled machine. (Pubmed Central) -  Sep 9, 2024   
    Lithium and clozapine have established anti-aggression properties and recent studies have linked low cholesterol levels and ultraviolet (UV) radiation with human aggression, while vitamin D3 reduces violent behaviors...In this review article, we take a closer look at aryl hydrocarbon receptor (AhR) and the dysfunctional lipidome in neuronal membranes, with emphasis on cholesterol and vitamin D3 depletion, as sources of aggressive behavior. We also discuss modalities to increase the fluidity of neuronal double layer via membrane lipid replacement (MLR) and natural or synthetic compounds.
  • ||||||||||  haloperidol / Generic mfg.
    Journal:  Investigating the Cardiotoxicity of N-n-Butyl Haloperidol Iodide: Inhibition Mechanisms on hERG Channels. (Pubmed Central) -  Sep 9, 2024   
    The results presented in this study demonstrate the potential cardiotoxicity of F2 and underscore the significance of considering hERG channel interactions during its clinical development. This study aims to provide comprehensive insights into the interaction between F2 and hERG, which will may guid us in the safe use of F2 and in the development of new derivatives with high efficiency while low toxicity.
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Overview Of a Novel Osmotin Abolishes Abnormal Metabolic-Associated Adiponectin Mechanism in Alzheimer's disease: Peripheral and CNS Insights. (Pubmed Central) -  Sep 9, 2024   
    Despite the failure of traditional treatments like memantine and cholinesterase inhibitors, natural plant bioactive substances like Osmotin (OSM) have been given a focus as potential therapeutics due to their antioxidant properties, better blood brain barrier (BBB) permeability, excellent cell viability, and especially nanoparticle approaches. The review highlights the published preclinical literature regarding the role of OSM in AD pathology while there is a need for more research to investigate the hidden therapeutic potential of OSM which may open a new gateway and further strengthen its healing role in the pathogenesis of neurodegeneration, especially AD.
  • ||||||||||  clozapine / Generic mfg.
    Retrospective data, Journal:  Increased COVID-19 mortality in patients with schizophrenia: A retrospective study in Brazil. (Pubmed Central) -  Sep 9, 2024   
    We also assessed in a logistic regression how clozapine could affect COVID-19 mortality controlling by sex, age, and presence of obesity...In Brazil, a middle-income nation, people with schizophrenia are more likely to die prematurely from COVID-19. The burden of schizophrenia is higher in younger and in patients with obesity.
  • ||||||||||  aripiprazole / Generic mfg., olanzapine / Generic mfg., amisulpride / Generic mfg.
    Journal:  Remission in schizophrenia spectrum disorders: A randomized trial of amisulpride, aripiprazole and olanzapine. (Pubmed Central) -  Sep 9, 2024   
    Negative symptoms showed the largest resistance to treatment. The lack of remission for the majority of the participants in this closely monitored antipsychotic drug trial is alarming and could act as a reminder that novel treatment principles are needed, especially targeted towards the negative symptoms in schizophrenia.
  • ||||||||||  clozapine / Generic mfg.
    Journal:  DRESS syndrome, seizures, and myocarditis on low dose clozapine - A case report. (Pubmed Central) -  Sep 9, 2024   
    The lack of remission for the majority of the participants in this closely monitored antipsychotic drug trial is alarming and could act as a reminder that novel treatment principles are needed, especially targeted towards the negative symptoms in schizophrenia. No abstract available
  • ||||||||||  fluoxetine / Generic mfg.
    Journal:  Peripheral serotonin controls dietary fat absorption and chylomicron secretion via 5-HT4 receptor in males. (Pubmed Central) -  Sep 9, 2024   
    Administration of serotonin or selective serotonin reuptake inhibitor, fluoxetine, increased postprandial plasma triglyceride (TG) and TG-rich lipoproteins (TRLs)...During the postprandial state, mRNA levels for serotonin receptors (5HTRs) were upregulated in the proximal intestine. Administration of cisapride, a 5HT4 receptor agonist, alleviated reductions in postprandial lipemia caused by serotonin synthesis inhibition, ind---icating that serotonin controls dietary fat absorption and chylomicron secretion via 5HT4 receptor.
  • ||||||||||  sertraline / Generic mfg.
    Journal:  A User-Driven Framework for Dose Selection in (Pubmed Central) -  Sep 9, 2024   
    An antenatal dose recommendation for sertraline, as a case study, was formulated using this approach and endorsed for clinical use by the working committee. Future applications of the framework for other drugs can further demonstrate its suitability for developing best evidence, acceptable and clinically feasible antenatal doses.
  • ||||||||||  memantine / Generic mfg.
    Review, Journal:  Mitigating radiation-induced cognitive toxicity in brain metastases: More questions than answers. (Pubmed Central) -  Sep 9, 2024   
    Future applications of the framework for other drugs can further demonstrate its suitability for developing best evidence, acceptable and clinically feasible antenatal doses. We thoroughly examine interventions such as memantine, hippocampal avoidance irradiation during BM treatment or in