Serotonin 

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  • ||||||||||  olanzapine / Generic mfg., clozapine / Generic mfg.
    Review, Journal:  EEG Techniques with Brain Activity Localization, Specifically LORETA, and Its Applicability in Monitoring Schizophrenia. (Pubmed Central) -  Sep 14, 2024   
    Antipsychotic drugs such as olanzapine or clozapine showed a change in P300 source density and increased activity in the delta and theta bands. Given the relatively low spatial resolution of LORETA, the method offers benefits such as accessibility, high temporal resolution, and the ability to map depth layers, emphasizing the potential of LORETA in monitoring the progression and treatment response in schizophrenia.
  • ||||||||||  imipramine / Generic mfg.
    Preclinical, Journal, IO biomarker:  Antidepressant Effects of Ginsenoside Rc on L-Alpha-Aminoadipic Acid-Induced Astrocytic Ablation and Neuroinflammation in Mice. (Pubmed Central) -  Sep 14, 2024   
    Mice were administered G-Rc, vehicle, or imipramine orally after L-AAA injection into the prefrontal cortex...Additionally, G-Rc modulated apoptosis-related proteins, decreasing caspase-3 and increasing Bcl-2 levels compared to the L-AAA-treated group. These findings suggest that G-Rc exerts antidepressant effects by regulating neuroinflammation, astrocyte-microglia crosstalk, and apoptotic pathways in the prefrontal cortex, highlighting its potential as a novel therapeutic agent for depression.
  • ||||||||||  haloperidol / Generic mfg.
    Journal:  Differential Effects of Haloperidol on Neural Oscillations During Wakefulness and Sleep. (Pubmed Central) -  Sep 14, 2024   
    Surprisingly, aperiodic activity was not significantly affected and exhibited inconsistent changes across the brain. This suggests a nuanced interplay between neuromodulation and the distinct components of brain oscillations, providing insights into the selective regulation of oscillatory dynamics in awake states.
  • ||||||||||  imipramine / Generic mfg., mianserin hydrochloride / Generic mfg.
    Journal:  Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants. (Pubmed Central) -  Sep 14, 2024   
    VMAT2 upregulation could be beneficial for disorders associated with reduced monoamine transmission, including mood disorders and BMVTD, a rare but often fatal condition caused by a lack of functional VMAT2. Our findings provide the first evidence that small molecules can upregulate VMAT2 and have potential therapeutic benefit for various neuropsychiatric conditions.
  • ||||||||||  risperidone / Generic mfg., olanzapine / Generic mfg., amantadine / Generic mfg.
    Journal:  A Case Series of Delusional Infestation in (Pubmed Central) -  Sep 13, 2024   
    The second experienced gradual resolution of DI with risperidone in the setting of iron repletion and amantadine discontinuation, although her other psychotic symptoms remained. These cases shed light on an uncommon condition and may help guide understanding of the most effective treatment for it.
  • ||||||||||  agomelatine / Generic mfg.
    Review, Journal:  Melatonergic antidepressant agomelatine: augmentation of antipsychotic drugs in treatment of post-schizophrenic depression (Pubmed Central) -  Sep 13, 2024   
    As a result, a pronounced effect was established in the indicators of respondents and patients in remission, combined with a favorable tolerability and safety profile, determining the prospects for the use of agomelatin in the therapy of PSD. Certain limitations in the methodology, including open and uncontrolled research design and small sample sizes, determine the relevance of systematic controlled trials to confirm the results obtained.
  • ||||||||||  Trintellix (vortioxetine) / Lundbeck, Takeda
    Journal:  Glial expression of Drosophila UBE3A causes spontaneous seizures that can be modulated by 5-HT signaling. (Pubmed Central) -  Sep 12, 2024   
    Here we found glial-driven dube3a flies fed the serotonin reuptake inhibitor vortioxetine and the 5-HT2A antagonist ketanserin displayed reduced immobilization and spike bursting, consistent with the previous study. Together these findings highlight the potential for glial pathophysiology to drive Dup15q syndrome-related seizure activity.
  • ||||||||||  lurasidone / Generic mfg.
    PK/PD data, Journal:  Contrasting the pharmacokinetic performance and gut microbiota effects of an amorphous solid dispersion and lipid nanoemulsion for a poorly water-soluble anti-psychotic. (Pubmed Central) -  Sep 12, 2024   
    The poorly soluble antipsychotic, lurasidone, was formulated with ASD and LNE due to its rate-limiting dissolution, poor oral bioavailability, and significant food effect...In contrast, the ASD exerted a 'gut neutral' effect, whereby a mild enrichment of alpha diversity and OTUs was observed. Importantly, this suggests that ASDs are effective solubility-enhancing formulations that can be used without comprising the integrity of the gut microbiota - an integral consideration in the treatment of mental health disorders, such as schizophrenia, due to the role of the gut microbiota in regulating mood and cognition.
  • ||||||||||  clozapine / Generic mfg.
    Preclinical, Journal:  Indole induces anxiety-like behaviour in mice mediated by brainstem locus coeruleus activation. (Pubmed Central) -  Sep 12, 2024   
    To delve deeper into the mechanistic aspects, we conducted chemogenetic activation experiments on LC norepinephrine neurons with two doses of clozapine N-oxide (CNO)...These findings support the neuroactive roles of indole in mediating gut-brain communication. It also highlights the LC as a novel hub in the gut-brain axis, encouraging further investigations.
  • ||||||||||  cisplatin / Generic mfg., memantine / Generic mfg.
    Preclinical, Journal:  Protective Effect of Memantine on Cisplatin-Induced Ototoxicity: An in Vitro Study. (Pubmed Central) -  Sep 12, 2024   
    Therefore, contezolid may hold great promise for managing this life-threatening condition. Our results suggest that memantine protects against cisplatin-induced ototoxicity in vitro, providing a potential new strategy for preventing hearing loss in patients undergoing cisplatin chemotherapy.
  • ||||||||||  Fintepla (low-dose fenfluramine) / UCB
    Journal:  Estrogen Oppositely Regulates Pulmonary Hypertension via METTL3/PFKFB3 Under Normoxia and Hypoxia. (Pubmed Central) -  Sep 12, 2024   
    Utilizing norfenfluramine- and hypoxia-induced rat models of PH, the study evaluated the impact of 17?-estradiol (E2) on PH progression...Both METTL3 and PFKFB3 proteins are upregulated in the pulmonary arteries of patients with PAH. Collectively, these findings suggest that E2 exerts differential effects on PH progression via dual regulation of the METTL3/PFKFB3 protein under normoxic and hypoxic conditions, positioning the METTL3/PFKFB3 protein as a potential therapeutic target for PH treatment.
  • ||||||||||  diphenhydramine / Generic mfg., fluoxetine / Generic mfg., cefotaxime / Generic mfg.
    Journal:  Toxicity of selected pharmaceuticals and their mixtures to the aquatic indicators Daphnia magna and Aliivibrio fischeri. (Pubmed Central) -  Sep 12, 2024   
    Additionally, three compounds (cefotaxime, polymyxin B, polymyxin E) also showed a moderate toxic effect on A. fischeri...Nonetheless, all the effects described at the acute or chronic level (for individual compounds or mixtures) were determined at concentrations higher than commonly reported at environmental levels. This work provides valuable ecotoxicological information for the risk assessment of pharmaceuticals and their mixtures in the environment.
  • ||||||||||  Botox (onabotulinumtoxin A) / GSK, AbbVie, Healis Therap
    Journal, Surgery:  Zoom Boom or Bust? Understanding Post-Pandemic Interest in Facial Plastic Surgery via Google Trends. (Pubmed Central) -  Sep 12, 2024   
    This work provides valuable ecotoxicological information for the risk assessment of pharmaceuticals and their mixtures in the environment. The "Zoom Boom" appears to be a real phenomenon reflected by sustained increase in public interest in relation to facial plastic procedures.
  • ||||||||||  Marplan (isocarboxazid) / Validus
    Review, Journal:  Antidepressant-Like Activity and Molecular Docking Analysis of a Sesquiterpene Lactone Isolated from the Root Bark of Ximenia americana (L.). (Pubmed Central) -  Sep 12, 2024   
    With a highly favorable docking score of -8.365?kcal/mol on an antidepressant target, monoamine oxidase A (MAO-A; pdb ID: 2BXS), dehydrocostus lactone (1) potentially outperforms the standard MAO-A inhibitor drug, isocarboxazid (-5.847?kcal/mol)...These findings highlight that the antidepressant-like activity of X. americana is partly attributed to the presence of dehydrocostus lactone. Additionally, it also supports the traditional medicinal use of the plant for treating depression.
  • ||||||||||  Journal:  Emergency department utilization in Veterans with spinal cord injuries & disorders. (Pubmed Central) -  Sep 11, 2024   
    Overall, more than half of Veterans with SCI/D required an ED visit during the five-year study period and over one third of Veterans in each fiscal year required an ED visit. Interventions to target prevention of ED visits and subsequent hospitalizations could focus on these areas.
  • ||||||||||  imipramine / Generic mfg., bupropion / Generic mfg., nortriptyline / Generic mfg.
    Journal:  Three safety indices for the fourteen most prescribed antidepressants in the US, 2013-2020. (Pubmed Central) -  Sep 11, 2024   
    SSRIs and SNRIs are safer than alternative agents on all measures. Bupropion exposure was as likely to cause mortality, and more likely to cause morbidity or require treatment in a healthcare facility, than TCAs nortriptyline and imipramine.